The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
Orexin Receptors: Pharmacology and Therapeutic Opportunities
Open accessAbstract
Orexin-A and -B (also known as hypocretin-1 and -2) are neuropeptides produced in the lateral hypothalamus that promote many aspects of arousal through the OX1 and OX2 receptors. In fact, they are necessary for normal wakefulness, as loss of the orexin-producing neurons causes narcolepsy in humans and rodents. This has generated considerable interest in developing small-molecule orexin receptor antagonists as a novel therapy for the treatment of insomnia. Orexin antagonists, especially those that block OX2 or both OX1 and OX2 receptors, clearly promote sleep in animals, and clinical results are encouraging: Several compounds are in Phase III trials. As the orexin system mainly promotes arousal, these new compounds will likely improve insomnia without incurring many of the side effects encountered with current medications.
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The nature of feelings: evolutionary and neurobiological origins
Damasio, A., & Carvalho, G. B. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3403 · Cited by 1,280
Sleep Neurobiology from a Clinical Perspective
(2011) · Sleep · doi:10.5665/sleep.1112 · Cited by 277
Multiple roles for orexin/hypocretin in addiction
Mahler, S. V., Smith, R. J., Moorman, D. E., Sartor, G. C., & Aston-Jones, G. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59489-1.00007-0 · Cited by 215
exercise influence on hippocampal function: possible involvement of orexin-A
Chieffi, S., Messina, G., Villano, I., Messina, A., Esposito, M., Monda, V., Valenzano, A., Moscatelli, F., Esposito, T., Carotenuto, M., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00085 · Cited by 90
Elliott, J. E., De Luche, S. E., Churchill, M. J., Moore, C., Cohen, A. S., Meshul, C. K., & Lim, M. M. (2018) · Sleep · doi:10.1093/sleep/zsx212 · Cited by 63
Metadata
- Authors
- Scammell, T. E., & Winrow, C. J.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2011-02-10
- Volume
- 51
- Issue
- 1
- Pages
- 243-266
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2132372764
- Cited by
- 381
- References
- 138
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- green
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