Cited by 426Iron Metabolism and DisordersFerroptosis and cancer prognosisHemoglobin structure and function

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Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation

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Xiao, Xia, Yeoh, Beng San, Vijay-Kumar, Matam·2017·Annual Review of Nutrition

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Abstract

Lipocalin 2 (Lcn2), an innate immune protein, has emerged as a critical iron regulatory protein during physiological and inflammatory conditions. As a bacteriostatic factor, Lcn2 obstructs the siderophore iron-acquiring strategy of bacteria and thus inhibits bacterial growth. As part of host nutritional immunity, Lcn2 facilitates systemic, cellular, and mucosal hypoferremia during inflammation, in addition to stabilizing the siderophore-bound labile iron pool. In this review, we summarize recent advances in understanding the interaction between Lcn2 and iron, and its effects in various inflammatory diseases. Lcn2 exerts mostly a protective role in infectious and inflammatory bowel diseases, whereas both beneficial and detrimental functions have been documented in neurodegenerative diseases, metabolic syndrome, renal disorders, skin disorders, and cancer. Further animal and clinical studies are necessary to unveil the multifaceted roles of Lcn2 in iron dysregulation during inflammation and to explore its therapeutic potential for treating inflammatory diseases.

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Epithelial–mesenchymal transitions in tumour progression
Thiery, J. P. (2002) · Nature reviews. Cancer · doi:10.1038/nrc822 · Cited by 6,767
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068
Self-citation
The epidemiology of global micronutrient deficiencies
Bailey, R. L., West Jr., K. P., & Black, R. E. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000371618 · Cited by 2,035
Matrix metalloproteinases and tumor metastasis
Deryugina, E. I., & Quigley, J. P. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-7886-9 · Cited by 1,974
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
Flo, T. H., Smith, K. D., Sato, S., Rodriguez, D. J., Holmes, M. A., Strong, R. K., Akira, S., & Aderem, A. (2004) · Nature · doi:10.1038/nature03104 · Cited by 1,877
The role of iron in brain ageing and neurodegenerative disorders
Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819
Chemistry and biology of siderophores
Hider, R. C., & Kong, X. (2010) · Natural Product Reports · doi:10.1039/b906679a · Cited by 1,722
Iron and cancer: more ore to be mined
Torti, S. V., & Torti, F. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3495 · Cited by 1,621
The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition
Goetz, D. H., Holmes, M. A., Borregaard, N., Bluhm, M. E., Raymond, K. N., & Strong, R. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00708-6 · Cited by 1,355
Inflammation in neurodegenerative diseases
Amor, S., Puentes, F., Baker, D., & Van Der Valk, P. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03225.x · Cited by 1,355

Show all 204 references

Research works printed but not linked: 5

Chakraborty S, 2012, Biochim. Biophys. Acta, 1826, 129
Gregory A, 2014, GeneReviews
Hraba-Renevey S, 1989, Oncogene, 4, 601
Lee EK, 2011, Int. J. Oncol., 38, 325
Vijay-Kumar M, 2007, J. Clin. Investig., 117, 3909

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Cavalcanti, L., Francati, S., Ferraguti, G., Fanfarillo, F., Peluso, D., Barbato, C., Greco, A., Minni, A., & Petrella, C. (2025) · Cells · doi:10.3390/cells14070506 · Cited by 4
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Authors: Xiao, X., Yeoh, B. S., & Vijay-Kumar, M.
Affiliations: Pennsylvania State University (US)
Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802;
ORCID: Xiao, Xia
Yeoh, Beng San
Venue: Annual Review of Nutrition
Publisher: Annual Reviews
Published: 2017-08-21
Volume: 37
Issue: 1
Pages: 103-130
ISSN: 0199-9885 (ISSN-L)
1545-4312
DOI: 10.1146/annurev-nutr-071816-064559
OpenAlex: W2527347986
Cited by: 426
References: 204
Citations by year: 2026: 45 · 2025: 64 · 2024: 83 · 2023: 59 · 2022: 57 · 2021: 52 · 2020: 32 · 2019: 20 · 2018: 13
FWCI: 2.81
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.annualreviews.org/licenses/tdm (tdm)
Locations: Annual Review of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK097865)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Keywords: neutrophil gelatinase-associated lipocalin, iron homeostasis, inflammation, nutritional immunity, siderophores, hypoferremia, labile iron pool, bacteriostatic activity, inflammatory bowel disease, neurodegenerative diseases, metabolic syndrome, kidney disease, skin diseases, cancer, therapeutic target
MeSH terms: Lipocalin-2, Animals, Bacteria, Homeostasis, Humans, Inflammation, Iron

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Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation

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