Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation

Epithelial–mesenchymal transitions in tumour progression

Thiery, J. P. (2002) · Nature reviews. Cancer · doi:10.1038/nrc822 · Cited by 6,767

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068

The epidemiology of global micronutrient deficiencies

Bailey, R. L., West Jr., K. P., & Black, R. E. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000371618 · Cited by 2,035

Matrix metalloproteinases and tumor metastasis

Deryugina, E. I., & Quigley, J. P. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-7886-9 · Cited by 1,974

Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

Flo, T. H., Smith, K. D., Sato, S., Rodriguez, D. J., Holmes, M. A., Strong, R. K., Akira, S., & Aderem, A. (2004) · Nature · doi:10.1038/nature03104 · Cited by 1,877

The role of iron in brain ageing and neurodegenerative disorders

Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819

Chemistry and biology of siderophores

Hider, R. C., & Kong, X. (2010) · Natural Product Reports · doi:10.1039/b906679a · Cited by 1,722

Iron and cancer: more ore to be mined

Torti, S. V., & Torti, F. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3495 · Cited by 1,621

The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition

Goetz, D. H., Holmes, M. A., Borregaard, N., Bluhm, M. E., Raymond, K. N., & Strong, R. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00708-6 · Cited by 1,355

Inflammation in neurodegenerative diseases

Amor, S., Puentes, F., Baker, D., & Van Der Valk, P. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03225.x · Cited by 1,355

System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

Li, F., Long, H., Zhou, Z.-W., Luo, H., Xu, S., & Gao, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.910292 · Cited by 476

Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

Funcke, J., & Scherer, P. E. (2019) · Journal of Lipid Research · doi:10.1194/jlr.r094060 · Cited by 357

A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

Yao, F., Deng, Y., Zhao, Y., Mei, Y., Zhang, Y., Liu, X., Martinez, C., Su, X., Rosato, R. R., Teng, H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27452-9 · Cited by 328

NUPR1 is a critical repressor of ferroptosis

Liu, J., Song, X., Kuang, F., Zhang, Q., Xie, Y., Kang, R., Kroemer, G., & Tang, D. (2021) · Nature Communications · doi:10.1038/s41467-021-20904-2 · Cited by 290

The Review of Current Knowledge on Neutrophil Gelatinase-Associated Lipocalin (NGAL)

Romejko, K., Markowska, M., & Niemczyk, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310470 · Cited by 264

Iron Metabolism in Obesity and Metabolic Syndrome

González-Domínguez, Á., Visiedo-García, F. M., Domínguez-Riscart, J., González-Domínguez, R., Mateos, R. M., & Lechuga-Sancho, A. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155529 · Cited by 227

The Impact of Dietary Transition Metals on Host-Bacterial Interactions

Lopez, C. A., & Skaar, E. P. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.008 · Cited by 190

Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase

Qi, B., & Han, M. (2018) · Cell · doi:10.1016/j.cell.2018.07.032 · Cited by 164

The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity

Golonka, R. M., Yeoh, B. S., & Vijay–Kumar, M. (2019) · Journal of Innate Immunity · doi:10.1159/000494627 · Cited by 180

Bacteroidetes Species Are Correlated with Disease Activity in Ulcerative Colitis

Nomura, K., Ishikawa, D., Okahara, K., Ito, S., Haga, K., Takahashi, M., Arakawa, A., Shibuya, T., Osada, T., Kuwahara-Arai, K., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081749 · Cited by 150

Iron Acquisition Systems of Gram-negative Bacterial Pathogens Define TonB-Dependent Pathways to Novel Antibiotics

Klebba, P. E., Newton, S. M. C., Six, D. A., Kumar, A., Yang, T., Nairn, B. L., Munger, C., & Chakravorty, S. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01005 · Cited by 150

More than a simple biomarker: the role of NGAL in cardiovascular and renal diseases

Buonafine, M., Martínez‐Martínez, E., & Jaisser, F. (2018) · Clinical Science · doi:10.1042/cs20171592 · Cited by 154

Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia

Llorens, F., Hermann, P., Villar‐Piqué, A., Lucena, D. D., Nägga, K., Hansson, O., Santana, I. J., Schmitz, M., Schmidt, C., Varges, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14373-2 · Cited by 115

LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia

Wang, D., Li, X., Jiao, D., Cai, Y., Qian, L., Shen, Y., Lu, Y., Zhou, Y., Fu, B., Sun, R., et al. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01429-1 · Cited by 112

Siderophore conjugates to combat antibiotic-resistant bacteria

Rayner, B., Verderosa, A. D., Ferro, V., & Blaskovich, M. A. T. (2023) · RSC Medicinal Chemistry · doi:10.1039/d2md00465h · Cited by 110

Reduced secretion of LCN2 (lipocalin 2) from reactive astrocytes through autophagic and proteasomal regulation alleviates inflammatory stress and neuronal damage

Jung, B.-K., Park, Y., Yoon, B., Bae, J.-S., Han, S.-W., Heo, J. E., Kim, D., & Ryu, K. (2023) · Autophagy · doi:10.1080/15548627.2023.2180202 · Cited by 110

Zebrafish: an efficient vertebrate model for understanding role of gut microbiota

Xia, H., Chen, H., Cheng, X., Yin, M., Yao, X., Ma, J., Huang, M., Chen, G., & Liu, H. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00579-1 · Cited by 109

Molecular and Cellular Mechanisms of Itch in Psoriasis

Komiya, E., Tominaga, M., Kamata, Y., Suga, Y., & Takamori, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218406 · Cited by 96

An Integrative Pan-Cancer Analysis Revealing LCN2 as an Oncogenic Immune Protein in Tumor Microenvironment

Xu, W., Zhang, J., Hua, Y.-T., Yang, S., Wang, D., & Tang, J.-H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.605097 · Cited by 93

Faecal Biomarkers in Inflammatory Bowel Diseases: Calprotectin Versus Lipocalin-2-a Comparative Study

Zollner, A., Schmiderer, A., Reider, S. J., Oberhuber, G., Pfister, A., Texler, B., Watschinger, C., Koch, R., Effenberger, M., Raine, T., et al. (2021) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjaa124 · Cited by 95

Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases

Dekens, D. W., Eisel, U. L. M., Gouweleeuw, L., Schoemaker, R. G., Deyn, P. P. D., & Naudé, P. J. W. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101414 · Cited by 93

The role of ferroptosis in acute lung injury

Liu, X., Zhang, J., & Xie, W. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04327-7 · Cited by 93

PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti‐PD‐1 Immunotherapy

Zheng, Y.-M., Wang, Y., Zhou, L., Wan, J., Jiang, L., Song, D., Wei, C., Gao, C., Shi, G., Zhou, J., et al. (2023) · Advanced Science · doi:10.1002/advs.202301928 · Cited by 92

Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity

Qiu, X., Macchietto, M. G., Liu, X., Lu, Y., Ma, Y., Guo, H., Saqui–Salces, M., Bernlohr, D., Chen, C., Shen, S., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-00712-2 · Cited by 90

Iron Homeostasis and Metabolism: Two Sides of a Coin

Venkataramani, V. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-62026-4_3 · Cited by 96

Mechanism of sorafenib resistance associated with ferroptosis in HCC

Guo, L., Hu, C., Yao, M., & Han, G. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1207496 · Cited by 97

Hepatocytes and neutrophils cooperatively suppress bacterial infection by differentially regulating lipocalin‐2 and neutrophil extracellular traps

Li, H., Feng, D., Cai, Y., Liu, Y., Xu, M., Xiang, X., Zhou, Z., Xia, Q., Kaplan, M. J., Kong, X., et al. (2018) · Hepatology · doi:10.1002/hep.29919 · Cited by 77

Iron status in the elderly: A review of recent evidence

Wawer, A. A., Jennings, A., & Fairweather‐Tait, S. J. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.07.003 · Cited by 77

Lipocalin-2: a therapeutic target to overcome neurodegenerative diseases by regulating reactive astrogliosis

Jung, B.-K., & Ryu, K. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01098-7 · Cited by 76

Obesity and Pancreatic Cancer: Insight into Mechanisms

Eibl, G., & Rozengurt, E. (2021) · Cancers · doi:10.3390/cancers13205067 · Cited by 76

Role of lipocalin 2 in stroke

Zhao, R., Wei, P., Sun, X., Zhang, D., He, Q., Liu, J., Chang, J., Yang, Y. R., & Guo, Z. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106044 · Cited by 72

PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma

Wang, J., Wang, C., Xu, P., Li, X., Lu, Y., Jin, D., Yin, X., Jiang, H., Huang, J. L., Xiong, H., et al. (2021) · Theranostics · doi:10.7150/thno.42345 · Cited by 70

Alterations in glutathione redox homeostasis among adolescents with obesity and anemia

Alkazemi, D. U. Z., Rahman, A., & Habra, B. (2021) · Scientific Reports · doi:10.1038/s41598-021-82579-5 · Cited by 77

Comprehensive review of lipocalin 2-mediated effects in lung inflammation

Guardado, E. S., Ojeda-Juárez, D., Kaul, M., & Nordgren, T. M. (2021) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00080.2021 · Cited by 70

Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer

Zhu, S., Ma, A.-H., Zhu, Z. G., Adib, E., Rao, T., Li, N., Ni, K., Chittepu, V. C. S. R., PRABHALA, R. H., Risco, J. G., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002917 · Cited by 66

Iron and iron-related proteins in COVID-19

Suriawinata, E., & Mehta, K. J. (2022) · Clinical and Experimental Medicine · doi:10.1007/s10238-022-00851-y · Cited by 69

Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors

Punziano, C., Trombetti, S., Cesaro, E., Grosso, M., & Faraonio, R. (2024) · Antioxidants · doi:10.3390/antiox13030298 · Cited by 75

The battle for iron in enteric infections

Sousa Gerós, A., Simmons, A., Drakesmith, H., Aulicino, A., & Frost, J. N. (2020) · Immunology · doi:10.1111/imm.13236 · Cited by 58

Lcn2-derived Circular RNA (hsa_circ_0088732) Inhibits Cell Apoptosis and Promotes EMT in Glioma via the miR-661/RAB3D Axis

Jin, T., Liu, M., Liu, Y., Li, Y., Xu, Z., He, H., Liu, J., Zhang, Y., & Ke, Y. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00170 · Cited by 62

Lipocalin 2 regulates iron homeostasis, neuroinflammation, and insulin resistance in the brains of patients with dementia: Evidence from the current literature

Lim, D., Jeong, J., & Song, J. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13653 · Cited by 64

A bacterial immunomodulatory protein with lipocalin-like domains facilitates host–bacteria mutualism in larval zebrafish

Rolig, A. S., Sweeney, E. G., Kaye, L. E., DeSantis, M. D., Perkins, A., Banse, A. V., Hamilton, M. K., & Guillemin, K. J. (2018) · eLife · doi:10.7554/elife.37172 · Cited by 61

Glioma-derived exosomes hijack the blood–brain barrier to facilitate nanocapsule delivery via LCN2

Yang, C., Wu, Y., Wang, L., Li, S., Zhou, J., Tan, Y., Song, J. L., Xing, H., Yi, K., Zhan, Q., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.038 · Cited by 61

Neutrophil extracellular trap-associated molecules: a review on their immunophysiological and inflammatory roles

Morales-Primo, A. U., Becker, I., & Zamora‐Chimal, J. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.1921174 · Cited by 64

IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase associated lipocalin during acute kidney injury

Skrypnyk, N. I., Gist, K. M., Okamura, K., Montford, J. R., You, Z.-Y., Yang, H.-C., Moldovan, R., Bodoni, E., Blaine, J., Edelstein, C., et al. (2019) · Kidney International · doi:10.1016/j.kint.2019.11.013 · Cited by 53

Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages

Lu, Y., Basatemur, G., Scott, I. C., Chiarugi, D., Clément, M., Harrison, J. E., Jugdaohsingh, R., Yu, X., Newland, S. A., Jolin, H. E., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.03.006 · Cited by 59

Lipocalin 2—not only a biomarker: a study of current literature and systematic findings of ongoing clinical trials

Asaf, S., Maqsood, F., Jalil, J., Sarfraz, Z., Sarfraz, A., Mustafa, S., & Chérrez-Ojeda, I. (2022) · Immunologic Research · doi:10.1007/s12026-022-09352-2 · Cited by 58

Single-cell and Spatial Transcriptomics Reveals Ferroptosis as The Most Enriched Programmed Cell Death Process in Hemorrhage Stroke-induced Oligodendrocyte-mediated White Matter Injury

Gu, L., Chen, H., Geng, R., Sun, M., Shi, Q., Chen, Y., Chang, J., Wei, J., Ma, W., Xiao, J., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.96262 · Cited by 58

Revisiting Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Cancer: Saint or Sinner?

Bauvois, B., & Susín, S. A. (2018) · Cancers · doi:10.3390/cancers10090336 · Cited by 56

Tumor necrosis factor-α-primed mesenchymal stem cell-derived exosomes promote M2 macrophage polarization via Galectin-1 and modify intrauterine adhesion on a novel murine model

Li, J., Pan, Y., Yang, J., Wang, J., Jiang, Q., Dou, H., & Hou, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.945234 · Cited by 60

Mechanisms of iron homeostasis in Pseudomonas aeruginosa and emerging therapeutics directed to disrupt this vital process

Sánchez-Jiménez, A., Marcos‐Torres, F. J., & Llamas, M. A. (2023) · Microbial Biotechnology · doi:10.1111/1751-7915.14241 · Cited by 59

Molecular characterization of PANoptosis-related genes with features of immune dysregulation in systemic lupus erythematosus

Sun, W., Li, P., Wang, M., Xu, Y., Shen, D., Zhang, X., & Liu, Y. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109660 · Cited by 56

Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response

Kuang, H., Dou, G., Cheng, L., Wang, X., Xu, H., Liu, X., Ding, F., Yang, X., Liu, S., Bao, L., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-022-00723-5 · Cited by 53

Hypoxia Induces Astrocyte-Derived Lipocalin-2 in Ischemic Stroke

Taklimie, F. R., Gasterich, N., Scheld, M., Weiskirchen, R., Beyer, C., Clarner, T., & Zendedel, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061271 · Cited by 52

Identification of Zinc-Dependent Mechanisms Used by Group B Streptococcus To Overcome Calprotectin-Mediated Stress

Burcham, L. R., Le Breton, Y., Radin, J. N., Spencer, B. L., Deng, L., Hiron, A., Ransom, M. R., Mendonça, J. D. C., Belew, A. T., El-Sayed, N. M., et al. (2020) · mBio · doi:10.1128/mbio.02302-20 · Cited by 47

Organokines, Sarcopenia, and Metabolic Repercussions: The Vicious Cycle and the Interplay with Exercise

Minniti, G., Pescinini-Salzedas, L. M., Minniti, G. A. D. S., Laurindo, L. F., Barbalho, S. M., Sinatora, R. V., Sloan, L. A., Haber, R. S. D. A., Araújo, A. C., Quesada, K. R., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113452 · Cited by 53

Identification of Lipocalin 2 as a Potential Ferroptosis-related Gene in Ulcerative Colitis

Deng, L., He, S., Li, Y., Ding, R., Li, X., Guo, N., & Luo, L. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad050 · Cited by 52

MafG/MYH9-LCN2 axis promotes liver fibrosis through inhibiting ferroptosis of hepatic stellate cells

Deng, Y., Lu, L., Zhu, D., Zhang, H., Fu, Y., Tan, Y., Tan, X., Guo, M., Zhang, Y., Yang, H., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01322-5 · Cited by 53

Mapping the Tooth Enamel Proteome and Amelogenin Phosphorylation Onto Mineralizing Porcine Tooth Crowns

Green, D. R., Schulte, F., Lee, K.-H., Pugach, M. K., Hardt, M., & Bidlack, F. B. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00925 · Cited by 48

3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis

Shao, C., Liu, Y., Chen, Z., Qin, Y., Wang, X., Wang, X., Yan, C., Zhu, H., Zhao, J., & Qian, Y. (2021) · Cell chemical biology · doi:10.1016/j.chembiol.2021.12.006 · Cited by 48

Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns

Qu, L., He, X., Tang, Q., Xiao, F., Liu, J., & Lin, A. (2022) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2200194 · Cited by 48

LCN2 Mediates Skin Inflammation in Psoriasis through the SREBP2‒NLRC4 Axis

Ma, J., Chen, J., Xue, K., Chen, Y., Dang, E., Qiao, H., Fang, H., Pang, B., Li, Q., Sun, Z., et al. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.01.012 · Cited by 50

The interaction of lipocalin-2 and astrocytes in neuroinflammation: mechanisms and therapeutic application

Tan, Q., Zhang, C., Rao, X., Wan, W., Lin, W. J., Huang, S., Ying, J., Lin, Y., & Hua, F. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1358719 · Cited by 47

Paradoxical role of lipocalin-2 in metabolic disorders and neurological complications

Bhusal, A., Rahman, M. H., Lee, W., Bae, Y. C., Lee, I., & Suk, K. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113626 · Cited by 44

Controversies and Opportunities in the Use of Inflammatory Markers for Diagnosis or Risk Prediction in Fatty Liver Disease

Lambrecht, J., & Tacke, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.634409 · Cited by 46

Fast and Robust Proteome Screening Platform Identifies Neutrophil Extracellular Trap Formation in the Lung in Response to Cobalt Ferrite Nanoparticles

Billing, A. M., Knudsen, K. B., Chetwynd, A. J., Ellis, L. A., Tang, S. V. Y., Berthing, T., Wallin, H., Lynch, I., Vogel, U. B., & Kjeldsen, F. (2020) · ACS Nano · doi:10.1021/acsnano.9b08818 · Cited by 42

Plasma lipocalin‐2 levels in the preclinical stage of Alzheimer's disease

Eruysal, E., Ravdin, L., Kamel, H., Iadecola, C., & Ishii, M. (2019) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2019.07.004 · Cited by 42

Role of iron and iron‐related proteins in mesenchymal stem cells: Cellular and clinical aspects

Mehta, K. J. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30383 · Cited by 43

Identification and analysis of a prognostic ferroptosis and iron-metabolism signature for esophageal squamous cell carcinoma

Zhao, M., Li, M., Zheng, Y., Hu, Z., Liang, J., Bi, G., Bian, Y., Sui, Q., Zhan, C., Lin, M., et al. (2022) · Journal of Cancer · doi:10.7150/jca.68568 · Cited by 43

Dihydromyricetin attenuates intracerebral hemorrhage by reversing the effect of LCN2 via the system Xc- pathway

Liu, X., Li, Y., Chen, S., Yang, J., Jing, J., Li, J., Wu, X., Wang, J., Wang, J., Zhang, G., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154756 · Cited by 41

GPX4 restricts ferroptosis of NKp46+ILC3s to control intestinal inflammation

Li, X., He, J., Gao, X., Zheng, G., Chen, C., Chen, Y., Xing, Z., Wang, T., Tang, J., Guo, Y., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07060-3 · Cited by 40

Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific

Zouboulis, C. C., da Costa, A. N., Fimmel, S., & Zouboulis, K. (2020) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.16264 · Cited by 40

Emerging role of ferrous iron in bacterial growth and host–pathogen interaction: New tools for chemical (micro)biology and antibacterial therapy

Gonciarz, R. L., & Renslo, A. R. (2021) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2021.01.015 · Cited by 39

Therapy-induced senescence promotes breast cancer cells plasticity by inducing Lipocalin-2 expression

Morales-Valencia, J., Lau, L., Martí-Nin, T., Özerdem, U., & David, G. (2022) · Oncogene · doi:10.1038/s41388-022-02433-4 · Cited by 42

Review of the potential of mesenchymal stem cells for the treatment of infectious diseases

Sharma, A., Chakraborty, A., & Jaganathan, B. G. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i6.568 · Cited by 39

Lipocalin-2 in Diabetic Complications of the Nervous System: Physiology, Pathology, and Beyond

Bhusal, A., Lee, W., & Suk, K. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.638112 · Cited by 37

Macrophage-derived mitochondria-rich extracellular vesicles aggravate bone loss in periodontitis by disrupting the mitochondrial dynamics of BMSCs

Yan, J., Tian, Y., Ma, S., Li, D., Hu, C., & Tan, J. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03178-4 · Cited by 40

Lipocalin-2 Functions as Inhibitor of Innate Resistance to Mycobacterium tuberculosis

Dahl, S. L., Woodworth, J. S., Lerche, C. J., Cramer, E. P., Nielsen, P. R., Moser, C. E., Thomsen, A. R., Borregaard, N., & Cowland, J. B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02717 · Cited by 38

Comparative analysis of inflammatory signature profiles in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyposis

Yao, Y., Yang, C., Yi, X., Xie, S., & Sun, H. (2020) · Bioscience Reports · doi:10.1042/bsr20193101 · Cited by 37

Caloric restriction reverses left ventricular hypertrophy through the regulation of cardiac iron homeostasis in impaired leptin signaling mice

An, H. S., Lee, J. Y., Choi, E. B., Jeong, E. A., Shin, H. J., Kim, K. E., Park, K.-A., Jin, Z. H., Lee, J. E., Koh, J. S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-64201-2 · Cited by 36

Lipocalin‐2 Protects Against Diet‐Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes

Xu, Y., Zhu, Y., Jadhav, K. S., Li, Y., Sun, H., Yin, L., Kasumov, T., Chen, X., & Zhang, Y. (2019) · Hepatology Communications · doi:10.1002/hep4.1341 · Cited by 36

Biological Roles of Lipocalins in Chemical Communication, Reproduction, and Regulation of Microbiota

Stopková, R., Otcenásková, T., Matějková, T., Kuntová, B., & Stopka, P. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.740006 · Cited by 33

Transcriptome Profile in Hippocampus During Acute Inflammatory Response to Surgery: Toward Early Stage of PND

Xiang, X., Yu, Y., Tang, X., Chen, M., Zheng, Y., & Zhu, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00149 · Cited by 33

Specific Commensal Bacterium Critically Regulates Gut Microbiota Osteoimmunomodulatory Actions During Normal Postpubertal Skeletal Growth and Maturation

Hathaway‐Schrader, J. D., Poulides, N. A., Carson, M. D., Kirkpatrick, J. E., Warner, A. J., Swanson, B. A., Taylor, E. V., Chew, M. E., Reddy, S. V., Liu, B., et al. (2020) · JBMR Plus · doi:10.1002/jbm4.10338 · Cited by 35

Role of Adipokines in Sarcopenia

Lu, W., Feng, W., Lai, J., Yuan, D., Xiao, W., & Li, Y. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002255 · Cited by 34

Whole-Blood Transcriptome Analysis of Feedlot Cattle With and Without Bovine Respiratory Disease

Jiminez, J. A., Timsit, E., Orsel, K., van der Meer, F. J. U. M., Guan, L. L., & Plastow, G. S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.627623 · Cited by 33

Lipocalin-2: A Nurturer of Tumor Progression and a Novel Candidate for Targeted Cancer Therapy

Živalj, M., Ginderachter, J. A. V., & Stijlemans, B. (2023) · Cancers · doi:10.3390/cancers15215159 · Cited by 35

Inflammation Mediated by Gut Microbiome Alterations Promotes Lung Cancer Development and an Immunosuppressed Tumor Microenvironment

Rahal, Z., Liu, Y., Peng, F., Yang, S., Jamal, M. A., Sharma, M., Moreno, H., Damania, A. V., Wong, M. C., Ross, M. C., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0469 · Cited by 34

Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease

Sfera, A., Gradini, R., Cummings, M., Diaz, E. L., Price, A. I., & Osorio, C. P. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01062 · Cited by 32

Metagenomic Analysis of the Pediatric-Onset Multiple Sclerosis Gut Microbiome

Mirza, A., Zhu, F., Knox, N., Forbes, J. D., Domselaar, G. V., Bernstein, C. N., Graham, M., Marrie, R. A., Hart, J., Yeh, E. A., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000013245 · Cited by 31

Identification of key candidate biomarkers for severe influenza infection by integrated bioinformatical analysis and initial clinical validation

Liu, S., Huang, Z., Deng, X., Zou, X., Li, H., Mu, S., & Cao, B. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16275 · Cited by 30

Severe anaemia, iron deficiency, and susceptibility to invasive bacterial infections

Abuga, K. M., Nairz, M., MacLennan, C. A., & Atkinson, S. H. (2023) · Wellcome Open Research · doi:10.12688/wellcomeopenres.18829.1 · Cited by 31

Loss of SREBP-1c ameliorates iron-induced liver fibrosis by decreasing lipocalin-2

Lee, E., Lee, J., ‍Kim, D. Y., Lee, Y.-S., Jo, Y., Dao, T., Kim, K. E., Song, D., Seo, J. H., Seo, Y., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01213-2 · Cited by 29

Enterobactin induces the chemokine, interleukin-8, from intestinal epithelia by chelating intracellular iron

Saha, P., Yeoh, B. S., Xiao, X., Golonka, R. M., Abokor, A. A., Wenceslau, C. F., Shah, Y. M., Joe, B., & Vijay‐Kumar, M. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1841548 · Cited by 29

Serum lipocalin-2 is a potential biomarker for the clinical diagnosis of nonalcoholic steatohepatitis

Xu, G., Wang, Y., Ying, M., Chen, S., Li, Z., Ma, H., Zheng, M., Wu, J. H., & Ding, C. (2021) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0261 · Cited by 30

Lipocalin-2 participates in sepsis-induced myocardial injury by mediating lipid accumulation and mitochondrial dysfunction

Liu, W., Guo, X., Jin, L., Hong, T., Zhang, Q., Su, F., Shen, Y. X., Li, S., & He, B. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1009726 · Cited by 29

Lipocalin-2 promotes CKD vascular calcification by aggravating VSMCs ferroptosis through NCOA4/FTH1-mediated ferritinophagy

Wang, Y., Zhang, Y., Gao, M., Chen, Z., Lu, J., Li, Y., Di, Y., Zhao, Y., Liu, B.-C., & Tang, R. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07260-x · Cited by 28

Compensatory intestinal antibody response against pro-inflammatory microbiota after bariatric surgery

Scheithauer, T. P. M., Davids, M., Winkelmeijer, M., Verdoes, X., Aydin, Ö., de Brauw, M., van de Laar, A. W. J. M., Meijnikman, A. S., Gerdes, V. E. A., van Raalte, D. H., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2031696 · Cited by 29

Endocrine disrupting chemicals: A promoter of non-alcoholic fatty liver disease

Chen, Y., Wang, Y., Cui, Z., Liu, W., Liu, B., Zeng, Q., Zhao, X., Dou, J., & Cao, J. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1154837 · Cited by 33

Bioinformatics and experimental approach identify lipocalin 2 as a diagnostic and prognostic indicator for lung adenocarcinoma

Li, A., Zhang, K., Zhou, J., Li, M., Fan, M., Gao, H., Ma, R., Gao, L., & Chen, M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132797 · Cited by 27

Lipocalin 2 alleviates iron toxicity by facilitating hypoferremia of inflammation and limiting catalytic iron generation

Xiao, X., Yeoh, B. S., Saha, P., Olvera, R. A., Singh, V., & Vijay–Kumar, M. (2016) · BioMetals · doi:10.1007/s10534-016-9925-5 · Cited by 29

Lipocalin 2, an innate immune protein, plays a key role in immune‐complex (IC) mediated inflammation

Aitken, J. D., Srinivasan, G., Sashidhramurthy, R., Parkos, C. A., Selvaraj, P., & Vijay–Kumar, M. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.55.11

Lipocalin-2 is involved in immune-complex mediated inflammation (102.23)

Shashidharamurthy, R., Parkos, C. A., Selvaraj, P., & Vijay–Kumar, M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.186.supp.102.23

13 Lipocalin 2 exerts protective activity by alleviating inflammatory responses

Li, S. (2019) · Journal of Animal Science · doi:10.1093/jas/skz258.035

Characterization of lipocalin 2 ontogenic expression profile

Cruz, R. F. S. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)