Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation

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Lung–brain ‘cross-talk’: systemic propagation of cytokines in the ARDS via the bloodstream using a blood transfusion model does not influence cerebral inflammatory response in pigs

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Single‐cell atlas of healthy vocal folds and cellular function in the endothelial‐to‐mesenchymal transition

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IgG Propels Atherosclerosis by Noncanonically Activating MacrophagesPreprint

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KIM-1 and Other Markers of Acute Kidney Injury in Cisplatin-Induced Nephrotoxicity

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Upregulation of lipocalin-2 in the retina of experimental autoimmune uveitis

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Exploring ferroptosis-associated immune characteristics in Kawasaki disease through bioinformatics

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Regulation of LCN-2/PI3K/Akt on TNF-α induced inflammatory response of porcine intramuscular adipocytes

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Investigating the genetic causal link between iron regulation and lung cancer risk: A 2-sample Mendelian randomization analysis

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Role of Lipocalin-2 in Brain Injury After Subarachnoid Hemorrhage in Female Mice

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Characterization of Ferroptosis-Associated Subtypes in Psoriasis and the Potential of CHAC1 as a Diagnostic Biomarker Based on Machine Learning

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Gingival Crevicular Fluid Proteomic Shift: From Gingivitis to Periodontitis

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Lipocalin-2 upregulation in hypoxic murine osteocytes enhances RANKL-induced osteoclastogenesis

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A Network‐Based Association of IBD and Colorectal Cancer Using Proteomics Data

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Ginseng polysaccharides prevent mastitis through Lactobacillus murinus‐derived deoxycholic acid and TGR5 signaling

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Study on the mechanism of action of HuaZhuoKeLi in modulating LCN2-mediated cellular pyroptosis to ameliorate ulcerative colitis

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Assessment of Serum Lipocalin-2 Level as Early Predictor Marker to Severe COVID-19 Disease

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Characteristics of immune cell infiltration in inflamed mucosa of ulcerative colitis patients, hub gene candidates and key pathways in intestinal macrophage expression

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Identification of aging-related genes in Helicobacter pylori infection

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A CLINICAL STUDY OF LIPOCALIN 2 AND ITS RELATION WITH OXIDATIVE AND ANTIOXIDATIVE FACTORS IN ARTHRITIS

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Backbone chemical shift and secondary structure assignments for mouse siderocalin

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Proteome and Dihydrorhodamine Profiling of Bronchoalveolar Lavage in Patients with Chronic Pulmonary Aspergillosis

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Identification of LPCAT1 as a key biomarker for Crohn's disease based on bioinformatics and machine learnings and experimental verification

Chen, W., Xu, Z., Jiang, J., Chen, H., & Shi, R. (2024) · Gene · doi:10.1016/j.gene.2024.148519 · Cited by 1

Chitinase 3-like protein 1 deficiency ameliorates drug-induced acute liver injury by inhibition of neutrophil recruitment through lipocalin-2

Kim, J. H., Yeo, I. J., Son, D. J., Han, S., Yoon, D. Y., Lee, D. H., & Hong, J. T. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1548832 · Cited by 1

Validation of Biomarkers and Immunotherapy With Crohn’s Disease Using WGCNA and Two‐Sample Mendelian Randomization Study

Hu, C., Nong, S., Liu, C., Chen, Y., Liao, C., & Wu, M. (2025) · Gastroenterology Research and Practice · doi:10.1155/grp/8194480 · Cited by 1

Impact of bovine lipocalin-2 haplotype on milk composition, somatic cell score and incidence of mastitis in Polish Holstein-Friesian cattle

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[Expression and Clinical Significance of Lipocalin-2 in the Serum of Lung Cancer Patients].

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Roles of iron uptake in the survival, colonization and virulence of Salmonella in animal guts

Tan, Z. (2019) · Mspace (University of Manitoba) · Cited by 1

Lipocalin 2 dictates cancer cell plasticity elicited by therapy-induced senescencePreprint

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LCN2 attenuates sepsis-induced liver injury by alleviating PTGS2-mediated FerroptosisPreprint

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Enterobactin carries iron into C. elegans and mammalian intestinal cells by a mechanism independent of divalent metal transporter DMT1Preprint

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Single-cell transcriptomics reveals spaceflight-induced accelerated aging and impaired recovery in the murine bone marrowPreprint

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Bioinformatics analysis of myocardial immune progression

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Disruption of the surfactant protein A receptor SP-R210 L (CD245α/MYO18Aα) alters respiratory function and iron sequestration in alveolar macrophages of aged micePreprint

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Functions and potential of lipocalin-2 as fecal biomarker for acute gastrointestinal infections (review of literature)

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Peer Review #2 of "Lung–brain ‘cross-talk’: systemic propagation of cytokines in the ARDS via the bloodstream using a blood transfusion model does not influence cerebral inflammatory response in pigs (v0.1)"

(2022) · PeerJ · doi:10.7287/peerj.13024v0.1/reviews/2

Peer Review #2 of "Lung–brain ‘cross-talk’: systemic propagation of cytokines in the ARDS via the bloodstream using a blood transfusion model does not influence cerebral inflammatory response in pigs (v0.2)"

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The Effect of Neutrophil Gelatinase-Associated Lipocalin in the Clinical Diagnosis of Diabetic Kidney Disease

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Research Advances of Detection Methods for NGAL in Renal Injury

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Excessive Iron in Diets Promotes Kidney Fibrosis via Disordering the Inflammation Factors in SheepPreprint

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Excessive iron in diets promotes kidney fibrosis via disordering the inflammation factors in SheepPreprint

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Excessive Iron in Diets Promotes Kidney Fibrosis Via Disordering the Inflammation Factors in SheepPreprint

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The effect of different iron sources on hemoglobin and myoglobin synthesis, and the key genes related to iron metabolism in skeletal muscle in the weanling pigletsPreprint

Xu, Q., Fan, J., Gu, D., Shi, B., Wang, D., Zhu, H., Liu, J., Liu, Y., & Kang, P. (2022) · Research Square · doi:10.21203/rs.3.rs-2028912/v1

The gut microbiota

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Data from Heterogeneity and Cancer-Related Features in Lymphangioleiomyomatosis Cells and Tissue

Espín, R., Baiges, A., Blommaert, E., Herranz, C., Román, A., Sáez, B., Ancochea, J., Valenzuela, C., Ussetti, P., Laporta, R., et al. (2023) · doi:10.1158/1541-7786.c.6545061.v1

Increased human neutrophil lipocalin and its clinical relevance in adult-onset Still's disease

Li, J., Li, Y., Li, R., Ma, X., Shi, L., Li, S., Guo, Q., Jia, Y., & Li, Z. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002580

Identifying Common Immune-Related Genes in Crohn’s Disease and Ulcerative Colitis

李, 迟. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.1351157

Lipocalin 2 als liquor und plasmabasierter Biomarker bei vaskulärer Enzephalopathie: Assoziationen mit klinischen Merkmalen und verschiedenen Formen der vaskulären Demenz

Lindemann, H. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9889

Exploring Key Genes and Molecular Mechanisms Related to Myocardial Hypertrophy Based on Bioinformatics

Dai, P., Wang, H., Mu, X., Ren, Z., Liu, G., & Gao, L. (2023) · Science of Advanced Materials · doi:10.1166/sam.2023.4488

The contribution of IL-17A-dependent low LCN2 levels to Helicobacter pylori infection: Insights from clinical and experimental studies

Cheng, M., Zheng, Y., Fan, Y., Yan, P., & Zhao, W. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110960

Dynamic changes and clinical value of lipocalin 2 in liver diseases caused by microbial infections

Chen, F., Wu, S., Chen, C., & Zhou, C. (2024) · World Journal of Hepatology · doi:10.4254/wjh.v16.i2.177

Evaluation of Lipocalin-2 and -10 Levels at Time of Diagnosis in Patients with Acute Pulmonary Embolism

Kerget, B., Özkan, H. B., Afşin, D. E., Laloğlu, E., & Sağlam, L. (2023) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750823600097

Plasma exosomes proteome profiling discovers protein markers to identify sepsisPreprint

Gong, S., Liu, T., Li, Z., Yang, Y., Yi, H. L., & Wang, X. (2024) · Research Square · doi:10.21203/rs.3.rs-4051424/v1

Alcohol in Baijiu Contributes to the Increased Probability of Host Infection by Clostridioides difficile Spores

Rui, W., Zhong, S., Li, X., Shen, C., Cao, X., & Yang, J. (2024) · Foodborne Pathogens and Disease · doi:10.1089/fpd.2023.0187

LCN2 aggravates diabetic cataracts by promoting ferroptosis in lens epithelial cells

Zhang, J., Sun, L., Yu, X., Yang, C., An, Q., Wei, C., & Ge, H. (2024) · Frigid Zone Medicine · doi:10.1515/fzm-2024-0018

The Fight for Iron: A Central Theme in Host-Pathogen Interactions

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The value of lipocalin-2 as an inflammatory marker in children with COVID-19

Yevtushenko, V. V., Seriakova, I. Y., Кramarov, S. O., Kyrytsia, N. S., Шадрин, В. О., & Voronov, O. O. (2025) · CHILD`S HEALTH · doi:10.22141/2224-0551.20.1.2025.1790

Piper Longum’s Neuroprotective Role Against Amyloid-β and Okadaic Acid-Induced Toxicity in U87MG Cells Through the Lipocalin-2 Pathway

Sung, S.-H., Shin, S. H., Kim, Y., & Cho, S. (2025) · Journal of pharmacopuncture · doi:10.3831/kpi.2025.28.2.92

Bioinformatics-based prediction of hsa-miR-4651 and hsa-miR-608 as novel biomarkers for diagnosing silicosis

Wu, J., Shi, Y., Zuo, C., Xu, Y., Wu, Y. F., Gong, H., Ke, Y., & Yi, X. (2025) · Biomarkers in Medicine · doi:10.1080/17520363.2025.2520160

Paneth Cells: Recent Updates on Elucidating Therapeutic Implications in Gastroenterological Disease Management

Sankova, M. V., Nikolenko, V. N., Bolotskaya, A. A., Oganesyan, M. V., Rizaeva, N. A., Sankov, A. V., Zharikova, T. S., Pontes‐Silva, A., Beeraka, N. M., R, H. V. P., et al. (2025) · Current Medicinal Chemistry · doi:10.2174/0109298673357073250526104619

Hydroxy-α-sanshool induces ferroptosis in renal cells via NF-κB/NGAL axis-driven lipid peroxidation

Ren, F., Hu, S. C., Zhou, X., Deng, H., Li, Z., Huang, Y., Xiang, Q., Hu, T., Tan, Z. W., Rao, C., et al. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107553

Lipocalin-2 in preoperative cerebrospinal fluid is a biomarker for postoperative delirium after hip fracture surgery in older adults: a prospective cohort study

Kang, N., Han, X., Liu, T., Huang, J., Li, Z., Li, Z., Yuan, Y., Song, Y., Yang, N., & Guo, X. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1653407

Shared Biomarkers LCN2 and CXCL11 for Ulcerative Colitis and Colon Cancer: Bioinformatics Analysis and Diagnostic Model Construction

Wu, Z., Sun, X., Li, B., Xie, Z., Zheng, J., Sun, N., Guan, Y., & Chen, J. (2025) · Digestive Diseases and Sciences · doi:10.1007/s10620-025-09443-8

LCN2 promotes HEI-OC1 cells senescence via activating NF-κB signal pathway in presbycusis

Wu, J., Liu, X., Zhu, D., Xu, B., & Guo, Y. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.10.018

Prolonged skin allograft survival by rM180 amelogenin in a murine skin transplantation model

Shida, M., Sanui, T., Yotsumoto, K., Li, J., Ahmad, M., Xiao, M., Wang, Z., Hayashi, C., Nishimura, Y., Shinjo, T., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1663437

Lipocalin-type prostaglandin D₂ synthase (L-PGDS) deficiency disrupts heme catabolism and iron homeostasis in mice

Stevenson, M., Chen, B., Srivastava, A., Hall, C., & Ragolia, L. (2025) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2025.107046

Plasma concentrations of the inflammatory adipokine lipocalin-2 are not affected by chronic alcohol exposure in rats or acute alcohol administration in people with alcohol use disorder

Richardson, R. S., Farokhnia, M., Vendruscolo, L. F., & Leggio, L. (2025) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2025.2582563

Additional file 2 of Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Wang, H., Wang, M., Chen, J., Hou, H., Guo, Z., Yang, H., Tang, H., & Chen, B. (2024) · Figshare · doi:10.6084/m9.figshare.24804787

Additional file 5 of Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Wang, H., Wang, M., Chen, J., Hou, H., Guo, Z., Yang, H., Tang, H., & Chen, B. (2024) · Figshare · doi:10.6084/m9.figshare.26653311

Additional file 4 of LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia

Wang, D., Li, X., Jiao, D., Cai, Y., Qian, L., Shen, Y., Lu, Y., Zhou, Y., Fu, B., Sun, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578028

Additional file 1 of Plasma Lipocalin 2 in Alzheimer’s disease: potential utility in the differential diagnosis and relationship with other biomarkers

Hermann, P., Villar‐Piqué, A., Schmitz, M., Schmidt, C., Varges, D., Goebel, S., Bunck, T., Lindemann, H., Bogner, C., Santana, I. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18393329

Additional file 9 of Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Wang, H., Wang, M., Chen, J., Hou, H., Guo, Z., Yang, H., Tang, H., & Chen, B. (2024) · Figshare · doi:10.6084/m9.figshare.26653323

Additional file 6 of LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia

Wang, D., Li, X., Jiao, D., Cai, Y., Qian, L., Shen, Y., Lu, Y., Zhou, Y., Fu, B., Sun, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578034

Additional file 7 of Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Wang, H., Wang, M., Chen, J., Hou, H., Guo, Z., Yang, H., Tang, H., & Chen, B. (2024) · Figshare · doi:10.6084/m9.figshare.26653317

Additional file 5 of LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia

Wang, D., Li, X., Jiao, D., Cai, Y., Qian, L., Shen, Y., Lu, Y., Zhou, Y., Fu, B., Sun, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578031

Additional file 2 of LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia

Wang, D., Li, X., Jiao, D., Cai, Y., Qian, L., Shen, Y., Lu, Y., Zhou, Y., Fu, B., Sun, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578022

Additional file 1 of LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia

Wang, D., Li, X., Jiao, D., Cai, Y., Qian, L., Shen, Y., Lu, Y., Zhou, Y., Fu, B., Sun, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578019

Additional file 1 of Iron oxide and iron oxyhydroxide nanoparticles impair SARS-CoV-2 infection of cultured cells

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Additional file 1 of Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Wang, H., Wang, M., Chen, J., Hou, H., Guo, Z., Yang, H., Tang, H., & Chen, B. (2023) · Figshare · doi:10.6084/m9.figshare.24804263

Additional file 6 of Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Wang, H., Wang, M., Chen, J., Hou, H., Guo, Z., Yang, H., Tang, H., & Chen, B. (2024) · Figshare · doi:10.6084/m9.figshare.26653314

Additional file 12 of Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Wang, H., Wang, M., Chen, J., Hou, H., Guo, Z., Yang, H., Tang, H., & Chen, B. (2024) · Figshare · doi:10.6084/m9.figshare.26653332

Additional file 13 of Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Wang, H., Wang, M., Chen, J., Hou, H., Guo, Z., Yang, H., Tang, H., & Chen, B. (2024) · Figshare · doi:10.6084/m9.figshare.26653335

Additional file 11 of Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Wang, H., Wang, M., Chen, J., Hou, H., Guo, Z., Yang, H., Tang, H., & Chen, B. (2024) · Figshare · doi:10.6084/m9.figshare.26653329

Additional file 4 of Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Wang, H., Wang, M., Chen, J., Hou, H., Guo, Z., Yang, H., Tang, H., & Chen, B. (2024) · Figshare · doi:10.6084/m9.figshare.26653308

Additional file 10 of Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Wang, H., Wang, M., Chen, J., Hou, H., Guo, Z., Yang, H., Tang, H., & Chen, B. (2024) · Figshare · doi:10.6084/m9.figshare.26653326

Additional file 3 of Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Wang, H., Wang, M., Chen, J., Hou, H., Guo, Z., Yang, H., Tang, H., & Chen, B. (2024) · Figshare · doi:10.6084/m9.figshare.26653305

Additional file 3 of LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia

Wang, D., Li, X., Jiao, D., Cai, Y., Qian, L., Shen, Y., Lu, Y., Zhou, Y., Fu, B., Sun, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578025

Additional file 8 of Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Wang, H., Wang, M., Chen, J., Hou, H., Guo, Z., Yang, H., Tang, H., & Chen, B. (2024) · Figshare · doi:10.6084/m9.figshare.26653320

Additional file 1 of Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population

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