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Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments
Open accessAbstract
Various organic reactions, including important synthetic reactions involving C–C, C–N, and C–O bond formation as well as reactions of biomolecules, are accelerated when the reagents are present in sprayed or levitated microdroplets or in thin films. The reaction rates increase by orders of magnitude with decreasing droplet size or film thickness. The effect is associated with reactions at the solution–air interface. A key factor is partial solvation of the reagents at the interface, which reduces the critical energy for reaction. This phenomenon is of intrinsic interest and potentially of practical value as a simple, rapid method of performing small-scale synthesis.
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Cites
Electrospray Ionization for Mass Spectrometry of Large Biomolecules
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634
Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization
Takáts, Z., Wiseman, J. M., Gologan, B., & Cooks, R. G. (2004) · Science · doi:10.1126/science.1104404 · Cited by 3,369
Self-citationThe E Factor: fifteen years on
Sheldon, R. A. (2007) · Green Chemistry · doi:10.1039/b713736m · Cited by 1,715
“On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension
Narayan, S., Muldoon, J., Finn, M. G., Fokin, V. V., Kolb, H. C., & Sharpless, K. B. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200462883 · Cited by 1,691
Dole, M., Mack, L. L., Hines, R. L., Mobley, R. C., Ferguson, L., & Alice, M. B. (1968) · The Journal of Chemical Physics · doi:10.1063/1.1670391 · Cited by 1,606
Scriven, L. E., & Sternling, C. V. (1960) · Nature · doi:10.1038/187186a0 · Cited by 1,393
Anomalously low dielectric constant of confined water
Fumagalli, L., Esfandiar, A., Fabregas, R., Hu, S., Ares, P., Janardanan, A., Yang, Q., Radha, B., Taniguchi, T., Watanabe, K., et al. (2018) · Science · doi:10.1126/science.aat4191 · Cited by 1,067
Interfacial turbulence: Hydrodynamic instability and the marangoni effect
Sternling, C. V., & Scriven, L. E. (1959) · AIChE Journal · doi:10.1002/aic.690050421 · Cited by 1,038
A two-dimensional quadrupole ion trap mass spectrometer
Schwartz, J. C., Senko, M. W., & Syka, J. E. P. (2002) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(02)00384-7 · Cited by 800
Mass spectrometry: principles and applications
(2008) · Choice Reviews Online · doi:10.5860/choice.45-4389 · Cited by 779
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Brown, E. K., Jones, Z. R., Sarkar, A., Wallace, B. J., Ajoy, A., & Wilson, K. R. (2026) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.6c01528
LIU, J., Yang, X., Gu, J., Qiu, L., Liu, L., An, N., Li, H., Lan, J., Francisco, J. S., & Zhang, X. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c01510
Goda, M. N., Khairy, M., & Abdulkhair, B. Y. (2026) · Inorganics · doi:10.3390/inorganics14070171
Molecular Framework Modification in Mass Spectrometry: Atom Exchange, Insertion, and Deletion
Edwards, M. Q., Holden, D. T., & Cooks, R. G. (2026) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.6c00171
Self-citationAcidic modulation of CO2 fixation by pyruvate in micron-sized water microdroplets
Hou, W., Xing, J., Qiao, L., Ju, Y., Liu, Y., He, J., Wei, W., Jiang, J., & Zhang, H. (2026) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2026.123910
Unicellular, Collective, and Extended Minds: From Cells to the Biosphere
Miller, W. B., Baluška, F., Slijepčević, P., & Reber, A. S. (2026) · Springer eBooks · doi:10.1007/978-3-032-23779-8_15
Mechanistic Insights into Ammonia Synthesis from Nitrogen and Water Microdroplets
Zhang, Q., Tang, B., & Li, Z. (2026) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.6c01842
Mukhopadhyay, S., Sarkar, D., & Pradeep, T. (2026) · Chemical Communications · doi:10.1039/d6cc04125f
Phase-preserved fragmentation of bulk WS 2 to nanoparticles in charged water microdroplets
Kundu, K., Manna, S., Som, A., Mahapatra, A., & Pradeep, T. (2026) · Chemical Communications · doi:10.1039/d6cc03938c
Hou, W., Xing, J., Zhu, S., Ju, Y., He, J. F., Qiao, L., Zhang, H., & Jiang, J. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c03761
Jiang, M., Dong, J., Wang, X., Liu, X., Ke, Y., Li, Y., Zheng, H., & Zhu, Z. (2026) · Journal of Analytical Atomic Spectrometry · doi:10.1039/d6ja00192k
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Xie, K., He, M., Wang, J., Li, B., Wen, Z., Gu, X., Zhang, W., Gou, Q., Yu, L., & Tang, X. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.143217
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Song, Q., Chen, B., Chen, B., Liang, Y., Hu, L., Shi, J., Song, M., Zhang, X., Yin, Y., Cai, Y. Z., et al. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c18883
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Hao, S., Xu, J., Li, J., Chen, F., & Xia, Y. (2026) · Langmuir · doi:10.1021/acs.langmuir.6c02278
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Song, J. Y., Wang, K., Shang, Q., Deng, J., & Luo, G. (2026) · Reaction Chemistry & Engineering · doi:10.1039/d6re00233a
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Hazen, G., Li, S., Rani, S., Nguyen, H. V., Gilhuly, E. D., Rangel, F., Asserghine, A., Schroeder, C. M., Assary, R. S., & Rodríguez‐López, J. (2026) · EES Catalysis · doi:10.1039/d6ey00123h
Egemba, C. C., Haq, H., Beck, V., Ohno, P. E., & Hill, E. A. (2026) · Langmuir · doi:10.1021/acs.langmuir.6c02905
Tumminello, P. R., Bays, N., Schafer, D. P., Kruse, S. M., Zenker, J., Sheps, L., & Davis, R. D. (2026) · ACS Measurement Science Au · doi:10.1021/acsmeasuresciau.6c00159
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Sølling, T. I., Andersson, M., & Beauchamp, J. L. (2026) · The Journal of Physical Chemistry A · doi:10.1021/acs.jpca.6c03272
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Liu, Y.-C., & Chen, Y. (2026) · Analytica Chimica Acta · doi:10.1016/j.aca.2026.346187
Rani, S., Nguyen, H. V., Zhu, L., Das, S., Schroeder, C. M., & Rodríguez‐López, J. (2026) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.6c05673
Plasma-Assisted Functionalization of Hydrocarbons for Enhanced Mass Spectrometric Detection
Ali, M. M., Jana, M., Edwards, M. Q., Ataei, S., & Cooks, R. G. (2026) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.6c00269
Self-citationMa, X., Li, Y., Wu, R., Wang, M., Liu, J., Chu, L., Wang, X., & Zhou, D. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c13880
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Zhang, W., Gong, K., & Grassian, V. H. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c11524
McPartlan, M. S., Chen, C. J., & Williams, E. R. (2026) · ACS Central Science · doi:10.1021/acscentsci.6c00443
An Atmospheric Perspective on Emerging Water Microdroplet Chemistry
Xia, K., Jing, B., Liu, Q., Li, K., & Ge, M. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.6c07174
Beyond bulk physics: interfacial and confinement effects in aqueous microdroplets
Pal, A., WATANABE, C., Masuda, K., Chen, C., & Yanagisawa, M. (2026) · Reports on Progress in Physics · doi:10.1088/1361-6633/aea9a7
Yang, D.-B., Chen, X., Trabelsi, T., & Francisco, J. S. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c14162
Khairy, M., Abdulkhair, B. Y., Alqarni, L. S., Ibrahim, T. G., Masoud, E. M., El-Reash, Y. G. A., Alotaibi, A. N., Alghamdi, M. A., Alzahrani, S. S., & Goda, M. N. (2026) · Journal of the Indian Chemical Society · doi:10.1016/j.jics.2026.103156
Zhang, X., Zhang, H., Zeng, Y., Li, T., Gao, R., Li, J., Ren, Y., Bi, F., Jinjuan, L., Li, H., et al. (2026) · Emerging contaminants · doi:10.1016/j.emcon.2026.100768
Li, S., Asserghine, A., Rodríguez‐López, J., & Assary, R. S. (2026) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.6c03799
Wang, X.-B., Ochirov, O., Bakar, N. H. A., & Urban, P. L. (2026) · European Journal of Mass Spectrometry · doi:10.1177/14690667261497251
hanhui, Y. I. N., Juan, J., Rui, W., Chen, X., Gao, Y., & Peng, C. (2026) · Journal of Chemical Education · doi:10.1021/acs.jchemed.6c00785
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Sarkar, A., Majumder, T., & Dawlaty, J. M. (2026) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.6c02801
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Metadata
- Authors
- Wei, Z., Li, Y., Cooks, R. G., & Yan, X.
- Affiliations
- Purdue University West Lafayette (US)
- Texas A&M University (US)
- Corresponding author
- Yan, Xin
- Venue
- Annual Review of Physical Chemistry
- Publisher
- Annual Reviews
- Published
- 2020-04-20
- Volume
- 71
- Issue
- 1
- Pages
- 31-51
- ISSN
- 0066-426X (ISSN-L)
- 1545-1593
- OpenAlex
- W3017097444
- Cited by
- 631
- References
- 122
- Citations by year
- 2026: 117 · 2025: 142 · 2024: 123 · 2023: 91 · 2022: 73 · 2021: 62 · 2020: 23
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Physical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (1905087)
- Defense Advanced Research Projects Agency (1905087, W911NF-16-2-0020)
- Advanced Research Projects Agency
- Topics
- Physical Sciences › Chemical Engineering › Fluid Flow and Transfer Processes › Innovative Microfluidic and Catalytic Techniques Innovation
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Physical Sciences › Engineering › Computational Mechanics › Fluid Dynamics and Heat Transfer
- Keywords
- microdroplets, reaction kinetics, air/solution interface, levitated droplets, thin films, C–C bond formation, C–N bond formation, C–O bond formation, small-scale synthesis, reaction rate enhancement
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