The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

Hydroperoxide metabolism in mammalian organs.

Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827

DNA Repair and Mutagenesis

Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683

Mechanism of Eukaryotic Homologous Recombination

Filippo, J. S., Sung, P., & Klein, H. L. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061306.125255 · Cited by 1,766

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,304

Meiotic Chromosomes: Integrating Structure and Function

Zickler, D., & Kleckner, N. E. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.603 · Cited by 1,256

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

Walker, J. R., Corpina, R. A., & Goldberg, J. D. (2001) · Nature · doi:10.1038/35088000 · Cited by 1,216

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Walker, E. H., Pacold, M. E., Perišić, O., Stephens, L., Hawkins, P. T., Wymann, M. P., & Williams, R. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00089-4 · Cited by 1,211

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

Ma, Y., Pannicke, U., Schwarz, K., & Lieber, M. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00671-2 · Cited by 1,166

ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

Stiff, T., O’Driscoll, M., Rief, N., Iwabuchi, K., Löbrich, M., & Jeggo, P. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3207 · Cited by 1,050

The Mechanism and Regulation of Chromosomal V(D)J Recombination

Bassing, C. H., Swat, W., & Alt, F. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00675-x · Cited by 1,006

Gene Editing With TALEN and CRISPR/Cas in Rice

Bi, H., & Yang, B. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.04.006 · Cited by 39

Apple Flavonoids Suppress Carcinogen‐Induced DNA Damage in Normal Human Bronchial Epithelial Cells

Vazhappilly, C. G., & Rupasinghe, H. P. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1767198 · Cited by 38

Genome Editing of Food-Grade Lactobacilli To Develop Therapeutic Probiotics

van Pijkeren, J., & Barrangou, R. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0013-2016 · Cited by 39

Production of Recombinant Proteins in the Milk of Transgenic Animals: Current State and Prospects

Shepelev, M. V., Калиниченко, С. В., Deykin, A. V., & Korobko, I. V. (2018) · Acta Naturae · doi:10.32607/20758251-2018-10-3-40-47 · Cited by 37

Improved Stress Tolerance of Saccharomyces cerevisiae by CRISPR-Cas-Mediated Genome Evolution

Mitsui, R., Yamada, R., & Ogino, H. (2019) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-019-03040-y · Cited by 37

Molecular roulette: nucleophosmin mutations in AML are orchestrated through N-nucleotide addition by TdT

Borrow, J., Dyer, S. A., Akiki, S. J., & Griffiths, M. (2019) · Blood · doi:10.1182/blood.2019001240 · Cited by 37

The Anticancer Drug 3-Bromopyruvate Induces DNA Damage Potentially Through Reactive Oxygen Species in Yeast and in Human Cancer Cells

Cal, M., Matyjaszczyk, I., Litwin, I., Augustyniak, D., Ogórek, R., Ko, Y. H., & Ułaszewski, S. (2020) · Cells · doi:10.3390/cells9051161 · Cited by 37

Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis

Öz, R., Wang, J., Guérois, R., Goyal, G., Sriram, K. K., Ropars, V., Sharma, R., Koca, F., Charbonnier, J., Modesti, M., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab083 · Cited by 37

LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer

Wang, Y.-H., Guo, Z., An, L., Zhou, Y., Xu, H., Xiong, J., Liu, Z., Chen, X.-P., Zhou, H., Li, X., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03728-2 · Cited by 38

Development of a versatile nuclease prime editor with upgraded precision

Li, X., Zhang, G., Huang, S., Liu, Y., Tang, J., Zhong, M., Wang, X., Sun, W., Yao, Y., Ji, Q., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-35870-0 · Cited by 39

RAD18 lives a double life: Its implication in DNA double-strand break repair

Liu, T., Jun, H., & Junjie, C. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.016 · Cited by 38

The Minimal Bacillus subtilis Nonhomologous End Joining Repair Machinery

de Vega, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064232 · Cited by 37

Toward Combined Cell and Gene Therapy for GenodermatosesPreprint

Rosa, L. D., Latella, M. C., Seconetti, A. S., Cattelani, C., Bauer, J. W., Bondanza, S., & Luca, M. D. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a035667 · Cited by 37

Predicting CRISPR/Cas9 Repair Outcomes by Attention-Based Deep Learning Framework

Liu, X., Wang, S., & Ai, D. (2022) · Cells · doi:10.3390/cells11111847 · Cited by 40

Advances in CRISPR Delivery Methods: Perspectives and Challenges

Demirci, S., Essawi, K., Germino-Watnick, P., Liu, X., Hakami, W., & Tisdale, J. F. (2022) · The CRISPR Journal · doi:10.1089/crispr.2022.0051 · Cited by 37

Regulation of pathway choice in DNA repair after double-strand breaks

Kumari, N., Kaur, E., Raghavan, S. C., & Sengupta, S. (2024) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2024.102496 · Cited by 36

Unique features of DNA replication in mitochondria: A functional and evolutionary perspective

Holt, I. J., & Jacobs, H. T. (2014) · BioEssays · doi:10.1002/bies.201400052 · Cited by 37

Mouse genetics: Catalogue and scissors

Sung, Y. H., Baek, I., Seong, J. K., Kim, J., & Lee, H. (2012) · BMB Reports · doi:10.5483/bmbrep.2012.45.12.242 · Cited by 36

Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one‐cell mouse embryos

Brandl, C., Ortiz, O., Röttig, B., Wefers, B., Wurst, W., & Kühn, R. (2014) · FEBS Open Bio · doi:10.1016/j.fob.2014.11.009 · Cited by 38

Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes

Hu, J., Tepsuporn, S., Meyers, R. M., Gostissa, M., & Alt, F. W. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410112111 · Cited by 38

Intrachromosomal mitotic nonallelic homologous recombination is the major molecular mechanism underlying type-2 NF1 deletions

Roehl, A. C., Vogt, J. A., Mußotter, T., Zickler, A. M., Spöti, H., Högel, J., Chuzhanova, N. A., Wimmer, K., Kluwe, L., Mautner, V., et al. (2010) · Human Mutation · doi:10.1002/humu.21340 · Cited by 36

Transposon Invasion of theParameciumGermline Genome Countered by a Domesticated PiggyBac Transposase and the NHEJ Pathway

Dubois, E., Bischerour, J., Marmignon, A., Mathy, N., Régnier, V., & Bétermier, M. (2012) · International Journal of Evolutionary Biology · doi:10.1155/2012/436196 · Cited by 36

Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms

Bezine, E., Malaisé, Y., Loeuillet, A., Chevalier, M., Boutet-Robinet, E. A., Salles, B., Mirey, G., & Vignard, J. (2016) · Scientific Reports · doi:10.1038/srep36022 · Cited by 35

The SWI/SNF ATP-dependent nucleosome remodeler promotes resection initiation at a DNA double-strand break in yeast

Wiest, N. E., Houghtaling, S. R., Sanchez, J. C., Tomkinson, A. E., & Osley, M. A. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx221 · Cited by 36

Alternative Splicing in Genetic Diseases: Improved Diagnosis and Novel Treatment Options

Bergsma, A. J., van der Wal, E., Broeders, M., van der Ploeg, A. T., & Pijnappel, W. W. M. P. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.07.008 · Cited by 42

Targeted deletion of the zebrafish actin-bundling protein L-plastin (lcp1)

Kell, M., Riccio, R. E., Baumgartner, E. A., Compton, Z. J., Pecorin, P. J., Mitchell, T. A., Topczewski, J., & LeClair, E. E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190353 · Cited by 36

Deletion of Adipose Triglyceride Lipase Links Triacylglycerol Accumulation to a More-Aggressive Phenotype in A549 Lung Carcinoma Cells

Tomin, T., Fritz, K., Gindlhuber, J., Waldherr, L., Pucher, B., Thallinger, G., Nomura, D. K., Schittmayer, M., & Birner‐Gruenberger, R. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00782 · Cited by 36

β 1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination

Ahmed, K. M., PANDITA, R. K., Singh, D. K., Hunt, C. R., & Pandita, T. K. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00672-17 · Cited by 40

Cis- and trans-factors affecting AID targeting and mutagenic outcomes in antibody diversification

Yeap, L.-S., & Meng, F. (2019) · Advances in immunology · doi:10.1016/bs.ai.2019.01.002 · Cited by 35

Roles of Ubiquitination and SUMOylation in DNA Damage Response

Su, S., Zhang, Y., & Liu, P. (2019) · Current Issues in Molecular Biology · doi:10.21775/cimb.035.059 · Cited by 37

A qPCR method for genome editing efficiency determination and single-cell clone screening in human cells

Li, B., Ren, N., Yang, L., Liu, J., & Huang, Q. (2019) · Scientific Reports · doi:10.1038/s41598-019-55463-6 · Cited by 36

Preserving genome integrity in human cells via DNA double-strand break repair

Jensen, R. B., & Rothenberg, E. (2020) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-10-0668 · Cited by 38

A New Twist in Protein Kinase B/Akt Signaling: Role of Altered Cancer Cell Metabolism in Akt-Mediated Therapy Resistance

Goetting, I., Jendrossek, V., & Matschke, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228563 · Cited by 37

Enhancement of the flower longevity of petunia by CRISPR/Cas9-mediated targeted editing of ethylene biosynthesis genes

Xu, J., Naing, A. H., Bunch, H., Jeong, J., Kim, H., & Kim, C. K. (2021) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2020.111460 · Cited by 36

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Yosaatmadja, Y., Baddock, H. T., Newman, J. A., Bielinski, M., Gavard, A. E., Mukhopadhyay, S. M. M., Dannerfjord, A. A., Schofield, C. J., McHugh, P. J., & Gileadi, O. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab693 · Cited by 40

DNA double-strand break repair in male germ cells during spermatogenesis and its association with male infertility development

Talibova, G., Bilmez, Y., & Öztürk, S. (2022) · DNA repair · doi:10.1016/j.dnarep.2022.103386 · Cited by 37

Current advances of CRISPR-Cas technology in cell therapy

Qiu, H.-Y., Ji, R.-J., & Zhang, Y. (2022) · Cell Insight · doi:10.1016/j.cellin.2022.100067 · Cited by 38

Gene Editing Using ssODNs with Engineered Endonucleases

Chen, F., Pruett‐Miller, S. M., & Davis, G. D. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1862-1_14 · Cited by 36

OECD Series on Adverse Outcome Pathways

OECD (2016) · OECD series on adverse outcome pathways · doi:10.1787/2415170x · Cited by 36

BIBR1532 combined with radiotherapy induces ferroptosis in NSCLC cells and activates cGAS-STING pathway to promote anti-tumor immunity

Bao, Y., Pan, Z., Zhao, L., Qiu, J., Cheng, J., Liu, L., & Qian, D. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05331-3 · Cited by 37

Transcriptomic analysis provides insights on hexavalent chromium induced DNA double strand breaks and their possible repair in midgut cells of Drosophila melanogaster larvae

Mishra, M., Sharma, A., Shukla, A. K., Pragya, P., Murthy, R. C., de Pomerai, D. I., Dwivedi, U. N., & Chowdhuri, D. K. (2013) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2013.04.005 · Cited by 34

N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku

Meek, K., Lees‐Miller, S. P., & Modesti, M. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1211 · Cited by 35

Multiplex CRISPR/Cas9-based genome engineering enhanced by Drosha-mediated sgRNA-shRNA structure

Yan, Q., Xu, K., Xing, J., Zhang, T., Wang, X., Wei, Z., Ren, C., Liu, Z., Shao, S., & Zhang, Z. (2016) · Scientific Reports · doi:10.1038/srep38970 · Cited by 33

Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination

Zhao, Q., Guan, J., Qin, Y., Ren, P., Zhang, Z., Lv, J., Sun, S., Zhang, C., & Mao, W. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.09.078 · Cited by 37

Promoter Hypermethylation of the ATM Gene as a Novel Biomarker for Breast Cancer

Begam, N., Jamil, K., & Raju, S. (2017) · Europe PMC (PubMed Central) · doi:10.22034/apjcp.2017.18.11.3003 · Cited by 35

Clinical significance of germline copy number variation in susceptibility of human diseases

Hu, L., Yao, X., Huang, H., Guo, Z., Cheng, X., Xu, Y., Shen, Y., Xu, B., & Li, D. (2018) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2018.01.001 · Cited by 34

Strategies for the Enrichment and Selection of Genetically Modified Cells

Ren, C., Xu, K., Segal, D. J., & Zhang, Z. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.07.017 · Cited by 35

Terminal deoxynucleotidyl transferase promotes acute myeloid leukemia by priming FLT3-ITD replication slippage

Borrow, J., Dyer, S. A., Akiki, S. J., & Griffiths, M. (2019) · Blood · doi:10.1182/blood.2019001238 · Cited by 38

CRISPR/Cas9: Nature's gift to prokaryotes and an auspicious tool in genome editing

Manzoor, K. N., & Khan, A. A. (2019) · Journal of Basic Microbiology · doi:10.1002/jobm.201900420 · Cited by 38

Chromothripsis and DNA Repair Disorders

Nazaryan‐Petersen, L., Bjerregaard, V. A., Nielsen, F. C., Tommerup, N., & Tümer, Z. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030613 · Cited by 34

Nucleolar localization of RAG1 modulates V(D)J recombination activity

Brecht, R. M., Liu, C. C., Beilinson, H. A., Khitun, A., Slavoff, S. A., & Schatz, D. G. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920021117 · Cited by 35

A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex

Rahman, S., Canny, M. D., Buschmann, T. A., & Latham, M. P. (2020) · Cells · doi:10.3390/cells9071678 · Cited by 35

CRL4ADTL degrades DNA-PKcs to modulate NHEJ repair and induce genomic instability and subsequent malignant transformation

Feng, M., Wang, Y., Bi, L., Zhang, P., Wang, H., Zhao, Z., Mao, J., & Wei, G. (2021) · Oncogene · doi:10.1038/s41388-021-01690-z · Cited by 36

Persistent variations of blood DNA methylation associated with treatment exposures and risk for cardiometabolic outcomes in long-term survivors of childhood cancer in the St. Jude Lifetime Cohort

Song, N., Hsu, C., Pan, H., Zheng, Y., Hou, L., Sim, J.-A., Li, Z., Mulder, H. L., Easton, J. B., Walker, E. V., et al. (2021) · Genome Medicine · doi:10.1186/s13073-021-00875-1 · Cited by 33

The Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives

Li, Y., Lu, L., Wu, X., Li, Q., Zhao, Y., Du, F., Chen, Y., Shen, J., Xiao, Z., Wu, Z., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.61410 · Cited by 35

Current Status and Perspectives on the Application of CRISPR/Cas9 Gene-Editing System to Develop a Low-Gluten, Non-Transgenic Wheat Variety

Verma, A. K., Tiwari, A., Lionetti, E., Srivastava, A., Monachesi, C., Catassi, G. N., Gatti, S., Galeazzi, T., & Catassi, C. (2021) · Foods · doi:10.3390/foods10102351 · Cited by 37

Assaying Break and Nick-Induced Homologous Recombination in Mammalian Cells Using the DR-GFP Reporter and Cas9 Nucleases

Vriend, L. E. M., Jasin, M., & Krawczyk, P. M. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-801185-0.00009-x · Cited by 35

Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining

Jessulat, M., Malty, R. H., Nguyen‐Tran, D., Deineko, V., Aoki, H., Vlasblom, J., Omidi, K., Jin, K., Minić, Z., Hooshyar, M., et al. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00007-15 · Cited by 34

Replication protein A and more: single-stranded DNA-binding proteins in eukaryotic cells

Liu, T., & Huang, J. (2016) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmw041 · Cited by 36

CRISPR/Cas9: a historical and chemical biology perspective of targeted genome engineering

Singh, A., Chakraborty, D., & Maiti, S. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00197a · Cited by 35

Recent advances in various adeno-associated viruses (AAVs) as gene therapy agents in hepatocellular carcinoma

Hadi, M., Allela, O. Q. B., Jabari, M., Jasoor, A. M., Naderloo, O., Yasamineh, S., Gholizadeh, O., & Kalantari, L. (2024) · Virology Journal · doi:10.1186/s12985-024-02286-1 · Cited by 35

Mechanisms of Hepatitis B Virus cccDNA and Minichromosome Formation and HBV Gene Transcription

Gómez-Moreno, A., & Ploß, A. (2024) · Viruses · doi:10.3390/v16040609 · Cited by 35

The SMC-5/6 Complex and the HIM-6 (BLM) Helicase Synergistically Promote Meiotic Recombination Intermediate Processing and Chromosome Maturation during Caenorhabditis elegans Meiosis

Hong, Y., Sonneville, R., Agostinho, A., Meier, B., Wang, B., Blow, J. J., & Gartner, A. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005872 · Cited by 34

The distinctive cellular responses to DNA strand breaks caused by a DNA topoisomerase I poison in conjunction with DNA replication and RNA transcription

Sakasai, R., & Iwabuchi, K. (2015) · Genes & Genetic Systems · doi:10.1266/ggs.15-00023 · Cited by 34

Applications of the CRISPR/Cas system beyond gene editing

Anton, T., Karg, E., & Bultmann, S. (2018) · Biology Methods and Protocols · doi:10.1093/biomethods/bpy002 · Cited by 32

Prevalence of Mutation-Prone Microhomology-Mediated End Joining in a Chordate Lacking the c-NHEJ DNA Repair Pathway

Deng, W., Henriet, S., & Chourrout, D. M. (2018) · Current Biology · doi:10.1016/j.cub.2018.08.048 · Cited by 34

Coupling DNA Damage and Repair: an Essential Safeguard during Programmed DNA Double-Strand Breaks?

Bétermier, M., Borde, V., & de Villartay, J. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.11.005 · Cited by 37

Limiting the DNA Double-Strand Break Resectosome for Genome Protection

Ronato, D. A., Mersaoui, S. Y., Busatto, F. F., Affar, E. B., Richard, S., & Masson, J. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.05.003 · Cited by 35

The Connection Between Cell Fate and Telomere

Engin, A. B., & Engin, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-49844-3_3 · Cited by 39

Epigenetic Alterations in Podocytes in Diabetic Nephropathy

Sugita, E., Hayashi, K., Hishikawa, A., & Itoh, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.759299 · Cited by 34

Advances in targeted therapy and immunotherapy for melanoma (Review)

Qin, Z., & Zheng, M. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.12115 · Cited by 36

Recent developments and clinical studies utilizing engineered zinc finger nuclease technology

Jo, Y.-I., Kim, S., & Ramakrishna, S. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1956-5 · Cited by 37

XRCC3 is essential for proper double-strand break repair and homologous recombination in rice meiosis

Zhang, B., Wang, M., Tang, D., Li, Y., Xu, M., Gu, M., Cheng, Z., & Yu, H. (2015) · Journal of Experimental Botany · doi:10.1093/jxb/erv253 · Cited by 34

The role of the Mpv17 protein mutations of which cause mitochondrial DNA depletion syndrome (MDDS): lessons from homologs in different species

Löllgen, S., & Weiher, H. (2015) · Biological Chemistry · doi:10.1515/hsz-2014-0198 · Cited by 34

Synthetic Genetic Targeting of Genome Instability in Cancer

Sajesh, B. V., Guppy, B. J., & McManus, K. J. (2013) · Cancers · doi:10.3390/cancers5030739 · Cited by 34

Multiple host‐cell recombination pathways act in A grobacterium ‐mediated transformation of plant cells

Mestiri, I., Norre, F., Gallego, M. E., & White, C. I. (2013) · The Plant Journal · doi:10.1111/tpj.12398 · Cited by 34

CK2‐defective Arabidopsis plants exhibit enhanced double‐strand break repair rates and reduced survival after exposure to ionizing radiation

Moreno‐Romero, J., Armengot, L., Marquès‐Bueno, M. M., Britt, A., & Martı́nez, M. C. (2012) · The Plant Journal · doi:10.1111/j.1365-313x.2012.05019.x · Cited by 35

Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ

Pawelczak, K. S., Bennett, S. M., & Turchi, J. J. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3368 · Cited by 33

Overcoming the Impact of Hypoxia in Driving Radiotherapy Resistance in Head and Neck Squamous Cell Carcinoma

Hill, R. M., Rocha, S., & Parsons, J. L. (2022) · Cancers · doi:10.3390/cancers14174130 · Cited by 33

Emerging Gene Therapeutics for Epidermolysis Bullosa under Development

Bischof, J., Hierl, M., & Koller, U. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042243 · Cited by 36

Targeted gene editing by transfection ofin vitroreconstitutedStreptococcus thermophilusCas9 nuclease complex

Glemzaite, M., Balciunaite, E., Karvelis, T., Gasiūnas, G., Grusyte, M. M., Alzbutas, G., Jurcyte, A., Anderson, E. M., Maksimova, E. M., Smith, A. J., et al. (2015) · RNA Biology · doi:10.1080/15476286.2015.1017209 · Cited by 33

Synthetic lethal approaches for assessing combinatorial efficacy of chemotherapeutic drugs

Jackson, R. A., & Chen, E. S. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.01.014 · Cited by 33

SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells

Roth, M., Wang, Z., & Chen, W. (2016) · Oncotarget · doi:10.18632/oncotarget.10328 · Cited by 32

Detailed analysis of targeted gene mutations caused by the Platinum-Fungal TALENs in Aspergillus oryzae RIB40 strain and a ligD disruptant

Mizutani, O., Arazoe, T., Toshida, K., Hayashi, R., Ohsato, S., Sakuma, T., Yamamoto, T., Kuwata, S., & Yamada, O. (2016) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2016.09.014 · Cited by 33

Effects of DNA end configuration on XRCC4-DNA ligase IV and its stimulation of Artemis activity

Gerodimos, C. A., Chang, H. H., Watanabe, G., & Lieber, M. R. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.798850 · Cited by 33

XLF/Cernunnos: An important but puzzling participant in the nonhomologous end joining DNA repair pathway

Menon, V., & Povirk, L. F. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.08.003 · Cited by 33

Homologous Recombination in Protozoan Parasites and Recombinase Inhibitors

Kelso, A. A., Waldvogel, S. M., Luthman, A. J., & Sehorn, M. G. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01716 · Cited by 33

Rad51 recruitment and exclusion of non-homologous end joining during homologous recombination at a Tus/Ter mammalian replication fork barrier

Willis, N. A., Panday, A., Duffey, E. E., & Scully, R. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007486 · Cited by 32

Stem cell-derived clade F AAVs mediate high-efficiency homologous recombination-based genome editing

Smith, L. J., Wright, J. B., Clark, G., Ul-Hasan, T., Jin, X., Fong, A., Chandra, M., Martin, T. S., Rubin, H. L., Knowlton, D., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802343115 · Cited by 33

Ways of improving precise knock-in by genome-editing technologies

Smirnikhina, S., Anuchina, A. A., & Лавров, А. В. (2018) · Human Genetics · doi:10.1007/s00439-018-1953-5 · Cited by 32

A nanofluidic device for real-time visualization of DNA–protein interactions on the single DNA molecule level

Öz, R., Sriram, K. K., & Westerlund, F. (2019) · Nanoscale · doi:10.1039/c8nr09023h · Cited by 33

Iteratively improving Hi-C experiments one step at a time

Golloshi, R., Sanders, J. T., & McCord, R. P. (2018) · Methods · doi:10.1016/j.ymeth.2018.04.033 · Cited by 28

Recent advances in mammalian reproductive biology

Wen, L., Liu, Q., Xu, J.-J., Liu, X., Shi, C.-Y., Yang, Z., Zhang, Y., Xu, H., Liu, J., Yang, H., et al. (2019) · Science China Life Sciences · doi:10.1007/s11427-019-1572-7 · Cited by 33

Precision Genome Engineering for the Breeding of Tomatoes: Recent Progress and Future Perspectives

Vu, T. V., Das, S., Tran, M. T., Hong, J. C., & Kim, J. (2020) · Frontiers in Genome Editing · doi:10.3389/fgeed.2020.612137 · Cited by 37

Improving FnCas12a Genome Editing by Exonuclease Fusion

Wu, Y., Yuan, Q., Zhu, Y., Gao, X., Song, J., & Yin, Z. (2020) · The CRISPR Journal · doi:10.1089/crispr.2020.0073 · Cited by 33

Breast Cancer Predisposition Genes and Synthetic Lethality

Neiger, H. E., Siegler, E. L., & Shi, Y. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115614 · Cited by 33

Y2O3 Nanoparticles and X-ray Radiation-Induced Effects in Melanoma Cells

Porosnicu, I., Butnaru, C. M., Tiseanu, I., Stancu, E., Munteanu, C. V. A., Bita, B. I., Duliu, O. G., & Sima, F. (2021) · Molecules · doi:10.3390/molecules26113403 · Cited by 33

Melatonin: A smart molecule in the DNA repair system

Mir, S. M., Aliarab, A., Goodarzi, G., Shirzad, M., Jafari, S. M., Qujeq, D., Tehrani, S. S., & Asadi, J. (2021) · Cell Biochemistry and Function · doi:10.1002/cbf.3672 · Cited by 35

Structural Biology of DNA Repair: Spatial Organisation of the Multicomponent Complexes of Nonhomologous End Joining

Ochi, T., Sibanda, B. L., Wu, Q., Chirgadze, D. Y., Bolaños-García, V. M., & Blundell, T. L. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/621695 · Cited by 39

The awakening of an advanced malignant cancer: An insult to the mitochondrial genome

Cook, C. C., & Higuchi, M. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.08.017 · Cited by 33

The mechanism of human nonhomologous DNA end joining

Lieber, M. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r700039200 · Cited by 720

Nonhomologous DNA End Joining (NHEJ) and Chromosomal Translocations in Humans

Lieber, M. R., Gu, J., Lu, H., Shimazaki, N., & Tsai, A. G. (2009) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-3471-7_14 · Cited by 153

The endless tale of non-homologous end-joining

Weterings, E., & Chen, D. J. (2008) · Cell Research · doi:10.1038/cr.2008.3 · Cited by 418

The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination

Lieber, M. R., Ma, Y., Pannicke, U., & Schwarz, K. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.015 · Cited by 225

Non-homologous DNA end joining and alternative pathways to double-strand break repair

Chang, H. H. Y., Pannunzio, N. R., Adachi, N., & Lieber, M. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.48 · Cited by 1,757