Cited by 856TGF-β signaling in diseasesT-cell and B-cell ImmunologyImmune Response and Inflammation

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TGF-β Activation and Function in Immunity

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Travis, Mark A., Sheppard, Dean·2014·Annual Review of Immunology

DOI 10.1146/annurev-immunol-032713-120257PMC PMC4010192

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Abstract

The cytokine TGF-β plays an integral role in regulating immune responses. TGF-β has pleiotropic effects on adaptive immunity, especially in the regulation of effector and regulatory CD4 + T cell responses. Many immune and nonimmune cells can produce TGF-β, but it is always produced as an inactive complex that must be activated to exert functional effects. Thus, activation of latent TGF-β provides a crucial layer of regulation that controls TGF-β function. In this review, we highlight some of the important functional roles for TGF-β in immunity, focusing on its context-specific roles in either dampening or promoting T cell responses. We also describe how activation of TGF-β controls its function in the immune system, with a focus on the key roles for members of the integrin family in this process.

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Authors: Travis, M. A., & Sheppard, D.
Affiliations: Wellcome Centre for Cell-Matrix Research (GB)
University of California, San Francisco (US)
ORCID: Travis, Mark A.
Sheppard, Dean
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2014-03-21
Volume: 32
Issue: 1
Pages: 51-82
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev-immunol-032713-120257
PMC: PMC4010192
OpenAlex: W2125061065
Semantic Scholar: 66463ee09c2d582938e4fe5e4679ce7db83f5c99
Cited by: 856
References: 191
Citations by year: 2026: 62 · 2025: 75 · 2024: 82 · 2023: 79 · 2022: 90 · 2021: 88 · 2020: 71 · 2019: 72 · 2018: 70 · 2017: 67 · 2016: 54 · 2015: 34 · 2014: 12
FWCI: 3.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: Pfizer
GlaxoSmithKline
Manchester Collaborative Centre for Inflammation Research
National Institutes of Health (AI077439, HL108794)
Directorate for Biological Sciences
Medical Research Council
National Heart, Lung, and Blood Institute (P01HL108794, HL108794, R01HL102292, HL102292, HL53947)
National Institute of Allergy and Infectious Diseases (AI077439, U19AI077439)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: TGF-beta, latent TGF-beta activation, immune regulation, adaptive immunity, CD4+ T cells, regulatory T cells, effector T cells, integrins, cytokine signaling
MeSH terms: Animals, Dendritic Cells, Humans, Immune System, Immunity, Protein Binding, Signal Transduction, Integrins, T-Lymphocyte Subsets, Transforming Growth Factor beta, Adaptive Immunity

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TGF-β Activation and Function in Immunity

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