Cited by 835Proteoglycans and glycosaminoglycans researchWound Healing and TreatmentsHydrogels: synthesis, properties, applications

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Hyaluronan in Tissue Injury and Repair

Jiang, Dianhua, Liang, Jiurong, Noble, Paul W.·2007·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev.cellbio.23.090506.123337

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Abstract

A hallmark of tissue injury and repair is the turnover of extracellular matrix components. This review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair. Both the synthesis and degradation of extracellular matrix are critical contributors to tissue repair and remodeling. Fragmented hyaluronan accumulates during tissue injury and functions in ways distinct from the native polymer. There is accumulating evidence that hyaluronan degradation products can stimulate the expression of inflammatory genes by a variety of immune cells at the injury site. CD44 is the major cell-surface hyaluronan receptor and is required to clear hyaluronan degradation products produced during lung injury; impaired clearance of hyaluronan results in persistent inflammation. However, hyaluronan fragment stimulation of inflammatory gene expression is not dependent on CD44 in inflammatory macrophages. Instead, hyaluronan fragments utilize both Toll-like receptor (TLR) 4 and TLR2 to stimulate inflammatory genes in macrophages. Hyaluronan also is present on the cell surface of lung alveolar epithelial cells and provides protection against tissue damage by interacting with TLR2 and TLR4 on these parenchymal cells. The simple repeating structure of hyaluronan appears to be involved in a number of important aspects of noninfectious tissue injury and repair that are dependent on the size and location of the polymer as well as the interacting cells. Thus, the interactions between the endogenous matrix component hyaluronan and its signaling receptors initiate inflammatory responses, maintain structural cell integrity, and promote recovery from tissue injury.

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Authors: Jiang, D., Liang, J., & Noble, P. W.
Affiliations: Duke University (US)
ORCID: Jiang, Dianhua
Liang, Jiurong
Noble, Paul W.
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2007-11-01
Volume: 23
Issue: 1
Pages: 435-461
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.23.090506.123337
OpenAlex: W2117566184
Cited by: 835
References: 157
Citations by year: 2026: 27 · 2025: 29 · 2024: 27 · 2023: 30 · 2022: 39 · 2021: 33 · 2020: 46 · 2019: 42 · 2018: 49 · 2017: 35 · 2016: 54 · 2015: 45 · 2014: 65 · 2013: 39 · 2012: 60
FWCI: 3.53
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Keywords: hyaluronic acid, tissue damage, tissue repair, extracellular matrix turnover, CD44, lung injury, inflammation, macrophages, TLR4, TLR2, alveolar epithelial cells, glycosaminoglycans, extracellular matrix remodeling
MeSH terms: Hyaluronan Synthases, Animals, Humans, Hyaluronic Acid, Immunity, Regeneration, Glucuronosyltransferase, Wound Healing, Signal Transduction, Hyaluronan Receptors, Toll-Like Receptors

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Hyaluronan in Tissue Injury and Repair

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