The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Chromatin Regulatory Mechanisms in Pluripotency
Open accessAbstract
Stem cells of all types are characterized by a stable, heritable state permissive of multiple developmental pathways. The past five years have seen remarkable advances in understanding these heritable states and the ways that they are initiated or terminated. Transcription factors that bind directly to DNA and have sufficiency roles have been most easy to investigate and, perhaps for this reason, are most solidly implicated in pluripotency. In addition, large complexes of ATP-dependent chromatin-remodeling and histone-modification enzymes that have specialized functions have also been implicated by genetic studies in initiating and/or maintaining pluripotency or multipotency. Several of these ATP-dependent remodeling complexes play non-redundant roles, and the esBAF complex facilitates reprogramming of induced pluripotent stem cells. The recent finding that virtually all histone modifications can be rapidly reversed and are often highly dynamic has raised new questions about how histone modifications come to play a role in the steady state of pluripotency. Another surprise from genetic studies has been the frequency with which the global effects of mutations in chromatin regulators can be largely reversed by a single target gene. These genetic studies help define the arena for future mechanistic studies that might be helpful to harness pluripotency for therapeutic goals.
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Cited by
Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Clapier, C. R., Iwasa, J., Cairns, B. R., & Peterson, C. L. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.26 · Cited by 1,305
Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality
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Open chromatin in pluripotency and reprogramming
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A Precarious Balance: Pluripotency Factors as Lineage Specifiers
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Metadata
- Authors
- Lessard, J. A., & Crabtree, G. R.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2010-11-10
- Volume
- 26
- Issue
- 1
- Pages
- 503-532
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2127311430
- Cited by
- 181
- References
- 54
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
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