Evolution of new miRNAs and cerebro-cortical development
Abstract
The noncoding portion of the genome, including microRNAs, has been fertile evolutionary soil for cortical development in primates. A major contribution to cortical expansion in primates is the generation of novel precursor cell populations. Because miRNA expression profiles track closely with cell identity, it is likely that numerous novel microRNAs have contributed to cellular diversity in the brain. The tools to determine the genomic context within which novel microRNAs emerge and how they become integrated into molecular circuitry are now in hand.
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Many human-specific miRNAs are expressed uniquely in the brain.
“There are, however, human-specific miRNAs, many of which are expressed uniquely in the brain [56]”
From Shared and distinct microRNA profiles between HT22, N2A and SH-SY5Y cell lines and primary mouse hippocampal neurons (2025) · cites this paper as [56]
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Development of prefrontal cortex
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- Authors
- Kosik, K. S., & Nowakowski, T.
- Affiliations
- Neuroscience Research Institute and Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106, USA;
- Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, California 94143, USA
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2018-07-08
- Volume
- 41
- Issue
- 1
- Pages
- 119-137
- ISSN
- 0147-006X
- 1545-4126
- Cited by
- 35
- References
- 23
- Language
- en
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