The DOI matches its Crossref record; 150 of the 151 references it cites were found in a registry or an index.
Neuronal Intrinsic Mechanisms of Axon Regeneration
Abstract
Failure of axon regeneration after central nervous system (CNS) injuries results in permanent functional deficits. Numerous studies in the past suggested that blocking extracellular inhibitory influences alone is insufficient to allow the majority of injured axons to regenerate, pointing to the importance of revisiting the hypothesis that diminished intrinsic regenerative ability critically underlies regeneration failure. Recent studies in different species and using different injury models have started to reveal important cellular and molecular mechanisms within neurons that govern axon regeneration. This review summarizes these observations and discusses possible strategies for stimulating axon regeneration and perhaps functional recovery after CNS injury.
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“There have been many studies of the molecules that block axonal sprouting after CNS injury, such as myelin proteins or chondroitin sulfate proteoglycans (CSPGs)8–10”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
In the citing paper
“Much scientific study has focused on the molecular components of the injury response that block axonal sprouting, such as the glial growth inhibitors NogoA and the chondroitin sulfate proteoglycans8–10.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
In the citing paper
“PTEN and SOCS3 inhibition induce axonal sprouting in multiple adult CNS systems, including optic nerve and spinal cord injury8,35.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
In the citing paper
“Axonal sprouting in the adult occurs in a limited manner after stroke, optic nerve lesions, spinal cord injury and in models of neurodegenerative diseases8,9.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
In the citing paper
“PTEN inhibition potentiates axonal sprouting in optic nerve injury and spinal cord injury, through induction of PI3kinase signaling and activation of mTOR.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
In the citing paper
“Inhibition of SOCS3 further promotes axonal sprouting on top of PTEN inhibition8,37,38.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [8]
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Metadata
- Authors
- Liu, K., Tedeschi, A., Park, K. K., & He, Z.
- Affiliations
- Harvard University (US)
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2011-07-21
- Volume
- 34
- Issue
- 1
- Pages
- 131-152
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2141003407
- Cited by
- 458
- References
- 151
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 30 · 2023: 30 · 2022: 15 · 2021: 28 · 2020: 26 · 2019: 31 · 2018: 35 · 2017: 33 · 2016: 52 · 2015: 36 · 2014: 33 · 2013: 30 · 2012: 40
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- axon regeneration, central nervous system injury, functional recovery
- MeSH terms
- Cyclic AMP, Animals, Axons, Axonal Transport, Central Nervous System Diseases, Humans, Inflammation, Models, Neurological, Nerve Regeneration, Neurons, Cytokines, Suppressor of Cytokine Signaling Proteins
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