The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Mechanisms of Organ Injury and Repair by Macrophages
Open accessAbstract
Macrophages regulate tissue regeneration following injury. They can worsen tissue injury by producing reactive oxygen species and other toxic mediators that disrupt cell metabolism, induce apoptosis, and exacerbate ischemic injury. However, they also produce a variety of growth factors, such as IGF-1, VEGF-α, TGF-β, and Wnt proteins that regulate epithelial and endothelial cell proliferation, myofibroblast activation, stem and tissue progenitor cell differentiation, and angiogenesis. Proresolving macrophages in turn restore tissue homeostasis by functioning as anti-inflammatory cells, and macrophage-derived matrix metalloproteinases regulate fibrin and collagen turnover. However, dysregulated macrophage function impairs wound healing and contributes to the development of fibrosis. Consequently, the mechanisms that regulate these different macrophage activation states have become active areas of research. In this review, we discuss the common and unique mechanisms by which macrophages instruct tissue repair in the liver, nervous system, heart, lung, skeletal muscle, and intestine and illustrate how macrophages might be exploited therapeutically.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“The relative quantification of CD68 and CD163 proteins roughly distinguishes the activation of M1 and M2 macrophages (Vannella and Wynn, 2017;Huang et al., 2018;Kim et al., 2019).”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as Vannella and Wynn, 2017
Experimental — accuracy not yet measuredIn the citing paper
“pro-fibrotic macrophages commonly coordinate scar formation via a range of interactions with fibroblasts, the major cellular source of pathological extracellular matrix deposition during fibrosis18,27,74–78.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [77]
In the citing paper
“Previous work has shown that proximity is crucial to allow crosstalk between macrophages and contractile fibroblasts27,77,78”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [77]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Stutchfield, B. M., Antoine, D. J., MacKinnon, A. C., Gow, D., Bain, C. C., Hawley, C. A., Hughes, M. J., Francis, B., Wojtacha, D., Man, T. Y., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.053 · Cited by 176
RetractedExploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269
Self-citationFate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684
Self-citationMacrophages in Tissue Repair, Regeneration, and Fibrosis
Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481
Self-citationNLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541
Self-citationNLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Cited by
Sorted by citations
Items 201–300 of 656
Yang, R., Zhang, Y., Kang, J., Zhang, C., & Ning, B. (2024) · Aging and Disease · doi:10.14336/ad.2023.0512 · Cited by 38
Banerjee, A., Singh, P., Shiekh, P. A., Kumar, A., Koul, V., & Bhattacharyya, J. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.213937 · Cited by 37
Li, X., Liu, Y., Tang, Y., & Xia, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1474688 · Cited by 46
Liu, B., Jiang, T., Hu, X., Liu, Z., Zhao, L., Liu, H., Liu, Z., & Ma, L. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9565 · Cited by 37
Oncomodulin: The Enigmatic Parvalbumin Protein
Climer, L. K., Cox, A. M., Reynolds, T., & Simmons, D. D. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00235 · Cited by 37
An, H. S., Lee, J. Y., Choi, E. B., Jeong, E. A., Shin, H. J., Kim, K. E., Park, K.-A., Jin, Z. H., Lee, J. E., Koh, J. S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-64201-2 · Cited by 36
Zhou, Q., Tao, X., Guo, F., Wu, Y. C., Deng, D., Lv, L., Dong, D., Shang, D., & Xiang, H. (2023) · BMC Medicine · doi:10.1186/s12916-023-02997-2 · Cited by 41
He, T., Bai, X., Jing, J., Liu, Y., Wang, H., Zhang, W., Li, X., Li, Y., Wang, L., Xie, S., et al. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108286 · Cited by 36
Astaxanthin: A promising therapeutic agent for organ fibrosis
Li, K., Wang, W., & Xiao, W. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106657 · Cited by 37
Micro- and nanoparticles-based immunoregulation of macrophages for tissue repair and regeneration
Ding, J., Venkatesan, R., Zhai, Z., Muhammad, W., Nakkala, J. R., & Gao, C. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111075 · Cited by 36
Wang, Z., Niu, Y., Tian, X., Yu, N. H., Yin, X., Xing, Z., Li, Y., Dong, L., & Wang, C. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202007408 · Cited by 35
Albanawany, N. M., Samy, D. M., Zahran, N. M., El‐Moslemany, R. M., Elsawy, S. M., & Nazel, M. W. A. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2105445 · Cited by 35
The physiological phenomenon and regulation of macrophage polarization in diabetic wound
Cai, F., Wang, P., Chen, W., Zhao, R., & Liu, Y. F. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08782-x · Cited by 34
Pan, Z., Wu, N., & Jin, C. (2023) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2023/3080969 · Cited by 36
Smart macrophage-targeting wound dressings accelerate diabetic wound healing
Chen, J., Luo, M., Chen, Y., Xing, Z., Peng, C., & Li, D. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.156860 · Cited by 36
Diamond‐Inspired DNA Hydrogel Based on Tetrahedral Framework Nucleic Acids for Burn Wound Healing
Liu, Z., Chen, X., Xu, Z., Li, S., Ma, W., Wang, Y., Chen, Y., Yao, L., Liang, J., Liao, S., et al. (2025) · Advanced Materials · doi:10.1002/adma.202509727 · Cited by 36
Cervadoro, A., Palomba, R., Vergaro, G., Cecchi, R., Menichetti, L., Decuzzi, P., Emdin, M., & Luin, S. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00177 · Cited by 35
Vinhas, A., Almeida, A. F., Gonçalves, A. I., Rodrigues, M. T., & Gomes, M. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155441 · Cited by 34
Cancer Cells Resistance Shaping by Tumor Infiltrating Myeloid Cells
Domagala, M., Laplagne, C., Leveque, E., Laurent, C., Fournié, J., Espinosa, É., & Poupot, M. (2021) · Cancers · doi:10.3390/cancers13020165 · Cited by 36
The Roles of Macrophages in Heart Regeneration and Repair After Injury
Gao, Y., Qian, N., Xu, J., & Wang, Y. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.744615 · Cited by 33
Heme Oxygenase-1 as Therapeutic Target for Diabetic Foot Ulcers
Leal, E. C., & Carvalho, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231912043 · Cited by 36
Improving the therapeutic efficacy of oncolytic viruses for cancer: targeting macrophages
Shen, Z., Liu, X., Guixiang, F., Na, J., Liu, Q., Lin, F., Zhang, Z., & Zhong, L. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04709-z · Cited by 39
Cross-Talk between the TGF-β and Cell Adhesion Signaling Pathways in Cancer
Liao, J., Chen, R., Lin, B., Deng, R., Liang, Y., Zeng, J., Ma, S., & Qiu, X. (2024) · International Journal of Medical Sciences · doi:10.7150/ijms.96274 · Cited by 38
Nickaeen, N., Ghaisari, J., Monika Heiner, A., Moein, S., & Gheisari, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-48865-z · Cited by 33
Yang, X. F., Shao, C., Duan, L., Hou, X., Huang, Y., Gao, L., Zong, C., Liu, W., Jiang, J., Ye, F., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.05.039 · Cited by 33
Gong, X., Han, Z., Fan, H., Wu, Y., He, Y., Fu, Y., Zhu, T., & Li, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1238673 · Cited by 35
Lipid metabolism orchestrates liver regeneration: an integrated metabolic network
Duan, L., Chang, Y., Dai, J., Lu, H., Zhao, W., Shen, Y., Lin, J., & Cai, X. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07232-5 · Cited by 35
Liu, R., Shen, Y., Wei, Y. J., Zhu, C., Yao, X., Gu, X., Qi, L., & Sun, H. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118025 · Cited by 37
TREM-1+ Macrophages Define a Pathogenic Cell Subset in the Intestine of Crohn’s Disease Patients
Caër, C., Gorreja, F., Forsskåhl, S. K., Brynjolfsson, S. F., Szeponik, L., Magnusson, M. K., Börjesson, L. G., Block, M., Lindskog, E. B., & Wick, M. J. (2021) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjab022 · Cited by 33
Sharifiaghdam, M., Shaabani, E., Sharifiaghdam, Z., Keersmaecker, H. D., Lucas, B., Lammens, J., Ghanbari, H., Teimoori‐Toolabi, L., Vervaet, C., Beer, T. D., et al. (2021) · Nanoscale · doi:10.1039/d1nr03830c · Cited by 32
Suess, P. M., Chinea, L. E., Pilling, D., & Gomer, R. H. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801559 · Cited by 28
Macrophages and Wnts in Tissue Injury and Repair
Park, M. H., Lee, E. D., & Chae, W. (2022) · Cells · doi:10.3390/cells11223592 · Cited by 29
Xiao, A., Jiang, X., Hu, Y., Li, H., Jiao, Y., Yin, D., Wang, Y., Sun, H. H., Wu, H., Lin, L., et al. (2024) · Advanced Materials · doi:10.1002/adma.202404534 · Cited by 34
Changes of pro-inflammatory and anti-inflammatory macrophages after peripheral nerve injury
Zhang, F., Miao, Y., Liu, Q., Li, S., & He, J. (2020) · RSC Advances · doi:10.1039/d0ra06607a · Cited by 31
Fibrin-based scaffolds for dental pulp regeneration: from biology to nanotherapeutics
nstitut de biologie et Chimie des Protéines, 7. P. D. V., Ducret, M., Costantini, A., Gobert, S., Farges, J.-C., & Bekhouche, M. (2021) · European Cells and Materials · doi:10.22203/ecm.v041a01 · Cited by 31
Specific repair by discerning macrophages
Bouchery, T., & Harris, N. L. (2017) · Science · doi:10.1126/science.aan6782 · Cited by 31
Lopez, E. M., Leclerc, K., Ramsukh, M., Parente, P. E., Patel, K., Aranda, C. J., Josephson, A. M., Remark, L. H., Kirby, D. J., Buchalter, D. B., et al. (2022) · Bone · doi:10.1016/j.bone.2021.116324 · Cited by 31
Wang, Y., Li, Z., Guo, G., & Xia, Y. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c03781 · Cited by 30
Observational Study of PD-L1, TGF-β, and Immune Cell Infiltrates in Hepatocellular Carcinoma
Ihling, C. H., Naughton, B. J., Zhang, Y., Rolfe, A., Frick-Krieger, E., Terracciano, L., & Dussault, I. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00015 · Cited by 30
Relaxin as an anti-fibrotic treatment: Perspectives, challenges and future directions
Samuel, C. S., & Bennett, R. G. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114884 · Cited by 31
Mucosal immunity and gut microbiota in dogs with chronic enteropathy
Eissa, N., Kittana, H., Neto, J. C. G., & Hussein, H. H. (2018) · Research in Veterinary Science · doi:10.1016/j.rvsc.2018.11.019 · Cited by 35
Shao, W., Wang, P., Lv, X., Wang, B., Gong, S., & Feng, Y. (2024) · Biomedicines · doi:10.3390/biomedicines12030664 · Cited by 29
Russo, R. C., & Ryffel, B. (2024) · Cells · doi:10.3390/cells13242058 · Cited by 35
Ruhl, T., Corsten, C., Beier, J. P., & Kim, B. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00166-3 · Cited by 29
Liu, H., Zhang, X., Shao, Y., Lin, X., Dong, F., & Liu, X. (2021) · Bioengineered · doi:10.1080/21655979.2021.1944020 · Cited by 29
Hou, Y., Ding, W., Wu, P., Liu, C., Ding, L., Liu, J., & Wang, X. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02760-z · Cited by 29
Single-cell multiomic analysis identifies macrophage subpopulations in promoting cardiac repair
Fu, M., Jia, S., Xu, L., Li, X., Lv, Y., Zhong, Y., & Ai, S. (2024) · Journal of Clinical Investigation · doi:10.1172/jci175297 · Cited by 30
Epigenetic regulatory mechanism of macrophage polarization in diabetic wound healing (Review)
Song, J., Wu, Y., Chen, Y., Sun, X., & Zhang, Z. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13367 · Cited by 34
CD44 Deficiency in Mice Protects the Heart Against Angiotensin Ii-Induced Cardiac Fibrosis
Yang, L., Qin, D., James, E. A., McKallip, R. J., Wang, N.-P., Zhang, W., Zheng, R., Han, Q., & Zhao, Z. (2018) · Shock · doi:10.1097/shk.0000000000001132 · Cited by 28
Renal sympathetic nerve activation via α2-adrenergic receptors in chronic kidney disease progression
Jang, H., Kim, J., & Padanilam, B. J. (2019) · Kidney Research and Clinical Practice · doi:10.23876/j.krcp.18.0143 · Cited by 28
Krzyszczyk, P., Kang, H. J., Kumar, S., Meng, Y., O'Reggio, M. D., Patel, K. P., Pires, I. S., Yarmush, M. L., Schloss, R. S., Palmer, A. F., et al. (2020) · Wound Repair and Regeneration · doi:10.1111/wrr.12814 · Cited by 28
Nephropathic Cystinosis: Pathogenic Roles of Inflammation and Potential for New Therapies
Elmonem, M. A., Veys, K. R. P., & Prencipe, G. (2022) · Cells · doi:10.3390/cells11020190 · Cited by 28
Oyesola, O. O., Hilligan, K. L., Namasivayam, S., Howard, N., Clancy, C. S., Zhao, M., Oland, S. D., Kiwanuka, K. N., Garza, N. L., Lafont, B. A. P., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.adf8161 · Cited by 33
Modulation of plasmacytoid dendritic cells response in inflammation and autoimmunity
Kioon, M. D. A., Laurent, P., Chaudhary, V., Du, Y., Crow, M. K., & Barrat, F. J. (2024) · Immunological Reviews · doi:10.1111/imr.13331 · Cited by 30
Cong, B., Dong, X., Yang, Z., Yü, P., Chai, Y., Liu, J., Zhang, M., Zang, Y., Kang, J., Feng, Y., et al. (2024) · Cell Discovery · doi:10.1038/s41421-024-00734-4 · Cited by 33
Tanshinone IIA prevents acute lung injury by regulating macrophage polarization
Zhao, J., Pu, J., Fan, J., Feng, X., Xu, J., Zhang, R., & Shang, Y. (2022) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2022.01.006 · Cited by 27
Zhang, L., Mao, L., & Wang, H. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03028-6 · Cited by 27
Li, S., Zhang, G., Feng, G., Jiang, L., Chen, Z., Xin, W., & Zhang, X. (2022) · Pharmaceuticals · doi:10.3390/ph15101276 · Cited by 27
Perkins, E. J., Woolard, A., & García‐Reyero, N. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.786057 · Cited by 25
Lei, X., Cheng, L., Lin, H., Pang, M., Yao, Z., Chen, C., Forouzanfar, T., Bikker, F. J., Wu, G., & Cheng, B. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00999 · Cited by 27
Crosstalk Between Innate and T Cell Adaptive Immunity With(in) the Muscle
Bonomo, A. C., Mariz, F. P., Riederer, I., Benjamim, C. F., Butler-Browne, G. S., Mouly, V., & Savino, W. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.573347 · Cited by 27
Wang, Q., Xie, Z., Wu, Q., Jin, Z., Yang, C., & Feng, J. (2021) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001288 · Cited by 26
Major signaling pathways and key mediators of macrophages in acute kidney injury (Review)
Li, N., Chen, J., Wang, P., Fan, H., Hou, S., & Gong, Y. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12094 · Cited by 26
Immune cells in lens injury repair and fibrosis
Walker, J. L., & Menko, A. S. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108664 · Cited by 26
mTOR activity is essential for retinal pigment epithelium regeneration in zebrafish
Lu, F., Leach, L. L., & Gross, J. M. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1009628 · Cited by 27
Jiang, X., Yang, J., Liu, F., Tao, J., Xu, J., & Zhang, M. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03000-0 · Cited by 26
Advances in Material-Based Strategies for Diabetic Bone Regeneration
Li, Z., Yue, M., & Zhou, Y. (2023) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szad092 · Cited by 26
Wang, J., Peng, X., Yuan, N., Wang, B., Chen, S., Wang, B., & Xie, L. (2024) · Translational research · doi:10.1016/j.trsl.2024.05.012 · Cited by 28
Hreha, T. N., Collins, C. A., Daugherty, A. L., Griffith, J. M., Hruska, K. A., & Hunstad, D. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01641 · Cited by 25
Inagaki, T., Fujiwara, K., Shinohara, Y., Azuma, M., Yamazaki, R., Mashima, K., Sakamoto, A., Yashiro, T., & Ohno, N. (2021) · Histochemistry and Cell Biology · doi:10.1007/s00418-020-01948-9 · Cited by 25
Myeloid cell diversification during regenerative inflammation: Lessons from skeletal muscle
Patsalos, A., Tzerpos, P., Wei, X., & Nagy, L. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.005 · Cited by 28
Wang, T., Zhao, J., Zhang, J., Mei, J., Shao, M., Pan, Y., Yang, W., Jiang, Y., Liu, F., & Jia, W. (2017) · Journal of Diabetes · doi:10.1111/1753-0407.12630 · Cited by 26
Immune cells in skin inflammation, wound healing, and skin cancer
Zhang, Y., & Lu, Q. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad107 · Cited by 27
Li, J. S., Zhang, L., Peng, J., Zhao, C., Li, W., Yu, Y., Huang, X., Yang, F., Deng, X., Yang, X., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1604320 · Cited by 28
Faz-López, B., Mayoral-Reyes, H., Hernández‐Pando, R., Labat, P. M., McKay, D. M., Medina-Andrade, I., Olguín, J. E., & Terrazas, L. I. (2019) · Pathogens · doi:10.3390/pathogens8040280 · Cited by 24
Roles of Oxidative Stress and Raftlin in Wound Healing Under Negative-Pressure Wound Therapy
Qiu, X., Wu, Y., Zhang, D., Zhang, H., Yu, A., & Li, Z. (2021) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s334248 · Cited by 24
Modulation of anti-cardiac fibrosis immune responses by changing M2 macrophages into M1 macrophages
Chen, S., Wang, K., Fan, Z., Zhou, T., Li, R., Zhang, B., Chen, J., Chi, J., Wei, K., Liu, J., et al. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00858-z · Cited by 26
Beez, C. M., Haag, M., Klein, O., Linthout, S. V., Sittinger, M., & Seifert, M. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0504-0 · Cited by 26
Periostin+ myeloid cells improved long bone regeneration in a mechanosensitive manner
Wang, Z., Lin, M., Pan, Y., Liu, Y., Yang, C., Wu, J., Wang, Y., Yan, B., Zhou, J., Chen, R., et al. (2024) · Bone Research · doi:10.1038/s41413-024-00361-5 · Cited by 23
Niche-specific dermal macrophage loss promotes skin capillary ageing
Mesa, K. R., O’Connor, K. A., Ng, C., Salvatore, S., Dolynuk, A., Lomeli, M. R., & Littman, D. R. (2025) · Nature · doi:10.1038/s41586-025-09639-y · Cited by 31
Microenvironmental Alterations in Carbon Nanotube-Induced Lung Inflammation and Fibrosis
Dong, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00126 · Cited by 22
Biomedical applications of electrospun nanofibers in the management of diabetic wounds
Pamu, D., Tallapaneni, V., Karri, V. V. S. R., & Singh, S. K. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00941-6 · Cited by 23
Renal Mononuclear Phagocytes in Lupus Nephritis
Davidson, A. (2021) · ACR Open Rheumatology · doi:10.1002/acr2.11269 · Cited by 22
Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation
Ledwoń, P., Papini, A. M., Rovero, P., & Latajka, R. (2021) · Materials · doi:10.3390/ma14123217 · Cited by 23
Fibrous Remodeling in Eosinophilic Esophagitis: Clinical Facts and Pathophysiological Uncertainties
Arias‐González, L., Rodríguez-Alcolado, L., Mendieta, E. J. L., Navarro, P., Lucendo, A. J., & Grueso-Navarro, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020927 · Cited by 22
Intracellular survival of Staphylococcus aureus in macrophages during osteomyelitis
Lathram, W. A., & Radka, C. D. (2025) · Virulence · doi:10.1080/21505594.2025.2553789 · Cited by 27
Mesaros, O., Jimbu, L., Neaga, A., Popescu, C., Berceanu, I., Tomuleasa, C., Fetică, B., & Zdrenghea, M. (2020) · Biomedicines · doi:10.3390/biomedicines8110516 · Cited by 21
Cai, C., Zeng, D., Gao, Q., Ma, L., Zeng, B., Zhou, Y., & Wang, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-92839-z · Cited by 22
Immunological mechanisms involved in macrophage activation and polarization in schistosomiasis
Licá, I. C. L., Gomes, G. C. C., Nogueira, R. A., Lira, M. G. S., dos Santos, V. A. F., Rodrigues, J. G. M., Miranda, G. S., Carvalho, R. C., Silva, L. A., Guerra, R. N. M., et al. (2023) · Parasitology · doi:10.1017/s0031182023000021 · Cited by 27
Garabuczi, É., Tarban, N., Fige, É., Patsalos, A., Halász, L., Szendi-Szatmári, T., Sarang, Z., Király, R., & Szondy, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1139204 · Cited by 22
Zhu, J., Fan, J., Xia, Y., Wang, H., Li, Y., Feng, Z., & Fu, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1219487 · Cited by 26
Li, Z., Qu, W., Zhang, D., Sun, Y., & Shang, D. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115227 · Cited by 23
Hou, J., Cong, Y., Ji, J., Liu, Y., Hong, H., & Han, X. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.12.006 · Cited by 25
Quan, W., Luo, Q., Hao, W., Tomic, I., Furihata, T., Schulz‐Schaeffer, W., Menger, M. D., Fassbender, K. C., & Liu, Y. (2021) · Glia · doi:10.1002/glia.24007 · Cited by 20
Mukai, K., Horike, S., Meguro‐Horike, M., Nakajima, Y., Iswara, A., & Nakatani, T. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264572 · Cited by 22
Klf4 has an unexpected protective role in perivascular cells within the microvasculature
Haskins, R. M., Nguyen, A. T., Alencar, G. F., Billaud, M., Kelly‐Goss, M. R., Good, M. E., Bottermann, K., Klibanov, A. L., French, B. A., Harris, T. E., et al. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00084.2018 · Cited by 21
Molina, C. P., Giglio, R. M., Gandhi, R. M., Sicari, B. M., Londoño, R., Hussey, G. S., Bartolacci, J. G., Luque, L. M. Q., Cramer, M. C., Dziki, J. L., et al. (2018) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2018.12.002 · Cited by 21
Alt, E., Rothoerl, R. D., Hoppert, M., Frank, H., Wuerfel, T., Alt, C., & Schmitz, C. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i7.944 · Cited by 21
Xia, L., Kano, F., Hashimoto, N., Liu, Y., Khurel‐Ochir, T., Ogasawara, N., Ding, C., Xu, Y., Hibi, H., Iwasaki, T., et al. (2024) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szae006 · Cited by 20
Metadata
- Authors
- Vannella, K. M., & Wynn, T. A.
- Affiliations
- National Institutes of Health (US)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2017-02-10
- Volume
- 79
- Issue
- 1
- Pages
- 593-617
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2467677013
- Semantic Scholar
- 00554bdce4ebdeef31bcb674e3634efc26188db4
- Cited by
- 656
- References
- 127
- Citations by year
- 2026: 52 · 2025: 76 · 2024: 102 · 2023: 78 · 2022: 89 · 2021: 73 · 2020: 66 · 2019: 60 · 2018: 41 · 2017: 19
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- macrophages, tissue repair, tissue regeneration, wound healing, macrophage polarization, reactive oxygen species, apoptosis, growth factors, angiogenesis, myofibroblast activation, matrix metalloproteinases, fibrosis, liver, nervous system, heart, lung, skeletal muscle, intestine, anti-inflammatory macrophages
- MeSH terms
- Animals, Cell Differentiation, Homeostasis, Humans, Macrophages, Regeneration, Wound Healing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
