The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Neurotransmitter Corelease: Mechanism and Physiological Role
Open accessAbstract
Neurotransmitter identity is a defining feature of all neurons because it constrains the type of information they convey, but many neurons release multiple transmitters. Although the physiological role for corelease has remained poorly understood, the vesicular uptake of one transmitter can regulate filling with the other by influencing expression of the H + electrochemical driving force. In addition, the sorting of vesicular neurotransmitter transporters and other synaptic vesicle proteins into different vesicle pools suggests the potential for distinct modes of release. Corelease thus serves multiple roles in synaptic transmission.
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“Although many of these neurotransmitter co-release patterns had been documented previously55–57”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [56]
In the citing paper
“This creates a pH gradient (DpH) and a vesicular membrane potential (DJ), both of which can power the uptake of neurotransmitters by vesicular transporters (Table 1).16”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [16]
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“In multitransmitter neurons, where vesicular packaging of more than one neurotransmitter occurs, it is important to consider how vesicular transporters are differentially sensitive to intravesicular factors such as pH or membrane potential.16”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [16]
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Citations
Cites
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · cited 1×
“Conversely, they slow or pause firing in response to rewards worse than predicted (98).”
Getting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574 · cited 1×
“One possibility is that the glutamate released by dopamine terminals contributes to the prediction-error signal encoded in the firing rates of dopamine neurons (96, 97).”
Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology
Forgac, M. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2272 · Cited by 1,626 · cited 2×
“However, rather than using H + flux to produce ATP, the vacuolar H + pump uses ATP hydrolysis to drive H + transport into membranes of the secretory pathway, including endosomes, lysosomes, synaptic vesicles, and LDCVs (16). μ H+ in turn comprises both a chemical gradient (pH) and a membrane potential (ψ), and the tra…”
The Expression of Vesicular Glutamate Transporters Defines Two Classes of Excitatory Synapse
Fremeau, R. T., Troyer, M. D., Pahner, I., Nygaard, G. O., Tran, C. H., Reimer, R. J., Bellocchio, E. E., Fortin, D. L., Storm‐Mathisen, J., & Edwards, R. H. (2001) · Neuron · doi:10.1016/s0896-6273(01)00344-0 · Cited by 1,266 · cited 1×
“The distribution of VGLUT1 and -2 originally suggested a correlation of VGLUT1 with synapses having a low probability of release (such as hippocampal synapses and parallel fiber synapses in the cerebellum) and VGLUT2 with synapses having a high probability of release (114).”
Self-citationDopamine neurons report an error in the temporal prediction of reward during learning
Hollerman, J. R., & Schultz, W. (1998) · Nature Neuroscience · doi:10.1038/1124 · Cited by 1,161 · cited 1×
“One possibility is that the glutamate released by dopamine terminals contributes to the prediction-error signal encoded in the firing rates of dopamine neurons (96, 97).”
Subsecond dopamine release promotes cocaine seeking
Phillips, P. E. M., Stuber, G. D., Heien, M. L. A. V., Wightman, R. M., & Carelli, R. M. (2003) · Nature · doi:10.1038/nature01476 · Cited by 1,113 · cited 1×
“Consistent with these changes in firing, extracellular dopamine measured by fast-scan cyclic voltammetry changes as predicted in rodents performing goal-directed tasks (99).”
Rizzoli, S. O., & Betz, W. J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1583 · Cited by 975 · cited 1×
“Considerable previous work has shown that only a fraction of the synaptic vesicles in a presynaptic bouton are available for evoked release, even after prolonged stimulation (113).”
Takamori, S., Rhee, J. S., Rosenmund, C., & Jahn, R. (2000) · Nature · doi:10.1038/35025070 · Cited by 862 · cited 1×
“We do not know the stoichiometry of ionic coupling by the VGLUTs, but the sensitivity to pH (27, 43, 48) supports a H+ exchange mechanism despite the primary dependence of VGLUTs on ψ.”
Uptake of Glutamate into Synaptic Vesicles by an Inorganic Phosphate Transporter
Bellocchio, E. E., Reimer, R. J., Fremeau, R. T., & Edwards, R. H. (2000) · Science · doi:10.1126/science.289.5481.957 · Cited by 795 · cited 3×
“We do not know the stoichiometry of ionic coupling by the VGLUTs, but the sensitivity to pH (27, 43, 48) supports a H+ exchange mechanism despite the primary dependence of VGLUTs on ψ.”
Self-citationCorelease of Two Fast Neurotransmitters at a Central Synapse
Jonas, P., Bischofberger, J., & Sandkühler, J. (1998) · Science · doi:10.1126/science.281.5375.419 · Cited by 784
Research works printed but not linked: 1
- Whittaker VP, 1972, Biochem. Soc. Symp., 1972, 49
Cited by
Sorted by citations
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Yao, Z., van Velthoven, C. T. J., Kunst, M., Zhang, M., McMillen, D., Lee, C., Jung, W., Goldy, J., Abdelhak, A., Aitken, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06812-z · Cited by 1,203
Dopamine: Functions, Signaling, and Association with Neurological Diseases
Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0632-3 · Cited by 1,073
The Meningeal Lymphatic System: A New Player in Neurophysiology
Da Mesquita, S., Fu, Z., & Kipnis, J. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.022 · Cited by 479
Functional consequences of neuropeptide and small-molecule co-transmission
Nusbaum, M. P., Blitz, D. M., & Marder, E. E. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.56 · Cited by 289
Spatial and temporal scales of dopamine transmission
Liu, C., Goel, P., & Kaeser, P. S. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00455-7 · Cited by 320
Metadata
- Authors
- Hnasko, T. S., & Edwards, R. H.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2012-03-17
- Volume
- 74
- Issue
- 1
- Pages
- 225-243
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- PMC
- PMC4090038
- OpenAlex
- W2136916973
- Cited by
- 284
- References
- 117
- Citations by year
- 2026: 11 · 2025: 7 · 2024: 27 · 2023: 15 · 2022: 22 · 2021: 19 · 2020: 20 · 2019: 18 · 2018: 22 · 2017: 24 · 2016: 26 · 2015: 24 · 2014: 27 · 2013: 14 · 2012: 8
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH050712)
- National Institute on Drug Abuse (K01DA026504)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- synaptic vesicles, vesicular uptake, vesicle sorting, synaptic transmission, neurotransmitter identity
- MeSH terms
- Acetylcholine, Animals, Anions, Cations, Chlorides, gamma-Aminobutyric Acid, Humans, Hydrogen-Ion Concentration, Synaptic Transmission, Protons, Synaptic Vesicles, Biogenic Monoamines, Neurotransmitter Agents, Glutamic Acid, Vesicular Neurotransmitter Transport Proteins
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