The DOI matches its Crossref record; 202 of the 202 references it cites were found in a registry or an index.
Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes
Abstract
▪ Abstract DNA repair is crucial to the well-being of all organisms from unicellular life forms to humans. A rich tapestry of mechanistic studies on DNA repair has emerged thanks to the recent discovery of Y-family DNA polymerases. Many Y-family members carry out aberrant DNA synthesis—poor replication accuracy, the favored formation of non-Watson-Crick base pairs, efficient mismatch extension, and most importantly, an ability to replicate through DNA damage. This review is devoted primarily to a discussion of Y-family polymerase members that exhibit error-prone behavior. Roles for these remarkable enzymes occur in widely disparate DNA repair pathways, such as UV-induced mutagenesis, adaptive mutation, avoidance of skin cancer, and induction of somatic cell hypermutation of immunoglobulin genes. Individual polymerases engaged in multiple repair pathways pose challenging questions about their roles in targeting and trafficking. Macromolecular assemblies of replication-repair “factories” could enable a cell to handle the complex logistics governing the rapid migration and exchange of polymerases.
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“Translesion synthesis (TLS) polymerases copy past lesions in DNA that block the major replicative polymerases (7)(8)(9)(10)(11).”
From DNA Replication Fidelity (2004) · cites this paper as [7]
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Cites
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Self-citation
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Friedberg, E. C. (2003) · Nature · doi:10.1038/nature01408 · Cited by 1,177
Proliferating cell nuclear antigen (PCNA): a dancer with many partners
Maga, G., & Hübscher, U. (2003) · Journal of Cell Science · doi:10.1242/jcs.00653 · Cited by 1,121
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Pfeifer, G. P., You, Y., & Nia, A. B. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.06.057 · Cited by 798
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Metadata
- Authors
- Goodman, M. F.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Goodman, Myron F.
- ORCID
- Goodman, Myron F.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2002-06
- Volume
- 71
- Issue
- 1
- Pages
- 17-50
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2142513910
- Cited by
- 727
- References
- 202
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 6 · 2020: 14 · 2019: 13 · 2018: 17 · 2017: 18 · 2016: 14 · 2015: 17 · 2014: 30 · 2013: 36 · 2012: 36
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ag017179-03, 5r01gm042554-13)
- National Institute on Aging (AG17179)
- National Institute of General Medical Sciences (GM 42554, GM 21422)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Y-family DNA polymerases, error-prone DNA replication, DNA repair, mismatch extension, UV mutagenesis, adaptive mutation, skin cancer prevention, immunoglobulin genes
- MeSH terms
- Animals, DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, DNA Replication, Escherichia coli, Eukaryotic Cells, Humans, Models, Genetic, Mutation, Nuclear Proteins, SOS Response, Genetics, Protein Structure, Tertiary, Somatic Hypermutation, Immunoglobulin
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