Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments

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Charge Effects on the Photodegradation of Single Optically Trapped Oleic Acid Aerosol Droplets

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In Situ Probing of the Surface Properties of Droplets in the Air

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Humidity drives spontaneous OH oxidation of organic particles

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Intra-cluster Charge Migration upon Hydration of Protonated Formic Acid Revealed by Anharmonic Analysis of Cold Ion Vibrational Spectra

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Femtoliter oil droplets act as CO2 micropumps for uninterrupted electrochemiluminescence at the water|oil interface

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The power of microdroplet photochemistry

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Single Liquid Aerosol Microparticle Electrochemistry on a Suspended Ionic Liquid Film

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Tailoring Heterostructure Growth on Liquid Metal Nanodroplets through Interface Engineering

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High-throughput microdroplet-based synthesis using automated array-to-array transfer

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In-situ fabrication of metal oxide nanocaps based on biphasic reactions with surface nanodroplets

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Deconstructing the origins of interfacial catalysis: Why electric fields are inseparable from solvation

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Photoinitiated Degradation Kinetics of the Organic UV Filter Oxybenzone in Solutions and Aerosols: Impacts of Salt, Photosensitizers, and the Medium

Cooper, A., Shenkiryk, A., Chin, H., Morris, M., Mehndiratta, L., Roundtree, K. I., Tafuri, T., & Slade, J. H. (2024) · ACS ES&T Air · doi:10.1021/acsestair.4c00149 · Cited by 14

Accelerated Forced Degradation of Therapeutic Peptides in Levitated Microdroplets

Li, Y., Hu, Y., Logsdon, D. L., Liu, Y., Zhao, Y., & Cooks, R. G. (2020) · Pharmaceutical Research · doi:10.1007/s11095-020-02868-y · Cited by 14

Size Effect on the Reaction Rate of Surface Nanodroplets

Li, Z., Kiyama, A., Zeng, H., & Zhang, X. (2021) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.1c04092 · Cited by 14

Interfacial Partitioning Enhances Microextraction by Multicomponent Nanodroplets

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Tracking Reaction Pathways by a Modular Flow Reactor Coupled to Electrospray Ionization Mass Spectrometry

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In Situ Detection of Chemical Compositions at Nanodroplet Surfaces and In-Nanodroplet Phases

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Ion-Size Dependent Adsorption Crossover on the Surface of a Water Droplet

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Nested-channel for on-demand alternation between electrospray ionization regimes

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Sustainable Imine Production Using Alkanes as Substrates via a Plasma-Microdroplet Approach

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A Critical Reappraisal of the Evidence for Spontaneous Generation of Hydroxyl Radicals in Aqueous Nanodroplets

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Facile Synthesis of Triazoles using Electrospray‐Deposited Copper Nanomaterials to Catalyze Azide‐Alkyne Cycloaddition (AAC) Click Reactions

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Organic acid evaporation kinetics from aqueous aerosols: implications for aerosol buffering capacity in the atmosphere

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Spiers Memorial Lecture: Water at interfaces

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External Force Field for Protein Folding in Chaperonins─Potential Application in In Silico Protein Folding

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Reactive Molecular Simulation with Size Extrapolation to Bridge the Polymerization Mechanism and Kinetics

Chen, X., Wu, L., Ge, M., Wang, X., Ren, N., Sun, H., & Zhu, X. (2024) · Macromolecules · doi:10.1021/acs.macromol.3c02590 · Cited by 13

Are Hydroxyl Radicals Spontaneously Generated in Unactivated Water Droplets?

Chen, C. J., & Williams, E. R. (2024) · Angewandte Chemie · doi:10.1002/ange.202407433 · Cited by 13

Merging Vibrational Spectroscopy with Fluorescence Microscopy: Combining the Best of Two Worlds

Qian, N., Xiong, H., Wei, L., Shi, L., & Min, W. (2025) · Annual Review of Physical Chemistry · doi:10.1146/annurev-physchem-082423-121033 · Cited by 14

Catalyst‐Free Cleavage of C─O/C─C Bonds in Lignin Linkages by Water Microdroplets

Wang, T., Chen, H., Xu, J., & Hu, J. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202514150 · Cited by 13

Location of carbon–carbon double bonds in unsaturated lipids using microdroplet mass spectrometry

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Digital Microfluidics Chips for the Execution and Real-Time Monitoring of Multiple Ribozymatic Cleavage Reactions

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Probing autoxidation of oleic acid at air-water interface: A neglected and significant pathway for secondary organic aerosols formation

He, J. F., Zhang, H., Wang, W., Ma, Y., Yang, M., He, Y., Liu, Z., Yu, K., & Jiang, J. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113232 · Cited by 13

Oxidation of Cysteine by Electrogenerated Hexacyanoferrate(III) in Microliter Droplets

Vannoy, K. J., & Dick, J. E. (2022) · Langmuir · doi:10.1021/acs.langmuir.2c01385 · Cited by 13

Efficiency in CO2-utilization strategies: The case of styrene carbonate synthesis in microdroplets conditions

Urbani, D., Rovegno, C., Massi, A., Leblebici, M. E., Kayahan, E., Polo, E., & Dambruoso, P. R. (2022) · Journal of CO2 Utilization · doi:10.1016/j.jcou.2022.102328 · Cited by 14

Stabilization of levitating clusters containing saltwater droplets

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Uncatalyzed N-Alkylation of Amines in Ionic Wind from Ambient Corona Discharge

Lee, S., Kulyk, D. S., Marano, N., & Badu-Tawiah, A. K. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.0c04440 · Cited by 13

Microfluidic platforms for CRISPR-based biosensing advancing molecular diagnostics from benchtop to point-of-care

Wang, Y., Jiang, H., Zhang, Y., Yang, Q., Song, Y., & Gao, Y. (2025) · Sensors & Diagnostics · doi:10.1039/d5sd00176e · Cited by 12

Chemical Reactions at Electrified Interfaces

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Collection and Characterization by Mass Spectrometry of the Neutral Serine Octamer Generated upon Sublimation

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Sulfuric Acid Catalyzed Esterification of Amino Acids in Thin Film

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Water Microdroplets Promote Spontaneous Oxidation of Amino Acid‐ and Peptide‐related Thiols to Disulfide Bonds

Zhang, H., Wang, Y., Yang, J., Ju, Y., He, J. F., Niu, Y., Liu, Y., Hou, W., Qiao, L., & Jiang, J. (2024) · Chemistry - A European Journal · doi:10.1002/chem.202404036 · Cited by 12

Air-water interface of microdroplet enhances photocatalytic oxidative species generation and utilization

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Atmospheric Sampling Mass Spectrometers Activate and Ionize Neutral Water Microdroplets to MeV Energies and up to 200,000+ Charges: Implications for Water Stability and Unusual Chemistry in Microdroplets

McPartlan, M. S., Chen, C. J., Harper, C. C., Miller, Z. M., Robles, J., Avadhani, V. S., Pedder, R. E., Metzler, L. J., & Williams, E. R. (2025) · ACS Central Science · doi:10.1021/acscentsci.5c01518 · Cited by 12

How reactive is water at the nanoscale and how to control it?

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Accelerated Keto–Enol Tautomerization Kinetics of Malonic Acid in Aqueous Droplets

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Effect of Relative Humidity in Air on the Transmission of Respiratory Viruses

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Spatial reorganization of analytes in charged aqueous microdroplets

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Abiotic synthesis with plausible emergence for primitive phospholipid in aqueous microdroplets

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Catalyst‐Free Three‐Component Petasis Reactions Accelerated in Microdroplets: Reaction Optimization and Senstive Detection by Mass Spectrometry

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The pluses and minuses of microdroplet separation

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Identification of the Electrogenerated Hidden Nitrenium Ions by In Situ Mass Spectrometry

Liu, C., Chen, Y., & Hu, J. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.3c04315 · Cited by 12

Impact of interfacial curvature on molecular properties of aqueous interfaces

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Accelerated d -Fructose Acid-Catalyzed Reactions in Thin Films Formed by Charged Microdroplets Deposition

Salvitti, C., de Petris, G., Troiani, A., Managò, M., Villani, C., Ciogli, A., Sorato, A., Ricci, A., & Pepi, F. (2022) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.1c00363 · Cited by 12

Control of Intermediates and Products by Combining Droplet Reactions and Ion Soft‐Landing

Yang, F., Urban, R. D., Lorenz, J., Griebel, J., Koohbor, N., Rohdenburg, M., Knorke, H., Fuhrmann, D. A., Charvát, A., Abel, B., et al. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202314784 · Cited by 11

Arc-Induced Electrospray Ionization Mass Spectrometry

Huang, K., Zeng, H., Li, X., Li, X., Pan, Y., & Gao, Y. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c04125 · Cited by 11

The Structure of Carbon Dioxide at the Air‐Water Interface and its Chemical Implications

Martins‐Costa, M. T. C., & Ruiz‐López, M. F. (2024) · Chemistry - A European Journal · doi:10.1002/chem.202400825 · Cited by 11

Mild Catalyst- and Additive-Free Three-Component Synthesis of 3-Thioisoindolinones and Tricyclic γ-Lactams Accelerated by Microdroplet Chemistry

Dai, C., Huang, C., Ye, M., Liu, J., & Cheng, H. (2024) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.4c01568 · Cited by 11

Hydroxymethanesulfonate formation accelerated at the air-water interface by synergistic enthalpy-entropy effects

Li, J., Tang, W., Zhu, J., Yang, J., & He, X. D. (2025) · Nature Communications · doi:10.1038/s41467-025-59712-3 · Cited by 11

Quantum tunneling on water. I. General framework for microdroplet redox chemistry

Zhuang, C., Qian, N., & Min, W. (2026) · The Journal of Chemical Physics · doi:10.1063/5.0326949 · Cited by 11

Kinetics of alkaline hydrolysis of synthetic organic esters

Maeng, D. Y., & McNeill, V. F. (2021) · International Journal of Chemical Kinetics · doi:10.1002/kin.21552 · Cited by 11

Molecular and Structural Characterization of Isomeric Compounds in Atmospheric Organic Aerosol Using Ion Mobility-Mass Spectrometry

West, C. P., Sanchez, D. M., Morales, A. C., Hsu, Y.-J., Ryan, J., Darmody, A., Slipchenko, L. V., Laskin, J., & Laskin, A. (2023) · The Journal of Physical Chemistry A · doi:10.1021/acs.jpca.2c06459 · Cited by 11

Water Reactivity in Electrified Interfaces: The Simultaneous Production of Electricity, Hydrogen, and Hydrogen Peroxide at Room Temperature

Santos, L. P., Lermen, D., Yoshimura, R. G., da Silva, B. L., Galembeck, A., Burgo, T. A. L., & Galembeck, F. (2023) · Langmuir · doi:10.1021/acs.langmuir.3c00186 · Cited by 11

Water Self‐Dissociation is Insensitive to Nanoscale Environments

Pino, S. D., Sirkin, Y. A. P., Morzan, U. N., Sánchez, V. M., Hassanali, A. A., & Scherlis, D. A. (2023) · Angewandte Chemie · doi:10.1002/ange.202306526 · Cited by 11

Prebiotic synthesis of mineral-bearing microdroplet from inorganic carbon photoreduction at air–water interface

Ge, Q., Liu, Y., You, W., Wang, W., Li, K., Ruan, X., Xie, L., Wang, T., & Zhang, L. (2023) · PNAS Nexus · doi:10.1093/pnasnexus/pgad389 · Cited by 11

Femtoamp and picoamp modes of electrospray and paper spray ionization

Allen, N. R., Li, H., Cheung, A., Xu, G., Zi, Y., & Li, A. (2021) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2021.116696 · Cited by 11

Peptide synthesis in aqueous microdroplets

Vaida, V., & Deal, A. M. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2216015119 · Cited by 10

Advancements in the preparation and application of microdroplets: A review

He, Y., Yang, S., Zhang, M., Wang, Z., Zhang, Y., & Gao, P. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.113901 · Cited by 10

Comparing Sprayed Water Microdroplets with Several Ionization Methods on the Capability of Ionizing Ambient Air

Li, B., Gao, X., Xing, D., & Zhang, X. (2025) · The Journal of Physical Chemistry A · doi:10.1021/acs.jpca.5c04034 · Cited by 10

Radical surface chemistry: Augmentation of reactivity by radicals at aqueous interfaces

Kołasiński, K. W. (2025) · Surface Science Reports · doi:10.1016/j.surfrep.2025.100668 · Cited by 10

Accelerated and Green Synthesis of N,S - and N,O -Heterocycles in Microdroplets

Ghosh, J., Morato, N. M., LeFever, W. A., & Cooks, R. G. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.5c12522 · Cited by 10

Water microdroplets: A catalyst-free source of reactive oxygen species for pollutants removal

Wang, S., Yang, J. T., Liu, F., Xiao, S., Xiao, F., Dong, X., & Shan, S. (2023) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2023.138444 · Cited by 10

Molecular hydration: Interfacial supersolidity and its functionality

Fang, H., Wang, X., Zhou, Y., Zhang, C., Tan, T., Yao, C., Huang, Y., Wang, B., & Sun, C. Q. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215576 · Cited by 10

Reaction acceleration at the surface of a levitated droplet by vapor dosing from a partner droplet

Qiu, L., Li, X., Holden, D. T., & Cooks, R. G. (2024) · Chemical Science · doi:10.1039/d4sc03528c · Cited by 10

Self-organization of stearic acid salts on the hemispherical surface of the aqueous subphase allows functionalization of matrix-assisted laser desorption/ionization mass spectrometry target plates for on-plate immobilized metal affinity chromatography enrichment

Gladchuk, A. S., Silyavka, E. S., Shilovskikh, V. V., Bocharov, V. N., Zorin, I. M., Tomilin, N. V., Андреевич, С. Н., Alexandrova, M. L., Krasnov, N. V., Gorbunov, A. Y., et al. (2022) · Thin Solid Films · doi:10.1016/j.tsf.2022.139374 · Cited by 10

A Kinetic Description of How Interfaces Accelerate Reactions in Micro-CompartmentsPreprint

Wilson, K. R., Prophet, A. M., Rovelli, G., Willis, M. D., Rapf, R. J., & Jacobs, M. (2020) · ChemRxiv · doi:10.26434/chemrxiv.12506117 · Cited by 10

Special Issue with Research Topics on “Recent Analysis and Applications of Mass Spectra on Biochemistry”

Ivanova, B. B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25041995 · Cited by 10

Quantifying the interfacial tension of adsorbed droplets on electrified interfaces

Herchenbach, P. J., Layman, B. R., & Dick, J. E. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.06.141 · Cited by 9

From Solution to Microstructures in Minutes: Microdroplet-Derived Stand-Alone TiO2 Surfaces for Simultaneous Water Harvesting and Treatment

Unni, K., Kumar, J. S., Som, A., Sarkar, D., & Pradeep, T. (2024) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.4c02806 · Cited by 9

Calibrating the Oxidative Capacity of Microdroplets

Majumder, T., Eremin, D. B., Delibas, B., Sarkar, A., Fokin, V. V., & Dawlaty, J. M. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202414746 · Cited by 9

Role of Interfacial Processes in Accelerated Reactions in Nano- and Microdroplets

Yang, S., Li, M., Wang, J. L., Grassian, V. H., Kumar, S., & Dutcher, C. S. (2025) · The Journal of Physical Chemistry A · doi:10.1021/acs.jpca.5c03287 · Cited by 9

From micro-to-nano in charged water microdroplets: unveiling steps in the weathering of minerals

Mahapatra, A., Som, A., Spoorthi, B. K., Sarkar, D., & Pradeep, T. (2025) · Chemical Communications · doi:10.1039/d5cc02952j · Cited by 9

Microdroplet Mechanochemistry

Pradeep, T. (2025) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.5c12102 · Cited by 9

Accelerated synthesis of energetic precursor cage compounds using confined volume systems

Brown, H. M., Doppalapudi, K. R., & Fedick, P. W. (2021) · Scientific Reports · doi:10.1038/s41598-021-02945-1 · Cited by 9

Elucidating the Mechanism for the Reaction of o-Phthalaldehyde with Primary Amines in the Presence of Thiols

Rovelli, G., & Wilson, K. R. (2023) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.2c08785 · Cited by 9

Reactivity of Monoethanolamine at the Air–Water Interface and Implications for CO2 Capture

Martins‐Costa, M. T. C., & Ruiz‐López, M. F. (2024) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.3c06856 · Cited by 9

Dielectrophoretic bead-droplet reactor for solid-phase synthesis

Padhy, P., Zaman, M. A., Jensen, M. A., Cheng, Y.-T., Huang, Y., Wu, M., Galambos, L., Davis, R. W., & Hesselink, L. (2024) · Nature Communications · doi:10.1038/s41467-024-49284-z · Cited by 9

Synthesis of 3-Substituted Indoles by Yonemitsu Three-Component Reactions Accelerated in Microdroplet/Thin Film

Wu, Y., Li, J., Sun, J., Wang, Y., Liu, J., & Cheng, H. (2024) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.4c02395 · Cited by 9

Acceleration of the thermal degradation of PETN in the microdroplets flow reactor

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