Excitatory Local Circuits and Their Implications for Olfactory Processing in the Fly Antennal Lobe

Shang, Yuhua; Claridge-Chang, Adam; Sjulson, Lucas; Pypaert, Marc; Miesenböck, Gero

doi:10.1016/j.cell.2006.12.034

Cited by 359Neurobiology and Insect Physiology ResearchNeuroscience and Neuropharmacology ResearchOlfactory and Sensory Function Studies

Excitatory Local Circuits and Their Implications for Olfactory Processing in the Fly Antennal Lobe

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Shang, Yuhua, Claridge-Chang, Adam, Sjulson, Lucas, Pypaert, Marc, Miesenböck, Gero·2007·Cell

DOI 10.1016/j.cell.2006.12.034PMC PMC2866183

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Abstract

Conflicting views exist of how circuits of the antennal lobe, the insect equivalent of the olfactory bulb, translate input from olfactory receptor neurons (ORNs) into projection-neuron (PN) output. Synaptic connections between ORNs and PNs are one-to-one, yet PNs are more broadly tuned to odors than ORNs. The basis for this difference in receptive range remains unknown. Analyzing a Drosophila mutant lacking ORN input to one glomerulus, we show that some of the apparent complexity in the antennal lobe's output arises from lateral, interglomerular excitation of PNs. We describe a previously unidentified population of cholinergic local neurons (LNs) with multiglomerular processes. These excitatory LNs respond broadly to odors but exhibit little glomerular specificity in their synaptic output, suggesting that PNs are driven by a combination of glomerulus-specific ORN afferents and diffuse LN excitation. Lateral excitation may boost PN signals and enhance their transmission to third-order neurons in a mechanism akin to stochastic resonance.

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Literature expected perhaps as many as approximately 15 cholinergic local neurons.
“We also expected perhaps as many as ∼ 15 cholinergic local neurons.63,189”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [63]
Among the lLN2T_abc neurons are approximately 13 neurons that have a cell body placement and general morphology most similar to reported cholinergic local neurons.
“Specifically, among them are ∼ 13 lLN2T_abc neurons that have a cell body placement and general morphology most similar to reported cholinergic local neurons.63,189”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [63]
The predicted cholinergic local neurons in 'ALl1 dorsal' are unilateral and pan-glomerular, in accordance with previous descriptions but more numerous.
“The predicted cholinergic neurons are unilateral and ‘broad’, i.e., pan-glomerular, in accordance with previous descriptions63,189 but more numerous.”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [63]
Antennal lobe local neurons are known to express acetylcholine, GABA, glutamate and various neuropeptides.
“They are known to express acetylcholine,63,189,190 GABA,62,89,151 glutamate61,89,104 and various neuropeptides transmitters.106”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [63]
The remainder of the lLN2T_abc neurons is most likely GABAergic, e.g., lLN2_d gross morphology looks more like related GABAergic neurons.
“The remainder is most likely GABAergic, e.g., lLN2_d gross morphology looks more like related GABAergic neurons.63,189”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [63]

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Self-citation
A Neuronal Network Model of Drosophila Antennal Lobe
(2013) · Arizona State University Library Digital Repository (Arizona State University)

Authors: Shang, Y., Claridge-Chang, A., Sjulson, L., Pypaert, M., & Miesenböck, G.
Affiliations: Yale University (US)
Corresponding author: Miesenböck, Gero
ORCID: Sjulson, Lucas
Miesenböck, Gero
Venue: Cell
Publisher: Elsevier BV
Published: 2007-02
Volume: 128
Issue: 3
Pages: 601-612
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2006.12.034
PMC: PMC2866183
OpenAlex: W2073936984
Cited by: 359
References: 56
Citations by year: 2026: 5 · 2025: 5 · 2024: 15 · 2023: 19 · 2022: 7 · 2021: 24 · 2020: 10 · 2019: 13 · 2018: 8 · 2017: 11 · 2016: 16 · 2015: 16 · 2014: 21 · 2013: 15 · 2012: 25
FWCI: 16.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2358 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Deafness and Other Communication Disorders (R01DC005810)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords: antennal lobe, olfactory processing, Drosophila, olfactory sensory neurons, projection neurons, local circuits, stochastic resonance
MeSH terms: Acetylcholine, Animals, Brain, Drosophila, Nerve Net, Neurons, Afferent, Odorants, Smell, Synapses, Olfactory Receptor Neurons, Receptors, Odorant, Drosophila Proteins

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Excitatory Local Circuits and Their Implications for Olfactory Processing in the Fly Antennal Lobe

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