The DOI matches its Crossref record; 150 of the 151 references it cites were found in a registry or an index.
Neuronal Intrinsic Mechanisms of Axon Regeneration
Abstract
Failure of axon regeneration after central nervous system (CNS) injuries results in permanent functional deficits. Numerous studies in the past suggested that blocking extracellular inhibitory influences alone is insufficient to allow the majority of injured axons to regenerate, pointing to the importance of revisiting the hypothesis that diminished intrinsic regenerative ability critically underlies regeneration failure. Recent studies in different species and using different injury models have started to reveal important cellular and molecular mechanisms within neurons that govern axon regeneration. This review summarizes these observations and discusses possible strategies for stimulating axon regeneration and perhaps functional recovery after CNS injury.
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In the citing paper
“There have been many studies of the molecules that block axonal sprouting after CNS injury, such as myelin proteins or chondroitin sulfate proteoglycans (CSPGs)8–10”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
In the citing paper
“Much scientific study has focused on the molecular components of the injury response that block axonal sprouting, such as the glial growth inhibitors NogoA and the chondroitin sulfate proteoglycans8–10.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
In the citing paper
“PTEN and SOCS3 inhibition induce axonal sprouting in multiple adult CNS systems, including optic nerve and spinal cord injury8,35.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
In the citing paper
“Axonal sprouting in the adult occurs in a limited manner after stroke, optic nerve lesions, spinal cord injury and in models of neurodegenerative diseases8,9.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
In the citing paper
“PTEN inhibition potentiates axonal sprouting in optic nerve injury and spinal cord injury, through induction of PI3kinase signaling and activation of mTOR.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
In the citing paper
“Inhibition of SOCS3 further promotes axonal sprouting on top of PTEN inhibition8,37,38.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
Citations
Cites
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,311
Degeneration and Regeneration of the Nervous System.
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Guertin, D. A., & Sabatini, D. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.05.008 · Cited by 2,833
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195
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Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., Xu, B., Connolly, L., Kramvis, I., Sahin, M., et al. (2008) · Science · doi:10.1126/science.1161566 · Cited by 1,686
Self-citationGrowing roles for the mTOR pathway
Sarbassov, D. D., Ali, S. M., & Sabatini, D. M. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.009 · Cited by 1,590
Glial inhibition of CNS axon regeneration
Yiu, G. C., & He, Z. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1956 · Cited by 1,525
Self-citation
Research works printed but not linked: 3
- Fishman HM, 2003, News Physiol. Sci., 18, 115
- Lasek RJ, Hoffman PN. 1976. The neuronal cytoskeleton, axonal transport and axonal growth. In Cold Spring Harbor Laboratory Conference on Cell Proliferation, Cell Motility. Vol. 3, ed. R Goldman, T Pollard, J Rosenbaum, pp. 1021–49. Cold Spring Harbor, NY: Cold Spring Harbor Lab. Press
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Cited by
Sorted by citations
Astrocyte scar formation aids central nervous system axon regeneration
Anderson, M. A., Burda, J. E., Ren, Y., Ao, Y., O’Shea, T. M., Kawaguchi, R., Coppola, G., Khakh, B. S., Deming, T. J., & Sofroniew, M. V. (2016) · Nature · doi:10.1038/nature17623 · Cited by 1,851
Conductive Polymers: Opportunities and Challenges in Biomedical Applications
Nezakati, T., Seifalian, A., Tan, A., & Seifalian, A. M. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00275 · Cited by 1,014
Intrinsic mechanisms of neuronal axon regeneration
Mahar, M., & Cavalli, V. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0001-8 · Cited by 611
Duan, X., Qiao, M., Bei, F., Kim, I.-J., He, Z., & Sanes, J. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.017 · Cited by 518
Self-citationLiu, Z., Wan, X., Wang, Z. L., & Li, L. (2021) · Advanced Materials · doi:10.1002/adma.202007429 · Cited by 495
Metadata
- Authors
- Liu, K., Tedeschi, A., Park, K. K., & He, Z.
- Affiliations
- Harvard University (US)
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2011-07-21
- Volume
- 34
- Issue
- 1
- Pages
- 131-152
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2141003407
- Cited by
- 458
- References
- 151
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 30 · 2023: 30 · 2022: 15 · 2021: 28 · 2020: 26 · 2019: 31 · 2018: 35 · 2017: 33 · 2016: 52 · 2015: 36 · 2014: 33 · 2013: 30 · 2012: 40
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- axon regeneration, central nervous system injury, functional recovery
- MeSH terms
- Cyclic AMP, Animals, Axons, Axonal Transport, Central Nervous System Diseases, Humans, Inflammation, Models, Neurological, Nerve Regeneration, Neurons, Cytokines, Suppressor of Cytokine Signaling Proteins
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