CoChat
Sign Up
Cited by 22Dementia and Cognitive Impairment ResearchTreatment of Major DepressionPharmaceutical Practices and Patient Outcomes

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Risk of incident dementia in late-life depression treated with antidepressants: A nationwide population cohort study

Su, Jian-An, Chang, Chih-Cheng, Yang, Yao-Hsu, Chen, Ko-Jung, Li, Yueh-Ping, Lin, Chung-Ying·2020·Journal of Psychopharmacology
DOI 10.1177/0269881120944152
Open this paper in CoChat — free account

Abstract

Background: Antidepressants are frequently used to treat depression in patients with dementia. In addition, late-life depression is associated with the incidence of subsequent cognitive impairment or dementia. However, the association between exposure to antidepressants in late-life depression and the development of incident dementia remains understudied. Methods: Through a population-based retrospective cohort design, data were extracted from the Taiwan National Health Insurance Research Dataset of medical claims registered from 1998–2013. We collected data of individuals who had received a new diagnosis of depression between 2000 and 2007. We excluded those who received a diagnosis of depression and were given antidepressants before 2000 and those younger than 60 years. The primary outcome was the occurrence of incident dementia. The time from the prescription of antidepressants or the diagnosis of depression until the outcome or the end of 2013 was calculated as the time to event. A total of 563,918 cases were included and were divided into either antidepressant users or antidepressant nonusers. Cox proportional hazards models were used to calculate the hazard ratio and 95% confidence interval. Results: Exposure to antidepressants did not increase the risk of dementia in patients with late-life depression at either a low exposure dosage (hazard ratio: 1.06, 95% confidence interval: 0.91–1.23) or a high exposure dosage (hazard ratio: 1.07, 95% confidence interval: 0.95–1.20). To confirm the validity of our results, we performed a sensitivity analysis and subgroup analysis, and the post-hoc results were consistent with the main results. Conclusion: Antidepressants did not increase the risk of incident dementia in patients with late-life depression.

Overview

Integrity signals

Registry

Crossref · 10.1177/0269881120944152

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The absence of a consistent association with dementia risk, cognitive decline, and brain atrophy is in concordance with earlier findings.

    “The absence of a consistent association with dementia risk, cognitive decline, and brain atrophy is in concordance with earlier findings. 15-17”

    From Antidepressant use in relation to dementia risk, cognitive decline, and brain atrophy (2024) · cites this paper as [17]

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 32

  1. 10.1038/s41398-019-0514-6 · DOI · Paper page
  2. 10.31887/DCNS.1999.1.2/galexopoulos · DOI
  3. 10.1097/00019442-200201000-00012 · DOI
  4. 10.1002/gps.4347 · DOI
  5. American Psychiatric Association, 2000, Diagnostic and Statistical Manual of Mental Disorders
  6. 10.1016/S0006-2952(02)00882-1 · DOI
  7. 10.1097/JGP.0b013e31822001c1 · DOI
  8. 10.1001/archgenpsychiatry.2010.35 · DOI
  9. 10.1016/j.ejphar.2009.10.022 · DOI
  10. 10.1186/s12916-017-0847-z · DOI
  11. 10.7326/0003-4819-147-7-200710020-00008 · DOI · Paper page
  12. 10.1016/j.biopsych.2006.03.082 · DOI · Paper page
  13. 10.1111/j.1468-1331.2009.02748.x · DOI · Paper page
  14. 10.1046/j.1532-5415.2003.51352.x · DOI
  15. 10.1002/gps.3845 · DOI
  16. 10.2174/187152409787601897 · DOI
  17. 10.1016/j.jad.2017.09.016 · DOI · Paper page
  18. 10.1017/S0033291701004731 · DOI
  19. 10.1016/j.biopsych.2012.11.003 · DOI · Paper page
  20. 10.2147/CLEP.S196293 · DOI
  21. 10.1016/j.tox.2012.11.013 · DOI
  22. 10.1007/s00406-010-0156-4 · DOI · Paper page
  23. 10.1111/j.1532-5415.1996.tb02942.x · DOI
  24. 10.1097/YIC.0b013e32834ace0f · DOI · Paper page
  25. 10.1002/(SICI)1099-1166(1998100)13:10<707::AID-GPS856>3.0.CO;2-Q · DOI
  26. Medicode, 1996, ICD-9-CM: International Classification of Diseases, 9th Revision, Clinical Modification
  27. 10.1002/gps.4406 · DOI
  28. 10.1097/jcp.0b013e31814b98c1 · DOI · Paper page
  29. 10.1016/j.jamda.2006.12.018 · DOI
  30. 10.1016/j.amjmed.2015.01.007 · DOI · Paper page
  31. 10.1159/000437299 · DOI · Paper page
  32. 10.1097/WAD.0000000000000103 · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Su, J.-A., Chang, C.-C., Yang, Y.-H., Chen, K.-J., Li, Y.-P., & Lin, C.-Y.
Affiliations
  • Chang Gung University of Science and Technology (TW)
  • Chi Mei Medical Center (TW)
  • Chang Gung University (TW)
  • Chang Gung Memorial Hospital (TW)
  • National Tainan Institute of Nursing (TW)
  • Hong Kong Polytechnic University (HK)
Corresponding author
Lin, Chung-Ying
ORCID
Venue
Journal of Psychopharmacology
Publisher
SAGE Publications
Published
2020-08-27
Volume
34
Issue
10
Pages
1134-1142
ISSN
  • 0269-8811 (ISSN-L)
  • 1461-7285
DOI
10.1177/0269881120944152
OpenAlex
W3081112480
Cited by
22
References
11
Citations by year
2026: 2 · 2025: 2 · 2024: 10 · 2023: 6 · 2022: 1 · 2021: 1
FWCI
1.33
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Chang Gung Memorial Hospital (CGRPG6J0011)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords
antidepressants, geriatric depression, incident dementia, dementia risk, cognitive impairment, drug safety, antidepressant dosage, older adults
MeSH terms
Age Factors, Aged, Aged, 80 and over, Antidepressive Agents, Dementia, Depression, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Taiwan, Time Factors, Cohort Studies, Incidence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review