Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells
Open accessAbstract
Neuronal progenitors in the mammalian brain derive from radial glia or specialized astrocytes. In developing neural retina, radial glia-like Müller cells are generated late in neurogenesis and are not considered to be neuronal progenitors, but they do proliferate after injury and can express neuronal markers, suggesting a latent neurogenic capacity. To examine the neurogenic capacity of retinal glial cells, we used lineage tracing in transgenic zebrafish with a glial-specific promoter (gfap, for glial fibrillary acid protein) driving green fluorescent protein in differentiated Müller glia. We found that all Müller glia in the zebrafish retina express low levels of the multipotent progenitor marker Pax6 (paired box gene 6), and they proliferate at a low frequency in the intact, uninjured retina. Müller glia-derived progenitors express Crx (cone rod homeobox) and are late retinal progenitors that generate the rod photoreceptor lineage in the postembryonic retina. These Müller glia-derived progenitors also remain competent to produce earlier neuronal lineages, in that they respond to loss of cone photoreceptors by specifically regenerating the missing neurons. We conclude that zebrafish Müller glia function as multipotent retinal stem cells that generate retinal neurons by homeostatic and regenerative developmental mechanisms.
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The zebrafish retina is a useful model for uncovering how stem cells activate and astrocytes dedifferentiate because it regenerates robustly after injury and this regeneration requires Müller glia dedifferentiation.
“The zebrafish retina is an important model for revealing these mechanisms since the retina is able to mount a robust regenerative response following injury and this response is dependent on the dedifferentiation of Müller glia (MG)”
From HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration (2012) · cites this paper as Bernardos et al., 2007
Müller glia are key to successful retina regeneration.
“Key to successful retina regeneration are Müller glia (MG), the major glial cell-type in the retina (Bernardos et al., 2007; Fausett and Goldman, 2006; Fimbel et al., 2007).”
From Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration (2014) · cites this paper as Bernardos et al., 2007
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“Key to successful retina regeneration are Müller glia (MG), the major glial cell-type in the retina (Bernardos et al., 2007; Fausett and Goldman, 2006; Fimbel et al., 2007).”
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- Authors
- Bernardos, R. L., Barthel, L. K., Meyers, J. R., & Raymond, P. A.
- Affiliations
- University of Michigan (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-06-27
- Volume
- 27
- Issue
- 26
- Pages
- 7028-7040
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672216
- OpenAlex
- W2016508121
- Cited by
- 647
- References
- 60
- Citations by year
- 2026: 28 · 2025: 22 · 2024: 32 · 2023: 40 · 2022: 39 · 2021: 38 · 2020: 38 · 2019: 33 · 2018: 31 · 2017: 27 · 2016: 36 · 2015: 32 · 2014: 33 · 2013: 45 · 2012: 33
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Eye Institute (R01EY004318, F32EY017251)
- National Institute of Neurological Disorders and Stroke (F31NS047909)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Müller cells, retinal stem cells, neuronal precursors, retinal neurogenesis, zebrafish retina, Pax6, CRX, rod photoreceptors, photoreceptor regeneration, glial fibrillary acidic protein, lineage tracing, retinal homeostasis, multipotent progenitors
- MeSH terms
- Aging, Animals, Cell Differentiation, Homeostasis, Neuroglia, Neurons, Regeneration, Retina, Species Specificity, Stem Cells, Zebrafish, Cell Lineage
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