Simultaneous Encoding of Odors by Channels with Diverse Sensitivity to Inhibition
Open accessAbstract
Odorant receptors in the periphery map precisely onto olfactory glomeruli ("coding channels") in the brain. However, the odor tuning of a glomerulus is not strongly correlated with its spatial position. This raises the question of whether lateral inhibition between glomeruli is specific or nonspecific. Here we show that, in the Drosophila brain, focal activation of even a single glomerulus recruits GABAergic interneurons in all glomeruli. Moreover, the relative level of interneuron activity in different glomeruli is largely odor invariant. Although interneurons are recruited nonspecifically, glomeruli differ dramatically in their sensitivity to interneuron activity, and this is explained by their varying sensitivity to GABA. Interestingly, a stimulus is typically encoded in parallel by channels having high and low sensitivity to inhibition. Because lateral inhibition confers both costs and benefits, the brain might rely preferentially on "high" and "low" channels in different behavioral contexts.
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Most neuropils of the Drosophila brain contain one or a few large GABAergic neurons private to that neuropil, with high in degree and out degree.
“Most neuropils of the Drosophila brain contain one or a few large GABAergic neurons private to that neuropil, with high in degree and out degree (see Lin et al.49 for further analysis on connectivity motifs); these neurons are considered to be important for local feedback gain control69.”
From Neuronal wiring diagram of an adult brain (2024) · cites this paper as [69]
The Discussion section on odor-invariant recruitment says GABAergic local neurons in the antennal lobe connect with all glomeruli, supporting broad connectivity in that neuropil. It does not establish that most Drosophila brain neuropils each have one or a few large, private GABAergic neurons, or report their in-degree and out-degree. The indexed copy provides no page numbers for these passages. (LLM, conf=0.84)
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- Authors
- Hong, E. J., & Wilson, R. I.
- Affiliations
- Harvard University (US)
- Corresponding author
- Wilson, Rachel I.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 85
- Issue
- 3
- Pages
- 573-589
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5495107
- OpenAlex
- W2009156797
- Cited by
- 93
- References
- 80
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 5 · 2023: 14 · 2022: 2 · 2021: 8 · 2020: 4 · 2019: 10 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 6
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute on Deafness and Other Communication Disorders (R01DC008174)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- odor coding, lateral inhibition, glomeruli, GABAergic interneurons, olfactory receptors, Drosophila olfactory system, GABA sensitivity
- MeSH terms
- Animals, Drosophila, Female, Neural Inhibition, Odorants, Olfactory Bulb, Smell, Receptors, Odorant, Animals, Genetically Modified
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