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Cited by 366

The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.

IgG4-Related Disease

Open access
Mahajan, Vinay S., Mattoo, Hamid, Deshpande, Vikram, Pillai, Shiv S., Stone, John H.·2014·Annual Review of Pathology: Mechanisms of Disease

Abstract

Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is an immune-mediated condition that can affect almost any organ and is now being recognized with increasing frequency. IgG4-RD is characterized by a lymphoplasmacytic infiltrate composed of IgG4+plasma cells, storiform fibrosis, obliterative phlebitis, and mild to moderate eosinophilia. The diagnosis of IgG4-RD unifies many eponymous fibroinflammatory conditions that had previously been thought to be confined to single organs. IgG4-RD lesions are infiltrated by T helper cells, which likely cause progressive fibrosis and organ damage. IgG4 antibodies are generally regarded as noninflammatory. Although autoreactive IgG4 antibodies are observed in IgG4-RD, there is no evidence that they are directly pathogenic. Rituximab-induced B cell depletion in IgG4-RD leads to rapid clinical and histological improvement accompanied by swift declines in serum IgG4 concentrations. Although IgG autoantibodies against various exocrine gland antigens have been described in IgG4-RD, whether they are members of the IgG4 subclass is unknown. The contribution of autoantibodies to IgG4-RD remains unclear.

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Metadata

Authors
Mahajan, V. S., Mattoo, H., Deshpande, V., Pillai, S. S., & Stone, J. H.
Venue
Annual Review of Pathology: Mechanisms of Disease
Published
2014-01-24
Volume
9
Issue
1
Pages
315-347
ISSN
  • 1553-4006 (ISSN-L)
  • 1553-4014
OpenAlex
W2614362231
Cited by
366
References
114
FWCI
7.13
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: IgG4-Related Disease. https://app.cochat.ai/papers/10.1146/annurev-pathol-012513-104708
The paper
Mahajan, V. S., Mattoo, H., Deshpande, V., Pillai, S. S., & Stone, J. H. (2014). IgG4-Related Disease. Annual Review of Pathology: Mechanisms of Disease. https://doi.org/10.1146/annurev-pathol-012513-104708

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.