Cited by 296Retinoids in leukemia and cellular processesPharmacogenetics and Drug MetabolismPeroxisome Proliferator-Activated Receptors

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Cytochrome P450s in the Regulation of Cellular Retinoic Acid Metabolism

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Catharine Ross, A., Zolfaghari, Reza·2011·Annual Review of Nutrition

DOI 10.1146/annurev-nutr-072610-145127PMC PMC3789243

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Abstract

The active metabolite of vitamin A, retinoic acid (RA), is a powerful regulator of gene transcription. RA is also a therapeutic drug. The oxidative metabolism of RA by certain members of the cytochrome P450 (CYP) superfamily helps to maintain tissue RA concentrations within appropriate bounds. The CYP26 family—CYP26A1, CYP26B1, and CYP26C1—is distinguished by being both regulated by and active toward all-trans-RA (at-RA) while being expressed in different tissue-specific patterns. The CYP26A1 gene is regulated by multiple RA response elements. CYP26A1 is essential for embryonic development, whereas CYP26B1 is essential for postnatal survival as well as germ cell development. Enzyme kinetic studies have demonstrated that several CYP proteins are capable of metabolizing at-RA; however, it is likely that CYP26A1 plays a major role in RA clearance. Thus, pharmacological approaches to limiting the activity of CYP26 enzymes may extend the half-life of RA and could be useful clinically in the future.

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Authors: Catharine Ross, A., & Zolfaghari, R.
Affiliations: Pennsylvania State University (US)
ORCID: Zolfaghari, Reza
Venue: Annual Review of Nutrition
Publisher: Annual Reviews
Published: 2011-08-21
Volume: 31
Issue: 1
Pages: 65-87
ISSN: 0199-9885 (ISSN-L)
1545-4312
DOI: 10.1146/annurev-nutr-072610-145127
PMC: PMC3789243
OpenAlex: W2167484695
Cited by: 296
References: 124
Citations by year: 2026: 19 · 2025: 8 · 2024: 18 · 2023: 16 · 2022: 16 · 2021: 16 · 2020: 34 · 2019: 24 · 2018: 14 · 2017: 18 · 2016: 24 · 2015: 21 · 2014: 22 · 2013: 24 · 2012: 19
FWCI: 1.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Nutrition (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (CA90214, R01CA090214)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK041479)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: retinoic acid, cytochrome P450, CYP26A1, CYP26B1, CYP26C1, retinoic acid metabolism, all-trans retinoic acid, vitamin A, transcriptional regulation, embryonic development, germ cell development, enzyme kinetics
MeSH terms: Retinoic Acid 4-Hydroxylase, Animals, Biotransformation, Cell Differentiation, Cytochrome P-450 Enzyme System, Humans, Isoenzymes, Liver, Stem Cells, Tretinoin, Gene Expression Regulation, Enzymologic, Embryonic Development, Retinoid X Receptors, Biocatalysis

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Cytochrome P450s in the Regulation of Cellular Retinoic Acid Metabolism

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