Cited by 638Innovative Microfluidic and Catalytic Techniques InnovationMass Spectrometry Techniques and ApplicationsFluid Dynamics and Heat Transfer

The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.

Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments

Open access

Wei, Zhenwei, Li, Yangjie, Cooks, R. Graham, Yan, Xin·2020·Annual Review of Physical Chemistry

DOI 10.1146/annurev-physchem-121319-110654

Open this paper in CoChat — free account Open PDF

Abstract

Various organic reactions, including important synthetic reactions involving C–C, C–N, and C–O bond formation as well as reactions of biomolecules, are accelerated when the reagents are present in sprayed or levitated microdroplets or in thin films. The reaction rates increase by orders of magnitude with decreasing droplet size or film thickness. The effect is associated with reactions at the solution–air interface. A key factor is partial solvation of the reagents at the interface, which reduces the critical energy for reaction. This phenomenon is of intrinsic interest and potentially of practical value as a simple, rapid method of performing small-scale synthesis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1146/annurev-physchem-121319-110654

Cites

122 of 122 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Electrospray Ionization for Mass Spectrometry of Large Biomolecules
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634
Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization
Takáts, Z., Wiseman, J. M., Gologan, B., & Cooks, R. G. (2004) · Science · doi:10.1126/science.1104404 · Cited by 3,369
Self-citation
The E Factor: fifteen years on
Sheldon, R. A. (2007) · Green Chemistry · doi:10.1039/b713736m · Cited by 1,715
“On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension
Narayan, S., Muldoon, J., Finn, M. G., Fokin, V. V., Kolb, H. C., & Sharpless, K. B. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200462883 · Cited by 1,691
Molecular Beams of Macroions
Dole, M., Mack, L. L., Hines, R. L., Mobley, R. C., Ferguson, L., & Alice, M. B. (1968) · The Journal of Chemical Physics · doi:10.1063/1.1670391 · Cited by 1,606
The Marangoni Effects
Scriven, L. E., & Sternling, C. V. (1960) · Nature · doi:10.1038/187186a0 · Cited by 1,393
Anomalously low dielectric constant of confined water
Fumagalli, L., Esfandiar, A., Fabregas, R., Hu, S., Ares, P., Janardanan, A., Yang, Q., Radha, B., Taniguchi, T., Watanabe, K., et al. (2018) · Science · doi:10.1126/science.aat4191 · Cited by 1,067
Interfacial turbulence: Hydrodynamic instability and the marangoni effect
Sternling, C. V., & Scriven, L. E. (1959) · AIChE Journal · doi:10.1002/aic.690050421 · Cited by 1,038
A two-dimensional quadrupole ion trap mass spectrometer
Schwartz, J. C., Senko, M. W., & Syka, J. E. P. (2002) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(02)00384-7 · Cited by 800
Mass spectrometry: principles and applications
(2008) · Choice Reviews Online · doi:10.5860/choice.45-4389 · Cited by 779

Show all 122 references

Sorted by citations

Items 401–500 of 638

Harnessing Oil–Water Microinterfaces for the Catalyst-Free Oxidative Degradation of Toxic Organic Pollutants
Bose, S., Lee, K., Choi, S. Q., & Zare, R. N. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c05344 · Cited by 4
Quantum tunneling on water. II. Quantitative rate formalism of barrierless electron transfer and application to oxidation reactions
Zhuang, C., Qian, N., & Min, W. (2026) · The Journal of Chemical Physics · doi:10.1063/5.0329741 · Cited by 4
Single-electron-mediated redox processes at the air–water interface of water microdroplets
Jin, S., Zhu, C., Zhang, J., & Zhang, X. (2023) · Scientia Sinica Chimica · doi:10.1360/ssc-2023-0192 · Cited by 4
Isomer-Specific, Cryogenic Ion Vibrational Spectroscopy Investigation of D2- and N2-Tagged, Protonated Formic Acid Complexes Using Two-Color, IR-IR Photobleaching
Bocanegra, E. L., Rana, A., McCoy, A. B., & Johnson, M. A. (2024) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.4c02685 · Cited by 4
Microdroplet Accelerating C(sp2)–H Halogenation in Organic, Pharmaceutical, Analytical, and Environmental Use
Chen, S., Sun, J., Hu, H., Ye, M., & Cheng, H. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c01782 · Cited by 4
Challenges in the study of chemistry and photochemistry at air–water interfaces: Toward in situ monitoring of reaction kinetics with spectroscopic techniques
Deal, A. M. (2025) · The Journal of Chemical Physics · doi:10.1063/5.0269541 · Cited by 4
Micro‐droplet Trapping and Manipulation: Understanding Aerosol Better for a Healthier Environment
Chang, Y., Devi, Y., & Chen, C. (2021) · Chemistry - An Asian Journal · doi:10.1002/asia.202100516 · Cited by 4
基于质谱的单细胞蛋白质组学分析方法及应用
Qin, S., Bai, Y., & Liu, H. (2021) · Chinese Journal of Chromatography · doi:10.3724/sp.j.1123.2020.08030 · Cited by 4
In situ droplet-based on-tissue chemical derivatization for lipid isomer characterization using LESA
Freitas, D. P., Chen, X., Hirtzel, E. A., Edwards, M. E., Kim, J., Wang, H., Sun, Y., Kocurek, K. I., Russell, D. H., & Yan, X. (2023) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-023-04653-3 · Cited by 4
Self-citation
A High-Throughput Screening Method for Determining the Optimized Synthesis Conditions of Quinoxaline Derivatives Using Microdroplet Reaction
Yang, Y., Liu, J., Chen, Z., Niu, W., Li, R., Niu, L., Yang, P., Mu, X., & Tang, B. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00789 · Cited by 4
Hammett Correlation in the Accelerated Formation of 2,3-Diphenylquinoxalines in Nebulizer Microdroplets
Fenwick, N. W., Telford, R., Saidykhan, A., Martin, W. H. C., & Bowen, R. D. (2021) · Molecules · doi:10.3390/molecules26165077 · Cited by 4
Simultaneous extraction and dissolution in surface nanodroplets for controlling the crystallization of small organic molecules
Lim, E., Kim, D. A., & You, J. B. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.137378 · Cited by 3
Catalyst‐Free Cleavage of C─O/C─C Bonds in Lignin Linkages by Water Microdroplets
Wang, T., Chen, H., Xu, J., & Hu, J. (2025) · Angewandte Chemie · doi:10.1002/ange.202514150 · Cited by 3
Effect of pH on the Kinetics of Cysteine-to-Cystine Conversion in Thin Films Formed by ESI Microdroplet Deposition
Managò, M., Salvitti, C., Troiani, A., Noi, A. D., Ricci, A., & Pepi, F. (2025) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.5c00195 · Cited by 3
Liquid Crystal‐Driven Chemical Feeding Accelerates Condensation Reactions in Droplet Microreactors
Xu, Y., Weible, A. H., Zhang, M., Deng, W., Fang, J., & Wang, X. (2025) · Advanced Science · doi:10.1002/advs.202504133 · Cited by 3
High-Throughput Small-Scale Platform for Synthesis, Characterization, and Modeling of Per- and Polyfluoroalkyl Substances Analogs
Huang, K., Narendra, N., Yap, K., Morato, N. M., Chen, K., Feng, Y., Cooks, R. G., Kubis, T., & Ferreira, C. R. (2025) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.5c00699 · Cited by 3
Self-citation
High-Speed Automated Microdroplet Reactions with Ion-Mobility for Rapid Therapeutic Protein Characterization
Anapindi, K. D. B., Hsieh, E. J., Walker, T., Lau, J., & Tomazela, D. M. (2025) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.5c00152 · Cited by 3
Facile Preparation of a SERS Substrate for Monitoring Photocatalytic Coupling Reactions
Tan, J., Wei, L., Liu, Q., Cai, Z., & Zheng, C. (2025) · Journal of Raman Spectroscopy · doi:10.1002/jrs.70068 · Cited by 3
Sulfur Chemistry at the Air-Water Interface
Liu, P., Huang, Q., Lei, T., Zhang, Y., Wang, W., & Ge, M. (2025) · Annual Review of Physical Chemistry · doi:10.1146/annurev-physchem-082324-095359 · Cited by 3
Photochemical transformation of weakly absorbing organics by visible light in microdroplets
Logozzo, A., & Preston, T. C. (2025) · Physical Chemistry Chemical Physics · doi:10.1039/d5cp03615a · Cited by 3
Rational Control of Interfacial Spontaneous Redox Reactions by Modulating Single-Microdroplet Charging
Wang, X.-Y., Han, J., Diao, X., Wang, X., Zeng, C., Li, Y., Wang, J., Cai, Z., & Wei, Z. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c06042 · Cited by 3
Self-citation
Negative charge acquisition by isolated single microdroplets from plasma exposure at atmospheric pressure
Hendawy, N., McQuaid, H. N., Uidhir, S. M., Rutherford, D., Diver, D. A., Mariotti, D., & Maguire, P. D. (2026) · Journal of Physics D Applied Physics · doi:10.1088/1361-6463/ae3326 · Cited by 3
Catalyst‐Free Ammonia Formation at the Gas‐Liquid Interface Enables Selective Nitrogen‐Saccharide Association Under Abiotic Conditions
Ma, S., Sui, B., Yuan, H., Yu, A., Chai, G., Zhang, Y., Zhang, H., Sun, S., & Zhao, W. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.202524389 · Cited by 3
Constructing scalable hydrophobe–water micro-interfaces for catalyst-free generation of H2O2 via macroporous resins
Gao, J. C., Zhou, K., Guo, X., Yang, K., Yang, S., Su, H., Zhang, Z., & Wang, W. (2026) · Nature Communications · doi:10.1038/s41467-026-69085-w · Cited by 3
Blue Shift in Electrochromic Dye Emission Indicates Distinct Electrostatic Environment at Air–Water Interfaces
Kol, A. M., Herriman, T., Salmon, W. C., DiLabio, G. A., & Jackson, M. N. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c01481 · Cited by 3
Microheterogeneous singlet oxygen generation at air–water interfaces
Mi, S., Fang, Y., Liu, X., Zheng, X., Ming, H., Li, X., Chen, B., Zhu, C., McNeill, K., & Chu, C. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2534956123 · Cited by 3
Evolution of the Composition and pH of Single Aqueous Aerosols Produced from Bulk Aqueous Sulfite Solutions
Tam, A., Gong, K., Young, M. A., McNeill, V. F., & Grassian, V. H. (2026) · The Journal of Physical Chemistry A · doi:10.1021/acs.jpca.6c00609 · Cited by 3
Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform
Morato, N. M., Feng, Y., Chen, K., Huang, K., Owen, A., Caruso, J. V., Yang, B., Kulathunga, S. C., Mesecar, A. D., Klumpp-Thomas, C. A., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536552123 · Cited by 3
Self-citation
Water Microdroplets Induce Heterocyclic Transmutation: Skeletal Editing of Aniline into Pyridine at the Air–Water Interface
Nandy, A., Kar, A., Chakrabarti, S., Rana, A., & Banerjee, S. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c06409 · Cited by 3
High-performance peptide and disulfide mapping by direct injection of intact proteins using on-line coupled UV-liquid chromatography microdroplet mass spectrometry (UVLC-MMS)
Kuo, C.-M., Jen, H., Chen, F., Akbarian, M., Ou, T.-H., Lin, J., Lin, J.-L., & Chen, S. (2023) · Analytica Chimica Acta · doi:10.1016/j.aca.2023.341790 · Cited by 3
Thermodynamics and Kinetics of Atmospherically Relevant Acetalization Reactions
Presberg, S. S., Waters, C. M., Lyon, S. A., & Elrod, M. J. (2024) · ACS Earth and Space Chemistry · doi:10.1021/acsearthspacechem.4c00136 · Cited by 3
New horizons in nanoelectrochemistry: concluding remarks
Ewing, A. G. (2024) · Faraday Discussions · doi:10.1039/d4fd00183d · Cited by 3
A New Potential Atmospheric Accretion Mechanism: Acid-Catalyzed Hetero-Michael Addition Reactions
Fenselau, R. Z., Alotbi, A. R., Lee, C. B., Cronin, J. S., Hill, D. R., Belitsky, J. M., & Elrod, M. J. (2025) · ACS Earth and Space Chemistry · doi:10.1021/acsearthspacechem.4c00342 · Cited by 3
Interfacial electromigration for accelerated reactions
Edwards, M. E., Sengupta, A., Freitas, D. P., Hirtzel, E. A., Chen, X., Kim, J. J., & Yan, X. (2025) · Analytica Chimica Acta · doi:10.1016/j.aca.2025.343854 · Cited by 3
Self-citation
Chemically Reactive Thin Films: Dynamics and Stability
Richter, T., Malgaretti, P., Koller, T. M., & Harting, J. (2025) · Advanced Materials Interfaces · doi:10.1002/admi.202400835 · Cited by 3
Rapid and Sensitive Detection of Quinones by In-Source Microdroplet Derivatization Coupled with Mass Spectrometry
Feng, L., Tan, S., Cheng, S., Feng, H., Xie, Z., Fang, X., Gong, X., Pan, Y., & Dai, X. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c06780 · Cited by 3
Real-time probing of fast chemical reactions at the oil/water interface during microdroplet generation
Liang, X., Zhang, J., Gao, K., Wang, H., Wang, K., & Luo, G. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.137786 · Cited by 3
Isomers and band assignments in the cryogenic vibrational spectrum of the binary complex between water and protonated formic acid using two color, IR–IR photobleaching and H/D isotopic substitution
Bocanegra, E. L., Rana, A., McCoy, A. B., & Johnson, M. A. (2025) · The Journal of Chemical Physics · doi:10.1063/5.0269798 · Cited by 3
Accelerating CO2 conversion through microdroplet chemistry
Zhang, Y. (2025) · Nature Reviews Clean Technology · doi:10.1038/s44359-025-00083-9 · Cited by 3
Changes in Protonation State of Atmospherically Relevant α-Hydroxyacids at the Air–Water Interface Measured by Surface Tension and IR-RAS
Rugeley, B. E., Holt, K. R., Peterson, E. B., Moulai-Khatir, S., Koltun, C. F. N., & Rapf, R. J. (2025) · The Journal of Physical Chemistry A · doi:10.1021/acs.jpca.5c02825 · Cited by 3
Electrokinetic multiphase hydrodynamics
Huang, Y., & Wang, M. (2025) · Applied Physics Reviews · doi:10.1063/5.0271535 · Cited by 3
Multiscale analysis of heat-mass-reaction coupling in the controlled synthesis of graphene oxide via heart-shaped microchannels
Li, Y., Xiong, X., Yang, H.-A., Yu, W., & Cao, B.-Y. (2025) · International Journal of Heat and Mass Transfer · doi:10.1016/j.ijheatmasstransfer.2025.127802 · Cited by 3
Self-citation
Numerical Simulations of Synthetic Ester Hydrolysis in the Indoor Environment
Maeng, D. Y., & McNeill, V. F. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c00847 · Cited by 3
Surface Nanodroplet‐Confined Engineering of Gold (I) ‐Thiolate Nanostructures
Yu, H., Li, M., Dyett, B., Dong, D., Conn, C. E., Drummond, C. J., & Bao, L. (2024) · Advanced Materials Interfaces · doi:10.1002/admi.202300939 · Cited by 3
Accelerating protein aggregation and amyloid fibrillation for rapid inhibitor screening
Fan, J., Liang, L., Zhou, X., & Ouyang, Z. (2024) · Chemical Science · doi:10.1039/d4sc00437j · Cited by 3
Applications of stimulated Raman scattering (SRS) microscopy in materials science
Cheng, Q., Miao, Y., Zhang, R., Min, W., & Yang, Y. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85158-9.00016-6 · Cited by 3
Limitations of Atomistic Molecular Dynamics to Reveal Ejection of Proteins from Charged Nanodroplets
Kwan, V., Ballaney, P., Titiksha, & Consta, S. (2023) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.3c01313 · Cited by 3
Template-Directed Replication and Chiral Resolution during Wet–Dry Cycling in Hydrothermal Pools
Ross, D. S., & Deamer, D. W. (2023) · Life · doi:10.3390/life13081749 · Cited by 3
Real-time investigation into thermal and photo decomposition of ruthenium complexes [Ru(acac)2(tmp-mian)] and [Ru(acac)2(tmp-bian)] in acetonitrile by aerodynamic thermal breakup droplet ionization mass spectrometry
Sheven, D. G., Bakaev⧫, I. V., & Pervukhin, V. V. (2023) · Microchemical Journal · doi:10.1016/j.microc.2023.109637 · Cited by 3
Reaction acceleration in microdroplet mass spectrometry: Inlet capillary and solvent composition effects
Ju, Y., He, Y., Kan, G., Yu, K., Jiang, J., Wang, X., & Zhang, H. (2023) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.9498 · Cited by 2
Chromatin Remodelers in Neuronal Gene Transcription
Cornejo, K. G., & Saha, R. N. (2024) · Springer eBooks · doi:10.1007/978-3-031-68550-7_9 · Cited by 2
Heterogeneous Adsorption of Volatile Organic Compounds to Aerosol Particle Surfaces Probed with In Situ Surface Vibrational Sum Frequency Scattering
Brown, J. B., Qian, Y., Wang, H., Fisher, H., Huang-Fu, Z.-C., McNeill, V. F., & Rao, Y. (2025) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.5c00575 · Cited by 2
Resonance-Driven Discrete Growth and Chemical Reactivity of Optically Levitated Droplets
Zhang, K., David, G., Zhao, Y., Xiao, H., Signorell, R., & Li, C. (2025) · Research · doi:10.34133/research.0813 · Cited by 2
Accelerated Chlorination at the Air-Organic Interface Revealed by Molecular Simulations and Kinetic Modeling
Cohen, L. M., Dodin, A., Wilson, K. R., & Limmer, D. T. (2025) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.5c01169 · Cited by 2
Microdroplet Mass Spectrometry Enables Rapid and Sensitive Measurement of Glucose Homeostasis for Elucidating Mechanism of Drug Action
Yao, H., Zhou, D., VanSickle, S., Zhou, H., McLaren, D. G., Chen, H., & Previs, S. F. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c01759 · Cited by 2
Size and Shape Effects on Nanoparticle-Catalyzed Reactions Enabled by High-Throughput Variable-Temperature Desorption Electrospray Ionization Mass Spectrometry
Edwards, M. E., Kar, N., Freitas, D. P., Zhang, L., Wahab, O. J., Baker, L. A., Skrabalak, S. E., & Yan, X. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c02537 · Cited by 2
Self-citation
Electronic Properties of SO 2 in Aqueous Nanodroplets from Machine Learning Molecular Dynamics and Electron Propagator Theory
de la Puente, M., Laage, D., & Cabral, B. J. C. (2025) · The Journal of Physical Chemistry A · doi:10.1021/acs.jpca.5c07004 · Cited by 2
Using induced charge detection to quantify the net charge of microdroplets within a quadrupole electrodynamic trap
Ahmed, F., & Jacobs, M. I. (2025) · Review of Scientific Instruments · doi:10.1063/5.0294542 · Cited by 2
Photochemical Degradation of Sunscreen Chemicals in Sea Spray Aerosols
Ma, X., Li, K., Chen, X., & Du, L. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c12704 · Cited by 2
Rapid Antibody Structural Characterization and Quantification via Microdroplet Trypsin Digestion
Xiao, M., Yang, Y., Schladebeck, A., Lau, J., Knierman, M. D., Zhao, H., Qiu, X., Luo, K. Y., Gunawardena, H. P., & Chen, H. (2026) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.5c00457 · Cited by 2
Aqueous-phase organic photochemistry: Distinct modes and interfaces
Jiang, X., König, B., & Tian, Y. (2026) · Chem · doi:10.1016/j.chempr.2026.102962 · Cited by 2
Rubrene–Oxalate Electrochemiluminescence Reveals Physicochemical Properties of Triphasic Boundaries
Hill, M. L., Stockwell, M., & Dick, J. E. (2026) · Chemical & Biomedical Imaging · doi:10.1021/cbmi.5c00295 · Cited by 2
Top-down and bottom-up reconstruction of matter in charged water microdroplets
Patidar, P., Mahapatra, A., Soni, B., Chowdhury, S., Manna, S., Kini, A. R., Som, A., Sarkar, D., & Pradeep, T. (2026) · Nanoscale · doi:10.1039/d6nr00658b · Cited by 2
Aqueous Microdroplets Catalyze Groebke–Blackburn–Bienaymé Reactions
Qi, Z., Dai, C., Luo, Q., Ye, M., & Cheng, H. (2026) · Langmuir · doi:10.1021/acs.langmuir.6c00260 · Cited by 2
Stockmayer fluid with a shifted dipole. II. Interfacial behavior
Varner, S., Walker, P. J., Venkatachalam, A., Zhuang, B., & Wang, Z. (2026) · The Journal of Chemical Physics · doi:10.1063/5.0331066 · Cited by 2
Revealing oxidative chemistry at the water–air interface using a levitated water droplet
Yu, M., Xia, Y., Yu, Z., Li, J., Liang, Y., Zare, R. N., & Shi, J. (2026) · Talanta · doi:10.1016/j.talanta.2026.130014 · Cited by 2
Microdroplet-Enabled Interfacial Electron Transfer Accelerates Schiff Base Condensation for Ultrafast Covalent Organic Framework Synthesis
Luo, Z., Jin, P., Mu, J., Yu, Z. L., Meng, S., Wu, J., Chen, X., Zhou, X., & Wang, F. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c03031 · Cited by 2
Origins of Size-Dependent Kinetics in Microdroplets
Liu, P., Wu, X., Huang, Q., Zhang, Y., & Ge, M. (2026) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.6c01394 · Cited by 2
Water‐Derived Radical Species Initiate Six‐Electron Oxidation of Cyclic Ketones in Microdroplets
Ali, M. M., Jana, M., LeFever, W. A., & Cooks, R. G. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.1888676 · Cited by 2
Self-citation
Localization and Orientation of Dye Molecules at the Surface of a Levitated Microdroplet in Air Revealed by Whispering Gallery Mode Resonances
Sano, M., Kamei, K., Yatsuhashi, T., & Sakota, K. (2024) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.4c01819 · Cited by 2
Electrostatically tuning radical addition and atom abstraction reactions with distonic radical ions
Shiels, O. J., Brydon, S. C., Poad, B. L. J., Marshall, D. L., Houston, S. D., Xing, H., Bernhardt, P. V., Savage, G. P., Williams, C. M., Harman, D. G., et al. (2025) · Chemical Science · doi:10.1039/d4sc06333c · Cited by 2
Droplet Flow Assisted Electrocatalytic Oxidation of Selected Alcohols under Ambient Condition
Suliman, M. A., AlAqad, K. M., & Basheer, C. (2022) · Molecules · doi:10.3390/molecules27020382 · Cited by 2
Chemical Processes at Aqueous Interfaces
Ruiz‐López, M. F., & Martins‐Costa, M. T. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821978-2.00085-4 · Cited by 2
Quantitative Determination of Water in Organic Liquids by Ambient Mass Spectrometry
Qiu, L., Saha, M., Kraft, S., Dziekonski, E. T., Welch, C. J., Dai, Y., Kaerner, A., & Cooks, R. G. (2023) · Angewandte Chemie · doi:10.1002/ange.202310884 · Cited by 2
Self-citation
Hydrodynamics of light levitated droplet evolution
Jiang, P., Yang, Y., Chen, R., Zhu, X., Ye, D., Yang, Y., Wang, H., An, L., & Liao, Q. (2024) · Applied Physics Letters · doi:10.1063/5.0198201 · Cited by 2
A Fast and Strong Microactuator Powered by Internal Combustion of Hydrogen and Oxygen
Uvarov, I. V., Shlepakov, P. S., & Svetovoy, V. B. (2024) · Advanced Materials Technologies · doi:10.1002/admt.202400690 · Cited by 2
Droplet-Assisted Synthesis of Nanostructured Copper Microparticles with Enhanced Plasmonic Photocatalytic Performance
Sarkar, D., Jagannath, J., Alexander, R., & Yusuf, S. M. (2024) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.4c02913 · Cited by 2
Inverse Phase Transition in Droplet Clusters Levitating over the Locally Heated Water Layer
Fedorets, A. A., Dombrovsky, L. A., Bormashenko, E. Y., Frenkel, M., & Nosonovsky, M. (2024) · Langmuir · doi:10.1021/acs.langmuir.4c01419 · Cited by 2
Deformable droplet under Poiseuille flow: Role of flow direction, channel inclination and off-centre dynamics
Lanjewar, S., & Ramji, S. (2024) · European Journal of Mechanics - B/Fluids · doi:10.1016/j.euromechflu.2024.12.005 · Cited by 2
Fall and breakup of miscible magnetic fluid drops in a Hele–Shaw cell
Krakov, M. S., Chernyshov, A. V., & Zakinyan, A. R. (2025) · Physics of Fluids · doi:10.1063/5.0256956 · Cited by 2
Integrating Flow Chemistry With Electrospray Ionization Mass Spectrometry
Duez, Q. (2025) · Chemistry - Methods · doi:10.1002/cmtd.202400036 · Cited by 2
Electronic Excitation and High‐Energy Reactions Originate From Anionic Microdroplets Formed by Electrospray or Pneumatic Nebulization
Chen, C. J., Avadhani, V. S., & Williams, E. R. (2025) · Angewandte Chemie · doi:10.1002/ange.202424662 · Cited by 2
Pulsed Airflow-Assisted Parametric Fabrication of Energetic Microspheres: Gel-Mediated Interfacial Reinforcement for Precise Energy Regulation
Liu, J., Wang, M., Zhai, Z., Liu, L., Ning, J., Zhou, B., & Zhu, P. (2025) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.5c02464 · Cited by 2
Accelerated and Concerted Aza‐Michael Addition and SuFEx Reaction in Microdroplets in Unitary and High‐Throughput Formats
Ghosh, J., Mendoza, J., & Cooks, R. G. (2022) · Angewandte Chemie · doi:10.1002/ange.202214090 · Cited by 2
Self-citation
Fluorescence profiles of water droplets in stable levitating droplet clusters
Fedorets, A. A., Kolmakov, E. E., Medvedev, D. N., Nosonovsky, M., & Dombrovsky, L. A. (2023) · Physical Chemistry Chemical Physics · doi:10.1039/d3cp00542a · Cited by 2
Secondary structure in polymorphic forms of alpha-synuclein amyloids
Roterman, I., Stąpor, K., Dułak, D., & Konieczny, L. (2023) · Acta Biochimica Polonica · doi:10.18388/abp.2020_6788 · Cited by 2
Salt Enrichment and Dynamics in the Interface of Supercooled Aqueous Droplets
Kwan, V., Maiti, S., Saika‐Voivod, I., & Consta, S. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c01159 · Cited by 2
In‐Situ Analysis of Anionic Coordination Polymerizations by Electrospray‐Ionization Mass Spectrometry
Kreyenschmidt, F., Eisele, N. F., Hevelke, V. V., Rahrt, R., Kreyenschmidt, A., & Koszinowski, K. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202210211 · Cited by 2
Gas-Phase Dopant Flow to Modify nanoLC-MS and nanoESI Protein Charge
Newsome, G. A., & Cleland, T. P. (2022) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2023.117026 · Cited by 1
Observation of Protein Unfolding during pH Ramp Evoked by Lipase-Catalyzed Ester Hydrolysis
Shiu, R.-T., Prabhu, G. R. D., Elpa, D. P., & Urban, P. L. (2023) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.3c00224 · Cited by 1
Inversion of Stabilized Large Droplet Clusters
Fedorets, A. A., Kolmakov, E. E., Dombrovsky, L. A., & Nosonovsky, M. (2024) · Langmuir · doi:10.1021/acs.langmuir.4c00138 · Cited by 1
Rapid yet Controlled Synthesis of 2D Covalent Organic Framework Nanocapsules as High‐Performance Photocatalytic Carriers
Ma, Y., Yu, S., Li, W., Chen, D., Zheng, Z., Mao, L., Yang, X., Wang, W., & Liu, P. (2024) · Angewandte Chemie · doi:10.1002/ange.202416980 · Cited by 1
Relating surface charges of a single droplet to an electrical current signal output from the droplet-generating solution for non-contact droplet sensing
Han, X., Lv, D., Wang, C., Song, C., Li, D., & Song, Y. (2025) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2025.116276 · Cited by 1
Induced merger of droplets containing various solutions in a levitating microdroplet cluster
Fedorets, A. A., Dombrovsky, L. A., Скорб, Е. В., & Nosonovsky, M. (2025) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2025.127520 · Cited by 1
A Fluorogenic Reaction for Monitoring Cross-Coupling with Turn-On Ratio Greater than a Hundred Thousand
Czerwinski, R. V., Brewster, B. A., Upadhyay, S. P., Cavell, A. C., Krasecki, V. K., Smith, M. A., Bartz, J. A., & Goldsmith, R. H. (2025) · Chemical & Biomedical Imaging · doi:10.1021/cbmi.5c00103 · Cited by 1
A novel method based on cyclic voltammetry for probing the kinetics of non-redox interfacial reactions
Dehnari, E., & Taherinia, D. (2025) · Surfaces and Interfaces · doi:10.1016/j.surfin.2025.107607 · Cited by 1
Study on the thermohydraulic reaction characteristics of carbon dioxide and liquid lead-bismuth eutectic
Wang, H., Lyu, H., Xing, W., Lun, X., Liu, F., Liang, R., Guo, Z., & Niu, F. (2025) · Progress in Nuclear Energy · doi:10.1016/j.pnucene.2025.106064 · Cited by 1
Distinct Oligomerization of Lactic Acid in Aqueous Microdroplets
Roy, T. K., Yang, S., Li, M., Kumar, S., Dutcher, C. S., & Grassian, V. H. (2025) · The Journal of Physical Chemistry A · doi:10.1021/acs.jpca.5c04592 · Cited by 1
Where Water Meets Air
Phan, C. M. (2025) · CRC Press eBooks · doi:10.1201/9781003656173 · Cited by 1
Regulating CO and CC reduction by positively charged ions in water microdroplets
Hou, W., Xu, Q., Niu, Y., Liu, Y., Ju, Y., He, J., Jiang, J., Qiao, L., Xie, H., & Zhang, H. (2026) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2025.121009 · Cited by 1

Authors: Wei, Z., Li, Y., Cooks, R. G., & Yan, X.
Affiliations: Purdue University West Lafayette (US)
Texas A&M University (US)
Corresponding author: Yan, Xin
ORCID: Wei, Zhenwei
Li, Yangjie
Cooks, R. Graham
Yan, Xin
Venue: Annual Review of Physical Chemistry
Publisher: Annual Reviews
Published: 2020-04-20
Volume: 71
Issue: 1
Pages: 31-51
ISSN: 0066-426X (ISSN-L)
1545-1593
DOI: 10.1146/annurev-physchem-121319-110654
OpenAlex: W3017097444
Cited by: 631
References: 122
Citations by year: 2026: 117 · 2025: 142 · 2024: 123 · 2023: 91 · 2022: 73 · 2021: 62 · 2020: 23
FWCI: 5.21
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Physical Chemistry (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (1905087)
Defense Advanced Research Projects Agency (1905087, W911NF-16-2-0020)
Advanced Research Projects Agency
Topics: Physical Sciences › Chemical Engineering › Fluid Flow and Transfer Processes › Innovative Microfluidic and Catalytic Techniques Innovation
Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
Physical Sciences › Engineering › Computational Mechanics › Fluid Dynamics and Heat Transfer
Keywords: microdroplets, reaction kinetics, air/solution interface, levitated droplets, thin films, C–C bond formation, C–N bond formation, C–O bond formation, small-scale synthesis, reaction rate enhancement

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks