Cited by 330Inflammasome and immune disordersImmune Response and InflammationCytokine Signaling Pathways and Interactions

The DOI matches its Crossref record; 228 of the 228 references it cites were found in a registry or an index.

Inflammasome-Independent Regulation of IL-1-Family Cytokines

Open access

Netea, Mihai G., van de Veerdonk, Frank L., van der Meer, Jos W.M., Dinarello, Charles A., Joosten, Leo A.B.·2015·Annual Review of Immunology

DOI 10.1146/annurev-immunol-032414-112306

Open this paper in CoChat — free account Open PDF

Abstract

Induction, production, and release of proinflammatory cytokines are essential steps to establish an effective host defense. Cytokines of the interleukin-1 (IL-1) family induce inflammation and regulate T lymphocyte responses while also displaying homeostatic and metabolic activities. With the exception of the IL-1 receptor antagonist, all IL-1 family cytokines lack a signal peptide and require proteolytic processing into an active molecule. One such unique protease is caspase-1, which is activated by protein platforms called the inflammasomes. However, increasing evidence suggests that inflammasomes and caspase-1 are not the only mechanism for processing IL-1 cytokines. IL-1 cytokines are often released as precursors and require extracellular processing for activity. Here we review the inflammasome-independent enzymatic processes that are able to activate IL-1 cytokines, paying special attention to neutrophil-derived serine proteases, which subsequently induce inflammation and modulate host defense. The inflammasome-independent processing of IL-1 cytokines has important consequences for understanding inflammatory diseases, and it impacts the design of IL-1-based modulatory therapies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1146/annurev-immunol-032414-112306

Cites

228 of 228 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Inflammasome
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
The Inflammasomes
Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475
Biologic basis for interleukin-1 in disease.
Dinarello, C. (1996) · Blood · doi:10.1182/blood.v87.6.2095.bloodjournal8762095 · Cited by 4,344
Self-citation
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026
IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines
Schmitz, J., Owyang, A. M., Oldham, E. R., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,777
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,087
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658

Show all 228 references

Research works printed but not linked: 5

Hacham M, 2002, Eur. Cytokine Netw., 13, 55
Dinarello CA, 2000, Eur. Cytokine Netw., 11, 483
Dorresteijn MJ, 2005, Eur. Cytokine Netw., 16, 191
10.4049/jimmunol.179.10.6933 · DOI
Barankin B, 2002, Can. Fam. Physician, 48, 712

Sorted by citations

Items 101–200 of 330

New discoveries in CRMO: IL-1β, the neutrophil, and the microbiome implicated in disease pathogenesis in Pstpip2-deficient mice
Ferguson, P. J., & Laxer, R. M. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0488-2 · Cited by 55
Cytokines of the IL-1 family: recognized targets in chronic inflammation underrated in organ transplantations
Střı́ž, I. (2017) · Clinical Science · doi:10.1042/cs20170098 · Cited by 54
Differential Anti-inflammatory Activity of HDAC Inhibitors in Human Macrophages and Rat Arthritis
Lohman, R., Iyer, A., Fairlie, T., Cotterell, A. J., Gupta, P. K., Reid, R. C., Vesey, D. A., Sweet, M. J., & Fairlie, D. P. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.229328 · Cited by 53
A Guide to IL ‐1 family cytokines in adjuvanticity
Muñoz‐Wolf, N., & Lavelle, E. C. (2018) · FEBS Journal · doi:10.1111/febs.14467 · Cited by 54
Interaction of Neutrophils with Macrophages Promotes IL-1β Maturation and Contributes to Hepatic Ischemia–Reperfusion Injury
Sadatomo, A., Inoue, Y., Ito, H., Karasawa, T., Kimura, H. J., Watanabe, S., Mizushina, Y., Nakamura, J., Kamata, R., Kasahara, T., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700717 · Cited by 52
Involvement of the IL-1 system in experimental autoimmune encephalomyelitis and multiple sclerosis: Breaking the vicious cycle between IL-1β and GM-CSF
Paré, A., Mailhot, B., Lévesque, S. A., & Lacroix, S. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.146 · Cited by 51
Sputum cell IL-1 receptor expression level is a marker of airway neutrophilia and airflow obstruction in asthmatic patients
Evans, M. D., Esnault, S. J., Denlinger, L. C., & Jarjour, N. N. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.09.035 · Cited by 50
IL‐1β activation in response to Staphylococcus aureus lung infection requires inflammasome‐dependent and independent mechanisms
Pires, S., & Parker, D. (2018) · European Journal of Immunology · doi:10.1002/eji.201847556 · Cited by 51
Inflammatory Response During Myocardial Infarction
Oliveira, J., Soares, A. A. S. M., & Sposito, A. C. (2018) · Advances in clinical chemistry · doi:10.1016/bs.acc.2017.12.002 · Cited by 54
Critical role of inflammatory mast cell in fibrosis: Potential therapeutic effect of IL ‐37
Conti, P., Caraffa, A., Mastrangelo, F., Tettamanti, L., Ronconi, G., Frydas, I., Kritas, S. K., & Theoharides, T. C. (2018) · Cell Proliferation · doi:10.1111/cpr.12475 · Cited by 51
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function
Fagan, V., Johansson, C., Gileadi, C., Monteiro, O., Dunford, J. E., Nibhani, R., Philpott, M., Malzahn, J., Wells, G., Faram, R., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00562 · Cited by 50
Perspectives and Advances in the Understanding of Tuberculosis
Kinsella, R. L., Zhu, D. X., Harrison, G. A., Bridwell, A. E. M., Prusa, J., Chavez, S. M., & Stallings, C. L. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-042120-032916 · Cited by 51
CCN1 promotes IL-1β production in keratinocytes by activating p38 MAPK signaling in psoriasis
Sun, Y., Zhang, J., Zhai, T., Li, H., Li, H., Huo, R., Shen, B., Wang, B., Chen, X., Li, N., et al. (2017) · Scientific Reports · doi:10.1038/srep43310 · Cited by 48
Shared microglial mechanisms underpinning depression and chronic fatigue syndrome and their comorbidities
Chaves-Filho, A. J. M., Macêdo, D. S., de Lucena, D. F., & Maes, M. H. J. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111975 · Cited by 47
NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating the IL-1α/G-CSF axis
Bagaitkar, J., Pech, N. K., Ivanov, S., Austin, A. M., Zeng, M. Y., Pallat, S., Huang, G., Randolph, G. J., & Dinauer, M. C. (2015) · Blood · doi:10.1182/blood-2015-05-644773 · Cited by 47
Persistent effects on bovine granulosa cell transcriptome after resolution of uterine disease
Piersanti, R. L., Horlock, A. D., Block, J., Santos, J. E. P., Sheldon, I. M., & Bromfield, J. J. (2019) · Reproduction · doi:10.1530/rep-19-0037 · Cited by 47
BRAF inhibitors stimulate inflammasome activation and interleukin 1 beta production in dendritic cells
Hajek, E., Krebs, F. K., Bent, R., Haas, K., Bast, A., Steinmetz, I., Tuettenberg, A., Grabbe, S., & Bros, M. (2018) · Oncotarget · doi:10.18632/oncotarget.25511 · Cited by 46
Regulation of IL-1 signaling by the decoy receptor IL-1R2
Schlüter, T., Schelmbauer, C., Karram, K., & Mufazalov, I. A. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1684-z · Cited by 50
Clinical chorioamnionitis at term IX: in vivo evidence of intra-amniotic inflammasome activation
Gomez‐Lopez, N., Romero, R. J., Maymon, E., Kusanovic, J. P., Panaitescu, B., Miller, D., Pacora, P., Tarca, A. L., Motomura, K., Erez, O., et al. (2018) · Journal of Perinatal Medicine · doi:10.1515/jpm-2018-0271 · Cited by 46
The brain cytokine orchestra in multiple sclerosis: from neuroinflammation to synaptopathology
Amoriello, R., Memo, C., Ballerini, L., & Ballerini, C. (2024) · Molecular Brain · doi:10.1186/s13041-024-01077-7 · Cited by 47
Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia
Nanjappa, S. G., Hernández‐Santos, N., Galles, K., Wüthrich, M., Suresh, M., & Klein, B. S. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005161 · Cited by 44
Macrocyclic Compounds for Drug and Gene Delivery in Immune-Modulating Therapy
Bai, H., Wang, J., Li, Z., & Tang, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092097 · Cited by 45
Perfusate adsorption during ex vivo lung perfusion improves early post-transplant lung function
İskender, İ., Arni, S., Maeyashiki, T., Çıtak, N., Sauer, M., Rodríguez, J. M. M., Frauenfelder, T., Opitz, I., Weder, W., & İnci, İ. (2020) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2019.12.128 · Cited by 45
Glucose regulates hypoxia‐induced NLRP3 inflammasome activation in macrophages
Watanabe, S., Usui‐Kawanishi, F., Karasawa, T., Kimura, H. J., Kamata, R., Komada, T., Inoue, Y., Mise, N., Kasahara, T., & Takahashi, M. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29659 · Cited by 46
Modeling IL-1 induced degradation of articular cartilage
Kar, S., Smith, D. W., Gardiner, B. S., Li, Y., Wang, Y., & Grodzinsky, A. J. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.02.008 · Cited by 40
Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16–STING–Type I IFN Pathway and AIM2 Sensor
Liu, F., Niu, Q., Fan, X., Liu, C., Zhang, J., Wei, Z., Hou, W., Kanneganti, T., Robb, M. L., Kim, J. H., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700698 · Cited by 44
MyD88 Signaling Regulates Steady-State Migration of Intestinal CD103+ Dendritic Cells Independently of TNF-α and the Gut Microbiota
Hägerbrand, K., Westlund, J., Yrlid, U., Agace, W. W., & Johansson‐Lindbom, B. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500210 · Cited by 44
Pirfenidone attenuates gentamicin-induced acute kidney injury by inhibiting inflammasome-dependent NLRP3 pathway in rats
Sharawy, M. H., & Serrya, M. S. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118454 · Cited by 43
Early Upregulation of NLRP3 in the Brain of Neonatal Mice Exposed to Hypoxia-Ischemia: No Early Neuroprotective Effects of NLRP3 Deficiency
Ystgaard, M. B., Sejersted, Y., Løberg, E. M., Lien, E., Yndestad, A., & Saugstad, O. D. (2015) · Neonatology · doi:10.1159/000437247 · Cited by 41
Integrated Stress Response Mediates Epithelial Injury in Mechanical Ventilation
Dolinay, T., Himes, B. E., Shumyatcher, M., Lawrence, G. G., & Margulies, S. S. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0404oc · Cited by 41
MyD88-dependent pro-interleukin-1β induction in dendritic cells exposed to food-grade synthetic amorphous silica
Winkler, H. C., Kornprobst, J., Wick, P., von Moos, L. M. E., Trantakis, I. A., Schraner, E. M., Bathke, B., Hochrein, H., Suter, M., & Naegeli, H. (2017) · Particle and Fibre Toxicology · doi:10.1186/s12989-017-0202-8 · Cited by 41
Gasdermin D: Evidence of pyroptosis in spontaneous preterm labor with sterile intra‐amniotic inflammation or intra‐amniotic infection
Gomez‐Lopez, N., Romero, R. J., Tarca, A. L., Miller, D., Panaitescu, B., Schwenkel, G., Gudicha, D. W., Hassan, S. S., Pacora, P., Jung, E., et al. (2019) · American Journal of Reproductive Immunology · doi:10.1111/aji.13184 · Cited by 41
The intrinsic and extrinsic elements regulating inflammation
Mollaei, M., Abbasi, A., Hassan, Z. M., & Pakravan, N. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118258 · Cited by 43
Evodiamine Attenuates Experimental Colitis Injury Via Activating Autophagy and Inhibiting NLRP3 Inflammasome Assembly
Ding, W., Ding, Z., Wang, Y., Zhu, Y., Gao, Q., Cao, W., & Du, R. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.573870 · Cited by 45
Targeting the residual cardiovascular risk by specific anti-inflammatory interventions as a therapeutic strategy in atherosclerosis
Hafiane, A., & Daskalopoulou, S. S. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106157 · Cited by 41
ZIKV infection regulates inflammasomes pathway for replication in monocytes
Khaiboullina, S. F., Uppal, T., Sarkar, R., Gorzalski, A. J., Jeor, S. S., & Verma, S. C. (2017) · Scientific Reports · doi:10.1038/s41598-017-16072-3 · Cited by 40
Matrix Metalloproteinase-9-Dependent Release of IL-1 β by Human Eosinophils
Esnault, S. J., KELLY, E. A. B., Johnson, S. H., Delain, L. P., Haedt, M. J., Noll, A. L., Sandbo, N. K., & Jarjour, N. N. (2019) · Mediators of Inflammation · doi:10.1155/2019/7479107 · Cited by 39
The IL-1 family of cytokines. Do they have a role in scleroderma fibrosis?
Artlett, C. M. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.11.012 · Cited by 41
Mitochondrial Bioenergetics and Dynamics in Secretion Processes
Martínez, J., Marmisolle, I., Tarallo, D., & Quijano, C. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00319 · Cited by 41
In vivoevidence of inflammasome activation during spontaneous labor at term
Panaitescu, B., Romero, R. J., Gomez‐Lopez, N., Xu, Y., Leng, Y., Maymon, E., Pacora, P., Erez, O., Yeo, L., Hassan, S. S., et al. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1422714 · Cited by 36
Next-Generation Vaccine Platforms: Integrating Synthetic Biology, Nanotechnology, and Systems Immunology for Improved Immunogenicity
Eslami, M., Dowlat, B. F., Yaghmayee, S., Habibian, A., Keshavarzi, S., Oksenych, V., & Naderian, R. (2025) · Vaccines · doi:10.3390/vaccines13060588 · Cited by 44
The role of IL‐1β during human immunodeficiency virus type 1 infection
Yaseen, M. M., Abuharfeil, N. M., & Darmani, H. (2022) · Reviews in Medical Virology · doi:10.1002/rmv.2400 · Cited by 35
Inflammatory cytokine signalling in vulvovaginal candidiasis: a hot mess driving immunopathology
Cheng, K. O., Montaño, D. E., Zelante, T., Dietschmann, A., & Gresnigt, M. S. (2024) · Oxford Open Immunology · doi:10.1093/oxfimm/iqae010 · Cited by 41
Rickettsia australis Activates Inflammasome in Human and Murine Macrophages
Smalley, C. A., Bechelli, J., Rockx-Brouwer, D., Saito, T. B., Azar, S. R., Ismail, N., Walker, D. H., & Fang, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157231 · Cited by 33
Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1–Dependent Neonatal Murine Sepsis Lethality
Benjamin, J. T., Moore, D. J., Bennett, C., van der Meer, R., Royce, A., Loveland, R., & Wynn, J. L. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1801089 · Cited by 34
Anti-inflammatory effect of gold nanoparticles supported on metal oxides
Fujita, T., Zysman, M., Elgrabli, D., Murayama, T., Haruta, M., Lanone, S., Ishida, T., & Boczkowski, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-02419-4 · Cited by 34
Effects of Warm Versus Cold Ischemic Donor Lung Preservation on the Underlying Mechanisms of Injuries During Ischemia and Reperfusion
İskender, İ., Cypel, M., Martinu, T., Chen, M., Sakamoto, J., Kim, H., Yu, K., Lin, H., Guan, Z., Hashimoto, K., et al. (2018) · Transplantation · doi:10.1097/tp.0000000000002140 · Cited by 36
Long-term cigarette smoking suppresses NLRP3 inflammasome activation in oral mucosal epithelium and attenuates host defense against Candida albicans in a rat model
Ye, P., Wang, X., Ge, S., Chen, W., Wang, W., & Han, X. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.01.058 · Cited by 33
Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes
Chéneau, C., Eichholz, K., Tran, T. H., Tran, T. T. P., Paris, O., Henriquet, C., Bajramovic, J. J., Pugnière, M., & Kremer, E. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.685218 · Cited by 31
The pathophysiologic basis of abdominal aortic aneurysm progression: a critical appraisal
Lindeman, J. H. N. (2015) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2015.1052408 · Cited by 32
Amyloidogenic proteins associated with neurodegenerative diseases activate the NLRP3 inflammasome
Shao, Q.-H., Zhang, X., Yang, P., Yuan, Y., & Chen, N. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.05.027 · Cited by 33
Inhibition of Inflammasome-Dependent Interleukin 1β Production by Streptococcal NAD + -Glycohydrolase: Evidence for Extracellular Activity
Hancz, D., Westerlund, E., Bastiat, B., Sharma, O., Valfridsson, C., Meyer, L., Love, J. F., O’Seaghdha, M., Wessels, M. R., & Persson, J. (2017) · mBio · doi:10.1128/mbio.00756-17 · Cited by 32
Zinc finger protein 91 positively regulates the production of IL‐1β in macrophages by activation of MAPKs and non‐canonical caspase‐8 inflammasome
Mi, C., Wang, Z., Li, M. Y., Zhang, Z. H., Ma, J., & Jin, X. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14493 · Cited by 32
‘Prototypical’ proinflammatory cytokine (IL-1) in multiple sclerosis: role in pathogenesis and therapeutic targeting
Musella, A., Fresegna, D., Rizzo, F. R., Gentile, A., Vito, F. D., Caioli, S., Guadalupi, L., Bruno, A., Dolcetti, E., Buttari, F., et al. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1709823 · Cited by 33
Leukotriene B 4 licenses inflammasome activation to enhance skin host defense
Salina, A. C. G., Brandt, S. L., Klopfenstein, N., Blackman, A., Bazzano, J. M. R., Sá‐Nunes, A., Glosson, N. L., Brodskyn, C., Tavares, N. M., Bonyek-Silva, Í., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002732117 · Cited by 32
TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling
Kumar, S. R. P., Biswas, M., Cao, D., Arisa, S., Muñoz-Melero, M., Lam, A. K., Piñeros, A. R., Kapur, R., Kaisho, T., Kaufman, R. J., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2023.11.029 · Cited by 31
Metabolism-inflammasome crosstalk shapes innate and adaptive immunity
Wu, J., Sun, X., & Jiang, P. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.04.006 · Cited by 32
Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells
Tran, T. T. P., Eichholz, K., Amelio, P., Moyer, C. L., Nemerow, G. R., Perreau, M., Mennechet, F. J. D., & Kremer, E. J. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007127 · Cited by 30
The effect of NLRP inflammasome on the regulation of AGE s‐induced inflammatory response in human periodontal ligament cells
Yi, X., Zhang, L., Lu, W., Tan, X., Yue, J., Wang, P., Xu, W., Ye, L., & Huang, D. (2019) · Journal of Periodontal Research · doi:10.1111/jre.12677 · Cited by 30
Calciprotein Particles Induce IL-1β/α–Mediated Inflammation through NLRP3 Inflammasome-Dependent and -Independent Mechanisms
Anzai, F., Karasawa, T., Komada, T., Yamada, N., Miura, Y., Sampilvanjil, A., Baatarjav, C., Fujimura, K., Matsumura, T., Tago, K., et al. (2021) · ImmunoHorizons · doi:10.4049/immunohorizons.2100066 · Cited by 31
Hyperamylinemia Increases IL-1β Synthesis in the Heart via Peroxidative Sarcolemmal Injury
Liu, M., Verma, N., Peng, X., Srodulski, S. J., Morris, A. J., Chow, M., Hersh, L. B., Chen, J., Zhu, H., Netea, M. G., et al. (2016) · Diabetes · doi:10.2337/db16-0044 · Cited by 31
Self-citation
Imbalanced production of IL-18 and its antagonist in human diseases, and its implications for HIV-1 infection
Samarani, S., Allam, O., Sagala, P., Aldabah, Z., Jenabian, M.-A., Mehraj, V., Tremblay, C. L., Routy, J., Amre, D. K., & Ahmad, A. (2016) · Cytokine · doi:10.1016/j.cyto.2016.01.006 · Cited by 31
Adenosine Triphosphate Release is Required for Toll-Like Receptor-Induced Monocyte/Macrophage Activation, Inflammasome Signaling, Interleukin-1β Production, and the Host Immune Response to Infection
Lee, A. H., Ledderose, C., Li, X., Slubowski, C. J., Sueyoshi, K., Staudenmaier, L., Bao, Y., Zhang, J., & JUNGER, W. G. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003446 · Cited by 29
IFN-τ Attenuates LPS-Induced Endometritis by Restraining HMGB1/NF-κB Activation in bEECs
Liu, J., Wu, Z., Guo, S., Zhang, T., Ma, X., Jiang, K., Guo, X., & Deng, G. (2021) · Inflammation · doi:10.1007/s10753-021-01433-y · Cited by 30
Lactobacillus reuteri supplements do not affect salivary IgA or cytokine levels in healthy subjects: A randomized, double-blind, placebo-controlled, cross-over trial
Jørgensen, M. R., Keller, M. K., Kragelund, C., Hamberg, K., Ericson, D., Nielsen, C. H., & Twetman, S. H. A. (2016) · Acta Odontologica Scandinavica · doi:10.3109/00016357.2016.1169439 · Cited by 30
Specific pathways mediating inflammasome activation by Candida parapsilosis
Tóth, A., Zajta, E., Csonka, K., Vágvölgyi, C., Netea, M. G., & Gácser, A. (2017) · Scientific Reports · doi:10.1038/srep43129 · Cited by 31
Self-citation
Bile acids induce IL-1α and drive NLRP3 inflammasome-independent production of IL-1β in murine dendritic cells
Oleszycka, E., O’Brien, E. C., Freeley, M., Lavelle, E. C., & Long, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1285357 · Cited by 29
Photobiomodulation with 670 nm light ameliorates Müller cell-mediated activation of microglia and macrophages in retinal degeneration
Lu, Y., Natoli, R., Madigan, M. C., Fernando, N., Saxena, K., Aggio‐Bruce, R., Jiao, H., Provis, J. M., & Valter, K. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2017.09.002 · Cited by 29
Transcriptome Profiling Reveals Pro-Inflammatory Cytokines and Matrix Metalloproteinase Activation in Zika Virus Infected Human Umbilical Vein Endothelial Cells
Khaiboullina, S. F., Uppal, T., Kletenkov, K., Jeor, S. C. S., Garanina, E. E., Rizvanov, A. A., & Verma, S. C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00642 · Cited by 28
NLRP6‐caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation
Tian, X., Li, R., Liu, C., Liu, F., Yang, L., Wang, S. P., & Wang, C. (2020) · International Endodontic Journal · doi:10.1111/iej.13469 · Cited by 28
IRAK 1 variant is protective for orthodontic‐induced external apical root resorption
Pereira, S. A., Nogueira, L., Canova, F., Lopez, M., & Silva, H. C. (2016) · Oral Diseases · doi:10.1111/odi.12514 · Cited by 28
Cytokine targeting in rheumatoid arthritis
Bui, V. L., & Brahn, E. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.04.001 · Cited by 28
Tuning the transformation and cellular signaling of 2D titanium carbide MXenes using a natural antioxidant
Malina, T., Hamawandi, B., Toprak, M. S., Chen, L., Björk, J., Zhou, J., Rosén, J., & Fadeel, B. (2023) · Matter · doi:10.1016/j.matt.2023.10.026 · Cited by 29
Dracorhodin targeting CMPK2 attenuates inflammation: A novel approach to sepsis therapy
Zhang, W., Jiang, H., Huang, P., Wu, G., Wang, Q., Luan, X., Zhang, H., Yu, D., Wang, H., Lu, D., et al. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1449 · Cited by 26
Inflammasome-Independent and Atypical Processing of IL-1β Contributes to Acid Aspiration–Induced Acute Lung Injury
Mizushina, Y., Karasawa, T., Aizawa, K., Kimura, H. J., Watanabe, S., Kamata, R., Komada, T., Mato, N., Kasahara, T., Koyama, S., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900168 · Cited by 27
Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity
Kimura, H. J., Karasawa, T., Usui, F., Kawashima, A., Endo, Y., Kobayashi, M., Sadatomo, A., Nakamura, J., Iwasaki, Y., Yada, T., et al. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00174.2016 · Cited by 26
Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema
Ruwanpura, S. M., McLeod, L., Dousha, L. F., Seow, H. J., West, A. C., West, A. J., Weng, T., Alanazi, M. A., MacDonald, M., King, P. T., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201494119 · Cited by 26
NLRP6 deficiency aggravates liver injury after allogeneic hematopoietic stem cell transplantation
Li, M., Chen, Y., Shi, J.-R., Ju, W., Qi, K., Fu, C., Li, Z., Zhang, X., Qiao, J., Xu, K., et al. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105740 · Cited by 26
Elevation of serum interleukin-1β levels as a potential indicator for malarial infection and severe malaria: a meta-analysis
Mahittikorn, A., Kwankaew, P., Rattaprasert, P., Kotepui, K. U., Masangkay, F. R., & Kotepui, M. (2022) · Malaria Journal · doi:10.1186/s12936-022-04325-0 · Cited by 25
Cytokines, Vascular Endothelial Growth Factors, and PlGF in Autoimmunity: Insights From Rheumatoid Arthritis to Multiple Sclerosis
Lee, Y., Lee, S., & Kim, W. (2024) · Immune Network · doi:10.4110/in.2024.24.e10 · Cited by 25
IL-1 family cytokines in cancer immunity – a matter of life and death
Mora, J., & Weigert, A. (2016) · Biological Chemistry · doi:10.1515/hsz-2016-0215 · Cited by 25
Major surgery leads to a proinflammatory phenotype: Differential gene expression following a laparotomy
Dobson, G. P., Morris, J. L., Biroš, E., Davenport, L. M., & Letson, H. L. (2021) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2021.102970 · Cited by 24
Expansion of Th17 Cells by Human Mast Cells Is Driven by Inflammasome-Independent IL-1β
Suurmond, J., Habets, K. L. L., Dorjée, A. L., Huizinga, T. W. J., & Toes, R. E. M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502640 · Cited by 24
Manual Acupuncture Suppresses the Expression of Proinflammatory Proteins Associated with the NLRP3 Inflammasome in the Hippocampus of SAMP8 Mice
Ding, N., Jiang, J. H., Lu, M., Hu, J., Xu, Y., Liu, X., & Li, Z. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/3435891 · Cited by 24
Pyroptosis Induction and Detection
den Hartigh, A. B., & Fink, S. L. (2018) · Current Protocols in Immunology · doi:10.1002/cpim.52 · Cited by 25
Danger signals in oral cavity-related diseases
Kay, J. G., Kramer, J. M., & Visser, M. B. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mir1118-439r · Cited by 24
An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes
Grinstein, L., Endter, K., Hedrich, C. M., Reinke, S., Luksch, H., Schulze, F., Robertson, A. A. B., Cooper, M. A., Rösen‐Wolff, A., & Winkler, S. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.11.011 · Cited by 21
Inflammasome activation in peritumoral astrocytes is a key player in breast cancer brain metastasis development
Mészáros, Á., Molnár, K., Fazakas, C., Nógrádi, B., Lüvi, A., Dudás, T., Tiszlavicz, L., Farkas, A. E., Krizbai, I. A., & Wilhelm, I. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01646-2 · Cited by 23
Alarmin(g) the innate immune system to invasive fungal infections
Caffrey, A. K., & Obar, J. J. (2016) · Current Opinion in Microbiology · doi:10.1016/j.mib.2016.06.002 · Cited by 22
IL-1 family cytokines and receptors in IgG4-related disease
Capecchi, R., Italiani, P., Puxeddu, I., Pratesi, F., Tavoni, A. G., Boraschi, D., & Migliorini, P. (2017) · Cytokine · doi:10.1016/j.cyto.2017.08.001 · Cited by 21
A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation
Nizami, S., Millar, V., Arunasalam, K., Zarganes‐Tzitzikas, T., Brough, D., Tresadern, G., Brennan, P. E., Davis, J. B., Ebner, D. V., & Daniel, E. D. (2021) · Scientific Reports · doi:10.1038/s41598-021-94850-w · Cited by 21
Interleukin-1 Blockade: An Update on Emerging Indications
Mistry, A., Savic, S., & van der Hilst, J. C. H. (2017) · BioDrugs · doi:10.1007/s40259-017-0224-7 · Cited by 21
Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement
Eichholz, K., Tran, T. H., Chéneau, C., Tran, T. T. P., Paris, O., Pugnière, M., & Kremer, E. J. (2022) · Journal of Virology · doi:10.1128/jvi.01850-21 · Cited by 20
Clinical and immunological allergy assessment in cancer patients
Carneiro, B. G. M. C. E., Petroianu, A., Machado, J. A. N., dos Anjos, P. M. F., da Silva, F. R., Alberti, L. R., Resende, V., & Barrientos, S. C. (2021) · Scientific Reports · doi:10.1038/s41598-021-97200-y · Cited by 20
The Immune System as a Therapeutic Target for Alzheimer’s Disease
Zieneldien, T., Kim, J., Sawmiller, D. R., & Cao, C. (2022) · Life · doi:10.3390/life12091440 · Cited by 19
Is Nuclear Factor Erythroid 2-Related Factor 2 a Target for the Intervention of Cytokine Storms?
Liu, Z., Deng, P., Liu, S., Bian, Y., Xu, Y., Zhang, Q., Wang, H., & Pi, J. (2023) · Antioxidants · doi:10.3390/antiox12010172 · Cited by 21
Mast cells enhance sterile inflammation in chronic nonbacterial osteomyelitis
Young, S., Sharma, N., Lee, J. H., Chiţu, V., Neumeister, V., Sohr, E., Stanley, E. R., Hedrich, C. M., & Craig, A. W. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.040097 · Cited by 19
Acute Alcohol Intoxication Modulates Monocyte Subsets and Their Functions in a Time-Dependent Manner in Healthy Volunteers
Janicova, A., Haag, F., Xu, B., Garza, A. P., Dunay, I. R., Neunaber, C., Nowak, A. J., Cavalli, P., Marzi, İ., Sturm, R., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.652488 · Cited by 19
Pyroptosis modulation by bacterial effector proteins
Chai, Q., Lei, Z., & Liu, C. H. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101804 · Cited by 18
The Role of Inflammasome in Abdominal Aortic Aneurysm and Its Potential Drugs
Pi, S., Xiong, S., Yuan, Y., & Deng, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25095001 · Cited by 18

Authors: Netea, M. G., van de Veerdonk, F. L., van der Meer, J. W. M., Dinarello, C. A., & Joosten, L. A. B.
Affiliations: Radboud University Medical Center (NL)
Department of Internal Medicine,
University of Colorado Anschutz (US)
ORCID: Netea, Mihai G.
Dinarello, Charles A.
Joosten, Leo A.B.
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2015-03-21
Volume: 33
Issue: 1
Pages: 49-77
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev-immunol-032414-112306
OpenAlex: W2156301166
Cited by: 326
References: 228
Citations by year: 2026: 8 · 2025: 6 · 2024: 26 · 2023: 15 · 2022: 24 · 2021: 27 · 2020: 30 · 2019: 33 · 2018: 46 · 2017: 46 · 2016: 41 · 2015: 24
FWCI: 3.49
Type: journal article
Language: en
Open access: green
hdl.handle.net
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: National Institutes of Health (CA-04-6934, 15614, AI‐15614)
National Cancer Institute (CA 046934, P30CA046934)
National Institute of Allergy and Infectious Diseases (AI‑15614)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR‑45584, R01AR045584)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: caspase-1, neutrophil serine proteases, inflammatory cytokines, cytokine activation, host defense, inflammatory diseases
MeSH terms: Animals, Disease Susceptibility, Humans, Inflammation, Interleukin-1, Cytokines, Inflammation Mediators, Inflammasomes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inflammasome-Independent Regulation of IL-1-Family Cytokines

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks