The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Hyaluronan in Tissue Injury and Repair
Abstract
A hallmark of tissue injury and repair is the turnover of extracellular matrix components. This review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair. Both the synthesis and degradation of extracellular matrix are critical contributors to tissue repair and remodeling. Fragmented hyaluronan accumulates during tissue injury and functions in ways distinct from the native polymer. There is accumulating evidence that hyaluronan degradation products can stimulate the expression of inflammatory genes by a variety of immune cells at the injury site. CD44 is the major cell-surface hyaluronan receptor and is required to clear hyaluronan degradation products produced during lung injury; impaired clearance of hyaluronan results in persistent inflammation. However, hyaluronan fragment stimulation of inflammatory gene expression is not dependent on CD44 in inflammatory macrophages. Instead, hyaluronan fragments utilize both Toll-like receptor (TLR) 4 and TLR2 to stimulate inflammatory genes in macrophages. Hyaluronan also is present on the cell surface of lung alveolar epithelial cells and provides protection against tissue damage by interacting with TLR2 and TLR4 on these parenchymal cells. The simple repeating structure of hyaluronan appears to be involved in a number of important aspects of noninfectious tissue injury and repair that are dependent on the size and location of the polymer as well as the interacting cells. Thus, the interactions between the endogenous matrix component hyaluronan and its signaling receptors initiate inflammatory responses, maintain structural cell integrity, and promote recovery from tissue injury.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the body, HA interacts with proteins, such as CD44 and Receptor for Hyaluronan Mediated Motility (RHAMM), which play roles in cell signaling, migration, and inflammation (Figure 6) [122,123].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [122]
In the citing paper
“Hyaluronan is also directly recognized by TLR2 and TLR4, and this interaction was shown to have a role in mediating inflammatory responses in a mouse model of sterile bleomycin-induced lung injury102.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [102]
In the citing paper
“Hyaluronan is also directly recognized by TLR2 and TLR4, and this interaction was shown to have a role in mediating inflammatory responses in a mouse model of sterile bleomycin-induced lung injury102.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [102]
In the citing paper
“Hyaluronan fragments, for example, can signal through CD44, leading to MAPK activation102.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [102]
Citations
Cites
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,680
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
CD44 is the principal cell surface receptor for hyaluronate
Aruffo, A. A., Stamenkovic, I., Melnick, M., Underhill, C. B., & Seed, B. (1990) · Cell · doi:10.1016/0092-8674(90)90694-a · Cited by 2,439
Hyaluronan: its nature, distribution, functions and turnover.
Fraser, J. R. E., Laurent, T. C., & Laurent, U. B. G. (1997) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1997.00170.x · Cited by 2,031
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.
Medzhitov, R., Preston-Hurlburt, P., Kopp, E., Stadlen, A., Chen, C.-Q., Ghosh, S., & Janeway, C. (1998) · Molecules and Cells · doi:10.1016/s1097-2765(00)80136-7 · Cited by 1,783
Ohashi, K., Burkart, V., Flohé, S. B., & Kolb, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.558 · Cited by 1,607
LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan
Banerji, S., Ni, J., Wang, S.-X., Clasper, S., Su, J. Y., Tammi, R., Jones, M., & Jackson, D. G. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.4.789 · Cited by 1,586
Research works printed but not linked: 7
- Adamson IY, 1974, Am. J. Pathol., 77, 185
- Bates EJ, 1984, Biochem. Int., 8, 629
- Hance AJ, 1975, Am. Rev. Respir. Dis., 112, 657
- 10.1042/0264-6021:3480029 · DOI
- Mouta Carreira C, 2001, Cancer. Res., 61, 8079
- Olman MA, 1996, Am. J. Physiol., 271, L519
- Slevin M, 1998, Lab. Invest., 78, 987
Cited by
Sorted by citations
Items 801–834 of 834
Islam, A., Bhat, K. A., Ahmad, F., Islam, Z., Syed, J., John, A., Allie, K. A., Shah, A. A., Ayaz, A., & Kaur, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-18776-6.00005-0
Proteoglycans and Hyaluronan in Normal and Aberrant Lung Development
Reszegi, A., Petővári, G., Damisetty, N., Garantziotis, S., & Savani, R. C. (2025) · Proteoglycan Research · doi:10.1002/pgr2.70026
Exploring Endothelial Injury Syndromes: Mechanisms, Markers, and Therapeutic Potential
(2025) · Frontiers research topics · doi:10.3389/978-2-8325-7154-5
Millican, A. A. (2014) · TigerPrints (Clemson University)
Ayten, M., Straub, T., Kaplan, L., Hauck, S. M., Grosche, A., & Koch, S. (2024) · Figshare · doi:10.6084/m9.figshare.26488424
Ayten, M., Straub, T., Kaplan, L., Hauck, S. M., Grosche, A., & Koch, S. (2024) · Figshare · doi:10.6084/m9.figshare.26488355
Effect of a Polynucleotide-Hyaluronic Acid Gel on Mandibular Third-Molar Extraction Discomfort
Ronsivalle, V., Cervino, G., Giudice, R., Santonocito, S., & Cicciù, M. (2025) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000012307
Hyaluronidase for Non-urgent Complications: When to Use It, How to Dose It, How to Inject
Ghasemi, S., & Zeynalzadeh, F. (2025) · Springer eBooks · doi:10.1007/978-3-031-85163-6_21
Kink, J. A., Forsberg, M. H., Krismer, D. M., Thickens, A. S., Chinnadurai, R., Chen, A. S., Chacko, D. J., Graham, M., Hematti, P., & Capitini, C. M. (2025) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szaf068
In Search for Biomarkers Reflecting Neural Implant-Induced Tissue Response DynamicsPreprint
Sharbatian, A., Joseph, K., Hofmann, U., Coenen, V., Stieglitz, T., & Vajari, D. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.19.712876
花林, 雅., & Hanabayashi, M. (2017) · Institutional Repositories DataBase (IRDB)
Caractérisation biochimique et fonctionnelle de l'enzyme HSULF
Seffouh, A. (2016) · theses.fr (ABES) · doi:10.70675/5bf677b8z1ba5z4350z99b3zec619fad83b1
Engineering microchannels for vascularization in bone tissue engineering
Aor, B. (2018) · theses.fr (ABES) · doi:10.70675/f73d9d75z1ee4z4234z9cfaz45d64737b767
Régulation de la cathepsine V par l’héparane-sulfate dans les mucopolysaccharidoses
Chazeirat, T. (2020) · theses.fr (ABES) · doi:10.70675/96a0d1a0zcf8az4a58zb268zd5e4beef4ceb
Li, J., Shi, S., Liu, L., He, Y., Jia, G.-L., Qu, L.-Y., Chi, Z.-C., Leng, J., Xu, H., Lan, T., et al. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71692
Millerand, M. (2020) · theses.fr (ABES) · doi:10.70675/d5e9dae6zd9d7z4a05z8fd2zf0ff4ffab0a6
Ronsivalle, V., Cammarata, U., Perrotta, R. E., Giudice, R., & Cicciù, M. (2026) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000012842
Saving the lung from ozone pollutant: a new role of hyaluronan in alveolar regeneration
Anand, P., Noble, P. W., & Liu, X. (2026) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1093/ajrcmb/aanag100
Self-citationJoshi, V., & Awasthi, R. (2026) · Next Materials · doi:10.1016/j.nxmate.2026.102376
Antioxidant and antiinflammatory bioactivities of eggshell membrane
Shi, Y., Pan, T., Luo, S., & Cheng, T. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27438-1.00010-4
Zhang, F., Liu, Y. H., Liu, R., Li, B., & Li, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1801258
The Role of Hyaluronan in Keloid and Hypertrophic Scar Pathogenesis and Treatment
Shah, J. B., Bhatt, A., Yu, S., Hill, K. A., Turley, E. A., & Symonette, C. J. (2026) · Plastic Surgery · doi:10.1177/22925503261457127
Kuridze, N., Gabunia, L., Gogokhia, N., Ghambashidze, K., Giorgadze, S., Janigashvili, G., Gvajaia, N., & Ratiani, L. (2026) · Revista română de medicină de laborator · doi:10.2478/rrlm-2026-0028
Jia, K., Ning, X., Song, L., & Cao, J. (2026) · Cosmetics · doi:10.3390/cosmetics13040180
Ali, S. A., Qiang, P., Zhou, X., Yang, X., Li, S., Shen, Y., Chen, Z., & Zhang, L. F. (2026) · Biogerontology · doi:10.1007/s10522-026-10476-3
Roztocil, E., Husain, F., Patrick, C. C., Thomas, S. B., Mack, T., Nyborg, A. C., Welch, B. D., Feldon, S. E., & Woeller, C. F. (2026) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgag299
Momeny, M., Hafezi, A. R., Afzal, S., Nouri, M., Zarrabi, M., Gholipourmalekabadi, M., Shafikhani, S. H., & Alizadeh, S. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.153856
Regulation of TMEM2-mediated hyaluronan degradation by CD44 and LYVE-1
Tobisawa, Y., Yano, F., Tomioka-Inagawa, R., Irie, F., Koie, T., & Yamaguchi, Y. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1852012
Tavallali, V., Nekouei, S., Darvishzadeh, M. D., Rahmati, S., & Ghorbanpour, M. (2026) · Surfaces and Interfaces · doi:10.1016/j.surfin.2026.110649
Glycosylation in Quality and Safety of Therapeutic Proteins
Matsumoto, Y., Kim, J., McKenna, K. R., Biel, T. G., Kirshner, S., Falkowski, V. M., & Ju, T. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100163
BindingDB (2023) · UC San Diego · doi:10.7270/q2rr236q
Metadata
- Authors
- Jiang, D., Liang, J., & Noble, P. W.
- Affiliations
- Duke University (US)
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2007-11-01
- Volume
- 23
- Issue
- 1
- Pages
- 435-461
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2117566184
- Cited by
- 835
- References
- 157
- Citations by year
- 2026: 27 · 2025: 29 · 2024: 27 · 2023: 30 · 2022: 39 · 2021: 33 · 2020: 46 · 2019: 42 · 2018: 49 · 2017: 35 · 2016: 54 · 2015: 45 · 2014: 65 · 2013: 39 · 2012: 60
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Keywords
- hyaluronic acid, tissue damage, tissue repair, extracellular matrix turnover, CD44, lung injury, inflammation, macrophages, TLR4, TLR2, alveolar epithelial cells, glycosaminoglycans, extracellular matrix remodeling
- MeSH terms
- Hyaluronan Synthases, Animals, Humans, Hyaluronic Acid, Immunity, Regeneration, Glucuronosyltransferase, Wound Healing, Signal Transduction, Hyaluronan Receptors, Toll-Like Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
