Multiple roles for orexin/hypocretin in addiction

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Orexin Mediates the Expression of Precipitated Morphine Withdrawal and Concurrent Activation of the Nucleus Accumbens Shell

Sharf, R., Sarhan, M., & Dileone, R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.006 · Cited by 144 · see citing works

Stress and Arousal: The Corticotrophin-Releasing Factor/Hypocretin Circuitry

Winsky‐Sommerer, R., Boutrel, B., & de Lecea, L. (2005) · Molecular Neurobiology · doi:10.1385/mn:32:3:285 · Cited by 144 · see citing works

Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking

James, M. H., Charnley, J. L., Levi, E. M., Jones, E., Yeoh, J. W., Smith, D. W., & Dayas, C. V. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000423 · Cited by 142 · see citing works

Differential Target-Dependent Actions of Coexpressed Inhibitory Dynorphin and Excitatory Hypocretin/Orexin Neuropeptides

Li, Y., & van den Pol, A. N. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3380-06.2006 · Cited by 141 · see citing works

Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons

Borgland, S. L., Storm, E. E., & Bonci, A. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06397.x · Cited by 141 · see citing works

Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats

Mahler, S. V., Smith, R. J., & Aston‐Jones, G. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2681-5 · Cited by 141 · see citing works

Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol–preferring Sprague–Dawley rats

Moorman, D. E., & Aston‐Jones, G. (2009) · Alcohol · doi:10.1016/j.alcohol.2009.07.002 · Cited by 140 · see citing works

Cholecystokinin Activates Orexin/Hypocretin Neurons through the Cholecystokinin A Receptor

Tsujino, N., Yamanaka, A., Ichiki, K., Muraki, Y., Kilduff, T. S., Yagami, K., Takahashi, S., Goto, K., & Sakurai, T. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1193-05.2005 · Cited by 139 · see citing works

The orexin1 receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats

Jupp, B., Krivdic, B., Krstew, E., & Lawrence, A. J. (2011) · Brain Research · doi:10.1016/j.brainres.2011.03.045 · Cited by 137 · see citing works

Characterisation of the binding of [3H]‐SB‐674042, a novel nonpeptide antagonist, to the human orexin‐1 receptor

Langmead, C. J., Jerman, J. C., Brough, S. J., Scott, C. M., Porter, R. A., & Herdon, H. J. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705610 · Cited by 136 · see citing works

Self-administration enhances excitatory synaptic transmission in the bed nucleus of the stria terminalis

Dumont, É. C., Mark, G. P., Mader, S. L., & Williams, J. T. (2005) · Nature Neuroscience · doi:10.1038/nn1414 · Cited by 136 · see citing works

Reinstatement of Cocaine Seeking by Hypocretin (Orexin) in the Ventral Tegmental Area: Independence from the Local Corticotropin-Releasing Factor Network

Wang, B., You, Z., & Wise, R. A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.018 · Cited by 135 · see citing works

Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development

Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337 · see citing works

The contribution of brain reward circuits to the obesity epidemic

Stice, E., Figlewicz, D. P., Gosnell, B. A., Levine, A. S., & Pratt, W. E. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.001 · Cited by 274 · see citing works

Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats

Brown, R. M., Khoo, S. Y.-S., & Lawrence, A. J. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000333 · Cited by 101 · see citing works

Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats

Schmeichel, B. E., Barbier, E., Misra, K. K., Contet, C., Schlosburg, J. E., Grigoriadis, D., Williams, J. P., Karlsson, C., Pitcairn, C., Heilig, M., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.293 · Cited by 79 · see citing works

The highly selective orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice

Lopez, M. F., Moorman, D. E., Aston-Jones, G., & Becker, H. C. (2016) · Brain Research · doi:10.1016/j.brainres.2016.01.049 · Cited by 62 · see citing works