Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation

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MVP-LCN2 axis triggers evasion of ferroptosis to drive hepatocarcinogenesis and sorafenib resistance

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Identification of candidate aberrantly methylated and differentially expressed genes in Esophageal squamous cell carcinoma

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Understanding the Potential and Risk of Bacterial Siderophores in Cancer

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Iron oxide and iron oxyhydroxide nanoparticles impair SARS-CoV-2 infection of cultured cells

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LCN2 as a Potential Diagnostic Biomarker for Ulcerative Colitis-Associated Carcinogenesis Related to Disease Duration

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Parsing the functional specificity of Siderocalin/Lipocalin 2/NGAL for siderophores and related small-molecule ligands

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Some more about dogs: Proteomics of neglected biological fluids

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REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis

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Lipocalin-2 inhibition alleviates neural injury by microglia ferroptosis suppression after experimental intracerebral hemorrhage in mice via enhancing ferritin light chain expression

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Iron requirement in the infection of Salmonella and its relevance to poultry health

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Ferroptosis resistance determines high susceptibility of murine A/J strain to iron‐induced renal carcinogenesis

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Lipocalin 2 Influences Bone and Muscle Phenotype in the MDX Mouse Model of Duchenne Muscular Dystrophy

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Lipocalin-2 is an essential component of the innate immune response to Acinetobacter baumannii infection

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Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury

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The role of bone in whole-body energy metabolism

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Diagnosis of cerebral malaria: Tools to reduce Plasmodium falciparum associated mortality

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Plasmatic lipocalin‐2 levels in chronic low‐grade inflammation syndromes: Comparison between metabolic syndrome, total and partial adult growth hormone deficiency

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Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner

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Skeletal Lipocalin-2 Is Associated with Iron-Related Oxidative Stress in ob/ob Mice with Sarcopenia

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Functional consequence of Iron dyshomeostasis and ferroptosis in systemic lupus erythematosus and lupus nephritis

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Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population

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Thionine-coordinated BCN nanosheets for electrochemical enzyme immunoassay of lipocalin-2 on biofunctionalized carbon-fiber microelectrode

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Enterobactin-Specific Antibodies Induced by a Novel Enterobactin Conjugate Vaccine

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Lipocalin-2 as a mediator of neuroimmune communication

Afridi, R., Kim, J., Bhusal, A., Lee, W., & Suk, K. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad157 · Cited by 23

Light-Induced Lipocalin 2 Facilitates Cellular Apoptosis by Positively Regulating Reactive Oxygen Species/Bim Signaling in Retinal Degeneration

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Proteomics analysis reveals suppression of IL-17 signaling pathways contributed to the therapeutic effects of Jia-Wei Bu-Shen-Yi-Qi formula in a murine asthma model

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A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice

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Tumor-associated macrophages and individual chemo-susceptibility are influenced by iron chelation in human slice cultures of gastric cancer

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Lipocalin-2 negatively regulates epithelial–mesenchymal transition through matrix metalloprotease-2 downregulation in gastric cancer

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Bioinformatic analysis of the LCN2–SLC22A17–MMP9 network in cancer: The role of DNA methylation in the modulation of tumor microenvironment

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Identification of LCN1 as a Potential Biomarker for Breast Cancer by Bioinformatic Analysis

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Perioperative neurocognitive disorders: Advances in molecular mechanisms and bioactive molecules

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Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells

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Lipocalin 2 Participates in the Epidermal Differentiation and Inflammatory Processes of Psoriasis

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Predicting diagnostic biomarkers associated with immune infiltration in Crohn's disease based on machine learning and bioinformatics

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3nLcn2, a teleost lipocalin 2 that possesses antimicrobial activity and inhibits bacterial infection in triploid crucian carp

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LCN2 depletion aggravates sepsis-induced liver injury by regulating PTGS2-dependent ferroptosis

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FBXO2 Alleviates Intervertebral Disc Degeneration via Dual Mechanisms: Activating PINK1‐Parkin Mitophagy and Ubiquitinating LCN2 to Suppress Ferroptosis

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Immunological and regenerative properties of lung stem cells

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Secondary ferroptosis promotes thrombogenesis after venous injury in rats

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Morphological Assessment and Biomarkers of Low-Grade, Chronic Intestinal Inflammation in Production Animals

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Lipocalin-2 promotes adipose–macrophage interactions to shape peripheral and central inflammatory responses in experimental autoimmune encephalomyelitis

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Increased lipocalin-2 expression in pulmonary inflammation and fibrosis

Galaris, A., Fanidis, D., Tsitoura, E., Kanellopoulou, P., Barbayianni, I., Ntatsoulis, K., Touloumi, K., Grammenoudi, S., Karampitsakos, Τ., Tzouvelekis, A., et al. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1195501 · Cited by 17

Ferroptosis in Glaucoma: A Promising Avenue for Therapy

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Impact of p. Gingivalis-induced chronic apical periodontitis on systemic iron homeostasis via the hepatic IL-6/STAT3/Hepcidin signaling pathway

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From iron-driven cell death to clot formation: The emerging role of ferroptosis in thrombogenesis

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Identification of ferroptosis-related genes in ulcerative colitis: a diagnostic model with machine learning

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Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine

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Exploring the ferroptosis-related gene lipocalin 2 as a potential biomarker for sepsis-induced acute respiratory distress syndrome based on machine learning

Zhan, J., Chen, J., Deng, L., Lu, Y., & Luo, L. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167101 · Cited by 17

Cyclic Dimeric Guanosine Monophosphate: Activation and Inhibition of Innate Immune Response

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Human host-defense peptide LL-37 targets stealth siderophores

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Lipocalin-2 and intestinal diseases

Zhang, Z.-X., Peng, J., & Ding, W. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i46.4864 · Cited by 16

Lipocalin-2: a novel link between the injured kidney and the bone

Courbon, G., & David, V. (2022) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000804 · Cited by 16

Iron Homeostasis in Pseudomonas aeruginosa: Targeting Iron Acquisition and Storage as an Antimicrobial Strategy

Llamas, M. A., & Sánchez-Jiménez, A. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-08491-1_2 · Cited by 18

Anchorless Bacterial Moonlighting Metabolic Enzymes Modulate the Immune System and Contribute to Pathogenesis

Liu, D., & Bhunia, A. K. (2024) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.4c00323 · Cited by 16

Relation of Neutrophil Gelatinase-Associated Lipocalin Overexpression to the Resistance to Apoptosis of Tumor B Cells in Chronic Lymphocytic Leukemia

Bauvois, B., Pramil, É., Jondreville, L., Chapiro, É., Quiney, C., Maloum, K., Susín, S. A., & Nguyen‐Khac, F. (2020) · Cancers · doi:10.3390/cancers12082124 · Cited by 16

Iron Dyshomeostasis in COVID-19: Biomarkers Reveal a Functional Link to 5-Lipoxygenase Activation

Dufrusine, B., Valentinuzzi, S., Bibbò, S., Damiani, V., Lanuti, P., Pieragostino, D., Boccio, P. D., D’Alessandro, E., Rabottini, A., Berghella, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010015 · Cited by 17

Combination of transcriptional biomarkers and clinical parameters for early prediction of sepsis indued acute respiratory distress syndrome

Yao, R.-Q., Shen, Z., Ma, Q.-M., Ling, P., Wei, C.-R., Zheng, L., Duan, Y., Li, W., Zhu, F., Sun, Y., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1084568 · Cited by 15

Expression Analysis of Lipocalin 2 (LCN2) in Reproductive and Non-Reproductive Tissues of Esr1-Deficient Mice

Kessel, J. C., Weiskirchen, R., & Schröder, S. K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119280 · Cited by 15

Cardiac and Renal Fibrosis, the Silent Killer in the Cardiovascular Continuum: An Up-to-Date

Chiuariu, T., Șalaru, D. L., Ureche, C., Tapoi, L. C., Lupu, A., Lupu, V. V., Șerban, A. M., Zăvoi, A., Benchea, L.-C., Clément, A., et al. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11020062 · Cited by 18

Altered Iron-Mediated Metabolic Homeostasis Governs the Efficacy and Toxicity of Tripterygium Glycosides Tablets Against Rheumatoid Arthritis

Ding, Z., Wang, X., Zhang, Y., Liu, J., Wan, L., Li, T., Chen, L., Lin, N., & Zhang, Y. (2024) · Engineering · doi:10.1016/j.eng.2024.04.003 · Cited by 15

Plasma Lipocalin 2 in Alzheimer’s disease: potential utility in the differential diagnosis and relationship with other biomarkers

Hermann, P., Villar‐Piqué, A., Schmitz, M., Schmidt, C., Varges, D., Goebel, S., Bunck, T., Lindemann, H., Bogner, C., Santana, I. J., et al. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00955-9 · Cited by 16

Modified Cangfu Daotan decoction ameliorates polycystic ovary syndrome with insulin resistance via NF-κB/LCN-2 signaling pathway in inflammatory microenvironment

Liu, S., Zhang, Y., Yang, F., Gu, J., Zhang, R., Kuang, Y., Mai, W., Zheng, C., Yu, Y. H., Lu, R., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.975724 · Cited by 17

Enterobactin-specific antibodies inhibit in vitro growth of different gram-negative bacterial pathogens

Wang, H., Zeng, X., & Lin, J. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.10.040 · Cited by 16

Ferroptosis Signaling in Pancreatic β-Cells: Novel Insights & Therapeutic Targeting

Elumalai, S., Karunakaran, U., Moon, J. S., & Won, K. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213679 · Cited by 16

Ovaries of estrogen receptor 1-deficient mice show iron overload and signs of aging

Schröder, S. K., Krizanac, M., Kim, P., Kessel, J. C., & Weiskirchen, R. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1325386 · Cited by 14

Targeting Lcn2 to Inhibit Myocardial Cell Ferroptosis is a Potential Therapy for Alleviating Septic Cardiomyopathy

Jiang, C. S., Hou, M., Sun, S., Chen, G., Bai, F., & Wang, S. (2025) · Inflammation · doi:10.1007/s10753-025-02250-3 · Cited by 14

A Unique Conformational Distortion Mechanism Drives Lipocalin 2 Binding to Bacterial Siderophores

Huang, X., Slavkovic, S., Song, E., Botta, A. M., Mehrazma, B., Lento, C., Johnson, P. E., Sweeney, G., & Wilson, D. J. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00820 · Cited by 14

Identification of Neutrophil-Related Factor LCN2 for Predicting Severity of Patients With Influenza A Virus and SARS-CoV-2 Infection

Huang, Z., Li, H., Liu, S., Jia, J., Zheng, Y. Y., & Cao, B. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.854172 · Cited by 15

Recombinant FGF21 Attenuates Polychlorinated Biphenyl-Induced NAFLD/NASH by Modulating Hepatic Lipocalin-2 Expression

Kim, H. Y., & Yoo, Y. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23168899 · Cited by 14

Iron in infectious diseases friend or foe?: The role of gut microbiota

Aksoyalp, Z. Ş., Temel, A., & Erdoğan, B. R. (2022) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.127093 · Cited by 15

Systematic analysis of myocardial immune progression in septic cardiomyopathy: Immune-related mechanisms in septic cardiomyopathy

Ma, D., Qin, X., Zhong, Z., Liao, H., Chen, P., & Zhang, B. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1036928 · Cited by 13

Nutritional Support: The Use of Antioxidants in Inflammatory Bowel Disease

Jarmakiewicz-Czaja, S., Ferenc, K., Sokal-Dembowska, A., & Filip, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084390 · Cited by 13

Lipocalin‐2 induced LDHA expression promotes vascular remodelling in pulmonary hypertension

Wang, G., Liu, S., Kong, X., Jiao, H., Tong, F., Guo, Z., Zhang, M., Guan, X., Ren, N., Li, W., et al. (2024) · Cell Proliferation · doi:10.1111/cpr.13717 · Cited by 14

The von Hippel-Lindau Tumor Suppressor Gene Mutations Modulate Lipocalin-2 Expression in Ferroptotic-Inflammatory Pathways

Kuo, C., Hsieh, P., Chiu, V. J.-Y., Lan, C., & Lu, K. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/7736638 · Cited by 15

Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice

Singh, V., Galla, S., Golonka, R. M., Patterson, A. D., Chassaing, B., Joe, B., & Vijay–Kumar, M. (2020) · Physiological Genomics · doi:10.1152/physiolgenomics.00118.2019 · Cited by 13

Synergistic effects of LCN2 and TWEAK on the progression of psoriasis

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Desferrioxamine Ameliorates Lipopolysaccharide-Induced Lipocalin-2 Upregulation via Autophagy Activation in Primary Astrocytes

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Lipocalin-2 regulates the expression of interferon-stimulated genes and the susceptibility of prostate cancer cells to oncolytic virus infection

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Systemic neutrophil degranulation and emergency granulopoiesis in patients with Clostridioides difficile infection

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Discovery and Verification of Sjögren’s Syndrome Protein Biomarkers in Tears by Targeted LC-MRM

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Lipocalin-2 silencing alleviates sepsis-induced liver injury through inhibition of ferroptosis

Li, Y., Li, L., Zhang, Y., Yun, Q., Du, R., Ye, H., Li, Z., & Gao, Q. (2024) · Annals of Hepatology · doi:10.1016/j.aohep.2024.101756 · Cited by 12

Serum levels of lipocalin-2 in patients with Parkinson’s disease

Xiong, M., Qian, Q., Liang, X., & Wei, Y. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05579-3 · Cited by 12

Stealthy microbes: How Neisseria gonorrhoeae hijacks bulwarked iron during infection

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Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects

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Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting

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Lipocalin 2 Is a Regulator During Macrophage Polarization Induced by Soluble Worm Antigens

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Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

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Lipocalin 2 (LCN2) Knockdown Regulates Treg/Th17 Balance to Improve Asthma in Mice

Xu, L., & Shi, M. (2023) · Journal of Asthma and Allergy · doi:10.2147/jaa.s418596 · Cited by 11

HIF-1α Pathway Orchestration by LCN2: A Key Player in Hypoxia-Mediated Colitis Exacerbation

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Lipocalin 2 Facilitates the Initial Compromise of the Blood–Brain Barrier Integrity in Chronic Cerebral Hypoperfusion

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Association Of Blood Lipocalin-2 Levels with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

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Protective Role for Smooth Muscle Cell Hepcidin in Abdominal Aortic Aneurysm

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Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis

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Dendritic Polyglycerols Are Modulators of Microglia-Astrocyte Crosstalk

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DZ2002 alleviates psoriasis-like skin lesions via differentially regulating methylation of GATA3 and LCN2 promoters

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Circulating lipocalin‐2 as a novel biomarker for early neurological deterioration and unfavorable prognosis after acute ischemic stroke

Xie, Y., Zhuo, X., Xing, K., Huang, Z., Guo, H., Gong, P., Zhang, X., & Li, Y. (2023) · Brain and Behavior · doi:10.1002/brb3.2979 · Cited by 11

Lipocalin-2 promotes NSCLC progression by activating the JAK2/STAT3 signaling pathway

Zhang, J., Xu, Q. L., & Sun, G. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06418-1 · Cited by 10

Patterns of partnership: surveillance and mimicry in host-microbiota mutualisms

Wiles, T. J., & Guillemin, K. J. (2020) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.01.012 · Cited by 8

Lipocalin 2 alleviates iron toxicity by facilitating hypoferremia of inflammation and limiting catalytic iron generation

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Lipocalin 2, an innate immune protein, plays a key role in immune‐complex (IC) mediated inflammation

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Lipocalin-2 is involved in immune-complex mediated inflammation (102.23)

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13 Lipocalin 2 exerts protective activity by alleviating inflammatory responses

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Characterization of lipocalin 2 ontogenic expression profile

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