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Uniting Germline and Stem Cells: The Function of Piwi Proteins and the piRNA Pathway in Diverse Organisms
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The topipotency of the germline is the full manifestation of the pluri- and multipotency of embryonic and adult stem cells, thus the germline and stem cells must share common mechanisms that guarantee their multipotentials in development. One of the few such known shared mechanisms is represented by Piwi proteins, which constitute one of the two subfamilies of the Argonaute protein family. Piwi proteins bind to Piwi-interacting RNAs (piRNAs) that are generally 26 to 31 nucleotides in length. Both Piwi proteins and piRNAs are most abundantly expressed in the germline. Moreover, Piwi proteins are expressed broadly in certain types of somatic stem/progenitor cells and other somatic cells across animal phylogeny. Recent studies indicate that the Piwi-piRNA pathway mediates epigenetic programming and posttranscriptional regulation, which may be responsible for its function in germline specification, gametogenesis, stem cell maintenance, transposon silencing, and genome integrity in diverse organisms.
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“components of the piRNA pathway are associated with stem cell self-renewal and are aberrantly expressed in several types of somatic tumors50”
From Tau promotes neurodegeneration through global chromatin relaxation (2014) · cites this paper as [50]
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Cites
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738
Phylogeny.fr: robust phylogenetic analysis for the non-specialist
Dereeper, A., Guignon, V., Blanc, G., Audic, S., Buffet, S., Chevenet, F., Dufayard, J.-F., Guindon, S., Lefort, V., Lescot, M., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn180 · Cited by 4,700
Biogenesis of small RNAs in animals
Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 2,814
Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila
Brennecke, J., Aravin, A. A., Stark, A., Dus, M., Kellis, M., Sachidanandam, R., & Hannon, G. J. (2007) · Cell · doi:10.1016/j.cell.2007.01.043 · Cited by 2,524
Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi
Volpe, T. A., Kidner, C. A., Hall, I. M., Teng, G., Grewal, S. I. S., & Martienssen, R. A. (2002) · Science · doi:10.1126/science.1074973 · Cited by 2,055
Broad phylogenomic sampling improves resolution of the animal tree of life
Dunn, C. W., Hejnol, A., Matus, D. Q., Pang, K., Browne, W. E., Smith, S. A., Seaver, E., Rouse, G. W., Obst, M., Edgecombe, G. D., et al. (2008) · Nature · doi:10.1038/nature06614 · Cited by 1,921
Tunicates and not cephalochordates are the closest living relatives of vertebrates
Delsuc, F., Brinkmann, H., Chourrout, D., & Philippe, H. (2006) · Nature · doi:10.1038/nature04336 · Cited by 1,651
Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization
Putnam, N. H., Srivastava, M., Hellsten, U., Dirks, B., Chapman, J., Salamov, A., Terry, A., Shapiro, H., Lindquist, E., Kapitonov, V. V., et al. (2007) · Science · doi:10.1126/science.1139158 · Cited by 1,555
Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity
Song, J., Smith, S. K., Hannon, G. J., & Joshua‐Tor, L. (2004) · Science · doi:10.1126/science.1102514 · Cited by 1,531
A novel class of small RNAs bind to MILI protein in mouse testes
Aravin, A., Gaidatzis, D., Pfeffer, S., Lagos-Quintana, M., Landgraf, P., Iovino, N., Morris, P., Brownstein, M. J., Kuramochi-Miyagawa, S., Nakano, T., et al. (2006) · Nature · doi:10.1038/nature04916 · Cited by 1,516
A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline
Vagin, V. V., Sigova, A. A., Li, C., Seitz, H., Gvozdev, V. A., & Zamore, P. D. (2006) · Science · doi:10.1126/science.1129333 · Cited by 1,385
P bodies and the control of mRNA translation and degradation
Parker, R., & Sheth, U. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.011 · Cited by 1,335
RNAi-Mediated Targeting of Heterochromatin by the RITS Complex
Verdel, A., Jia, S., Gerber, S. A., Sugiyama, T., Gygi, S. P., Grewal, S. I. S., & Moazed, D. (2004) · Science · doi:10.1126/science.1093686 · Cited by 1,268
A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice
Aravin, A. A., Sachidanandam, R., Bourc’his, D., Schaefer, C. B., Pezić, D., Tóth, K. F., Bestor, T. H., & Hannon, G. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.09.003 · Cited by 1,223
A Slicer-Mediated Mechanism for Repeat-Associated siRNA 5' End Formation in Drosophila
Gunawardane, L. S., Saito, K., Nishida, K. M., Miyoshi, K., Kawamura, Y., Nagami, T., Siomi, H., & Siomi, M. C. (2007) · Science · doi:10.1126/science.1140494 · Cited by 1,173
MIWI2 Is Essential for Spermatogenesis and Repression of Transposons in the Mouse Male Germline
Carmell, M. A., Girard, A., van de Kant, H. J. G., Bourc’his, D., Bestor, T. H., de Rooij, D. G., & Hannon, G. J. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.001 · Cited by 1,170
A Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish
Houwing, S., Kamminga, L. M., Berezikov, E., Cronembold, D., Girard, A., van den Elst, H., Filippov, D. V., Blaser, H., Raz, E., Moens, C. B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.026 · Cited by 1,132
Developmentally Regulated piRNA Clusters Implicate MILI in Transposon Control
Aravin, A. A., Sachidanandam, R., Girard, A., Tóth, K. F., & Hannon, G. J. (2007) · Science · doi:10.1126/science.1142612 · Cited by 1,046
Cox, D. N., Chao, A. T., Baker, J. J., Chang, L., Qiao, D., & Lin, H. (1998) · Genes & Development · doi:10.1101/gad.12.23.3715 · Cited by 995
Self-citationCharacterization of the piRNA Complex from Rat Testes
Lau, N. C., Seto, A. G., Kim, J., Kuramochi‐Miyagawa, S., Nakano, T., Bartel, D. P., & Kingston, R. E. (2006) · Science · doi:10.1126/science.1130164 · Cited by 987
Kuramochi‐Miyagawa, S., Watanabe, T., Gotoh, K., Totoki, Y., Toyoda, A., Ikawa, M., Asada, N., Kojima, K., Yamaguchi, Y., Ijiri, T. W., et al. (2008) · Genes & Development · doi:10.1101/gad.1640708 · Cited by 963
miwi, a Murine Homolog of piwi, Encodes a Cytoplasmic Protein Essential for Spermatogenesis
Deng, W. W., & Lin, H. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00165-x · Cited by 883
Self-citationA novel class of small RNAs in mouse spermatogenic cellsPreprint
Grivna, S. T., Beyret, E., Wang, Z., & Lin, H. (2006) · Genes & Development · doi:10.1101/gad.1434406 · Cited by 874
Self-citationDistinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathwaysPreprint
岡村, 勝., Ishizuka, A., Siomi, H., & Siomi, M. C. (2004) · Genes & Development · doi:10.1101/gad.1210204 · Cited by 866
Chapman, J. A., Kirkness, E. F., Simakov, O., Hampson, S. E., Mitros, T., Weinmaier, T., Rattei, T., Balasubramanian, P. G., Borman, J., Busam, D., et al. (2010) · Nature · doi:10.1038/nature08830 · Cited by 810
Mili, a mammalian member ofpiwifamily gene, is essential for spermatogenesis
Kuramochi‐Miyagawa, S., Kimura, T., Ijiri, T. W., Isobe, T., Asada, N., Fujita, Y., Ikawa, M., Iwai, N., Okabe, M., Deng, W. W., et al. (2004) · Development · doi:10.1242/dev.00973 · Cited by 763
Self-citationEarly origins and evolution of microRNAs and Piwi-interacting RNAs in animals
Grimson, A., Srivastava, M., Fahey, B., Woodcroft, B. J., Chiang, H. R., King, N., Degnan, B. M., Rokhsar, D. S., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07415 · Cited by 756
MicroRNAs: key regulators of stem cells
Gangaraju, V. K., & Lin, H. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2621 · Cited by 751
Self-citationCharacterization of the piRNA Complex from Rat Testes
Iseni, F., Barge, A., Baudin, F., Blondel, D., Ruigrok, R. W. H., Schoehn, G., & Mavrakis, M. (2006) · Cited by 714
Phylogenomics Revives Traditional Views on Deep Animal Relationships
Philippe, H., Derelle, R., Lopez, P., Pick, K., Borchiellini, C., Boury-Esnault, N., Vacelet, J., Renard, E., Houliston, E., Quéinnec, E., et al. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.052 · Cited by 695
Lin, H., & Spradling, A. C. (1997) · Development · doi:10.1242/dev.124.12.2463 · Cited by 694
Self-citationSaito, K., Nishida, K. M., Mori, T., Kawamura, Y., Miyoshi, K., Nagami, T., Siomi, H., & Siomi, M. C. (2006) · Genes & Development · doi:10.1101/gad.1454806 · Cited by 669
Heterochromatic Silencing and HP1 Localization in Drosophila Are Dependent on the RNAi Machinery
Pal‐Bhadra, M., Leibovitch, B. A., Gandhi, S. G., Rao, M., Bhadra, U., Birchler, J. A., & Elgin, S. C. R. (2004) · Science · doi:10.1126/science.1092653 · Cited by 655
SMEDWI-2 Is a PIWI-Like Protein That Regulates Planarian Stem Cells
Reddien, P. W., Oviedo, N. J., Jennings, J. R., Jenkin, J. C., & Alvarado, A. S. (2005) · Science · doi:10.1126/science.1116110 · Cited by 631
Analysis of a piwi-Related Gene Implicates Small RNAs in Genome Rearrangement in Tetrahymena
Mochizuki, K., Fine, N. A., Fujisawa, T., & Gorovsky, M. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00909-1 · Cited by 610
Watanabe, T., Takeda, A., Tsukiyama, T., Mise, K., Okuno, T., Sasaki, H., Minami, N., & Imai, H. (2006) · Genes & Development · doi:10.1101/gad.1425706 · Cited by 589
The Biogenesis and Function of PIWI Proteins and piRNAs: Progress and Prospect
Thomson, T., & Lin, H. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175327 · Cited by 565
Self-citationCollapse of Germline piRNAs in the Absence of Argonaute3 Reveals Somatic piRNAs in Flies
Li, C., Vagin, V. V., Lee, S., Xu, J. L., Ma, S., Xi, H. S., Seitz, H., Horwich, M. D., Syrzycka, M., Honda, B. M., et al. (2009) · Cell · doi:10.1016/j.cell.2009.04.027 · Cited by 562
Cox, D. N., Chao, A. T., & Lin, H. (2000) · Development · doi:10.1242/dev.127.3.503 · Cited by 557
Self-citationOn the origin and functions of RNA-mediated silencing: from protists to man
Cerutti, H. D., & Casas-Mollano, J. A. (2006) · Current Genetics · doi:10.1007/s00294-006-0078-x · Cited by 515
Bromodeoxyuridine Specifically Labels the Regenerative Stem Cells of Planarians
Newmark, P. A., & Alvarado, A. S. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9645 · Cited by 511
Schüpbach, T., & Wieschaus, E. F. (1991) · Genetics · doi:10.1093/genetics/129.4.1119 · Cited by 510
DNA repair mediated by endonuclease-independent LINE-1 retrotransposition
Morrish, T. A., Gilbert, N., Myers, J. S., Vincent, B. J., Stamato, T. D., Taccioli, G. E., Batzer, M. A., & Moran, J. V. (2002) · Nature Genetics · doi:10.1038/ng898 · Cited by 488
Klattenhoff, C., Xi, H. S., Li, C., Lee, S., Xu, J. L., Khurana, J. S., Zhang, F., Schultz, N., Koppetsch, B. S., Nowosielska, A., et al. (2009) · Cell · doi:10.1016/j.cell.2009.07.014 · Cited by 472
Reprogramming of genome function through epigenetic inheritance
Surani, M. A. (2001) · Nature · doi:10.1038/35102186 · Cited by 453
The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members
Farazi, T. A., Juranek, S., & Tuschl, T. (2008) · Development · doi:10.1242/dev.005629 · Cited by 447
Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo
Rouget, C., Papin, C., Boureux, A., Meunier, A., Franco, B., Robine, N., Lai, E. C., Pélisson, A., & Simonelig, M. (2010) · Nature · doi:10.1038/nature09465 · Cited by 439
An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster
Yin, H., & Lin, H. (2007) · Nature · doi:10.1038/nature06263 · Cited by 424
Self-citationLet Me Count the Ways: Mechanisms of Gene Regulation by miRNAs and siRNAs
Wu, L., & Belasco, J. G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.010 · Cited by 409
tudor, a gene required for assembly of the germ plasm in Drosophila melanogaster
Boswell, R. E. (1985) · Cell · doi:10.1016/0092-8674(85)90015-7 · Cited by 409
Tethering RITS to a Nascent Transcript Initiates RNAi- and Heterochromatin-Dependent Gene Silencing
Bühler, M., Verdel, A., & Moazed, D. (2006) · Cell · doi:10.1016/j.cell.2006.04.025 · Cited by 405
Lim, A. K., & Kai, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701920104 · Cited by 385
A Broadly Conserved Pathway Generates 3′UTR-Directed Primary piRNAs
Robine, N., Lau, N. C., Balla, S., Jin, Z., Okamura, K., Kuramochi‐Miyagawa, S., Blower, M. D., & Lai, E. C. (2009) · Current Biology · doi:10.1016/j.cub.2009.11.064 · Cited by 356
Shoji, M., Tanaka, T. S. T., Hosokawa, M., Reuter, M., Stark, A., Kato, Y., Kondoh, G., Okawa, K., Chujo, T., Suzuki, T., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.10.012 · Cited by 352
Drosophila PIWI associates with chromatin and interacts directly with HP1a
Brower-Toland, B., Findley, S. D., Jiang, L., Liu, L., Yin, H., Dus, M., Zhou, P., Elgin, S. C. R., & Lin, H. (2007) · Genes & Development · doi:10.1101/gad.1564307 · Cited by 350
Self-citationThe maternal gene nanos has a central role in posterior pattern formation of the Drosophila embryo
Lehmann, R., & Nüsslein‐Volhard, C. (1991) · Development · doi:10.1242/dev.112.3.679 · Cited by 347
Kotaja, N., Bhattacharyya, S. N., Jaśkiewicz, Ł., Kimmins, S., Parvinen, M., Filipowicz, W., & Sassone‐Corsi, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509333103 · Cited by 337
Improved phylogenomic taxon sampling noticeably affects nonbilaterian relationships
Pick, K. S., Philippe, H., Schreiber, F., Erpenbeck, D., Jackson, D. J., Wrede, P., Wiens, M., Alie, A., Morgenstern, B., Manuel, M., et al. (2010) · Molecular Biology and Evolution · doi:10.1093/molbev/msq089 · Cited by 334
Zili is required for germ cell differentiation and meiosis in zebrafish
Houwing, S., Berezikov, E., & Ketting, R. F. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.204 · Cited by 331
Harris, A. N., & Macdonald, P. M. (2001) · Development · doi:10.1242/dev.128.14.2823 · Cited by 329
Grivna, S. T., Pyhtila, B., & Lin, H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605506103 · Cited by 327
Self-citationVagin, V. V., Wohlschlegel, J. A., Qu, J., Jónsson, Z. O., Huang, X., Chuma, S., Girard, A., Sachidanandam, R., Hannon, G. J., & Aravin, A. A. (2009) · Genes & Development · doi:10.1101/gad.1814809 · Cited by 323
Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians
Newmark, P. A., Reddien, P. W., Cebrià, F., & Alvarado, A. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834205100 · Cited by 302
Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in DrosophilaPreprint
Saito, K., Ishizu, H., Komai, M., Kotani, H., Kawamura, Y., Nishida, K. M., Siomi, H., & Siomi, M. C. (2010) · Genes & Development · doi:10.1101/gad.1989510 · Cited by 301
Qiao, D., Zeeman, A., Deng, W. W., Looijenga, L. H. J., & Lin, H. (2002) · Oncogene · doi:10.1038/sj.onc.1205505 · Cited by 300
Self-citationTransgenic Hydra allow in vivo tracking of individual stem cells during morphogenesis
Wittlieb, J., Khalturin, K., Lohmann, J. U., Anton‐Erxleben, F., & Bosch, T. C. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510163103 · Cited by 298
Klattenhoff, C., Bratu, D. P., McGinnis-Schultz, N., Koppetsch, B. S., Cook, H. A., & Theurkauf, W. E. (2007) · Developmental Cell · doi:10.1016/j.devcel.2006.12.001 · Cited by 297
A C. elegans Piwi, PRG-1, Regulates 21U-RNAs during Spermatogenesis
Wang, G., & Reinke, V. (2008) · Current Biology · doi:10.1016/j.cub.2008.05.009 · Cited by 297
Cytoplasmic Compartmentalization of the Fetal piRNA Pathway in Mice
Aravin, A. A., van der Heijden, G. W., Castaneda, J. M., Vagin, V. V., Hannon, G. J., & Bortvin, A. L. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000764 · Cited by 291
Germline development in vertebrates and invertebrates
Saffman, E. E., & Lasko, P. F. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050363 · Cited by 291
Baguñà, J., Saló, E., & Auladell, C. (1989) · Development · doi:10.1242/dev.107.1.77 · Cited by 287
Ectopic Expression of Germline Genes Drives Malignant Brain Tumor Growth in Drosophila
Janic, A., Mendizabal, L., Llamazares, S., Rossell, D., & González, C. (2010) · Science · doi:10.1126/science.1195481 · Cited by 266
The Role of PIWI and the miRNA Machinery in Drosophila Germline Determination
Megosh, H. B., Cox, D. N., Campbell, C. R., & Lin, H. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.051 · Cited by 266
Self-citationA conserved germline multipotency program
Juliano, C. E., Swartz, S. Z., & Wessel, G. M. (2010) · Development · doi:10.1242/dev.047969 · Cited by 265
Self-citationHsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons
Specchia, V., Piacentini, L., Tritto, P., Fanti, L., D’Alessandro, R., Palumbo, G., Pimpinelli, S., & Bozzetti, M. P. (2010) · Nature · doi:10.1038/nature08739 · Cited by 263
Reuter, M., Chuma, S., Tanaka, T. S. T., Franz, T., Stark, A., & Pillai, R. S. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1615 · Cited by 256
Lee, J. H., Schütte, D., Wulf, G. G., FÜZESI, L., Radzun, H., Schweyer, S., Engel, W., & Nayernia, K. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi430 · Cited by 251
Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability
Kirino, Y., Kim, N., Planell-Saguer, M. D., Khandros, E., Chiorean, S., Klein, P. S., Rigoutsos, I., Jongens, T. A., & Mourelatos, Z. (2009) · Nature Cell Biology · doi:10.1038/ncb1872 · Cited by 237
RNAi-dependent formation of heterochromatin and its diverse functions
Grewal, S. I. S. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.02.003 · Cited by 236
Palakodeti, D., Smielewska, M., Lu, Y.-C., Yeo, G. W.-M., & Graveley, B. R. (2008) · RNA · doi:10.1261/rna.1085008 · Cited by 235
Unhavaithaya, Y., Hao, Y., Beyret, E., Yin, H., Kuramochi‐Miyagawa, S., Nakano, T., & Lin, H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m809104200 · Cited by 225
Self-citationMochizuki, K., & Gorovsky, M. A. (2004) · Genes & Development · doi:10.1101/gad.1265105 · Cited by 214
Klenov, M. S., Lavrov, S. A., Stolyarenko, A. D., Ryazansky, S. S., Aravin, A. A., Tuschl, T., & Gvozdev, V. A. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm576 · Cited by 204
Human CD34+ stem cells express the hiwigene, a human homologue of the Drosophila genepiwi
Sharma, A. K., Nelson, M. C., Brandt, J., Wessman, M., Mahmud, N., Weller, K. P., & Hoffman, R. (2001) · Blood · doi:10.1182/blood.v97.2.426 · Cited by 199
Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines
Nishida, K. M., Okada, T. N., Kawamura, T., Mituyama, T., Kawamura, Y., Inagaki, S., Huang, H., Chen, D., Kodama, T., Siomi, H., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.365 · Cited by 197
Tudor domains in proteins that interact with RNA
Ponting, C. P. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)30049-2 · Cited by 196
Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells
Liu, X., Sun, Y. L., Guo, J., Ma, H., Li, J., Dong, B., Jin, G., Zhang, J., Wu, J. L., Lin, M., et al. (2005) · International Journal of Cancer · doi:10.1002/ijc.21575 · Cited by 195
Vasileva, A., Tiedau, D., Firooznia, A., Müller‐Reichert, T., & Jessberger, R. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.047 · Cited by 193
Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell linePreprint
Lau, N. C., Robine, N., Martin, R., Chung, W., Niki, Y., Berezikov, E., & Lai, E. C. (2009) · Genome Research · doi:10.1101/gr.094896.109 · Cited by 189
Small RNA-Mediated Quiescence of Transposable Elements in Animals
Saito, K., & Siomi, M. C. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.10.011 · Cited by 188
Chen, C., Jin, J., James, D. A., Adams-Cioaba, M. A., Park, J. G., Guo, Y., Tenaglia, E., Xu, C., Gish, G. D., Min, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911640106 · Cited by 186
Patil, V. S., & Kai, T. (2010) · Current Biology · doi:10.1016/j.cub.2010.02.046 · Cited by 178
aubergine enhances oskar translation in the Drosophila ovary
Wilson, J. E. B., Connell, J. E., & Macdonald, P. M. (1996) · Development · doi:10.1242/dev.122.5.1631 · Cited by 167
FGF signalling controls formation of the apical sensory organ in the cnidarianNematostella vectensis
Rentzsch, F., Fritzenwanker, J. H., Scholz, C. B., & Technau, U. (2008) · Development · doi:10.1242/dev.020784 · Cited by 166
Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation
Gangaraju, V. K., Yin, H., Weiner, M. M., Wang, J., Huang, X., & Lin, H. (2010) · Nature Genetics · doi:10.1038/ng.743 · Cited by 166
Self-citationLiu, Y., Mochizuki, K., & Gorovsky, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305421101 · Cited by 162
Mili Interacts with Tudor Domain-Containing Protein 1 in Regulating Spermatogenesis
Wang, J., Saxe, J. P., Tanaka, T. S. T., Chuma, S., & Lin, H. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.061 · Cited by 158
Self-citationStructural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain
Liu, K., Chen, C., Guo, Y., Lam, R., Bian, C., Xu, C., Zhao, D. Y., Jin, J., MacKenzie, F., Pawson, T. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013106107 · Cited by 157
2′- O -methylation stabilizes Piwi-associated small RNAs and ensures DNA elimination in Tetrahymena
Kurth, H. M., & Mochizuki, K. (2009) · RNA · doi:10.1261/rna.1455509 · Cited by 157
Alié, A., Leclère, L., Jager, M., Dayraud, C., Chang, P., Guyader, H. L., Quéinnec, É., & Manuel, M. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.10.019 · Cited by 147
RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis
Pan, J., Goodheart, M. L., Chuma, S., Nakatsuji, N., Page, D. C., & Wang, P. J. (2005) · Development · doi:10.1242/dev.02003 · Cited by 145
The germ line and somatic stem cell gene Cniwi in the jellyfish Podocoryne carnea.
Seipel, K., Yanze, N., & Schmid, V. J. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.15005568 · Cited by 143
Qi, H., Watanabe, T., Ku, H.-Y., Liu, N., Zhong, M., & Lin, H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.193888 · Cited by 142
Self-citationGamma radiation increases endonuclease-dependent L1 retrotransposition in a cultured cell assay
Farkash, E. A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj522 · Cited by 141
High-resolution profiling and discovery of planarian small RNAs
Friedländer, M. R., Adamidi, C., Han, T., Lebedeva, S., Isenbarger, T. A., Hirst, M., Marra, M. A., Nusbaum, C., Lee, W. L., Jenkin, J. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905222106 · Cited by 137
Structural basis for methylarginine-dependent recognition of Aubergine by TudorPreprint
Liu, H., Wang, J.-Y. S., Huang, Y., Li, Z., Gong, W., Lehmann, R., & Xu, R.-M. (2010) · Genes & Development · doi:10.1101/gad.1956010 · Cited by 134
Self-citationTaubert, H. W., Greither, T., Kaushal, D., Würl, P., Bache, M., Bartel, F., Kehlen, A., Lautenschläger, C., Harris, L. C., Kraemer, K., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209880 · Cited by 134
Denker, E., Manuel, M., Leclère, L., Guyader, H. L., & Rabet, N. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.12.023 · Cited by 130
Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization
Kirino, Y., Vourekas, A., Sayed, N., Alves, F. D. L., Thomson, T., Lasko, P. F., Rappsilber, J., Jongens, T. A., & Mourelatos, Z. (2009) · RNA · doi:10.1261/rna.1869710 · Cited by 129
Chuma, S., Hiyoshi, M., Yamamoto, A., Hosokawa, M., Takamune, K., & Nakatsuji, N. (2003) · Mechanisms of Development · doi:10.1016/s0925-4773(03)00181-3 · Cited by 117
Funayama, N., Nakatsukasa, M., Mohri, K., Masuda, Y., & Agata, K. (2010) · Evolution & Development · doi:10.1111/j.1525-142x.2010.00413.x · Cited by 116
Precancerous Stem Cells Have the Potential for both Benign and Malignant Differentiation
Chen, L., Shen, R. Z., Ye, Y., Pu, X.-A., Liu, X., Duan, W., Wen, J., Zimmerer, J., Wang, Y., Liu, Y., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000293 · Cited by 111
Self-citationLiu, L., Qi, H., Wang, J., & Lin, H. (2011) · Development · doi:10.1242/dev.059287 · Cited by 109
Self-citationRinkevich, Y., Rosner, A., Rabinowitz, C., Lapidot, Z., Moiseeva, E., & Rinkevich, B. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.05.500 · Cited by 109
Distinct Functions for the Drosophila piRNA Pathway in Genome Maintenance and Telomere Protection
Khurana, J. S., Xu, J. L., Weng, Z., & Theurkauf, W. E. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001246 · Cited by 100
Thomson, T., & Lasko, P. F. (2004) · genesis · doi:10.1002/gene.20079 · Cited by 95
Liu, J. J., Shen, R. Z., Chen, L., Ye, Y., He, G., Hua, K., Jarjoura, D. G., Nakano, T., Ramesh, G. K., Shapiro, C. L., et al. (2010) · PubMed Central · Cited by 91
Chera, S., de Rosa, R., Miljkovic‐Licina, M., Dobretz, K., Ghila, L., Kaloulis, K., & Galliot, B. (2006) · Journal of Cell Science · doi:10.1242/jcs.02807 · Cited by 90
Systematic and single cell analysis of Xenopus Piwi‐interacting RNAs and Xiwi
Lau, N. C., Ohsumi, T. K., Borowsky, M. L., Kingston, R. E., & Blower, M. D. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.237 · Cited by 90
Whole body regeneration in a colonial ascidian, Botrylloides violaceus
Brown, F. D., Keeling, E. L., Le, A. D., & Swalla, B. J. (2009) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21303 · Cited by 87
Couvillion, M., Lee, S. R., Hogstad, B., Malone, C. D., Tonkin, L. A., Sachidanandam, R., Hannon, G. J., & Collins, K. (2009) · Genes & Development · doi:10.1101/gad.1821209 · Cited by 83
Two different evolutionary origins of stem cell systems and their molecular basis
Agata, K., Nakajima, E., Funayama, N., Shibata, N., Saito, Y., & Umesono, Y. (2006) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2006.05.004 · Cited by 81
Mulder, K. D., Pfister, D., Kuales, G., Egger, B., Salvenmoser, W., Willems, M., Steger, J., Fauster, K., Micura, R., Borgonie, G., et al. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.07.019 · Cited by 80
HP1 Recruitment in the Absence of Argonaute Proteins in Drosophila
Moshkovich, N., & Lei, E. P. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000880 · Cited by 77
Dynamic nuclear reorganization during genome remodeling of Tetrahymena
Chalker, D. L. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.07.012 · Cited by 68
Cell biology of stem cells: an enigma of asymmetry and self-renewal
Lin, H. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712159 · Cited by 65
Self-citationKojima, K., Kuramochi‐Miyagawa, S., Chuma, S., Tanaka, T. S. T., Nakatsuji, N., Kimura, T., & Nakano, T. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01342.x · Cited by 64
Schwartz, J. L., Jordan, R. T., Liber, H. L., Murnane, J. P., & Evans, H. H. (2001) · Genes Chromosomes and Cancer · doi:10.1002/1098-2264(2000)9999:9999 · Cited by 27
Creed, T. M., Loganathan, S. N., Varonin, D., Jackson, C. A., & Arkov, A. L. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.10.040 · Cited by 15
The RecQ DNA helicases: Jacks-of-all-trades or master-tradesmen?
Hunter, N. M. (2008) · Cell Research · doi:10.1038/cr.2008.33 · Cited by 13
Research works printed but not linked: 1
- Liu JJ, 2010, Int. J. Clin. Exp. Pathol., 3, 328
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Metadata
- Authors
- Juliano, C., Wang, J., & Lin, H.
- Affiliations
- Yale University (US)
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2011-12-15
- Volume
- 45
- Issue
- 1
- Pages
- 447-469
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- PMC
- PMC3832951
- OpenAlex
- W2141749757
- Cited by
- 374
- References
- 130
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 20 · 2023: 12 · 2022: 18 · 2021: 21 · 2020: 26 · 2019: 38 · 2018: 34 · 2017: 31 · 2016: 20 · 2015: 26 · 2014: 38 · 2013: 38 · 2012: 26
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DP1OD006852, DP1OD006825)
- National Cancer Institute (DP1CA174418)
- National Institute of General Medical Sciences (F32GM090372)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD37760S1, R03HD042042, R01HD42042, R01HD042012, R01HD033760)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- PIWI proteins, piRNA pathway, piRNA, germline, stem cells, Argonaute proteins, epigenetic programming, post-transcriptional regulation, germline specification, gametogenesis, stem cell maintenance, transposon silencing, genome stability
- MeSH terms
- Animals, DNA Transposable Elements, Drosophila, Germ Cells, Humans, Repressor Proteins, Reproduction, RNA Processing, Post-Transcriptional, RNA, Messenger, Stem Cells, Protein Biosynthesis, Evolution, Molecular, RNA, Small Interfering, Epigenesis, Genetic, Protein Interaction Domains and Motifs, Argonaute Proteins
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