Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
Open accessAbstract
Ependymomas are common childhood brain tumours that occur throughout the nervous system, but are most common in the paediatric hindbrain. Current standard therapy comprises surgery and radiation, but not cytotoxic chemotherapy as it does not further increase survival. Whole-genome and whole-exome sequencing of 47 hindbrain ependymomas reveals an extremely low mutation rate, and zero significant recurrent somatic single nucleotide variants. Although devoid of recurrent single nucleotide variants and focal copy number aberrations, poor-prognosis hindbrain ependymomas exhibit a CpG island methylator phenotype. Transcriptional silencing driven by CpG methylation converges exclusively on targets of the Polycomb repressive complex 2 which represses expression of differentiation genes through trimethylation of H3K27. CpG island methylator phenotype-positive hindbrain ependymomas are responsive to clinical drugs that target either DNA or H3K27 methylation both in vitro and in vivo. We conclude that epigenetic modifiers are the first rational therapeutic candidates for this deadly malignancy, which is epigenetically deregulated but genetically bland.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Many of the enzymes targeted by epigenetic therapies, particularly lysine and arginine methyltransferases, have non-histone substrates.
“many of the enzymes targeted, particularly lysine and arginine methyltransferases, have non-histone substrates”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [183]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Román‐Gómez, J., Jiménez‐Velasco, A., Agirre, X., Prósper, F., Heiniger, A., & Torres, A. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.01.4944 · Cited by 125 · see citing works
RetractedComprehensive molecular portraits of human breast tumours
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11412 · Cited by 12,129 · see citing works
Comprehensive molecular characterization of human colon and rectal cancer
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11252 · Cited by 8,499 · see citing works
Integrated genomic analyses of ovarian carcinoma
Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927 · see citing works
Mutational heterogeneity in cancer and the search for new cancer-associated genes
Lawrence, M. S., Stojanov, P., Polak, P., Kryukov, G. V., Cibulskis, K., Sivachenko, A., Carter, S. L., Stewart, C., Mermel, C. H., Roberts, S. A., et al. (2013) · Nature · doi:10.1038/nature12213 · Cited by 5,461 · see citing works
Self-citationThe Somatic Genomic Landscape of Glioblastoma
Brennan, C. W., Verhaak, R. G. W., McKenna, A., Campos, B., Noushmehr, H., Salama, S. R., Zheng, S., Chakravarty, D., Sanborn, J. Z., Berman, S. H., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.034 · Cited by 5,016 · see citing works
Self-citationComprehensive genomic characterization of squamous cell lung cancers
The Cancer Genome Atlas Research Network (2012) · Nature · doi:10.1038/nature11404 · Cited by 3,994 · see citing works
Self-citationDriver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Schwartzentruber, J., Korshunov, A., Liu, X.-Y., Jones, D. T. W., Pfaff, E., Jacob, K., Sturm, D., Fontebasso, A. M., Quang, D.-A. K., Tönjes, M., et al. (2012) · Nature · doi:10.1038/nature10833 · Cited by 2,631 · see citing works
Self-citationA landscape of driver mutations in melanoma
Hodis, E., Watson, I. R., Kryukov, G. V., Arold, S. T., Imielinski, M., Theurillat, J.-P., Nickerson, E., Auclair, D., Li, L., Place, C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.024 · Cited by 2,610 · see citing works
Ben‐Porath, I., Thomson, M., Carey, V. J., Ge, R., Bell, G. W., Regev, A., & Weinberg, R. A. (2008) · Nature Genetics · doi:10.1038/ng.127 · Cited by 2,523 · see citing works
CpG island methylator phenotype in colorectal cancer
Toyota, M., Ahuja, N., Ohe-Toyota, M., Herman, J. G., Baylin, S. B., & Issa, J. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8681 · Cited by 2,506 · see citing works
Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
Noushmehr, H., Weisenberger, D. J., Diefes, K., Phillips, H. S., Pujara, K., Berman, B. P., Pan, F., Pelloski, C. E., Sulman, E. P., Bhat, K. P., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.03.017 · Cited by 2,337 · see citing works
Self-citationWeisenberger, D. J., Siegmund, K. D., Campan, M., Young, J. P., Long, T. I., Faasse, M. A., Kang, G. H., Widschwendter, M., Weener, D., Buchanan, D. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1834 · Cited by 1,990 · see citing works
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
Turcan, S., Rohle, D., Goenka, A., Walsh, L. A., Fang, F., Yilmaz, E., Campos, C., Fabius, A. W. M., Lu, C., Ward, P. S., et al. (2012) · Nature · doi:10.1038/nature10866 · Cited by 1,974 · see citing works
Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
Imielinski, M., Berger, A. H., Hammerman, P. S., Hernandez, B., Pugh, T. J., Hodis, E., Cho, J., Suh, J., Capelletti, M., Sivachenko, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.029 · Cited by 1,789 · see citing works
Self-citationEZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
McCabe, M. T., Ott, H. M., Ganji, G., Korenchuk, S., Thompson, C., Van Aller, G. S., Liu, Y., Graves, A. P., III, A. D. P., Diaz, E., et al. (2012) · Nature · doi:10.1038/nature11606 · Cited by 1,786 · see citing works
Self-citationSt. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project (2012) · Nature Genetics · doi:10.1038/ng.1102 · Cited by 1,724 · see citing works
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
Zhang, J., Ding, L., Holmfeldt, L., Wu, G., Heatley, S. L., Payne-Turner, D., Easton, J., Chen, X., Wang, J., Rusch, M., et al. (2012) · Nature · doi:10.1038/nature10725 · Cited by 1,596 · see citing works
Self-citationTruncating mutations of hSNF5/INI1 in aggressive paediatric cancer
Versteege, I., Sévenet, N., Lange, J., Rousseau-Merck, M.-F., Ambros, P. F., Handgretinger, R., Aurias, A., & Delattre, O. (1998) · Nature · doi:10.1038/28212 · Cited by 1,552 · see citing works
Decitabine improves patient outcomes in myelodysplastic syndromes
Kantarjian, H. M., Issa, J. J., Rosenfeld, C. S., Bennett, J. M., Albitar, M. X., DiPersio, J. F., Klimek, V. M., Slack, J. L., de Castro, C., Ravandi, F., et al. (2006) · Cancer · doi:10.1002/cncr.21792 · Cited by 1,530 · see citing works
Initial genome sequencing and analysis of multiple myeloma
Chapman, M. A., Lawrence, M. S., Keats, J. J., Cibulskis, K., Sougnez, C. L., Schinzel, A. C., Harview, C. L., Brunet, J.-P., Ahmann, G. J., Adli, M., et al. (2011) · Nature · doi:10.1038/nature09837 · Cited by 1,422 · see citing works
Self-citationIntegrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Peifer, M., Fernandez‐Cuesta, L., Sos, M. L., George, J., Seidel, D., Kasper, L. H., Plenker, D., Leenders, F., Sun, R., Zander, T., et al. (2012) · Nature Genetics · doi:10.1038/ng.2396 · Cited by 1,390 · see citing works
The genomic complexity of primary human prostate cancer
Berger, M. F., Lawrence, M. S., Demichelis, F., Drier, Y., Cibulskis, K., Sivachenko, A., Sboner, A., Esgueva, R., Pflueger, D., Sougnez, C. L., et al. (2011) · Nature · doi:10.1038/nature09744 · Cited by 1,213 · see citing works
Self-citationThe genetic landscape of high-risk neuroblastoma
Pugh, T. J., Morozova, O., Attiyeh, E. F., Asgharzadeh, S., Wei, J. S., Auclair, D., Carter, S. L., Cibulskis, K., Hanna, M., Kieżun, A., et al. (2013) · Nature Genetics · doi:10.1038/ng.2529 · Cited by 1,170 · see citing works
Self-citationOhm, J. E., McGarvey, K. M., Yu, X., Cheng, L., Schuebel, K. E., Cope, L., Mohammad, H. P., Chen, W., Daniel, V. C., Yu, W., et al. (2007) · Nature Genetics · doi:10.1038/ng1972 · Cited by 1,130 · see citing works
Increased methylation variation in epigenetic domains across cancer types
Hansen, K. D., Timp, W., Bravo, H. C., Sabunciyan, S., Langmead, B., McDonald, O. G., Wen, B., Wu, H., Liu, Y., Diep, D. H., et al. (2011) · Nature Genetics · doi:10.1038/ng.865 · Cited by 1,053 · see citing works
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
Williams, K., Christensen, J., Pedersen, M. T., Johansen, J. V., Cloos, P. A. C., Rappsilber, J., & Helin, K. (2011) · Nature · doi:10.1038/nature10066 · Cited by 1,021 · see citing works
FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription
Lupien, M., Eeckhoute, J., Meyer, C. A., Wang, Q., Zhang, Y., Li, W., Carroll, J. S., Liu, X. S., & Brown, M. (2008) · Cell · doi:10.1016/j.cell.2008.01.018 · Cited by 983 · see citing works
Self-citationTan, J., Yang, X., Zhuang, L., Jiang, X., Chen, W., Lee, P. L., Karuturi, R. K. M., Tan, P. B. O., Liu, E. T., & Yu, Q. (2007) · Genes & Development · doi:10.1101/gad.1524107 · Cited by 895 · see citing works
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Northcott, P. A., Shih, D. J. H., Peacock, J., Garzia, L., Morrissy, A. S., Zichner, T., Stütz, A. M., Korshunov, A., Reimand, J., Schumacher, S. E., et al. (2012) · Nature · doi:10.1038/nature11327 · Cited by 887 · see citing works
Self-citationDissecting the genomic complexity underlying medulloblastoma
Jones, D. T. W., Jäger, N., Kool, M., Zichner, T., Hutter, B., Sultan, M., Cho, Y.-J., Pugh, T. J., Hovestadt, V., Stütz, A. M., et al. (2012) · Nature · doi:10.1038/nature11284 · Cited by 839 · see citing works
Self-citationNovel mutations target distinct subgroups of medulloblastoma
Robinson, G. W., Parker, M. D., Kranenburg, T. A., Lu, C., Chen, X. '., Ding, L., Phoenix, T. N., Hedlund, E., Wei, L., Zhu, X., et al. (2012) · Nature · doi:10.1038/nature11213 · Cited by 835 · see citing works
Radial glia cells are candidate stem cells of ependymoma
Taylor, M. D., Poppleton, H., Fuller, C. E., Su, X., Liu, Y., Jensen, P., Magdaleno, S. M., Dalton, J., Calabrese, C. R., Julian Board, et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.09.001 · Cited by 822 · see citing works
Self-citationMedulloblastoma exome sequencing uncovers subtype-specific somatic mutations
Pugh, T. J., Weeraratne, S. D., Archer, T. C., Pomeranz Krummel, D. A., Auclair, D., Bochicchio, J., Carneiro, M. O., Carter, S. L., Cibulskis, K., Erlich, R. L., et al. (2012) · Nature · doi:10.1038/nature11329 · Cited by 750 · see citing works
Self-citationMuSiC: Identifying mutational significance in cancer genomesPreprint
Dees, N. D., Zhang, Q., Kandoth, C., Wendl, M. C., Schierding, W. S., Koboldt, D. C., Mooney, T. B., Callaway, M. B., Dooling, D. J., Mardis, E. R., et al. (2012) · Genome Research · doi:10.1101/gr.134635.111 · Cited by 669 · see citing works
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis
Down, T. A., Rakyan, V. K., Turner, D., Flicek, P., Li, H., Kulesha, E., Gräf, S., Johnson, N., Herrero, J., Tomazou, E. M., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1414 · Cited by 651 · see citing works
Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma
Witt, H., Mack, S. C., Ryzhova, M. V., Bender, S., Sill, M., Isserlin, R., Benner, A., Hielscher, T., Milde, T., Remke, M., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.07.007 · Cited by 554 · see citing works
Self-citationA novel retinoblastoma therapy from genomic and epigenetic analyses
Zhang, J., Benavente, C. A., McEvoy, J. D., Flores‐Otero, J., Ding, L., Chen, X. '., Ulyanov, A. V., Wu, G., Wilson, M. W., Wang, J., et al. (2012) · Nature · doi:10.1038/nature10733 · Cited by 515 · see citing works
Conformal radiotherapy after surgery for paediatric ependymoma: a prospective study
Merchant, T. E., Li, C., Xiong, X., Kun, L. E., Boop, F. A., & Sanford, R. A. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70342-5 · Cited by 508 · see citing works
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers
Lee, R. S., Stewart, C., Carter, S. L., Ambrogio, L., Cibulskis, K., Sougnez, C. L., Lawrence, M. S., Auclair, D., Mora, J., Golub, T. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64400 · Cited by 424 · see citing works
Sausen, M., Leary, R. J., Jones, S., Wu, J., Reynolds, C. P., Liu, X., Blackford, A. L., Parmigiani, G., Diaz, L. A., Papadopoulos, N., et al. (2012) · Nature Genetics · doi:10.1038/ng.2493 · Cited by 414 · see citing works
Northcott, P. A., Nakahara, Y., Wu, X., Feuk, L., Ellison, D. W., Croul, S. E., Mack, S. C., Kongkham, P. N., Peacock, J., Dubuc, A. M., et al. (2009) · Nature Genetics · doi:10.1038/ng.336 · Cited by 413 · see citing works
Self-citationCross-species genomics matches driver mutations and cell compartments to model ependymoma
Johnson, R. A., Wright, K. D., Poppleton, H., Mohankumar, K. M., Finkelstein, D., Pounds, S. B., Rand, V., Leary, S. E. S., White, E. L., Eden, C., et al. (2010) · Nature · doi:10.1038/nature09173 · Cited by 363 · see citing works
Self-citationBreast Cancer Methylomes Establish an Epigenomic Foundation for Metastasis
Fang, F., Turcan, Ş., Rimner, A., Kaufman, A., Giri, D. D., Morris, L. G. T., Shen, R., Seshan, V., Mo, Q., Heguy, A., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001875 · Cited by 266 · see citing works
Methylation Subtypes and Large-Scale Epigenetic Alterations in Gastric Cancer
Zouridis, H., Deng, N., Ivanova, T., Zhu, Y., Wong, B. H., Huang, D., Wu, Y. H., Wu, Y., Tan, I. B., Liem, N. L. M., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004504 · Cited by 186 · see citing works
A prognostic gene expression signature in infratentorial ependymoma
Wani, K., Armstrong, T. S., Vera‐Bolanos, E., Raghunathan, A., Ellison, D. W., Gilbertson, R. J., Vaillant, B. D., Goldman, S., Packer, R. J., Fouladi, M., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0941-4 · Cited by 161 · see citing works
Self-citationSurvival Benefit for Pediatric Patients With Recurrent Ependymoma Treated With Reirradiation
Bouffet, É., Hawkins, C. E., Ballourah, W., Taylor, M. D., Bartels, U. K., Schoenhoff, N. J., Tsangaris, E., Huang, A., Kulkarni, A. V., Mabbott, D., et al. (2012) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2011.10.039 · Cited by 139 · see citing works
Self-citationIntegrated genomic analyses of ovarian carcinoma
The Cancer Genome Atlas Research Network (2011) · Nature · doi:10.1038/nature10166 · Cited by 129 · see citing works
Chemotherapy for intracranial ependymomas
Bouffet, É., & Foreman, N. K. (1999) · Child s Nervous System · doi:10.1007/s003810050544 · Cited by 120 · see citing works
An Integrated In Vitro and In Vivo High-Throughput Screen Identifies Treatment Leads for Ependymoma
Atkinson, J. M., Shelat, A. A., Carcaboso, A. M., Kranenburg, T. A., Arnold, L. A., Boulos, N., Wright, K. D., Johnson, R. A., Poppleton, H., Mohankumar, K. M., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.08.013 · Cited by 115 · see citing works
A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells
Gallo, M., Ho, J. S. L., Coutinho, F. J., Vanner, R. J., Lee, L., Head, R., Ling, E. K. M., Clarke, I. D., & Dirks, P. B. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1881 · Cited by 93 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
DNA methylation-based classification of central nervous system tumours
Capper, D., Jones, D., Sill, M., Hovestadt, V., Schrimpf, D., Sturm, D., Koelsche, C., Sahm, F., Chávez, L., Reuß, D., et al. (2018) · Nature · doi:10.1038/nature26000 · Cited by 3,046 · see citing works
Self-citationReimand, J., Isserlin, R., Voisin, V., Kucera, M., Tannus-Lopes, C., Rostamianfar, A., Wadi, L., Meyer, M., Wong, J., Xu, C., et al. (2019) · Nature Protocols · doi:10.1038/s41596-018-0103-9 · Cited by 1,970 · see citing works
Self-citationThe landscape of genomic alterations across childhood cancers
ICGC PedBrain-Seq Project, Gröbner, S. N., ICGC MMML-Seq Project, Worst, B. C., Weischenfeldt, J., Buchhalter, I., Kleinheinz, K., Rudneva, V. A., Johann, P. D., Balasubramanian, G. P., et al. (2018) · Nature · doi:10.1038/nature25480 · Cited by 1,572 · see citing works
Self-citationRoulois, D., Loo Yau, H., Singhania, R., Wang, Y., Danesh, A., Shen, S. Y., Han, H., Liang, G., Jones, P. A., Pugh, T. J., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.056 · Cited by 1,527 · see citing works
Self-citationEpigenetic plasticity and the hallmarks of cancer
Flavahan, W. A., Gaskell, E., & Bernstein, B. E. (2017) · Science · doi:10.1126/science.aal2380 · Cited by 1,340 · see citing works
Pajtler, K. W., Witt, H., Sill, M., Jones, D., Hovestadt, V., Kratochwil, F., Wani, K., Tatevossian, R., Punchihewa, C., Johann, P. D., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.002 · Cited by 1,226 · see citing works
Self-citationTargeting the cancer epigenome for therapy
Jones, P. A., Issa, J. J., & Baylin, S. B. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.93 · Cited by 1,132 · see citing works
Weller, M., Wick, W., Aldape, K. D., Brada, M., Berger, M. S., Pfister, S. M., Nishikawa, R., Rosenthal, M. A., Wen, P. Y., Stupp, R., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.17 · Cited by 1,130 · see citing works
Self-citationEpigenetic modulators, modifiers and mediators in cancer aetiology and progression
Feinberg, A. P., Koldobskiy, M. A., & Göndör, A. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.13 · Cited by 878 · see citing works
Glioma Subclassifications and Their Clinical Significance
Chen, R., Smith-Cohn, M., Cohen, A. L., & Colman, H. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0519-x · Cited by 812 · see citing works
Advances in the molecular genetics of gliomas — implications for classification and therapy
Reifenberger, G., Wirsching, H.-G., Knobbe-Thomsen, C. B., & Weller, M. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.204 · Cited by 662 · see citing works
The Key Role of Epigenetics in Human Disease Prevention and Mitigation
Feinberg, A. P. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1402513 · Cited by 638 · see citing works
Tumour hypoxia causes DNA hypermethylation by reducing TET activity
Thienpont, B., Steinbacher, J., Zhao, H., D’Anna, F., Kuchnio, A., Ploumakis, A., Ghesquière, B., Van Dyck, L., Boeckx, B., Schoonjans, L., et al. (2016) · Nature · doi:10.1038/nature19081 · Cited by 635 · see citing works
Johann, P. D., Erkek, S., Zapatka, M., Kerl, K., Buchhalter, I., Hovestadt, V., Jones, D., Sturm, D., Hermann, C., Segura‐Wang, M., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.02.001 · Cited by 572 · see citing works
Self-citationThe roles of DNA, RNA and histone methylation in ageing and cancer
Michalak, E. M., Burr, M. L., Bannister, A. J., & Dawson, M. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0143-1 · Cited by 549 · see citing works
DNA methylation and DNA methyltransferases
Edwards, J. R., Yarychkivska, O., Boulard, M., & Bestor, T. H. (2017) · Epigenetics & Chromatin · doi:10.1186/s13072-017-0130-8 · Cited by 487 · see citing works
Wang, Y., Springer, S. U., Zhang, M., McMahon, K. W., Kinde, I., Dobbyn, L., Ptak, J., Brem, H., Chaichana, K. L., Gallia, G. L., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511694112 · Cited by 455 · see citing works
Childhood cerebellar tumours mirror conserved fetal transcriptional programs
Vladoiu, M. C., El-Hamamy, I., Donovan, L., Farooq, H., Holgado, B., Sundaravadanam, Y., Ramaswamy, V., Hendrikse, L. D., Kumar, S. A., Mack, S. C., et al. (2019) · Nature · doi:10.1038/s41586-019-1158-7 · Cited by 425 · see citing works
Self-citationTumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Zhang, S., Xiao, X., Yi, Y., Wang, X., Zhu, L., Shen, Y., Lin, D., & Wu, C. H. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01848-7 · Cited by 440 · see citing works
Self-citationLin, H., Liu, C., Hu, A.-K., Zhang, D., Yang, H., & Mao, Y. Q. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01544-7 · Cited by 424 · see citing works
The cancer epigenome: Concepts, challenges, and therapeutic opportunities
Dawson, M. A. (2017) · Science · doi:10.1126/science.aam7304 · Cited by 377 · see citing works
Gritsch, S., Batchelor, T. T., & Castro, L. N. G. (2021) · Cancer · doi:10.1002/cncr.33918 · Cited by 380 · see citing works
Pajtler, K. W., Mack, S. C., Ramaswamy, V., Smith, C. A., Witt, H., Smith, A., Hansford, J. R., von Hoff, K., Wright, K. D., Hwang, E. I., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1643-0 · Cited by 337 · see citing works
Self-citationPathway and network analysis of cancer genomes
Creixell, P., Linding, R., Reimand, J., Bader, G. D., Haider, S., Wu, G., Ouellette, B. F. F., Boutros, P. C., Stein, L. D., Shibata, T., et al. (2015) · Nature Methods · doi:10.1038/nmeth.3440 · Cited by 326 · see citing works
Self-citationPathway Commons 2019 Update: integration, analysis and exploration of pathway data
Rodchenkov, I. V., Babur, Ö., Luna, A., Aksoy, B. A., Wong, J. V., Fong, D., Franz, M., Siper, M. C., Cheung, M., Wrana, M., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz946 · Cited by 306 · see citing works
Self-citationAMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells
Pei, S., Minhajuddin, M., Adane, B., Khan, N., Stevens, B. M., Mack, S. C., Lai, S., Rich, J. N., Sheth, A. I., Shannon, K., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.05.021 · Cited by 300 · see citing works
Self-citationDNA Methylation Profiling: An Emerging Paradigm for Cancer Diagnosis
Papanicolau‐Sengos, A., & Aldape, K. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-042220-022304 · Cited by 283 · see citing works
Self-citationPisco, A. O., & Huang, S. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.146 · Cited by 278 · see citing works
cIMPACT‐NOW update 7: advancing the molecular classification of ependymal tumors
Ellison, D. W., Aldape, K., Capper, D., Fouladi, M., Gilbert, M. R., Gilbertson, R. J., Hawkins, C. E., Merchant, T. E., Pajtler, K. W., Venneti, S., et al. (2020) · Brain Pathology · doi:10.1111/bpa.12866 · Cited by 278 · see citing works
Self-citationHuse, J. T., Snuderl, M., Jones, D., Brathwaite, C. D., Altman, N. R., Lavi, E., Saffery, R., Sexton‐Oates, A., Blümcke, I., Capper, D., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1639-9 · Cited by 267 · see citing works
Self-citationMechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
Leao, R. R. N., Apolónio, J. D., Lee, D., Figueiredo, A., Tabori, U. Y., & Castelo‐Branco, P. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0422-8 · Cited by 266 · see citing works
Self-citationMolecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas
Pajtler, K. W., Wen, J., Sill, M., Lin, T., Orisme, W., Tang, B., Hübner, J.-M., Ramaswamy, V., Jia, S., Dalton, J., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1877-0 · Cited by 261 · see citing works
Self-citationOncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure
Pagliarini, R. A., Shao, W., & Sellers, W. R. (2015) · EMBO Reports · doi:10.15252/embr.201439949 · Cited by 255 · see citing works
Poirier, J. T., Gardner, E. E., Connis, N., Moreira, A. L., de Stanchina, E., Hann, C. L., & Rudin, C. M. (2015) · Oncogene · doi:10.1038/onc.2015.38 · Cited by 247 · see citing works
Panwalkar, P., Clark, J. R., Ramaswamy, V., Hawes, D., Yang, F., Dunham, C. P., Yip, S. S. F., Hukin, J., Sun, Y., Schipper, M. J., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1752-4 · Cited by 250 · see citing works
Self-citationDonovan, L., Delaidelli, A., Joseph, S. K., Bielamowicz, K., Fousek, K., Holgado, B., Manno, A., Srikanthan, D., Gad, A. Z., Ommeren, R. V., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0827-2 · Cited by 244 · see citing works
Self-citationCirculating Tumor DNA as Biomarkers for Cancer Detection
Han, X., Wang, J., & Sun, Y. (2017) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2016.12.004 · Cited by 241 · see citing works
Adorno-Cruz, V., Kibria, G., Liu, X., Doherty, M. R., Junk, D. J., Guan, D., Hubert, C., Venere, M., Mulkearns-Hubert, E. E., Sinyuk, M., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3225 · Cited by 238 · see citing works
Developmental origins and emerging therapeutic opportunities for childhood cancer
Filbin, M. G., & Monje, M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0383-9 · Cited by 240 · see citing works
Gajjar, A. J., Bowers, D. C., Karajannis, M. A., Leary, S. E. S., Witt, H., & Gottardo, N. G. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.59.9217 · Cited by 220 · see citing works
Self-citationAn integrative view on sex differences in brain tumors
Sun, T., Plutynski, A., Ward, S., & Rubin, J. B. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1930-2 · Cited by 218 · see citing works
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
Mack, S. C., Pajtler, K. W., Chávez, L., Okonechnikov, K., Bertrand, K. C., Wang, X., Erkek, S., Alexander Joel Federation, Song, A., Lee, C., et al. (2017) · Nature · doi:10.1038/nature25169 · Cited by 217 · see citing works
Self-citationEpigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches
Uddin, M. S., Mamun, A. A., Alghamdi, B. S. A., Tewari, D., Jeandet, P., Sarwar, M. S., & Ashraf, G. M. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.12.015 · Cited by 215 · see citing works
PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
Jain, S. U., Do, T. J., Lund, P. J., Rashoff, A. Q., Diehl, K. L., Cieslik, M. P., Bajic, A., Juretic, N., Deshmukh, S., Venneti, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09981-6 · Cited by 206 · see citing works
Self-citationEpigenetics in cancer therapy and nanomedicine
Roberti, A., Valdes, A. F., Torrecillas, R., Fraga, M. F., & Fernández, A. F. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0675-4 · Cited by 208 · see citing works
Ramaswamy, V., Hielscher, T., Mack, S. C., Lassaletta, Á., Lin, T., Pajtler, K. W., Jones, D., Luu, B., Cavalli, F. M. G., Aldape, K., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.65.7825 · Cited by 205 · see citing works
Self-citationWang, T., Zeng, Y., Li, Z., Jing, D., Fan, G., Liu, M., Zhuo, Q., Ji, S., Yu, X., Xu, X., et al. (2023) · Cell Proliferation · doi:10.1111/cpr.13478 · Cited by 200 · see citing works
Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas
Castro‐Vega, L. J., Letouzé, É., Burnichon, N., Buffet, A., Disderot, P.-H., Khalifa, E., Loriot, C., Elarouci, N., Morin, A., Menara, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7044 · Cited by 195 · see citing works
Olar, A., Wani, K., Wilson, C. D., Zadeh, G. M., DeMonte, F., Jones, D., Pfister, S. M., Sulman, E. P., & Aldape, K. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1678-x · Cited by 193 · see citing works
Self-citationBayliss, J. M., Mukherjee, P., Lü, C., Jain, S. U., Chung, C., Martínez, D., Sabari, B. R., Margol, A., Panwalkar, P., Parolia, A., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aah6904 · Cited by 192 · see citing works
Self-citationBiology and management of ependymomas
Wu, J., Armstrong, T. S., & Gilbert, M. R. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now016 · Cited by 190 · see citing works
Conversion of Stem Cells to Cancer Stem Cells: Undercurrent of Cancer Initiation
Afify, S. M., & Seno, M. (2019) · Cancers · doi:10.3390/cancers11030345 · Cited by 151 · see citing works
2016 Updates to the WHO Brain Tumor Classification System: What the Radiologist Needs to Know
Johnson, D. R., Guerin, J. B., Giannini, C., Morris, J. M., Eckel, L. J., & Kaufmann, T. J. (2017) · Radiographics · doi:10.1148/rg.2017170037 · Cited by 177 · see citing works
Transient loss of Polycomb components induces an epigenetic cancer fate
Parreno, V., Loubière, V., Schuettengruber, B., Fritsch, L., Rawal, C. C., Erokhin, M., Győrffy, B., Normanno, D., Stefano, M. D., Moreaux, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07328-w · Cited by 169 · see citing works
Patient Similarity Networks for Precision Medicine
Pai, S., & Bader, G. D. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.05.037 · Cited by 154 · see citing works
Self-citationEpigenetic regulation in cancer progression
Baxter, E., Windloch, K., Gannon, F., & Lee, J. S. (2014) · Cell & Bioscience · doi:10.1186/2045-3701-4-45 · Cited by 155 · see citing works
Gibaja, V, Shen, F., Harari, J., Korn, J., Ruddy, D., Saenz-Vash, V, Zhai, H., Rejtar, T., Paris, C. G., Yu, Z., et al. (2016) · Oncogene · doi:10.1038/onc.2015.114 · Cited by 149 · see citing works
The dualistic origin of human tumors
Liu, J. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.07.004 · Cited by 148 · see citing works
Molecular Insights into Pediatric Brain Tumors Have the Potential to Transform Therapy
Gajjar, A. J., Pfister, S. M., Taylor, M. D., & Gilbertson, R. J. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0833 · Cited by 147 · see citing works
Self-citationMechanisms of Polycomb group protein function in cancer
Parreno, V., Martinez, A., & Cavalli, G. (2022) · Cell Research · doi:10.1038/s41422-021-00606-6 · Cited by 147 · see citing works
Hübner, J.-M., Müller, T., Papageorgiou, D. N., Mauermann, M., Krijgsveld, J., Russell, R. B., Ellison, D. W., Pfister, S. M., Pajtler, K. W., & Kool, M. (2019) · Neuro-Oncology · doi:10.1093/neuonc/noz058 · Cited by 144 · see citing works
Self-citationMethylation across the central dogma in health and diseases: new therapeutic strategies
Liu, R., Zhao, E., Yu, H., Yuan, C., Abbas, M. N., & Cui, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01528-y · Cited by 147 · see citing works
Béchet, D., Gielen, G. H., Korshunov, A., Pfister, S. M., Rousso, C., Faury, D., Fiset, P., Benlimame, N., Lewis, P. W., Lü, C., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1337-4 · Cited by 137 · see citing works
Self-citationFinal results of the second prospective AIEOP protocol for pediatric intracranial ependymoma
Massimino, M., Miceli, R., Giangaspero, F., Boschetti, L., Modena, P., Antonelli, M., Ferroli, P., Bertin, D., Pecori, E., Valentini, L. G., et al. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now108 · Cited by 136 · see citing works
Mechanisms and Consequences of Cancer Genome Instability: Lessons from Genome Sequencing Studies
Lee, J. J.-K., Choi, Y., Kwon, M., & Park, P. J. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012615-044446 · Cited by 132 · see citing works
RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia
Lipka, D. B., Witte, T., Tóth, R., Yang, J., Wiesenfarth, M., Noellke, P., Fischer, A., Brocks, D., Gu, Z., Park, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02177-w · Cited by 135 · see citing works
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma
Michealraj, K. A., Kumar, S. A., Kim, L. J. Y., Cavalli, F. M. G., Przelicki, D., Wojcik, J. B., Delaidelli, A., Bajic, A., Saulnier, O., MacLeod, G. D. A. H., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.047 · Cited by 134 · see citing works
Self-citationClinical course and progression-free survival of adult intracranial and spinal ependymoma patients
Vera‐Bolanos, E., Aldape, K., Yuan, Y., Wu, J., Wani, K., Necesito-Reyes, M. J., Colman, H., Dhall, G., Lieberman, F. S., Métellus, P., et al. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou162 · Cited by 132 · see citing works
Self-citationon behalf of the Japan Pediatric Molecular Neuro-Oncology Group (JPMNG), Fukuoka, K., Kanemura, Y., Shofuda, T., Fukushima, S., Yamashita, S., Narushima, D., Kato, M., Honda‐Kitahara, M., Ichikawa, H., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0630-1 · Cited by 132 · see citing works
Self-citationThe α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity
Vatrinet, R., Leone, G., Luise, M. D., Girolimetti, G., Vidone, M., Gasparre, G., & Porcelli, A. M. (2017) · Cancer & Metabolism · doi:10.1186/s40170-017-0165-0 · Cited by 130 · see citing works
Heterogeneity within the PF-EPN-B ependymoma subgroup
Cavalli, F. M. G., Hübner, J.-M., Sharma, T. S., Luu, B., Sill, M., Zápotocký, M., Mack, S. C., Witt, H., Lin, T., Shih, D. J. H., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1888-x · Cited by 128 · see citing works
Self-citationCharacterization of gliomas: from morphology to molecules
Ferris, S. P., Hofmann, J. W., Solomon, D. A., & Perry, A. (2017) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-017-2181-4 · Cited by 130 · see citing works
Henrich, K., Bender, S., Saadati, M., Dreidax, D., Gartlgruber, M., Shao, C., Herrmann, C., Wiesenfarth, M., Parzonka, M., Wehrmann, L., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2507 · Cited by 122 · see citing works
Self-citationDanchin, É., Pocheville, A., Rey, O., Pujol, B., & Blanchet, S. (2018) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12453 · Cited by 123 · see citing works
Dynamics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape
Li, Q., Wennborg, A., Aurell, E. M., Dekel, E., Zou, J., Xu, Y., Huang, S., & Ernberg, I. T. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519210113 · Cited by 121 · see citing works
Kurmasheva, R. T., Sammons, M. C., Favours, E., Wu, J., Kurmashev, D., Cosmopoulos, K., Keilhack, H., Klaus, C. R., Houghton, P. J., & Smith, M. A. (2016) · Pediatric Blood & Cancer · doi:10.1002/pbc.26218 · Cited by 122 · see citing works
Pediatric Brain Tumor Genetics: What Radiologists Need to Know
AlRayahi, J., Zápotocký, M., Ramaswamy, V., Hanagandi, P. B., Branson, H. M., Mubarak, W. M., Raybaud, C., & Laughlin, S. (2018) · Radiographics · doi:10.1148/rg.2018180109 · Cited by 122 · see citing works
Self-citationHamamoto, R., Komatsu, M., Takasawa, K., Asada, K., & Kaneko, S. (2019) · Biomolecules · doi:10.3390/biom10010062 · Cited by 126 · see citing works
Carén, H., Stricker, S. H., Bulstrode, H. J. C. J., Gagrica, S., Johnstone, E. R., Bartlett, T. E., Feber, A., Wilson, G. A., Teschendorff, A. E., Bertone, P., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.09.014 · Cited by 120 · see citing works
The “life code”: A theory that unifies the human life cycle and the origin of human tumors
Liu, J. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.09.005 · Cited by 119 · see citing works
Molecular classification of gliomas
Masui, K., Mischel, P. S., & Reifenberger, G. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-12-802997-8.00006-2 · Cited by 114 · see citing works
Medulloblastoma: From Molecular Subgroups to Molecular Targeted Therapies
Wang, J., Garancher, A., Ramaswamy, V., & Wechsler-Reya, R. J. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-013838 · Cited by 113 · see citing works
Self-citationHit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
Saunderson, E. A., Stepper, P., Gomm, J. J., Hoa, L., Morgan, A. A., Allen, M. D., Jones, J. L., Gribben, J. G., Jurkowski, T. P., & Ficz, G. (2017) · Nature Communications · doi:10.1038/s41467-017-01078-2 · Cited by 113 · see citing works
Epistemology of the origin of cancer: a new paradigm
Brücher, B. L. D. M., & Jamall, I. S. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-331 · Cited by 112 · see citing works
Epigenetic Priming in Cancer Initiation
Vicente‐Dueñas, C., Hauer, J., Cobaleda, C., Borkhardt, A., & Sánchez-Garcı́a, I. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.04.007 · Cited by 107 · see citing works
LSD1/KDM1A, a Gate-Keeper of Cancer Stemness and a Promising Therapeutic Target
Karakaidos, P., Verigos, J., & Magklara, A. (2019) · Cancers · doi:10.3390/cancers11121821 · Cited by 108 · see citing works
Clinical advances in targeting epigenetics for cancer therapy
Feng, S., & Carvalho, D. D. D. (2021) · FEBS Journal · doi:10.1111/febs.15750 · Cited by 107 · see citing works
An epigenetic gateway to brain tumor cell identity
Mack, S. C., Hubert, C. G., Miller, T. E., Taylor, M. D., & Rich, J. N. (2015) · Nature Neuroscience · doi:10.1038/nn.4190 · Cited by 104 · see citing works
Self-citationYamamoto, K., Tateishi, K., Kudo, Y., Sato, T., Yamamoto, S., Miyabayashi, K., Matsusaka, K., Asaoka, Y., Ijichi, H., Hirata, Y., et al. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu136 · Cited by 104 · see citing works
Convection-Enhanced Delivery for Diffuse Intrinsic Pontine Glioma Treatment
Zhou, Z., Singh, R., & Souweidane, M. M. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160614093615 · Cited by 104 · see citing works
Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment
Wheeler, D. A., Takebe, N., Hinoue, T., Hoadley, K. A., Cardenas, M., Hamilton, A. M., Laird, P. W., Wang, L., Johnson, A., Dewal, N., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.10.015 · Cited by 101 · see citing works
Saleh, R., Toor, S. M., Nair, V. S., & Elkord, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01469 · Cited by 103 · see citing works
Fukushima, S., Yamashita, S., Kobayashi, H., Takami, H., Fukuoka, K., Nakamura, T., Yamasaki, K., Matsushita, Y., Nakamura, H. K., Totoki, Y., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1673-2 · Cited by 101 · see citing works
Poised chromatin in the mammalian germ line
Lesch, B. J., & Page, D. (2014) · Development · doi:10.1242/dev.113027 · Cited by 92 · see citing works
Zheng, T., Ghasemi, D. R., Okonechnikov, K., Korshunov, A., Sill, M., Maaß, K. K., da Silva, P. B. G., Ryzhova, M. V., Gojo, J., Stichel, D., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0963 · Cited by 94 · see citing works
Self-citationBiological significance of the CpG island methylator phenotype
Suzuki, H., Yamamoto, E., Maruyama, R., Niinuma, T., & Kai, M. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.07.007 · Cited by 95 · see citing works
Mutations in chromatin machinery and pediatric high-grade glioma
Lulla, R. R., Saratsis, A. M., & Hashizume, R. (2016) · Science Advances · doi:10.1126/sciadv.1501354 · Cited by 93 · see citing works
Somatic Mutation Theory - Why it's Wrong for Most Cancers
Brücher, B. L. D. M., & Jamall, I. S. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000443106 · Cited by 96 · see citing works
Marinoff, A. E., Ma, C., Guo, D., Snuderl, M., Wright, K. D., Manley, P. E., Al‐Sayegh, H., Sinai, C. E., Ullrich, N. J., Marcus, K. J., et al. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2568-8 · Cited by 95 · see citing works
Evidence of H3 K27M mutations in posterior fossa ependymomas
Gessi, M., Capper, D., Sahm, F., Huang, K. T. L., von Deimling, A., Tippelt, S., Fleischhack, G., Scherbaum, D., Alfer, J., Juhnke, B.-O., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1608-3 · Cited by 93 · see citing works
Self-citation
- Authors
- Mack, S. C., Witt, H., Piro, R. M., Gu, L., Zuyderduyn, S., Stütz, A. M., Wang, X., Gallo, M., Garzia, L., Zayne, K., Zhang, X., Ramaswamy, V., Jäger, N., Jones, D. T. W., Sill, M., Pugh, T. J., Ryzhova, M., Wani, K. M., Shih, D. J. H., Head, R., Remke, M., Bailey, S. D., Zichner, T., Faria, C. C., Barszczyk, M., Stark, S., Seker-Cin, H., Hutter, S., Johann, P., Bender, S., Hovestadt, V., Tzaridis, T., Dubuc, A. M., Northcott, P. A., Peacock, J., Bertrand, K. C., Agnihotri, S., Cavalli, F. M. G., Clarke, I., Nethery-Brokx, K., Creasy, C. L., Verma, S. K., Koster, J., Wu, X., Yao, Y., Milde, T., Sin-Chan, P., Zuccaro, J., Lau, L., Pereira, S., Castelo-Branco, P., Hirst, M., Marra, M. A., Roberts, S. S., Fults, D., Massimi, L., Cho, Y. J., Van Meter, T., Grajkowska, W., Lach, B., Kulozik, A. E., von Deimling, A., Witt, O., Scherer, S. W., Fan, X., Muraszko, K. M., Kool, M., Pomeroy, S. L., Gupta, N., Phillips, J., Huang, A., Tabori, U., Hawkins, C., Malkin, D., Kongkham, P. N., Weiss, W. A., Jabado, N., Rutka, J. T., Bouffet, E., Korbel, J. O., Lupien, M., Aldape, K. D., Bader, G. D., Eils, R., Lichter, P., Dirks, P. B., Pfister, S. M., Korshunov, A., & Taylor, M. D.
- Affiliations
- University of Toronto (CA)
- German Cancer Research Center (DE)
- European Molecular Biology Laboratory (DE)
- Hospital for Sick Children (CA)
- Dartmouth–Hitchcock Medical Center (US)
- Boston Children's Hospital (US)
- The University of Texas MD Anderson Cancer Center (US)
- Ontario Institute for Cancer Research (CA)
- GlaxoSmithKline (United States) (US)
- BC Cancer Agency (CA)
- Uniformed Services University of the Health Sciences (US)
- University of Utah (US)
- Agostino Gemelli University Polyclinic (IT)
- Stanford Medicine (US)
- Children's Memorial Health Institute (PL)
- Hamilton General Hospital (CA)
- Heidelberg University (DE)
- University of Michigan (US)
- University of California, San Francisco (US)
- McGill University Health Centre (CA)
- Corresponding author
- Korshunov, A.
- Taylor, M. D.
- ORCID
- Mack, S. C.
- Witt, H.
- Piro, R. M.
- Gu, L.
- Stütz, A. M.
- Wang, X.
- Gallo, M.
- Garzia, L.
- Zhang, X.
- Ramaswamy, V.
- Jäger, N.
- Jones, D. T. W.
- Sill, M.
- Pugh, T. J.
- Ryzhova, M.
- Wani, K. M.
- Shih, D. J. H.
- Remke, M.
- Bailey, S. D.
- Zichner, T.
- Faria, C. C.
- Barszczyk, M.
- Hutter, S.
- Johann, P.
- Hovestadt, V.
- Tzaridis, T.
- Dubuc, A. M.
- Northcott, P. A.
- Bertrand, K. C.
- Agnihotri, S.
- Cavalli, F. M. G.
- Creasy, C. L.
- Verma, S. K.
- Wu, X.
- Yao, Y.
- Milde, T.
- Zuccaro, J.
- Lau, L.
- Pereira, S.
- Hirst, M.
- Marra, M. A.
- Roberts, S. S.
- Fults, D.
- Massimi, L.
- Cho, Y. J.
- Grajkowska, W.
- Lach, B.
- Kulozik, A. E.
- Witt, O.
- Scherer, S. W.
- Fan, X.
- Muraszko, K. M.
- Kool, M.
- Pomeroy, S. L.
- Gupta, N.
- Phillips, J.
- Huang, A.
- Tabori, U.
- Hawkins, C.
- Malkin, D.
- Kongkham, P. N.
- Weiss, W. A.
- Jabado, N.
- Rutka, J. T.
- Korbel, J. O.
- Lupien, M.
- Aldape, K. D.
- Bader, G. D.
- Eils, R.
- Lichter, P.
- Dirks, P. B.
- Pfister, S. M.
- Korshunov, A.
- Taylor, M. D.
- Venue
- Nature
- Published
- 2014-02
- Volume
- 506
- Issue
- 7489
- Pages
- 445-450
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4174313
- OpenAlex
- W2113432767
- Cited by
- 607
- References
- 50
- Citations by year
- 2026: 15 · 2025: 29 · 2024: 30 · 2023: 29 · 2022: 37 · 2021: 51 · 2020: 56 · 2019: 55 · 2018: 68 · 2017: 64 · 2016: 73 · 2015: 57 · 2014: 40
- FWCI
- 39.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Pediatric Brain Tumor Foundation
- CureSearch for Children's Cancer
- Deutsches Krebsforschungszentrum
- Government of Ontario
- Bundesministerium für Bildung und Forschung (01KU1201A, 01GS0883)
- Terry Fox Research Institute
- Deutsche Krebshilfe (109252)
- Deutschen Konsortium für Translationale Krebsforschung
- National Institutes of Health
- Canadian Institutes of Health Research
- National Cancer Institute (R01CA148699, R01CA148621, R01CA121941, R01CA163737, R01CA159859, P30CA016672, P50CA097257)
- Topics
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- ependymoma, CpG island methylator phenotype, pediatric brain tumors, C11orf95-RELA fusion, chromothripsis, NF-κB signaling, H3K27me3, polycomb repressive complex 2, DNA methylation, EZH2 inhibitors, epigenetic therapy, tumor suppressor
- MeSH terms
- Animals, Brain Neoplasms, Ependymoma, Female, Histones, Humans, Infant, Mutation, Phenotype, Prognosis, Rhombencephalon, Gene Expression Regulation, Neoplastic, Mice, SCID, Mice, Inbred NOD, CpG Islands, DNA Methylation, Gene Silencing, Xenograft Model Antitumor Assays, Epigenesis, Genetic, Mice, Embryonic Stem Cells, Epigenomics, Polycomb Repressive Complex 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
