The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Functional Anatomy of T Cell Activation and Synapse Formation
Open accessAbstract
T cell activation and function require a structured engagement of antigen-presenting cells. These cell contacts are characterized by two distinct dynamics in vivo: transient contacts resulting from promigratory junctions called immunological kinapses or prolonged contacts from stable junctions called immunological synapses. Kinapses operate in the steady state to allow referencing to self-peptide-MHC (pMHC) and searching for pathogen-derived pMHC. Synapses are induced by T cell receptor (TCR) interactions with agonist pMHC under specific conditions and correlate with robust immune responses that generate effector and memory T cells. High-resolution imaging has revealed that the synapse is highly coordinated, integrating cell adhesion, TCR recognition of pMHC complexes, and an array of activating and inhibitory ligands to promote or prevent T cell signaling. In this review, we examine the molecular components, geometry, and timing underlying kinapses and synapses. We integrate recent molecular and physiological data to provide a synthesis and suggest ways forward.
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Cites
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Self-citation
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CD28 Costimulation: From Mechanism to Therapy
Esensten, J. H., Helou, Y. A., Chopra, G., Weiss, A., & Bluestone, J. A. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.020 · Cited by 937
Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’
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Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums
Ravichandran, K. S. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20101157 · Cited by 549
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Self-citationBrewitz, A., Eickhoff, S., Dähling, S., Quast, T., Bedoui, S., Kroczek, R. A., Kurts, C., Garbi, N., Barchet, W., Iannacone, M., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.003 · Cited by 339
Metadata
- Authors
- Fooksman, D. R., Vardhana, S., Vasiliver-Shamis, G., Liese, J., Blair, D. A., Waite, J., Sacristán, C., Victora, G. D., Zanin-Zhorov, A., & Dustin, M. L.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2010-03-01
- Volume
- 28
- Issue
- 1
- Pages
- 79-105
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2127424425
- Cited by
- 446
- References
- 13
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- green
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