The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Optical Imaging Using Endogenous Contrast to Assess Metabolic State
Abstract
Optical microscopic imaging offers opportunities to perform noninvasive assessments of numerous parameters associated with the biochemistry, morphology, and functional state of biological samples. For example, it is possible to detect the endogenous fluorescence from a small number of important biomolecules, including NADH and FAD, which are two coenzymes involved in key metabolic pathways such as glycolysis, the Krebs cycle, and oxidative phosphorylation. Here, we review different imaging approaches to isolate the fluorescence from these chromophores in two- and three-dimensional samples and discuss the origins and potential interpretation of the observed signals in terms of cell metabolic status. Finally, we discuss the challenges and limitations of these approaches, as well as important research directions that we expect will evolve in the near future.
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Cites
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Intravital imaging by simultaneous label-free autofluorescence-multiharmonic microscopy
You, S., Tu, H., Chaney, E. J., Sun, Y., Zhao, Y., Bower, A. J., Liu, Y.-Z., Marjanovic, M., Sinha, S., Pu, Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04470-8 · Cited by 271
Metabolic Remodeling during Liver Regeneration
Caldez, M. J., Van Hul, N., Koh, H. W. L., Teo, X. Q., Fan, J. J., Tan, P. Y., Dewhurst, M. R., Too, P. G., Talib, S. Z. A., Chiang, B. E., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.09.020 · Cited by 133
Hinderer, S., Brauchle, E., & Schenke‐Layland, K. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201400762 · Cited by 68
Metadata
- Authors
- Georgakoudi, I., & Quinn, K. P.
- Venue
- Annual Review of Biomedical Engineering
- Publisher
- Annual Reviews
- Published
- 2012-08-15
- Volume
- 14
- Issue
- 1
- Pages
- 351-367
- ISSN
- 1523-9829 (ISSN-L)
- 1545-4274
- OpenAlex
- W2134479430
- Cited by
- 316
- References
- 63
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
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