Structure-Based Vaccine Antigen Design

The Burden of Respiratory Syncytial Virus Infection in Young Children

Hall, C. B., Weinberg, G. A., Iwane, M. K., Blumkin, A. K., Edwards, K. M., Staat, M. A., Auinger, P., Griffin, M. R., Poehling, K. A., Erdman, D. D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0804877 · Cited by 2,250

RESPIRATORY SYNCYTIAL VIRUS DISEASE IN INFANTS DESPITE PRIOR ADMINISTRATION OF ANTIGENIC INACTIVATED VACCINE12

KIM, H. W., CANCHOLA, J. G., BRANDT, C. D., PYLES, G., CHANOCK, R. M., JENSEN, K., & PARROTT, R. H. (1969) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a120955 · Cited by 1,981

Structure of Dengue Virus

Kuhn, R. J., Zhang, W., Rossmann, M. G., Pletnev, S. V., Corver, J., Lenches, E. M., Jones, C. T., Mukhopadhyay, S., Chipman, P. R., Strauss, E. G., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00660-8 · Cited by 1,565

Risk of Primary Infection and Reinfection With Respiratory Syncytial Virus

Glezen, W. P. (1986) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1986.02140200053026 · Cited by 1,517

The envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution

Rey, F. A., Heinz, F. X., Mandl, C. W., Künz, C., & Harrison, S. C. (1995) · Nature · doi:10.1038/375291a0 · Cited by 1,439

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

Corti, D., Voss, J., Gamblin, S. J., Codoni, G., Macagno, A., Jarrossay, D., Vachieri, S. G., Pinna, D., Minola, A., Vanzetta, F., et al. (2011) · Science · doi:10.1126/science.1205669 · Cited by 1,203

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

McLellan, J. S., Chen, M., Joyce, M. G., Sastry, M., Stewart-Jones, G. B. E., Yang, Y., Zhang, B., Chen, L., Srivatsan, S., Zheng, A., et al. (2013) · Science · doi:10.1126/science.1243283 · Cited by 1,126

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

Pallesen, J., Wang, N., Corbett, K. S., Wrapp, D., Kirchdoerfer, R. N., Turner, H. L., Cottrell, C. A., Becker, M. M., Wang, L., Shi, W., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707304114 · Cited by 1,073

Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older

Cunningham, A. L., Lal, H., Kovac, M., Chlibek, R., Hwang, S.-J., Díez-Domingo, J., Godeaux, O., Levin, M. J., McElhaney, J. E., Puig-Barberà, J., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1603800 · Cited by 1,070

AN EPIDEMIOLOGIC STUDY OF ALTERED CLINICAL REACTIVITY TO RESPIRATORY SYNCYTIAL (RS) VIRUS INFECTION IN CHILDREN PREVIOUSLY VACCINATED WITH AN INACTIVATED RS VIRUS VACCINE

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Commercial influenza vaccines vary in both the structural arrangements of HA complexes and in induction of antibodies to cross-reactive HA epitopesPreprint

Myers, M. L., Gallagher, J. R., Kim, A. J., Payne, W. H., Bock, K. W., Torian, U., Moore, I. N., & Harris, A. K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.22.509041 · Cited by 1

Editorial: Intersection of biophysical and structural approaches in vaccine design

Ptak, C. P., Hsieh, C., Garnett, J. A., Rappuoli, R., & Lin, Y. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1142656 · Cited by 1

YiNet: An Integrated Traditional Chinese and Western Medicine Platform for Viral Infectious DiseasesPreprint

Dong, F., Guo, J., Liu, L., Han, A., Zhang, J., He, Z., Qu, X., Lei, S., Wang, Z., Zhou, L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.09.552248 · Cited by 1

Structure-Based Design of a Highly Immunogenic, Conformationally Stabilized FimH Antigen for a Urinary Tract Infection VaccinePreprint

de Monerri, N. C. S., Che, Y., Lees, J. A., Jasti, J., Wu, H., Griffor, M. C., Kodali, S., Hawkins, J. C., Lypowy, J., Ponce, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.10.598184 · Cited by 1

Mechanistic insights into structure-based design of a Lyme disease subunit vaccinePreprint

Brangulis, K., Malfetano, J., Marcinkiewicz, A. L., Wang, A., Chen, Y., Lee, J., Liu, Z., Yang, X., Strych, U., Bottazzi, M. E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.23.619738 · Cited by 1

mRNA Vaccines for HIV‐1

Lusso, P. (2024) · Wiley eBooks · doi:10.1002/9783527838394.ch9 · Cited by 1

Plasma cell immunoglobulin heavy chain repertoire dynamics before and after tetanus booster vaccination

Wolf, K. J., Adeyemo, A., & Williamson, K. C. (2021) · Immunogenetics · doi:10.1007/s00251-021-01215-8

A Comprehensive Review on the Hantavirus Epidemiology and Potential Therapeutic Prospects

Raj, U., Gupta, S., Rai, S., & Ghosh, R. (2021) · International Journal of Pharmaceutical and Phytopharmacological Research · doi:10.51847/wwbmgrtyua

Designing Synthetic Dna Encoded Immunotherapeutics And Nanoparticle Vaccines For Enhanced Immunity-Mediated Protection

Xu, Z. (2020) · ScholarlyCommons (University of Pennsylvania)

Structural characterization of a cross-protective natural chimera of factor H binding protein from meningococcal serogroup B strain NL096

Veggi, D., Malito, E., Surdo, P. L., Pansegrau, W., Rippa, V., Wahome, N., Savino, S., Masignani, V., Pizza, M., & Bottomley, M. J. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.04.011

Freshly remodeled and ready to fight malaria

Sather, D. N. (2022) · Immunity · doi:10.1016/j.immuni.2022.08.013

Mapping interaction between big spaces; active space from protein structure and available chemical space

Kumar, P., Khan, T., & Ghosh, I. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85713-0.00029-3

Vaccines

Sellers, R. S., & Nelson, K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821047-5.00029-4

The Role of the Vaccine Ingredients Used in the Manufacture of Vaccine

Chouhan, A. S. (2023) · Global Academic Journal of Pharmacy and Drug Research · doi:10.36348/gajpdr.2023.v05i01.002

New approaches to vaccines for infectious diseases

Bagwe, P., Vijayanand, S., Patil, S., Akanksha, K., Menon, I., Gomes, K. B., Uddin, M. N., & D’Souza, M. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18564-9.00003-5

Bactericidal human monoclonal antibody 1B1 shows specificity for meningococcal factor H binding protein variant 2 and displaces human factor H

Veggi, D., Chesterman, C. C., Santini, L., Huang, Y., Pacchiani, N., Sierra, J., Chen, L., Laliberte, J. P., Bianchi, F. B., Cozzi, R., et al. (2024) · FASEB BioAdvances · doi:10.1096/fba.2023-00077

Molecular Mechanism of pH-Induced Protrusion Configuration Switching in Piscine Betanodavirus Implies a Novel Antiviral Strategy

Štěrbová, P., Wang, C.-H., Carillo, K. J., Lou, Y., Kato, T., Namba, K., Tzou, D. M., & Chang, W. (2024) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.4c00407

Development and reproductive safety of AdCLD-CoV19, an adenoviral vector-based COVID-19 vaccine, in female Sprague–Dawley rats and their offspring

Park, S., Kim, S., Kim, S., Shin, K.-S., Kang, C., Hong, E., Im, W., Jeong, J., Yu, W., Ko, K., et al. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117503

The oral antigen-adjuvant multivalent fusion vaccine P-VP56310-500-FlaC provides effective protective effect against grass carp reovirus infectionPreprint

Tang, B., Cheng, G., Yi-zhong, L., Li, W., Xu, Y., Yang, C., Xu, Z., Kong, W., & Su, J. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5430201

Engineering mucosal immunity: Advanced vaccine platforms against respiratory pathogens

Wang, M., Chang, Q., Li, B., Yang, R., Chen, X., Bai, Y., He, H., & Zheng, B. (2025) · Precision medicine and engineering. · doi:10.1016/j.preme.2025.100040 · Cited by 3

Structural profiling of the pneumolysin epitope landscape uncovers a cross-species neutralising site across cholesterol-dependent cytolysinsPreprint

Tang, D., Kučinskaitė-Kodzė, I., Ströbaek, J., Gueto-Tettay, C. A., Simanavičius, M., Plečkaitytė, M., Hultgren, L., Håkansson, A., Malmström, L., Ekström, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.27.708574

Protein structure prediction

Leach, A. R., & Mobarec, J. C. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29808-0.00086-8

A fusion protein LT25 containing Rv2660c failed to provide protection against Mycobacterium bovis infection due to limited humoral immune responses

Liu, Y., Wang, J., Yao, T., Chen, D., Wang, Y., Li, F., & Zhu, B. (2026) · Tuberculosis · doi:10.1016/j.tube.2026.102771

Prediction of pre- and postfusion conformations of class I fusion proteins with AlphaFold2

Güleşen, S., Most, V., Schoeder, C. T., & Meiler, J. (2026) · PLoS ONE · doi:10.1371/journal.pone.0351662

In Vitro Selection of Antibodies Targeting Yersinia pestis Membrane Lipids Using Nanodisc-Based Antigen Presentation

Bolding, M., Mozden, S. C., Pimentel, O. R. C., Montoya, M. M., Kubicek-Sutherland, J. Z., & Velappan, N. (2026) · Pathogens · doi:10.3390/pathogens15060651

Cavity-Filling Mutations as a Strategy to Stabilize Prefusion Viral Fusion Proteins for Vaccine Design

Kumar, R., Muthuramalingam, P., Tiwari, S., Gupta, J., Gupta, R., Agarwal, P., Yadav, H., Kumar, N., Rawat, J. M., Ravi, K., et al. (2026) · Computational and Structural Biotechnology Journal · doi:10.34133/csbj.0199

Non-human primate LIBRA-Seq accelerates neutralizing antibody discovery in RM vaccinated against HIV-1

Edwards, C. T., Trenkle, A. D. S., Sahoo, A., Cruickshank, K., Nelson, S., Lapp, S. A., Raju, N., Ton, T., Metz, A., McGhee, E., et al. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1013831

Advancing human metapneumovirus vaccine development through fusion protein stabilization

Sabir, A. J., & Ross, T. M. (2026) · Virology · doi:10.1016/j.virol.2026.111043

A Modular Biomimetic Nanovaccine for TBEV: Orchestrating Cascade Immunoprotection via Programmed Dendritic Cell Targeting and Antigen–Adjuvant Co-delivery

Li, N. Y., Miao, K., Zhang, M., Li, H., Wang, D., Xie, X., wang, H., & Li, Y. (2026) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.6c00544

Structural biology approaches in vaccine development

Taiyab, A., & Hassan, I. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44988-8.00011-3

Antigen prioritization and selection for vaccine design and development: A comprehensive pipeline

Chelan, E. M., Pourseif, M. M., Zarebkohan, A., Moghaddam, H. G., Kiani, J., Tohidkia, M., Almasian, B., Parhizkar, A., & Omidi, Y. (2026) · Biotechnology Advances · doi:10.1016/j.biotechadv.2026.109063

Plug-and-display labeling system for modular subunit vaccine development

Tang, W., Lu, L., Shi, X., 杨益民, Deng, D., Liu, M., Lovell, J. F., Sun, Y., & Jin, H. (2026) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2026.218594

Biophysical analysis of therapeutic proteins: methods and applications

Amin, Z., Sunny, N., & Chugh, J. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44536-1.00007-9

Transgenic Plasmodium berghei expressing P. vivax pre-erythrocytic antigens SSP3 and SPECT1 to elucidate their efficacy towards vaccine development

Kolli, S. K., Subramani, P. A., Ramesar, J., Nicholas, J., Ogbondah, M. M., Barnes, S. J., Mahdavi, P., Salman, A. M., Ntumngia, F. B., Janse, C. J., et al. (2026) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0014810

A proof of concept for structure-based vaccine design targeting RSV in humans

Crank, M. C., Ruckwardt, T. J., Chen, M., Morabito, K. M., Phung, E., Costner, P. J., Holman, L. A., Hickman, S. P., Berkowitz, N. M., Gordon, I. J., et al. (2019) · Science · doi:10.1126/science.aav9033 · Cited by 333

Innovations in structure-based antigen design and immune monitoring for next generation vaccines

Ward, A. B., & Wilson, I. A. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.03.013 · Cited by 62

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

McLellan, J. S., Chen, M., Joyce, M. G., Sastry, M., Stewart-Jones, G. B. E., Yang, Y., Zhang, B., Chen, L., Srivatsan, S., Zheng, A., et al. (2013) · Science · doi:10.1126/science.1243283 · Cited by 1,126

Novel antigens for RSV vaccines

Graham, B. S., Modjarrad, K., & McLellan, J. S. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.04.005 · Cited by 153

Structure-based Vaccine Design: Lessons from RSV F

McLellan, J. S. (2016)