The endless tale of non-homologous end-joining

Genome maintenance mechanisms for preventing cancer

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DNA double-strand breaks: signaling, repair and the cancer connection

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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Chromosomal stability and the DNA double-stranded break connection

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Regulation of p53 in response to DNA damage

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Artemis, a Novel DNA Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated in Human Severe Combined Immune Deficiency

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The DNA-dependent protein kinasePreprint

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XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining

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V(D)J Recombination: RAG Proteins, Repair Factors, and Regulation

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Cernunnos, a Novel Nonhomologous End-Joining Factor, Is Mutated in Human Immunodeficiency with Microcephaly

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Regulation and mechanisms of mammalian double-strand break repair

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DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

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Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaksPreprint

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Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

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Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4

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Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

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Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends

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Repair of DNA double strand breaks by non-homologous end joining

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Synapsis of DNA ends by DNA‐dependent protein kinase

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A Biochemically Defined System for Mammalian Nonhomologous DNA End Joining

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DNA‐PK autophosphorylation facilitates Artemis endonuclease activity

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A Gradient of Template Dependence Defines Distinct Biological Roles for Family X Polymerases in Nonhomologous End Joining

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Interaction of DNA‐dependent protein kinase with DNA and with Ku: biochemical and atomic‐force microscopy studies

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Autophosphorylation of the Catalytic Subunit of the DNA-Dependent Protein Kinase Is Required for Efficient End Processing during DNA Double-Strand Break Repair

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Cell Cycle Dependence of DNA-dependent Protein Kinase Phosphorylation in Response to DNA Double Strand Breaks

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Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining

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DNA Ligases: Structure, Reaction Mechanism, and Function

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Ataxia Telangiectasia Mutated (ATM) Is Essential for DNA-PKcs Phosphorylations at the Thr-2609 Cluster upon DNA Double Strand Break

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Association of DNA Polymerase μ (pol μ) with Ku and Ligase IV: Role for pol μ in End-Joining Double-Strand Break Repair

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Leaky Scid Phenotype Associated with Defective V(D)J Coding End Processing in Artemis-Deficient Mice

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Autophosphorylation of DNA-Dependent Protein Kinase Regulates DNA End Processing and May Also Alter Double-Strand Break Repair Pathway Choice

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Nuclear Retention of ATM at Sites of DNA Double Strand Breaks

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Involvement of human polynucleotide kinase in double‐strand break repair by non‐homologous end joining

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Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

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Crystal structure of an Xrcc4-DNA ligase IV complex.

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Structure of an XRCC1 BRCT domain: a new protein–protein interaction module

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Mapping of protein-protein interactions within the DNA-dependent protein kinase complex

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Implication of DNA Polymerase λ in Alignment-based Gap Filling for Nonhomologous DNA End Joining in Human Nuclear Extracts

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The C Terminus of Ku80 Activates the DNA-Dependent Protein Kinase Catalytic Subunit

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Structure and function of mammalian DNA ligases

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Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends

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trans Autophosphorylation at DNA-Dependent Protein Kinase's Two Major Autophosphorylation Site Clusters Facilitates End Processing but Not End Joining

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Nonhomologous end joining and V(D)J recombination require an additional factor

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Crystal structure of the Xrcc4 DNA repair protein and implications for end joining

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XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps

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DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains

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Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK

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Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends

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Non-homologous End Joining Requires That the DNA-PK Complex Undergo an Autophosphorylation-dependent Rearrangement at DNA Ends

Reddy, Y. V. R., Ding, Q., Lees‐Miller, S. P., Meek, K., & Ramsden, D. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406432200 · Cited by 136 · see citing works

Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence

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Structural model of full‐length human Ku70–Ku80 heterodimer and its recognition of DNA and DNA‐PKcs

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The DNA-Dependent Protein Kinase Catalytic Subunit Is Phosphorylated In Vivo on Threonine 3950, a Highly Conserved Amino Acid in the Protein Kinase Domain

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The role of DNA dependent protein kinase in synapsis of DNA ends

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DNA-PKcs Dependence of Artemis Endonucleolytic Activity, Differences between Hairpins and 5′ or 3′ Overhangs

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Defining interactions between DNA-PK and ligase IV/XRCC4

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DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

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The DNA-dependent Protein Kinase Catalytic Activity Regulates DNA End Processing by Means of Ku Entry into DNA

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Processing of 3′-Phosphoglycolate-terminated DNA Double Strand Breaks by Artemis Nuclease

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DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining

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Association of terminal deoxynucleotidyl transferase with Ku

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DNA Ligase IV and XRCC4 Form a Stable Mixed Tetramer That Functions Synergistically with Other Repair Factors in a Cell-free End-joining System

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Tetramerization and DNA Ligase IV Interaction of the DNA Double-strand Break Repair Protein XRCC4 are Mutually Exclusive

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The two edges of the ATM sword: Co-operation between repair and checkpoint functions

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DNA-dependent Protein Kinase-independent Activation of p53 in Response to DNA Damage

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DNA Double-Strand Break Repair: A Relentless Hunt Uncovers New Prey

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Ageing or cancer: A review

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Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation.

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Processing of DNA for Nonhomologous End-joining Is Controlled by Kinase Activity and XRCC4/Ligase IV

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Modulation of Terminal Deoxynucleotidyltransferase Activity by the DNA-Dependent Protein Kinase

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A central region of Ku80 mediates interaction with Ku70 in vivo

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Functions and regulation of human artemis in double strand break repair

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Electron microscopy reconstructions of DNA repair complexes

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Mechanisms of DNA damage, repair, and mutagenesis

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Complex landscapes of somatic rearrangement in human breast cancer genomes

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Ionizing Radiation-Induced DNA Damage, Response, and Repair

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Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica

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ATM and Artemis promote homologous recombination of radiation‐induced DNA double‐strand breaks in G2

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Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells

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DNA double strand break repair via non-homologous end-joining.

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The MRN complex in double‐strand break repair and telomere maintenance

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CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy

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The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer

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Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

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Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition

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Selenium: a double-edged sword for defense and offence in cancer

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DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

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Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4–ligase IV during chromosomal translocation formation

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Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up

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