The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Pathogenesis of Human B Cell Lymphomas
Open accessAbstract
The mechanisms that drive normal B cell differentiation and activation are frequently subverted by B cell lymphomas for their unlimited growth and survival. B cells are particularly prone to malignant transformation because the machinery used for antibody diversification can cause chromosomal translocations and oncogenic mutations. The advent of functional and structural genomics has greatly accelerated our understanding of oncogenic mechanisms in lymphomagenesis. The signaling pathways that normal B cells utilize to sense antigens are frequently derailed in B cell malignancies, leading to constitutive activation of prosurvival pathways. These malignancies co-opt transcriptional regulatory systems that characterize their normal B cell counterparts and frequently alter epigenetic regulators of chromatin structure and gene expression. These mechanistic insights are ushering in an era of targeted therapies for these cancers based on the principles of pathogenesis.
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Cites
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Genetics and pathogenesis of diffuse large B-cell lymphoma
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Self-citationDynamics of B cells in germinal centres
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Metadata
- Authors
- Shaffer, A. L., Young, R. M., & Staudt, L. M.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2012-04-23
- Volume
- 30
- Issue
- 1
- Pages
- 565-610
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2116031853
- Cited by
- 437
- References
- 22
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
