The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Physiology and Pharmacology of the Enteroendocrine Hormone Glucagon-Like Peptide-2
Open accessAbstract
Glucagon-like peptide-2 (GLP-2) is a 33-amino-acid proglucagon-derived peptide secreted from enteroendocrine L cells. GLP-2 circulates at low basal levels in the fasting period, and plasma levels rise rapidly after food ingestion. Renal clearance and enzymatic inactivation control the elimination of bioactive GLP-2. GLP-2 increases mesenteric blood flow and activates proabsorptive pathways in the gut, facilitating nutrient absorption. GLP-2 also enhances gut barrier function and induces proliferative and cytoprotective pathways in the small bowel. The actions of GLP-2 are transduced via a single G protein–coupled receptor (GLP-2R), expressed predominantly within the gastrointestinal tract. Disruption of GLP-2R signaling increases susceptibility to gut injury and impairs the adaptive mucosal response to refeeding. Sustained augmentation of GLP-2R signaling reduces the requirement for parenteral nutrition in human subjects with short-bowel syndrome. Hence GLP-2 integrates nutrient-derived signals to optimize mucosal integrity and energy absorption.
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Induction of intestinal epithelial proliferation by glucagon-like peptide 2.
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International Union of Pharmacology. XXXV. The Glucagon Receptor Family
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Self-citationJeppesen, P. B., Pertkiewicz, M., Messing, B., Iyer, K., Seidner, D. L., O'keefe, S. J. D., Forbes, A., Heinze, H., & Joelsson, B. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.09.007 · Cited by 505
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Self-citationEnteroendocrine localization of GLP-2 receptor expression in humans and rodents
Yusta, B., Huang, L., Munroe, D., Wolff, G., Fantaske, R., Sharma, S., Demchyshyn, L., Asa, S. L., & Drucker, D. J. (2000) · Gastroenterology · doi:10.1053/gast.2000.16489 · Cited by 339
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Cited by
Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1
Drucker, D. J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.001 · Cited by 2,170
Self-citationMicrobial Regulation of Host Physiology by Short-chain Fatty Acids
van der Hee, B., & Wells, J. M. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.02.001 · Cited by 980
Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium
Gribble, F. M., & Reimann, F. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105439 · Cited by 683
Function and mechanisms of enteroendocrine cells and gut hormones in metabolism
Gribble, F. M., & Reimann, F. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0168-8 · Cited by 670
Discovery, characterization, and clinical development of the glucagon-like peptides
Drucker, D. J., Habener, J. F., & Holst, J. J. (2017) · Journal of Clinical Investigation · doi:10.1172/jci97233 · Cited by 418
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Metadata
- Authors
- Drucker, D. J., & Yusta, B.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2014-02-10
- Volume
- 76
- Issue
- 1
- Pages
- 561-583
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2159620113
- Cited by
- 342
- References
- 105
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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