Cited by 148Neurobiology and Insect Physiology ResearchNeuroscience and Neuropharmacology ResearchOlfactory and Sensory Function Studies

Functional Connectivity and Selective Odor Responses of Excitatory Local Interneurons in Drosophila Antennal Lobe

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Huang, Ju, Zhang, Wei, Qiao, Wenhui, Hu, Aiqun, Wang, Zuoren·2010·Neuron

Abstract

Local interneurons in the Drosophila antennal lobe are thought to play important roles in shaping odor responses. However, the physiological properties of excitatory local interneurons (eLNs) and their connectivity in the antennal lobe remain unclear. We first characterized the firing patterns of krasavietz-Gal4-labeled eLNs (krasavietz eLNs) in response to depolarizing currents. Paired recordings of krasavietz eLNs and PNs showed reciprocal excitatory connections mediated by dendrodendritic cholinergic synapses and gap junctions. Reciprocal connections were also found between two krasavietz eLNs but were rare between krasavietz eLNs and inhibitory LNs. Analysis of response onset latencies showed that krasavietz eLNs received monosynaptic inputs from ORNs. Furthermore, each eLN responded with distinct patterns to different odors, and each odor elicited distinct responses in different eLNs, with specific temporal patterns of spiking, indicating that eLNs serve specific coding functions in addition to global excitation in Drosophila olfactory processing.

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Crossref · 10.1016/j.neuron.2010.08.025

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Authors
Huang, J., Zhang, W., Qiao, W., Hu, A., & Wang, Z.
Affiliations
Chinese Academy of Sciences (CN)
Corresponding author
Wang, Zuoren
Venue
Neuron
Publisher
Elsevier BV
Published
2010-09
Volume
67
Issue
6
Pages
1021-1033
ISSN
0896-6273 (ISSN-L)
OpenAlex
W1986154944
Cited by
148
References
28
Citations by year
2026: 1 · 2025: 4 · 2024: 10 · 2023: 13 · 2022: 11 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 13 · 2014: 12 · 2013: 18 · 2012: 17
FWCI
6.43
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords
antennal lobe, Drosophila olfaction, olfactory response, functional connectivity, cholinergic synapses, gap junctions, dendrodendritic synapses, odor coding
MeSH terms
Action Potentials, Adenosine Triphosphate, Animals, Bungarotoxins, Drosophila, Electric Stimulation, Female, Gene Expression Regulation, Interneurons, Lysine, Mecamylamine, Nerve Net, Odorants, Olfactory Pathways, Organophosphorus Compounds, Picrotoxin, Sense Organs, Smell, Gap Junctions, Receptors, Purinergic P2, Patch-Clamp Techniques, Cholinergic Antagonists, Nicotinic Antagonists, GABA Antagonists, Drosophila Proteins, Animals, Genetically Modified, Eukaryotic Initiation Factor-5, Green Fluorescent Proteins, Inhibitory Postsynaptic Potentials, Receptors, Purinergic P2X2

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