The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Rethinking m6A Readers, Writers, and Erasers
Open accessAbstract
In recent years, m 6 A has emerged as an abundant and dynamically regulated modification throughout the transcriptome. Recent technological advances have enabled the transcriptome-wide identification of m 6 A residues, which in turn has provided important insights into the biology and regulation of this pervasive regulatory mark. Also central to our current understanding of m 6 A are the discovery and characterization of m 6 A readers, writers, and erasers. Over the last few years, studies into the function of these proteins have led to important discoveries about the regulation and function of m 6 A. However, during this time our understanding of these proteins has also evolved considerably, sometimes leading to the reversal of early concepts regarding the reading, writing and erasing of m 6 A. In this review, we summarize recent advances in m 6 A research, and we highlight how these new findings have reshaped our understanding of how m 6 A is regulated in the transcriptome.
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Citations
Cites
N6-methyladenosine-dependent regulation of messenger RNA stability
Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., et al. (2014) · Nature · doi:10.1038/nature12730 · Cited by 4,558 · cited 8×
“…and stability, as well as the epigenetic effects of certain noncoding RNAs (Dominissini et al. 2012; Meyer et al. 2012, 2015; Patil et al. 2016; X. Wang et al. 2014, 2015; Xiao et al. 2016). m6A was first detected in poly(A) RNA fractions in 1974 (Desrosiers et al. 1974, Perry & Kelley 1974), but…”
BackgroundMethodInfluentialComprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
Meyer, K. D., Saletore, Y., Zumbo, P., Elemento, O., Mason, C. E., & Jaffrey, S. R. (2012) · Cell · doi:10.1016/j.cell.2012.05.003 · Cited by 4,223
Self-citationN6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
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“This study proposed that FTO, an enzyme previously associated with human obesity, is an m6A demethylase (Jia et al. 2011).”
BackgroundInfluentialALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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N6-methyladenosine Modulates Messenger RNA Translation Efficiency
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Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing
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m6A RNA methylation promotes XIST-mediated transcriptional repression
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Self-citationSingle-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome
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Self-citationHNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
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Cited by
Reading, writing and erasing mRNA methylation
Zaccara, S., Ries, R. J., & Jaffrey, S. R. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0168-5 · Cited by 2,597
Self-citationStem cell programs in cancer initiation, progression, and therapy resistance
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Interactions, localization, and phosphorylation of the m6A generating METTL3–METTL14–WTAP complex
Schöller, E., Weichmann, F., Treiber, T., Ringle, S., Treiber, N., Flatley, A., Feederle, R., Bruckmann, A., & Meister, G. (2018) · RNA · doi:10.1261/rna.064063.117 · Cited by 439
The molecular biology of FMRP: new insights into fragile X syndrome
Richter, J. D., & Zhao, X. (2021) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00432-0 · Cited by 390
Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay
Mugridge, J. S., Coller, J., & Gross, J. D. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0164-z · Cited by 133
Metadata
- Authors
- Meyer, K. D., & Jaffrey, S. R.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2017-10-06
- Volume
- 33
- Issue
- 1
- Pages
- 319-342
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2608560932
- Cited by
- 1,150
- References
- 11
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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