IL-6 Revisited: From Rheumatoid Arthritis to CAR T Cell Therapy and COVID-19

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Clinical characteristics of coronavirus disease 2019 in China

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Toll-like receptor signalling

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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Endothelial cell infection and endotheliitis in COVID-19

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Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

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Targeting IL-6 trans-signalling: past, present and future prospects

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Targeting cytokine and chemokine signaling pathways for cancer therapy

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Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach

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The advent of immune stimulating CAFs in cancer

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Hemophagocytic lymphohistiocytosis: current treatment advances, emerging targeted therapy and underlying mechanisms

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The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases

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Idiopathic multicentric Castleman disease and associated autoimmune and autoinflammatory conditions: practical guidance for diagnosis

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Long COVID and hypertension-related disorders: a report from the Japanese Society of Hypertension Project Team on COVID-19

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Anti‐Acidification and Immune Regulation by Nano‐Ceria‐Loaded Mg–Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy

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Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers: Tumorigenesis and Immunosurveillance

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Roles of RNA-binding proteins in immune diseases and cancer

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A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice

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Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs

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Structure of the IL-27 quaternary receptor signaling complex

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Osteoarthritis: molecular pathogenesis and potential therapeutic options

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N-linked glycosylation of PD-L1/PD-1: an emerging target for cancer diagnosis and treatment

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IL-6 Signaling in Immunopathology: From Basic Biology to Selective Therapeutic Intervention

Schumertl, T., Lokau, J., & Garbers, C. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s485684 · Cited by 45

Perspectives of JAK Inhibitors for Large Vessel Vasculitis

Watanabe, R., & Hashimoto, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.881705 · Cited by 36

Association between premature vascular smooth muscle cells senescence and vascular inflammation in Takayasu's arteritis

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Immunotherapy Strategy for Systemic Autoimmune Diseases: Betting on CAR-T Cells and Antibodies

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Structural insights into IL-6 signaling inhibition by therapeutic antibodies

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Roles of Interleukin-6-mediated immunometabolic reprogramming in COVID-19 and other viral infection-associated diseases

Li, Y., Ren, H.-C., & Cao, J.-H. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109005 · Cited by 34

Pathogenic role of monocytes/macrophages in large vessel vasculitis

Watanabe, R., & Hashimoto, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.859502 · Cited by 25

Characterization of the Biological Activity of the Ethanolic Extract from the Roots of Cannabis sativa L. Grown in Aeroponics

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Roles of inflammasomes in viral myocarditis

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CAR-T cells targeting CD38 and LMP1 exhibit robust antitumour activity against NK/T cell lymphoma

Li, H., Song, W., Wu, J., Shi, Z., Gao, Y., Li, J. Y., Han, L., Zhang, J., Li, Z., Li, Y., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-03040-0 · Cited by 23

The prospects of interleukin-6 inhibition in rheumatoid arthritis: Olokizumab (novel monoclonal antibodies to IL-6)

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Monocyte/macrophage-mediated venous thrombus resolution

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Vasculitogenic T Cells in Large Vessel Vasculitis

Watanabe, R., & Hashimoto, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.923582 · Cited by 23

Bronchoalveolar lavage fluid analysis in patients with checkpoint inhibitor pneumonitis

Chen, R., Shi, Y., Fang, N., Shao, C., Huang, H. F., Pan, R., Xu, Y., Wang, M., Liu, X., Xu, K. L., et al. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03834-y · Cited by 18

Exploring the mechanism of Celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics

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Drugs targeting CMPK2 inhibit pyroptosis to alleviate severe pneumonia caused by multiple respiratory viruses

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Fluorinated dendrimer-mediated miR-30a delivery regulates the inflammation of macrophages and mitigates the symptoms of rheumatoid arthritis

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Gp130–HIF1α axis–induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling

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Association between tocilizumab treatment of hyperinflammatory patients with COVID-19 in a critical care setting and elevated incidence of hospital-acquired bacterial and invasive fungal infections

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Ultrasound-triggered piezocatalytic MOF(Hf)-Pt nanozymes for efficient ROS scavenging in the treatment of osteoarthritis

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Improving the safety of CAR‐T‐cell therapy: The risk and prevention of viral infection for patients with relapsed or refractory B‐cell lymphoma undergoing CAR‐T‐cell therapy

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The new era of immunological treatment, last updated and future consideration of CAR T cell-based drugs

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Human retinal endothelial cells express functional interleukin-6 receptor

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Amelioration of inflammation through reduction of oxidative stress in rheumatoid arthritis by treating fibroblast-like synoviocytes (FLS) with DMF-loaded PLGA nanoparticles

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New bitongling regulates gut microbiota to predict angiogenesis in rheumatoid arthritis via the gut-joint axis: a deep neural network approach

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Effect of fluvoxamine on plasma interleukin-6 in patients with major depressive disorder: a prospective follow-up study

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The NQR Complex Regulates the Immunomodulatory Function of Bacteroides thetaiotaomicron

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Coronavirus disease 2019 (COVID-19) pandemic and autoimmune rheumatic diseases: Outcomes and prospects

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Anemia in elderly rheumatoid arthritis patients: a cohort study

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Role of T cells and cytokines in the pathogenesis of rheumatoid arthritis

Anandan, M., & Narayanan, J. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102278 · Cited by 11

Interleukin 6 Inhibition in Rheumatoid Arthritis: Highlight on Olokizumab

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Long-COVID-19: the persisting imprint of SARS-CoV-2 infections on the innate immune system

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LC-MS-based rheumatoid arthritis serum metabolomics reveals the role of deoxyinosine in attenuating collagen-induced arthritis in mice

Xu, D., Tang, L., Wang, Y., Pan, J., & Su, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30903 · Cited by 10

Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis

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Carnosol Alleviates Collagen‐Induced Arthritis by Inhibiting Th17‐Mediated Immunity and Favoring Suppressive Activity of Regulatory T Cells

Chen, J., Sun, N., Li, F., Li, H., Tian, J., Zheng, S., Zhang, L., Wang, H., & Luo, Y. (2023) · BioMed Research International · doi:10.1155/2023/1179973 · Cited by 10

The latest advances in the use of biological DMARDs to treat Still’s disease

Cola, I. D., & Ruscitti, P. (2024) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2024.2307340 · Cited by 10

Preventing Preterm Birth

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Tissue-Resident Memory T Cells in Rheumatoid Immune Diseases: Pathogenic Mechanisms and Therapeutic Strategies

Tian, Y., Zhang, J., Wu, L., Zhang, C., Zheng, F., Yang, Y., Lu, G., & Xie, D. (2025) · Biomedicines · doi:10.3390/biomedicines13122945 · Cited by 12

Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma

Hashimoto, A., Handa, H., Hata, S., & Hashimoto, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1005566 · Cited by 9

Development and validation of machine learning-based models for predicting healthcare-associated bacterial/fungal infections among COVID-19 inpatients: a retrospective cohort study

Wang, M., Li, W., Wang, H., & Song, P. (2024) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-024-01392-7 · Cited by 10

Serum GM-CSF level is a predictor of treatment response to tocilizumab in rheumatoid arthritis patients: a prospective observational cohort study

Su, J., Hu, W., Ding, Y., Zhang, P., Li, T.-F., Liu, S., & Xing, L. (2024) · Arthritis Research & Therapy · doi:10.1186/s13075-024-03373-y · Cited by 8

Association between vitamin B6 levels and rheumatoid arthritis: a two-sample Mendelian randomization study

Liu, Y., Wang, X., You, M. S., Zheng, M., Yu, M., & Leng, X. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1442214 · Cited by 8

Impact of NSAIDs corticosteroids DMARDs biologics and their comparisons with natural products in C-reactive proteins (CRP) linked cardiovascular disorders

Satapathy, T., Minj, A., & Verma, M. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01767-1 · Cited by 11

Associations of Rheumatoid Factor, Rheumatoid Arthritis, and Interleukin-6 Inhibitor with the Prognosis of Ischemic Stroke: a Prospective Multicenter Cohort Study and Mendelian Randomization Analysis

Jia, Y., Zhang, K., Shi, M., Guo, D., Yang, P., Bu, X., Chen, J., Wang, A., Xu, T., He, J., et al. (2023) · Translational Stroke Research · doi:10.1007/s12975-023-01161-5 · Cited by 9

Associations of inflammatory cytokines with palmoplantar pustulosis: a bidirectional Mendelian randomization study

Liu, C., Liu, X., Xin, H., & Li, X. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1387210 · Cited by 6

Determination of Heterogeneous Proteomic and Metabolomic Response in anti-TNF and anti-IL-6 Treatment of Patients with Rheumatoid Arthritis

Stepanov, A. A., Malsagova, K. A., Kopylov, A. T., Rudnev, V. R., Karateev, D. E., Markelova, E. I., Лучихина, Е. Л., Borisova, E. E., & Kaysheva, A. L. (2023) · Life · doi:10.3390/life13020596 · Cited by 7

Ferroptosis-Modulating Natural Products for Targeting Inflammation-Related Diseases: Challenges and Opportunities in Manipulating Redox Signaling

Liang, Y., Qiu, S., Zou, Y., Leung, E. L., & Luo, L. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0556 · Cited by 7

Unveiling novel insights into human IL-6 − IL-6R interaction sites through 3D computer-guided docking and systematic site mutagenesis

Li, K., Cai, J., Jiang, Z., Meng, Q., Zhao, M., Xiao, H. M., Chen, G., Qiao, C., Luo, L., Yu, J., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-69429-w · Cited by 7

Advances in pharmacotherapy for immunoinflammatory rheumatic diseases in the 21st century

Nasonov, E. L. (2025) · Terapevticheskii arkhiv · doi:10.26442/00403660.2025.05.203213 · Cited by 6

Blood Inflammatory Markers and Cytokines in COVID‐19 Patients With Bacterial Coinfections

Bi, Q., Zhu, J., Zheng, J., Xu, Q., Chen, J., Zhang, L., & Mu, X. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.70105 · Cited by 6

Factors Associated with Mortality Among Severe Omicron Patients for COVID-19

Wu, S., Liao, G., Mao, J., Yan, H., Chen, J., & Peng, J. (2024) · Infection and Drug Resistance · doi:10.2147/idr.s450504 · Cited by 6

A New IL-6-Inducing Mechanism in Cancer with New Therapeutic Possibilities

Håkansson, L., Dunér, P., Broströmer, E., Gustavsson, B. G., Wettergren, Y., Ghafouri, B., Håkansson, A., & Clinchy, B. (2024) · Cancers · doi:10.3390/cancers16213588 · Cited by 6

Exploration of a bioactive oligosaccharide fragment from Saposhnikoviae Radix polysaccharides: preparation, structural characterization, and immunomodulatory mechanism

Sun, M., Cui, Y., Ma, W., Cui, L., Liang, P., Liang, M., Song, J., Tu, G., Ma, B., Jiang, Y., et al. (2026) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2026.124975 · Cited by 5

Targeting PI3Kγ Pathway for Treating Dengue virus Infection

Santos, F. R. D. S., Valadão, D. F., Bambirra, J. L., Moreira, T. P., de Souza, C. D., Passos, I. B. S., Queiroz‐Junior, C. M., Fagundes, C. T., Teixeira, M. M., Costa, V. V., et al. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.107060 · Cited by 5

A novel modulator of IL-6R prevents inflammation-induced preterm birth and improves newborn outcome

Côté, F., Prairie, É., Sierra, E. M., Quiniou, C., Habelrih, T., Xu, W., Ferri, B., Hou, X., Lahaie, I., Côté, N., et al. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00257-9 · Cited by 6

Lymph node-inspired immunoregulatory hydrogel with siRNA delivery property for postoperative glioblastoma treatment

Wang, Z., Geng, H., Zhang, Y., Shao, Y., Li, D., Li, Z., Ma, Y., Zhang, Y., Xi, K., Xue, Z., et al. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.146343 · Cited by 5

Normal butanol fraction of Polygonum hydropiper L. flavonoids reduces inflammation caused by PCV2 infections in cell and mouse models

Wei, Y., Zhou, S., Zhao, W. H., Chen, Q., Wang, Q.-H., Yu, M., Wei, Y., & Hu, T. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1539448 · Cited by 4

RNA Binding Protein YTHDF2 Inhibits Synovial Fibroblast Inflammation and Bone Injury in Rheumatoid Arthritis by Reducing the mRNA Stability of IL ‐ 6R

Zhang, Y., Cao, X., Ma, X., Guo, Y., Zhang, T., Wu, L., Yang, Y., Hao, C., Liu, W., & Guo, J. (2025) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.70010 · Cited by 4

The role of interleukin-6 in diabetic retinal disease: pathophysiology and therapeutic targeting

Harlow, R. E. A., Rose‐John, S., Hašková, Z., Fauser, S., & Mesquida, M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1805665 · Cited by 5

Analysis of potential diagnostic markers and therapeutic targets for rheumatoid arthritis with comorbid depression immunologic indicators

Fu, T., Liu, Y., Jia, H., Yao, L., Zhang, S., & Tian, F. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115098 · Cited by 4

Methyl 2-[3-(4-hydroxyphenyl)prop-2-enoylamino]-3-phenylpropanoate Is a Potent Cell-Permeable Anti-Cytokine Compound To Inhibit Inflammatory Cytokines in Monocyte/Macrophage-Like Cells

Park, J. B. (2023) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.123.001830 · Cited by 4

Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations

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Clinical efficacy of exercise in the treatment of post-COVID-19 syndrome: a systematic review and network meta-analysis

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