The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Neurotransmitter Corelease: Mechanism and Physiological Role
Open accessAbstract
Neurotransmitter identity is a defining feature of all neurons because it constrains the type of information they convey, but many neurons release multiple transmitters. Although the physiological role for corelease has remained poorly understood, the vesicular uptake of one transmitter can regulate filling with the other by influencing expression of the H + electrochemical driving force. In addition, the sorting of vesicular neurotransmitter transporters and other synaptic vesicle proteins into different vesicle pools suggests the potential for distinct modes of release. Corelease thus serves multiple roles in synaptic transmission.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Although many of these neurotransmitter co-release patterns had been documented previously55–57”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [56]
In the citing paper
“This creates a pH gradient (DpH) and a vesicular membrane potential (DJ), both of which can power the uptake of neurotransmitters by vesicular transporters (Table 1).16”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [16]
In the citing paper
“In multitransmitter neurons, where vesicular packaging of more than one neurotransmitter occurs, it is important to consider how vesicular transporters are differentially sensitive to intravesicular factors such as pH or membrane potential.16”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · cited 1×
“Conversely, they slow or pause firing in response to rewards worse than predicted (98).”
Getting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574 · cited 1×
“One possibility is that the glutamate released by dopamine terminals contributes to the prediction-error signal encoded in the firing rates of dopamine neurons (96, 97).”
Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology
Forgac, M. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2272 · Cited by 1,626 · cited 2×
“However, rather than using H + flux to produce ATP, the vacuolar H + pump uses ATP hydrolysis to drive H + transport into membranes of the secretory pathway, including endosomes, lysosomes, synaptic vesicles, and LDCVs (16). μ H+ in turn comprises both a chemical gradient (pH) and a membrane potential (ψ), and the tra…”
The Expression of Vesicular Glutamate Transporters Defines Two Classes of Excitatory Synapse
Fremeau, R. T., Troyer, M. D., Pahner, I., Nygaard, G. O., Tran, C. H., Reimer, R. J., Bellocchio, E. E., Fortin, D. L., Storm‐Mathisen, J., & Edwards, R. H. (2001) · Neuron · doi:10.1016/s0896-6273(01)00344-0 · Cited by 1,266 · cited 1×
“The distribution of VGLUT1 and -2 originally suggested a correlation of VGLUT1 with synapses having a low probability of release (such as hippocampal synapses and parallel fiber synapses in the cerebellum) and VGLUT2 with synapses having a high probability of release (114).”
Self-citationDopamine neurons report an error in the temporal prediction of reward during learning
Hollerman, J. R., & Schultz, W. (1998) · Nature Neuroscience · doi:10.1038/1124 · Cited by 1,161 · cited 1×
“One possibility is that the glutamate released by dopamine terminals contributes to the prediction-error signal encoded in the firing rates of dopamine neurons (96, 97).”
Subsecond dopamine release promotes cocaine seeking
Phillips, P. E. M., Stuber, G. D., Heien, M. L. A. V., Wightman, R. M., & Carelli, R. M. (2003) · Nature · doi:10.1038/nature01476 · Cited by 1,113 · cited 1×
“Consistent with these changes in firing, extracellular dopamine measured by fast-scan cyclic voltammetry changes as predicted in rodents performing goal-directed tasks (99).”
Rizzoli, S. O., & Betz, W. J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1583 · Cited by 975 · cited 1×
“Considerable previous work has shown that only a fraction of the synaptic vesicles in a presynaptic bouton are available for evoked release, even after prolonged stimulation (113).”
Takamori, S., Rhee, J. S., Rosenmund, C., & Jahn, R. (2000) · Nature · doi:10.1038/35025070 · Cited by 862 · cited 1×
“We do not know the stoichiometry of ionic coupling by the VGLUTs, but the sensitivity to pH (27, 43, 48) supports a H+ exchange mechanism despite the primary dependence of VGLUTs on ψ.”
Uptake of Glutamate into Synaptic Vesicles by an Inorganic Phosphate Transporter
Bellocchio, E. E., Reimer, R. J., Fremeau, R. T., & Edwards, R. H. (2000) · Science · doi:10.1126/science.289.5481.957 · Cited by 795 · cited 3×
“We do not know the stoichiometry of ionic coupling by the VGLUTs, but the sensitivity to pH (27, 43, 48) supports a H+ exchange mechanism despite the primary dependence of VGLUTs on ψ.”
Self-citationCorelease of Two Fast Neurotransmitters at a Central Synapse
Jonas, P., Bischofberger, J., & Sandkühler, J. (1998) · Science · doi:10.1126/science.281.5375.419 · Cited by 784
VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate
Fremeau, R. T., Voglmaier, S., Seal, R. P., & Edwards, R. H. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2003.11.005 · Cited by 745
Self-citationIdentifying autism loci and genes by tracing recent shared ancestry
Morrow, E. M., Yoo, S.-Y., Flavell, S. W., Kim, T.-K., Lin, Y., Hill, R. S., Mukaddes, N. M., Balkhy, S., Gascon, G., Hashmi, A., et al. (2008) · Science · doi:10.1126/science.1157657 · Cited by 737 · cited 1×
“Interestingly, recent human genetic studies have implicated intracellular isoform NHE6 in Angelman syndrome (75) and NHE9 in autism (76).”
Diversity of the mammalian sodium/proton exchanger SLC9 gene family
Orlowski, J., & Grinstein, S. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1110-3 · Cited by 659 · cited 1×
“NHEs catalyze the electroneutral exchange of monovalent cation for H+, and plasma membrane isoforms have an important role in the regulation of cytosolic pH (73).”
A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons
Gras, C., Herzog, E., Bellenchi, G. C., Bernard, V., Ravassard, P., Pohl, M., Gasnier, B., Giros, B., & El Mestikawy, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05442.2002 · Cited by 639
Nair‐Roberts, R. G., Chatelain-Badie, S. D., Benson, E. M., White‐Cooper, H., Bolam, J. P., & Ungless, M. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.046 · Cited by 635 · cited 16×
“Robust glutamate-mediated AMPA receptor currents were observed in the ventral striatum but not in the dorsal striatum, even though light evoked dopamine release at both sites (94), consistent with the restricted expression of VGLUT2 by dopamine neurons in the VTA but not in the SNc (53, 54).”
InfluentialSecondary active transport mediated by a prokaryotic homologue of ClC Cl- channels
Accardi, A., & Miller, C. (2004) · Nature · doi:10.1038/nature02314 · Cited by 612
Fremeau, R. T., Burman, J. L., Qureshi, T., Tran, C. H., Proctor, J. M., Johnson, J., Zhang, H., Sulzer, D. L., Copenhagen, D. R., Storm‐Mathisen, J., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222546799 · Cited by 568
Self-citationDopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate
Stuber, G. D., Hnasko, T. S., Britt, J. P., Edwards, R. H., & Bonci, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1754-10.2010 · Cited by 529 · cited 3×
“Furthermore, the cKO of VGLUT2 in dopamine neurons completely abolished these responses (94).”
Self-citationWojcik, S. M., Rhee, J. S., Herzog, É., Sigler, A., Jahn, R., Takamori, S., Brose, N., & Rosenmund, C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401764101 · Cited by 510
Stobrawa, S. M., Breiderhoff, T., Takamori, S., Engel, D., Schweizer, M., Zdebik, A. A., Bösl, M. R., Rüether, K., Jahn, H., Draguhn, A., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00189-1 · Cited by 508 · cited 2×
“Intracellular members of the ClC Cl− channel family are considered to mediate the Cl− permeability of acidic vesicles, with ClC-3 the predominant but probably not the only isoform on synaptic vesicles (30).”
Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins
Scheel, O., Zdebik, A., Lourdel, S., & Jentsch, T. (2005) · Nature · doi:10.1038/nature03860 · Cited by 483
Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5
Picollo, A., & Pusch, M. (2005) · Nature · doi:10.1038/nature03720 · Cited by 454
Distinct Endocytic Pathways Control the Rate and Extent of Synaptic Vesicle Protein Recycling
Voglmaier, S. M., Kam, K., Yang, H., Fortin, D. L., Hua, Z., Nicoll, R. A., & Edwards, R. H. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.027 · Cited by 425 · cited 1×
“Although it has been difficult to understand how the transporter might control fusion, recent work has indeed suggested that the known interaction of VGLUT1 with the endocytic protein endophilin (115) may also influence exocytosis (116).”
Self-citationIdentification of a vesicular nucleotide transporter
Sawada, K., Echigo, N., Juge, N., Miyaji, T., Otsuka, M., Omote, H., Yamamoto, A., & Moriyama, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800141105 · Cited by 418 · cited 1×
“Manipulation of the recently described vesicular nucleotide transporter VNUT (47) will therefore be required to assess the physiological role of ATP.”
Schäfer, M. K.-H., Varoqui, H., Defamie, N., Weihe, E., & Erickson, J. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206738200 · Cited by 410
Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo
Hnasko, T. S., Chuhma, N., Zhang, H., Goh, G. Y., Sulzer, D., Palmiter, R. D., Rayport, S., & Edwards, R. H. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.012 · Cited by 405
Self-citationMetabolic Control of Vesicular Glutamate Transport and Release
Juge, N., Gray, J. A., Omote, H., Miyaji, T., Inoue, T., Hara, C., Uneyama, H., Edwards, R. H., Nicoll, R. A., & Moriyama, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.002 · Cited by 401
Self-citationThe Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes
Graves, A. R., Curran, P. K., Smith, C. L., & Mindell, J. A. (2008) · Nature · doi:10.1038/nature06907 · Cited by 399
From glutamate co-release to vesicular synergy: vesicular glutamate transporters
El Mestikawy, S., Wallén-Mackenzie, Å., Fortin, G. M., Descarries, L., & Trudeau, L.-E. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2969 · Cited by 385
The Neurotransmitter Cycle and Quantal Size
Edwards, R. H. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.001 · Cited by 378
Self-citationA shared vesicular carrier allows synaptic corelease of GABA and glycine
Wojcik, S. M., Katsurabayashi, S., Guillemin, I., Friauf, E., Rosenmund, C., Brose, N., & Rhee, J.-S. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.016 · Cited by 374
Glutamatergic neurons are present in the rat ventral tegmental area
Yamaguchi, T., Sheen, W., & Morales, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05263.x · Cited by 367 · cited 17×
“Robust glutamate-mediated AMPA receptor currents were observed in the ventral striatum but not in the dorsal striatum, even though light evoked dopamine release at both sites (94), consistent with the restricted expression of VGLUT2 by dopamine neurons in the VTA but not in the SNc (53, 54).”
InfluentialMaycox, P. R., Deckwerth, T. L., Hell, J. W., & Jahn, R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37605-7 · Cited by 361 · cited 4×
“Despite the primary reliance on ψ, VGLUT activity retains some dependence on pH even after dissipation of ψ (26, 27), suggesting that the mechanism involves H+ exchange.”
InfluentialNakamura, N., Tanaka, S., Teko, Y., Mitsui, K., & Kanazawa, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410041200 · Cited by 353 · cited 1×
“Intracellular isoforms recognize K+ as well as Na+, and several isoforms localize to endosomes (74), where they should dissipate pH and thus enable the H+ pump to increase ψ.”
Morphine reward in dopamine-deficient mice
Hnasko, T. S., Sotak, B. N., & Palmiter, R. D. (2005) · Nature · doi:10.1038/nature04172 · Cited by 338 · cited 1×
“However, mice can also learn CPP in the absence of dopamine (102, 103), and the cue-reward pairing involved in CPP occurs continuously over the course of 20 min and may therefore not depend on transient subsecond bursts in dopamine neuron firing.”
Self-citationPresynaptic Regulation of Quantal Size by the Vesicular Glutamate Transporter VGLUT1
Wilson, N. R., Kang, J., Hueske, E. V., Leung, T., Varoqui, H., Murnick, J. G., Erickson, J. D., & Liu, G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3003-04.2005 · Cited by 335
Silinsky, E. M. (1975) · The Journal of Physiology · doi:10.1113/jphysiol.1975.sp010925 · Cited by 334
Mesocorticolimbic Glutamatergic Pathway
Yamaguchi, T., Wang, H.-L., Li, X., Ng, T. H., & Morales, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1598-11.2011 · Cited by 332 · cited 5×
“Robust glutamate-mediated AMPA receptor currents were observed in the ventral striatum but not in the dorsal striatum, even though light evoked dopamine release at both sites (94), consistent with the restricted expression of VGLUT2 by dopamine neurons in the VTA but not in the SNc (53, 54).”
InfluentialTransient Uptake and Storage of Serotonin in Developing Thalamic Neurons
Lebrand, C., Cases, O., Adelbrecht, C., Doye, A., Alvarez, C., Mestikawy, S. E., Seif, I., & Gaspar, P. (1996) · Neuron · doi:10.1016/s0896-6273(00)80215-9 · Cited by 327 · cited 1×
“In addition, glutamate-releasing thalamocortical neurons (as well as some retinal ganglion cells) express SERT and VMAT2 transiently during development, conferring the ability to take up and release serotonin during the critical period for maturation of this projection (11).”
Dopamine neurons make glutamatergic synapses in vitro
Sulzer, D. L., Joyce, M. P., Lin, L., Geldwert, D., Haber, S. N., Hattori, T., & Rayport, S. (1998) · PubMed Central · doi:10.7916/d8-snm4-r132 · Cited by 316
Ren, J., Qin, C., Hu, F., Tan, J., Qiu, L., Zhao, S., Feng, G., & Luo, M. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.038 · Cited by 315
Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens
Tecuapetla, F., Patel, J. C., Xenias, H., English, D., Tadros, I., Shah, F., Berlin, J., Deisseroth, K., Rice, M. E., Tepper, J. M., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0265-10.2010 · Cited by 310
Dopamine Neurons Make Glutamatergic SynapsesIn Vitro
Sulzer, D. L., Joyce, M. P., Lin, L., Geldwert, D., Haber, S. N., Hattori, T., & Rayport, S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04588.1998 · Cited by 304 · cited 3×
“Stimulation of both serotonin (12) and dopamine (13) neurons produced fast excitatory currents blocked by glutamate receptor antagonists, indicating the potential for glutamate corelease to activate postsynaptic receptors.”
A cation counterflux supports lysosomal acidification
Steinberg, B. E., Huynh, K. K., Brodovitch, A., Jabs, S., Stauber, T., Jentsch, T. J., & Grinstein, S. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200911083 · Cited by 288 · cited 1×
“Although the dissipation of ψ required for vesicle acidification has generally been attributed to anion entry, recent observations from non-neural cells suggest a role for cation efflux in lysosome pH (69).”
VGLUTs: ‘Exciting’ times for glutamatergic research?
Takamori, S. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.04.016 · Cited by 249
Fast synaptic subcortical control of hippocampal circuits
Varga, V., Losonczy, A., Zemelman, B. V., Borhegyi, Z., Nyiri, G., Domonkos, A., Hangya, B., Holderith, N., Magee, J. C., & Freund, T. F. (2009) · Science · doi:10.1126/science.1178307 · Cited by 248
Lysosomal Pathology and Osteopetrosis upon Loss of H + -Driven Lysosomal Cl – Accumulation
Weinert, S., Jabs, S., Supanchart, C., Schweizer, M., Gimber, N., Richter, M., Rademann, J., Stauber, T., Kornak, U., & Jentsch, T. J. (2010) · Science · doi:10.1126/science.1188072 · Cited by 242 · cited 2×
“KO: knockout Conversion of two ClCs into Cl− channels in knockin mice indeed impaired the function of the endocytic pathway (36, 37).”
Role of ACh-GABA cotransmission in detecting image motion and motion direction
Lee, S., Kim, K., & Zhou, Z. J. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.031 · Cited by 241
The Recurrent Mossy Fiber Pathway of the Epileptic Brain
Nadler, J. V. (2003) · Neurochemical Research · doi:10.1023/a:1026004904199 · Cited by 241
Mammalian motor neurons corelease glutamate and acetylcholine at central synapses
Nishimaru, H., Restrepo, C. E., Ryge, J., Yanagawa, Y., & Kiehn, O. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501331102 · Cited by 235 · cited 1×
“Even motor neurons thought to release only ACh may corelease glutamate from collateral synapses within the spinal cord (15).”
Mesocortical Dopamine Neurons Operate in Distinct Temporal Domains Using Multimodal Signaling
Lavin, A., Nogueira, L., Lapish, C. C., Wightman, R. M., Phillips, P. E. M., & Seamans, J. K. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0557-05.2005 · Cited by 233 · cited 1×
“The next year, the Seamans laboratory (92) showed that VTA stimulation in vivo rapidly leads to glutamate release in the prefrontal cortex (PFC).”
Gilfillan, G. D., Selmer, K. K., Roxrud, I., Smith, R., Kyllerman, M., Eiklid, K., Kroken, M., Mattingsdal, M., Egeland, T., Stenmark, H., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.013 · Cited by 232 · cited 1×
“Interestingly, recent human genetic studies have implicated intracellular isoform NHE6 in Angelman syndrome (75) and NHE9 in autism (76).”
Kawano, M., Kawasaki, A., Sakata‐Haga, H., Fukui, Y., Kawano, H., Nogami, H., & Hisano, S. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21054 · Cited by 230 · cited 17×
“Robust glutamate-mediated AMPA receptor currents were observed in the ventral striatum but not in the dorsal striatum, even though light evoked dopamine release at both sites (94), consistent with the restricted expression of VGLUT2 by dopamine neurons in the VTA but not in the SNc (53, 54).”
InfluentialDevelopmental switch from GABA to glycine release in single central synaptic terminals
Nabekura, J., Katsurabayashi, S., Kakazu, Y., Shibata, S., Matsubara, A., Jinno, S., Mizoguchi, Y., Sasaki, A., & Ishibashi, H. (2004) · Nature Neuroscience · doi:10.1038/nn1170 · Cited by 228
Dopamine Neurons Mediate a Fast Excitatory Signal via Their Glutamatergic Synapses
Chuhma, N., Zhang, H., Masson, J., Zhuang, X., Sulzer, D. L., Hen, R., & Rayport, S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4317-03.2004 · Cited by 228 · cited 1×
“In 2004, the Rayport laboratory (91) published a landmark study that used an acute, horizontal slice preparation to demonstrate the presence of a monosynaptic glutamatergic projection from VTA to nucleus accumbens at both P10 and P21.”
Hioki, H., Nakamura, H., Ma, Y., Konno, M., Hayakawa, T., Nakamura, K., Fujiyama, F., & Kaneko, T. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22237 · Cited by 225
Inhibitory synapses in the developing auditory system are glutamatergic
Gillespie, D. C., Kim, G., & Kandler, K. (2005) · Nature Neuroscience · doi:10.1038/nn1397 · Cited by 222 · cited 3×
“In VGLUT3 KO mice, MNTB cells still form synapses onto LSO neurons that are indistinguishable from those in control animals at P1–2; however, the strengthening of these inhibitory synapses that normally occurs by P10–12 fails to occur in VGLUT3-null mice (82).”
Burnstock, G. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.08.001 · Cited by 216
The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone
Gras, C., Amilhon, B., Lepicard, È. M., Poirel, O., Vinatier, J., Herbin, M., Dumas, S., Tzavara, E. T., Wade, M. R., Nomikos, G. G., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2052 · Cited by 211
The TRPM7 Ion Channel Functions in Cholinergic Synaptic Vesicles and Affects Transmitter Release
Krapivinsky, G. B., Mochida, S., Krapivinsky, L., Cibulsky, S. M., & Clapham, D. E. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.033 · Cited by 209 · cited 1×
“Interestingly, the TRPM7 (transient receptor potential cation channel, subfamily M, member 7) channel localizes to synaptic vesicles and influences quantal size, although it also interacts with proteins involved in fusion and affects the frequency of release (77, 78).”
Protonmotive force and catecholamine transport in isolated chromaffin granules.
Johnson, R. G., & Scarpa, A. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50650-5 · Cited by 193 · cited 1×
“, pH ∼ 3 pH units, ψ ∼180 mV, or a combination of both) (38, 39), 3 = log10([H]i/[H]o ) + ψ/(2.”
Endosomal Chloride-Proton Exchange Rather Than Chloride Conductance Is Crucial for Renal Endocytosis
Novarino, G., Weinert, S., Rickheit, G., & Jentsch, T. J. (2010) · Science · doi:10.1126/science.1188070 · Cited by 192 · cited 2×
“KO: knockout Conversion of two ClCs into Cl− channels in knockin mice indeed impaired the function of the endocytic pathway (36, 37).”
Grønborg, M., Pavlos, N. J., Brunk, I., Chua, J. J. E., Münster‐Wandowski, A., Riedel, D., Ahnert‐Hilger, G., Urlaub, H., & Jahn, R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4074-09.2010 · Cited by 192
Amilhon, B., Lepicard, È., Renoir, T., Mongeau, R., Popa, D., Poirel, O., Miot, S., Gras, C., Gardier, A. M., Gallego, J., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5196-09.2010 · Cited by 186 · cited 2×
“Although Cl− suffices to promote pH and to stimulate the pH-dependent storage of cationic transmitters (29, 49), we and others found that glutamate can also increase the packaging of monoamines (29, 50, 51) and ACh (52) into isolated synaptic vesicles.”
Corelease of Dopamine and Serotonin from Striatal Dopamine Terminals
Zhou, F.-M., Liang, Y., Salas, R., Zhang, L., Biasi, M. D., & Dani, J. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.010 · Cited by 186 · cited 1×
“For example, the antidepressant drug fluoxetine, which selectively inhibits the plasma membrane serotonin transporter (SERT), redistributes serotonin from serotonergic to dopaminergic terminals, where serotonin also undergoes release, and this redistribution may contribute to the antidepressant action of fluoxetine (1…”
Walker, M. C., Ruiz, A. J., & Kullmann, D. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00245-8 · Cited by 185
Tabb, J. S., Kish, P. E., Van Dyke, R., & Ueda, T. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49549-5 · Cited by 182 · cited 5×
“Glutamate Independently of the Cl− flux that may be mediated by VGLUTs, vesicular glutamate transport itself has profound effects on pH (26, 27).”
InfluentialGlutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map
Noh, J., Seal, R. P., Garver, J. A., Edwards, R. H., & Kandler, K. (2010) · Nature Neuroscience · doi:10.1038/nn.2478 · Cited by 175
Self-citationCholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum
Higley, M. J., Gittis, A. H., Oldenburg, I. A., Balthasar, N., Seal, R. P., Edwards, R. H., Lowell, B. B., Kreitzer, A. C., & Sabatini, B. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019155 · Cited by 175 · cited 1×
“Consistent with VGLUT3 expression by these cells, the response was abolished in VGLUT3 KO mice (110).”
Cellular Mechanisms for Direction Selectivity in the Retina
Demb, J. B. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.001 · Cited by 159 · cited 2×
“Indeed, GABA release, presumably from SACs, appears to be essential for direction selectivity (79).”
Bo, G. D., St-Gelais, F., Danik, M., Williams, S., Cotton, M., & Trudeau, L. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02277.x · Cited by 159 · cited 1×
“However, the postnatal decline in VGLUT2 expression by midbrain dopamine neurons (60, 63) raised the possibility that VGLUT2 expression in vitro (67) might simply reflect dedifferentiation.”
A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles
Schenck, S., Wojcik, S. M., Brose, N., & Takamori, S. (2009) · Nature Neuroscience · doi:10.1038/nn.2248 · Cited by 158
Synaptic and Vesicular Coexistence of VGLUT and VGAT in Selected Excitatory and Inhibitory Synapses
Zander, J.-F., Münster‐Wandowski, A., Brunk, I., Pahner, I., Gómez‐Lira, G., Heinemann, U., Gutiérrez, R., Laube, G., & Ahnert‐Hilger, G. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0141-10.2010 · Cited by 154 · cited 1×
“Although Cl− suffices to promote pH and to stimulate the pH-dependent storage of cationic transmitters (29, 49), we and others found that glutamate can also increase the packaging of monoamines (29, 50, 51) and ACh (52) into isolated synaptic vesicles.”
The ability of the mesocortical dopamine system to operate in distinct temporal modes
Lapish, C. C., Kroener, S., Durstewitz, D., Lavı́n, A., & Seamans, J. K. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0527-8 · Cited by 153
Busch, A. E., Schuster, A., Waldegger, S., Wagner, C. A., Zempel, G., Bröer, S., Biber, J., Murer, H., & Lang, F. J. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5347 · Cited by 142 · cited 2×
“Taken together, however, the data suggest that synaptic vesicles storing glutamate, which are the most abundant in brain, express more VGLUT than ClC; Cl− entry would indeed dissipate the ψ required for vesicular glutamate transport, and previous work has suggested that substrates can inhibit the Cl− conductance assoc…”
Staggered development of GABAergic and glycinergic transmission in the MNTB
Awatramani, G. B., Turecek, R., & Trussell, L. O. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00798.2004 · Cited by 138
Synaptic glutamate release by postnatal rat serotonergic neurons in microculture
Johnson, M. D. (1994) · Neuron · doi:10.1016/0896-6273(94)90283-6 · Cited by 137 · cited 2×
“Stimulation of both serotonin (12) and dopamine (13) neurons produced fast excitatory currents blocked by glutamate receptor antagonists, indicating the potential for glutamate corelease to activate postsynaptic receptors.”
Regulation of Glutamate Transport into Synaptic Vesicles by Chloride and Proton Gradient
Wolosker, H., Souza, D. O., & MEIS, L. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.20.11726 · Cited by 137 · cited 1×
“In addition, the Cl− dependence of glutamate transport may reflect allosteric activation rather than effects on the driving force (44).”
Weston, M. C., Nehring, R. B., Wojcik, S. M., & Rosenmund, C. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.002 · Cited by 134
Glutamate in dopamine neurons: Synaptic versus diffuse transmission
Descarries, L., Bérubé‐Carrière, N., Riad, M., Bo, G. D., Méndez, J. A. T., & Trudeau, L. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.10.005 · Cited by 128
Plasticity of the GABAergic Phenotype of the “Glutamatergic” Granule Cells of the Rat Dentate Gyrus
Gutiérrez, R., Parra, H. R., Maqueda, J., Vivar, C., Ramı́rez, M., Morales, M. A., & Lamas, M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05594.2003 · Cited by 124
Hell, J. W., Maycox, P. R., & Jahn, R. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39947-8 · Cited by 120 · cited 1×
“GABA and glycine exchange for an unknown number of H+, and as zwitterions, their uptake depends equally on pH and on ψ (20, 21).”
VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation
Birgner, C., Nordenankar, K., Lundblad, M., Méndez, J. A. T., Smith, C., Grevès, M. L., Galter, D., Olson, L., Fredriksson, A., Trudeau, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910986107 · Cited by 119 · cited 2×
“However, mature conditional knockout (cKO) mice lacking VGLUT2 selectively in dopamine neurons clearly show a reduction in both dopamine storage and evoked dopamine release (29) that presumably accounts for their reduced response to psychostimulants (29, 64).”
Active transport of gamma-aminobutyric acid and glycine into synaptic vesicles
Kish, P. E., Fischer-Bovenkerk, C., & Ueda, T. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3877 · Cited by 119 · cited 1×
“GABA and glycine exchange for an unknown number of H+, and as zwitterions, their uptake depends equally on pH and on ψ (20, 21).”
A Leucine-based Motif Mediates the Endocytosis of Vesicular Monoamine and Acetylcholine Transporters
Tan, P. K., Waites, C. L., Liu, Y., Krantz, D. E., & Edwards, R. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17351 · Cited by 116 · cited 1×
“Indeed, all known transporters contain signals that target them to endocytic vesicles, even in non-neural cells (28), and the expression of μH+ by endosomes should in principle drive their activity.”
Self-citationMéndez, J. A. T., Bourque, M.-J., Bo, G. D., Bourdeau, M. L., Danik, M., Williams, S., Lacaille, J., & Trudeau, L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1331-08.2008 · Cited by 108 · cited 1×
“However, the postnatal decline in VGLUT2 expression by midbrain dopamine neurons (60, 63) raised the possibility that VGLUT2 expression in vitro (67) might simply reflect dedifferentiation.”
Gutiérrez, R. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.6.3088 · Cited by 103
Neagoe, I., Stauber, T., Fidzinski, P., Bergsdorf, E.-Y., & Jentsch, T. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.125971 · Cited by 101
Co-Transmission of Dopamine and GABA in Periglomerular Cells
Maher, B. J., & Westbrook, G. L. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00636.2007 · Cited by 100 · cited 1×
“Conversely, many monoamine neurons corelease glutamate when grown in culture (12, 13), and dopaminergic periglomerular cells in the olfactory bulb also corelease GABA (14).”
Cocaine-Conditioned Place Preference by Dopamine-Deficient Mice Is Mediated by Serotonin
Hnasko, T. S., Sotak, B. N., & Palmiter, R. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3133-07.2007 · Cited by 99 · cited 1×
“However, mice can also learn CPP in the absence of dopamine (102, 103), and the cue-reward pairing involved in CPP occurs continuously over the course of 20 min and may therefore not depend on transient subsecond bursts in dopamine neuron firing.”
Self-citationThe dual dopamine‐glutamate phenotype of growing mesencephalic neurons regresses in mature rat brain
Bérubé‐Carrière, N., Riad, M., Bo, G. D., Lévesque, D., Trudeau, L., & Descarries, L. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22194 · Cited by 98 · cited 2×
“The segregation of monoamine and glutamate markers to different release sites may indeed contribute to the failure to detect VGLUT expression in tyrosine hydroxylase–positive striatal projections by immunoelectron microscopy (60, 68).”
Gorelova, N., Mulholland, P. J., Chandler, L. J., & Seamans, J. K. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr107 · Cited by 98 · cited 2×
“The next year, the Seamans laboratory (92) showed that VTA stimulation in vivo rapidly leads to glutamate release in the prefrontal cortex (PFC).”
Proton: substrate stoichiometries during active transport of biogenic amines in chromaffin ghosts
Johnson, R. G., Carty, S. E., & Scarpa, A. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69274-4 · Cited by 96
TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane
Brauchi, S., Krapivinsky, G. B., Krapivinsky, L., & Clapham, D. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800881105 · Cited by 94 · cited 1×
“Interestingly, the TRPM7 (transient receptor potential cation channel, subfamily M, member 7) channel localizes to synaptic vesicles and influences quantal size, although it also interacts with proteins involved in fusion and affects the frequency of release (77, 78).”
Bo, G. D., Bérubé‐Carrière, N., Méndez, J. A. T., Leo, D., Riad, M., Descarries, L., Lévesque, D., & Trudeau, L. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.032 · Cited by 86
Hattori, T., Takada, M., Moriizumi, T., & van der Kooy, D. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903090308 · Cited by 85 · cited 2×
“In midbrain dopamine neurons, heterologous expression of differentially tagged vesicular glutamate and monoamine transporters shows colocalization at most boutons, but a significant fraction express only one or the other (112), consistent with the original suggestion that catecholamine and glutamate markers may segreg…”
Stoichiometry of hydrogen ion-linked dopamine transport in chromaffin granule ghosts
KNOTH, J., Zallakian, M., & Njus, D. (1981) · Biochemistry · doi:10.1021/bi00526a016 · Cited by 85
Characterization of ATP Transport into Chromaffin Granule Ghosts
Bankston, L. A., & Guidotti, G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.29.17132 · Cited by 83 · cited 1×
“Previous work has also demonstrated the synergistic effect of ATP (also an anion) on serotonin uptake by chromaffin granules (46).”
Hioki, H. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh088 · Cited by 83
Glutamate‐Dopamine Cotransmission and Reward Processing in Addiction
Lapish, C. C., Seamans, J. K., & Chandler, L. J. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00176.x · Cited by 82
Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampus
Riazanski, V., Deriy, L. V., Shevchenko, P., Le, B. N., Gomez, E. A., & Nelson, D. J. (2011) · Nature Neuroscience · doi:10.1038/nn.2775 · Cited by 68 · cited 2×
“Indeed, recent work using ClC-3 KO mice has shown major defects in GABA release, apparently due to the impaired acidification of GABAergic synaptic vesicles (40).”
Nguyen, M. L., Cox, G. D., & Parsons, S. M. (1998) · Biochemistry · doi:10.1021/bi9802263 · Cited by 66
Vesicular Monoamine and Glutamate Transporters Select Distinct Synaptic Vesicle Recycling Pathways
Onoa, B., Li, H., Gagnon-Bartsch, J. A., Elias, L., & Edwards, R. H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5298-09.2010 · Cited by 66
Self-citationJackson, J., Bland, B. H., & Antle, M. C. (2008) · Synapse · doi:10.1002/syn.20581 · Cited by 66
Gois, S. D., Jeanclos, E. M., Morris, M. E. K., Grewal, S., Varoqui, H., & Erickson, J. D. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9054-8 · Cited by 63
Lehmann, H., Ebert, U., & Löscher, W. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12777-4 · Cited by 63
Vesicular Inhibitory Amino Acid Transporter Is a Cl−/γ-Aminobutyrate Co-transporter
Juge, N., Muroyama, A., Hiasa, M., Omote, H., & Moriyama, Y. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.062414 · Cited by 58 · cited 2×
“Previous work had not identified a requirement for Cl−, but the apparent affinity of VGAT for Cl− appears high, suggesting that only low concentrations may be required (22).”
Whittaker, V. P., Dowdall, M. J., & Boyne, A. F. (1972) · PubMed · Cited by 55
Shutoh, F., Ina, A., Yoshida, S., Konno, J., & Hisano, S. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2007.12.050 · Cited by 47
On Cotransmission & Neurotransmitter Phenotype Plasticity
Trudeau, L., & Gutiérrez, R. (2007) · Molecular Interventions · doi:10.1124/mi.7.3.5 · Cited by 46
Parra, H. R., Vivar, C., Maqueda, J., Morales, M. A., & Gutiérrez, R. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00985.2002 · Cited by 45
Erickson, J. D., Masserano, J. M., Barnes, E. M., Ruth, J. A., & Weiner, N. (1990) · Brain Research · doi:10.1016/0006-8993(90)90912-u · Cited by 35 · cited 1×
“Although Cl− suffices to promote pH and to stimulate the pH-dependent storage of cationic transmitters (29, 49), we and others found that glutamate can also increase the packaging of monoamines (29, 50, 51) and ACh (52) into isolated synaptic vesicles.”
Maqueda, J., Ramı́rez, M., Lamas, M., & Gutiérrez, R. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.08.077 · Cited by 31
Moss, J., Ungless, M. A., & Bolam, J. P. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07594.x · Cited by 31 · cited 1×
“The segregation of monoamine and glutamate markers to different release sites may indeed contribute to the failure to detect VGLUT expression in tyrosine hydroxylase–positive striatal projections by immunoelectron microscopy (60, 68).”
Mintz, E. M., & Scott, T. J. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.033 · Cited by 27
Coupling of H+ Gradients to Catecholamine Transport in Chromaffin Granulesa
Johnson, R. G., Carty, S. E., & Scarpa, A. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb14874.x · Cited by 18 · cited 1×
“, pH ∼ 3 pH units, ψ ∼180 mV, or a combination of both) (38, 39), 3 = log10([H]i/[H]o ) + ψ/(2.”
Meredith, G. E., & Wouterlood, F. G. (1993) · Microscopy Research and Technique · doi:10.1002/jemt.1070240105 · Cited by 10 · cited 1×
“These data are also consistent with the presence of TH+ asymmetric (presumably excitatory) synapses in the ventral but not the dorsal striatum (65, 66).”
Research works printed but not linked: 1
- Whittaker VP, 1972, Biochem. Soc. Symp., 1972, 49
Cited by
Sorted by citations
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Yao, Z., van Velthoven, C. T. J., Kunst, M., Zhang, M., McMillen, D., Lee, C., Jung, W., Goldy, J., Abdelhak, A., Aitken, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06812-z · Cited by 1,203
Dopamine: Functions, Signaling, and Association with Neurological Diseases
Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0632-3 · Cited by 1,073
The Meningeal Lymphatic System: A New Player in Neurophysiology
Da Mesquita, S., Fu, Z., & Kipnis, J. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.022 · Cited by 479
Functional consequences of neuropeptide and small-molecule co-transmission
Nusbaum, M. P., Blitz, D. M., & Marder, E. E. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.56 · Cited by 289
Spatial and temporal scales of dopamine transmission
Liu, C., Goel, P., & Kaeser, P. S. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00455-7 · Cited by 320
Metadata
- Authors
- Hnasko, T. S., & Edwards, R. H.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2012-03-17
- Volume
- 74
- Issue
- 1
- Pages
- 225-243
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- PMC
- PMC4090038
- OpenAlex
- W2136916973
- Cited by
- 284
- References
- 117
- Citations by year
- 2026: 11 · 2025: 7 · 2024: 27 · 2023: 15 · 2022: 22 · 2021: 19 · 2020: 20 · 2019: 18 · 2018: 22 · 2017: 24 · 2016: 26 · 2015: 24 · 2014: 27 · 2013: 14 · 2012: 8
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH050712)
- National Institute on Drug Abuse (K01DA026504)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- synaptic vesicles, vesicular uptake, vesicle sorting, synaptic transmission, neurotransmitter identity
- MeSH terms
- Acetylcholine, Animals, Anions, Cations, Chlorides, gamma-Aminobutyric Acid, Humans, Hydrogen-Ion Concentration, Synaptic Transmission, Protons, Synaptic Vesicles, Biogenic Monoamines, Neurotransmitter Agents, Glutamic Acid, Vesicular Neurotransmitter Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
