The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease
Open accessAbstract
The macrophage, a versatile cell type prominently involved in host defense and immunity, assumes a distinct state of alternative activation in the context of polarized type 2 immune responses such as allergic inflammation and helminth infection. This alternatively activated phenotype is induced by the canonical type 2 cytokines interleukin (IL)-4 and IL-13, which mediate expression of several characteristic markers along with a dramatic shift in macrophage metabolic pathways that influence surrounding cells and tissues. We discuss recent advances in the understanding of IL-4- and IL-13-mediated alternatively activated macrophages and type 2 immune responses; such advances have led to an expanded appreciation for functions of these cells beyond immunity, including maintenance of physiologic homeostasis and tissue repair.
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Cites
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Cited by
The M1 and M2 paradigm of macrophage activation: Time for reassessment
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Type 2 immunity in tissue repair and fibrosis
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Targeting key proximal drivers of type 2 inflammation in disease
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Metadata
- Authors
- Van Dyken, S. J., & Locksley, R. M.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2013-03-21
- Volume
- 31
- Issue
- 1
- Pages
- 317-343
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2151941382
- Cited by
- 714
- References
- 44
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Van Dyken, S. J., & Locksley, R. M. (2013). Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease. Annual Review of Immunology. https://doi.org/10.1146/annurev-immunol-032712-095906
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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