The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Hox Genes and Segmentation of the Hindbrain and Axial Skeleton
Abstract
Segmentation is an important process that is frequently used during development to segregate groups of cells with distinct features. Segmental compartments provide a mechanism for generating and organizing regional properties along an embryonic axis and within tissues. In vertebrates the development of two major systems, the hindbrain and the paraxial mesoderm, displays overt signs of compartmentalization and depends on the process of segmentation for their functional organization. The hindbrain plays a key role in regulating head development, and it is a complex coordination center for motor activity, breathing rhythms, and many unconscious functions. The paraxial mesoderm generates somites, which give rise to the axial skeleton. The cellular processes of segmentation in these two systems depend on ordered patterns of Hox gene expression as a mechanism for generating a combinatorial code that specifies unique identities of the segments and their derivatives. In this review, we compare and contrast the signaling inputs and transcriptional mechanisms by which Hox gene regulatory networks are established during segmentation in these two different systems.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Retinoic acid in development: Towards an integrated view
Niederreither, K., & Dollé, P. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2340 · Cited by 726
McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1999) · Nature Genetics · doi:10.1038/10320 · Cited by 471
A Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock
Dequéant, M.-L., Glynn, E., Gaudenz, K., Wahl, M., Chen, J., Mushegian, A., & Pourquié, O. (2006) · Science · doi:10.1126/science.1133141 · Cited by 460
Retinoid signalling in the development of the central nervous system
Maden, M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn963 · Cited by 428
Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development
Hernandez, R. E., Putzke, A. P., Myers, J. P., Margaretha, L., & Moens, C. B. (2007) · Development · doi:10.1242/dev.02706 · Cited by 245
Hox genes specify vertebral types in the presomitic mesoderm
Carapuço, M., Nóvoa, A., Bobola, N., & Mallo, M. (2005) · Genes & Development · doi:10.1101/gad.338705 · Cited by 226 · cited 2×
“Strengthening the argument that Hox genes function in the PSM to assign axial identity to the somites, it has been demonstrated that overexpression of Hoxa10 in the PSM and newly formed somites results in homeotic transformations within the vertebral column (Carapuco et al. 2005).”
BackgroundTümpel, S., Cambronero, F., Ferretti, E., Blasi, F., Wiedemann, L. M., & Krumlauf, R. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2006.10.029 · Cited by 79
Self-citation
Cited by
Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells
Zuin, J., Dixon, J. R., van der Reijden, M. I. J. A., Ye, Z., Kolovos, P., Brouwer, R. W. W., van de Corput, M. P. C., van de Werken, H. J. G., Knoch, T. A., van IJcken, W. F. J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317788111 · Cited by 779
Hox Genes: Choreographers in Neural Development, Architects of Circuit Organization
Philippidou, P., & Dasen, J. S. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.020 · Cited by 423
Assembly and function of spinal circuits for motor control
Catela, C., Shin, M. M., & Dasen, J. S. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125155 · Cited by 77
van Eif, V. W. W., Stefanovic, S., Mohan, R. A., & Christoffels, V. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.07.004 · Cited by 30
Höglund, A., Strempfl, K., Fogelholm, J., Wright, D., & Henriksen, R. (2020) · BMC Genomics · doi:10.1186/s12864-020-06908-0 · Cited by 14
Metadata
- Authors
- Alexander, T., Nolte, C., & Krumlauf, R.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2009-11-01
- Volume
- 25
- Issue
- 1
- Pages
- 431-456
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W1972879541
- Cited by
- 298
- References
- 7
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Hox Genes and Segmentation of the Hindbrain and Axial Skeleton. https://app.cochat.ai/papers/10.1146/annurev.cellbio.042308.113423
- The paper
- Alexander, T., Nolte, C., & Krumlauf, R. (2009). Hox Genes and Segmentation of the Hindbrain and Axial Skeleton. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.042308.113423
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
