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Cited by 17Planarian Biology and ElectrostimulationDevelopmental Biology and Gene RegulationPluripotent Stem Cells Research

Regulation of genomic output and (pluri)potency in regeneration

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Duncan, Elizabeth M., Sánchez Alvarado, Alejandro·2019·Annual Review of Genetics
DOI 10.1146/annurev-genet-112618-043733PMC PMC11108649
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Abstract

Regeneration is a remarkable phenomenon that has been the subject of awe and bafflement for hundreds of years. Although regeneration competence is found in highly divergent organisms throughout the animal kingdom, recent advances in tools used for molecular and genomic characterization have uncovered common genes, molecular mechanisms, and genomic features in regenerating animals. In this review we focus on what is known about how genome regulation modulates cellular potency during regeneration. We discuss this regulation in the context of complex tissue regeneration in animals, from Hydra to humans, with reference to ex vivo–cultured cell models of pluripotency when appropriate. We emphasize the importance of a detailed molecular understanding of both the mechanisms that regulate genomic output and the functional assays that assess the biological relevance of such molecular characterizations.

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  • Genes controlling embryonic development are often reused for adult tissue repair.

    “Genes controlling embryonic development are often reused for adult tissue repair, 16,24”

    From Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers (2023) · cites this paper as [24]

    The review’s “Pioneers of Regeneration” section gives a relevant example: ascl1a is required for retinal regeneration in zebrafish, while its mammalian homolog Ascl1 has a developmental role. It does not establish the broader claim that genes controlling embryonic development are often reused for adult tissue repair; it also notes that Ascl1 is not upregulated after retinal damage in mice. No page number is available in our copy. (LLM, conf=0.78)

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Authors
Duncan, E. M., & Sánchez Alvarado, A.
Affiliations
  • University of Kentucky (US)
  • Howard Hughes Medical Institute, Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA;
ORCID
Duncan, Elizabeth M.
Venue
Annual Review of Genetics
Publisher
Annual Reviews
Published
2019-12-03
Volume
53
Issue
1
Pages
327-346
ISSN
  • 0066-4197 (ISSN-L)
  • 1545-2948
DOI
10.1146/annurev-genet-112618-043733
PMC
PMC11108649
OpenAlex
W2972854533
Cited by
17
References
7
Citations by year
2025: 2 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 3
FWCI
0.26
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of General Medical Sciences (R37GM057260)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords
regeneration, genome regulation, cellular potency, pluripotency, tissue regeneration, Hydra, molecular mechanisms of regeneration
MeSH terms
Animals, Chromatin, Histones, Humans, Hydra, Regeneration, Stem Cells, Genome, Feedback, Physiological, Pluripotent Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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