Hyaluronan in Tissue Injury and Repair

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LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan

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Sterile inflammation: sensing and reacting to damage

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Biological roles of glycans

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Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full‐Thickness Skin Regeneration During Wound Healing

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Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

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Hyaluronic acid based scaffolds for tissue engineering—A review

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Hyaluronan as an Immune Regulator in Human Diseases

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Biocompatibility of hydrogel-based scaffolds for tissue engineering applications

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Hyaluronic Acid in the Third Millennium

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Skin anti-aging strategies

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High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat

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A domain swap approach reveals a role of the plant wall-associated kinase 1 (WAK1) as a receptor of oligogalacturonides

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Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications

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Mammalian glycosylation in immunity

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Hyaluronan: A simple polysaccharide with diverse biological functions

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Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

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Macrophage activation by endogenous danger signals

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Hyaluronic acid for anticancer drug and nucleic acid delivery

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Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells

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Proteoglycans: from structural compounds to signaling molecules

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Applications and emerging trends of hyaluronic acid in tissue engineering, as a dermal filler and in osteoarthritis treatment

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Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation

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Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

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Inflammation in intervertebral disc degeneration and regeneration

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Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology

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Myocardial Extracellular Matrix

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Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities

Toole, B. P. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0479 · Cited by 370

DAMPs, MAMPs, and NAMPs in plant innate immunity

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Skin aging from mechanisms to interventions: focusing on dermal aging

Shin, S. H., Lee, Y. H., Rho, N., & Park, K. Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1195272 · Cited by 355

The lymphatic system: integral roles in immunity

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Beyond Tissue Injury—Damage-Associated Molecular Patterns, Toll-Like Receptors, and Inflammasomes Also Drive Regeneration and Fibrosis

Anders, H., & Schaefer, L. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014010117 · Cited by 341

Toll-like receptors as targets in chronic liver diseases

Mencin, A. M., Kluwe, J., & Schwabe, R. F. (2009) · Gut · doi:10.1136/gut.2008.156307 · Cited by 340

Hyaluronan in wound healing: Rediscovering a major player

Aya, K., & Stern, R. (2014) · Wound Repair and Regeneration · doi:10.1111/wrr.12214 · Cited by 339

Hyaluronan: Biosynthesis and signaling

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Organ-on-a-chip platforms: a convergence of advanced materials, cells, and microscale technologies

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Macrophage-based therapeutic strategies in regenerative medicine

Spiller, K. L., & Koh, T. J. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.010 · Cited by 310

The High and Low Molecular Weight Forms of Hyaluronan Have Distinct Effects on CD44 Clustering

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Regenerative Therapies for Central Nervous System Diseases: a Biomaterials Approach

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Oxidative stress in biological systems and its relation with pathophysiological functions: the effect of physical activity on cellular redox homeostasis

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NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury

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Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice

Liang, J., Zhang, Y., Xie, T., Liu, N., Chen, H., Geng, Y., Kurkciyan, A., Mena, J. M., Stripp, B. R., Jiang, D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4192 · Cited by 287

4-Methylumbelliferone Treatment and Hyaluronan Inhibition as a Therapeutic Strategy in Inflammation, Autoimmunity, and Cancer

Nagy, N., Kuipers, H. F., Frymoyer, A. R., Ishak, H. D., Bollyky, J., Wight, T. N., & Bollyky, P. L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00123 · Cited by 288

Patterning network structure to spatially control cellular remodeling and stem cell fate within 3-dimensional hydrogels

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Chemical Synthesis of Glycosaminoglycans

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Glycointeractions in bacterial pathogenesis

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Biological interplay between proteoglycans and their innate immune receptors in inflammation

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The Role of CD44 in Disease Pathophysiology and Targeted Treatment

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Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?

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Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions

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Oxidative depolymerization of polysaccharides by reactive oxygen/nitrogen species

Duan, J., & Kasper, D. L. (2011) · Glycobiology · doi:10.1093/glycob/cwq171 · Cited by 267

Hyaluronic Acid and Its Derivatives in Coating and Delivery Systems: Applications in Tissue Engineering, Regenerative Medicine and Immunomodulation

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Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

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Hyaluronidase: An overview of its properties, applications, and side effects

Jung, H. (2020) · Archives of Plastic Surgery · doi:10.5999/aps.2020.00752 · Cited by 253

The role of hyaluronan in wound healing

Frenkel, J. S. (2012) · International Wound Journal · doi:10.1111/j.1742-481x.2012.01057.x · Cited by 255

Hyaluronidase with pH‐responsive Dextran Modification as an Adjuvant Nanomedicine for Enhanced Photodynamic‐Immunotherapy of Cancer

Wang, H., Han, X., Dong, Z., Xu, J., Wang, J., & Liu, Z. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201902440 · Cited by 243

Hyaluronan as a therapeutic target in human diseases

Liang, J., Jiang, D., & Noble, P. W. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.017 · Cited by 245

Biomaterials for cell transplantation

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Comparative genetics of longevity and cancer: insights from long-lived rodents

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Guiding Lights: Tissue Bioprinting Using Photoactivated Materials

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Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis

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Extracellular matrix regulation of inflammation in the healthy and injured spinal cord

Gaudet, A. D., & Popovich, P. G. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.11.020 · Cited by 227

Hyaluronan: A constitutive regulator of chemoresistance and malignancy in cancer cells

Toole, B. P., & Slomiany, M. G. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.03.009 · Cited by 224

Advanced glycoxidation products and impaired diabetic wound healing

Peppa, Μ., Stavroulakis, P., & Raptis, S. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00518.x · Cited by 220

Development of Injectable Hyaluronic Acid/Cellulose Nanocrystals Bionanocomposite Hydrogels for Tissue Engineering Applications

Domingues, R. M. A., Silva, M., Гершович, П. М., Betta, S., Babo, P. S., Caridade, S. G., Mano, J. F., Motta, A., Reis, R. L., & Gomes, M. E. (2015) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5b00209 · Cited by 214

The Extracellular Matrix: Its Composition, Function, Remodeling, and Role in Tumorigenesis

Dzobo, K., & Dandara, C. (2023) · Biomimetics · doi:10.3390/biomimetics8020146 · Cited by 228

Hydrogel scaffolds as in vitro models to study fibroblast activation in wound healing and disease

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An injectable drug delivery platform for sustained combination therapy

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Best Practices for Preparing a Single Cell Suspension from Solid Tissues for Flow Cytometry

Reichard, A., & Asosingh, K. (2019) · Cytometry Part A · doi:10.1002/cyto.a.23690 · Cited by 201

Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis

Ghatak, S., Maytin, E. V., Mack, J. A., Hascall, V., Atanelishvili, I., Moreno‐Rodriguez, R. A., Markwald, R. R., & Misra, S. (2015) · International Journal of Cell Biology · doi:10.1155/2015/834893 · Cited by 208

Absorption, distribution, metabolism and excretion of the biomaterials used in Nanocarrier drug delivery systems

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Hydrolytically Degradable Hyaluronic Acid Hydrogels with Controlled Temporal Structures

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Intrathecal delivery of a polymeric nanocomposite hydrogel after spinal cord injury

Baumann, M. D., Kang, C. E., Tator, C. H., & Shoichet, M. S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.004 · Cited by 191

Hyaluronan, Inflammation, and Breast Cancer Progression

Schwertfeger, K. L., Cowman, M. K., Telmer, P. G., Turley, E. A., & McCarthy, J. B. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00236 · Cited by 188

Chemical functionalization of hyaluronic acid for drug delivery applications

Vasi, A.-M., Popa, M., Butnaru, M., Dodi, G., & Vereștiuc, L. (2014) · Materials Science and Engineering C · doi:10.1016/j.msec.2014.01.052 · Cited by 188

Sequential crosslinking to control cellular spreading in 3-dimensional hydrogels

Khetan, S., Katz, J. S., & Burdick, J. A. (2009) · Soft Matter · doi:10.1039/b820385g · Cited by 185

Hyaluronan – A Functional and Structural Sweet Spot in the Tissue Microenvironment

Monslow, J., Govindaraju, P. K., & Puré, E. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00231 · Cited by 184

Endothelial Glycocalyx Impairment in Disease

Dogné, S., & Flamion, B. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.11.016 · Cited by 184

Hyaluronan, CD44 and Emmprin: Partners in cancer cell chemoresistance

Toole, B. P., & Slomiany, M. G. (2008) · Drug Resistance Updates · doi:10.1016/j.drup.2008.04.002 · Cited by 188

Low Molecular Weight Hyaluronic Acid Increases the Self-Defense of Skin Epithelium by Induction of β-Defensin 2 via TLR2 and TLR4

Gariboldi, S., Palazzo, M., Zanobbio, L., Selleri, S., Sommariva, M., Sfondrini, L., Cavicchini, S., Balsari, A., & Rumio, C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.2103 · Cited by 180

A review on biocompatibility nature of hydrogels with 3D printing techniques, tissue engineering application and its future prospective

Saroia, J., Yanen, W., Wei, Q., Zhang, K., Lu, T., & Zhang, B. (2018) · Bio-Design and Manufacturing · doi:10.1007/s42242-018-0029-7 · Cited by 181

Activation of immune signals during organ transplantation

Li, Q., & Lan, P. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01377-9 · Cited by 175

Synergistic anabolic actions of hyaluronic acid and platelet-rich plasma on cartilage regeneration in osteoarthritis therapy

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Hyaluronic acid in the treatment of dry eye disease

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Molecular size hyaluronan differently modulates toll-like receptor-4 in LPS-induced inflammation in mouse chondrocytes

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Small hyaluronan oligosaccharides induce inflammation by engaging both toll-like-4 and CD44 receptors in human chondrocytes

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Neural stem cell niches: Roles for the hyaluronan-based extracellular matrix

Preston, M. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/218 · Cited by 160

Mammalian N-Glycan Branching Protects against Innate Immune Self-Recognition and Inflammation in Autoimmune Disease Pathogenesis

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Toll-like Receptor 4 and Hepatic Fibrogenesis

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CD44 Costimulation Promotes FoxP3+ Regulatory T Cell Persistence and Function via Production of IL-2, IL-10, and TGF-β

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The Double Life of Group B Streptococcus: Asymptomatic Colonizer and Potent Pathogen

Armistead, B., Oler, E., Waldorf, K. M. A., & Rajagopal, L. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.01.035 · Cited by 164

TLR4 Activity Is Required in the Resolution of Pulmonary Inflammation and Fibrosis after Acute and Chronic Lung Injury

Yang, H.-Z., Wang, J.-P., Mi, S., Liu, H.-Z., Cui, B., Yan, H.-M., Yan, J., Li, Z., Liu, H., Hua, F., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.09.019 · Cited by 155

Extracellular Matrix Dynamics and Fetal Membrane Rupture

Strauss, J. F. (2012) · Reproductive Sciences · doi:10.1177/1933719111424454 · Cited by 156

Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?

Goto, M. (2008) · PubMed · Cited by 154

Review: Manipulating the extracellular matrix and its role in brain and spinal cord plasticity and repair

Burnside, E. R., & Bradbury, E. J. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12114 · Cited by 161

High and Low Molecular Weight Hyaluronic Acid Differentially Regulate Human Fibrocyte Differentiation

Maharjan, A. S., Pilling, D., & Gomer, R. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026078 · Cited by 156

The danger from within: alarmins in arthritis

Nefla, M., Holzinger, D., Berenbaum, F., & Jacques, C. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.162 · Cited by 158

Hyaluronan oligosaccharides are potential stimulators to angiogenesis via RHAMM mediated signal pathway in wound healing

Gao, F., Yang, C. X., Mo, W., Liu, Y. W., & He, Y.-Q. (2008) · Clinical and investigative medicine · doi:10.25011/cim.v31i3.3467 · Cited by 150

Extracellular DAMPs in Plants and Mammals: Immunity, Tissue Damage and Repair

Lorenzo, G. D., Ferrari, S., Cervone, F., & Okun, E. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.09.006 · Cited by 148

Inducible Innate Resistance of Lung Epithelium to Infection

Evans, S. E., Xu, Y., Tuvim, M. J., & Dickey, B. F. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135909 · Cited by 148

Hyaluronan: Towards novel anti-cancer therapeutics

Karbownik, M. S., & Nowak, J. Z. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71465-8 · Cited by 142

Matrix Regulation of Lung Injury, Inflammation, and Repair: The Role of Innate Immunity

Noble, P. W., & Jiang, D. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200604-097aw · Cited by 107

Matrix Regulation of Lung Injury, Inflammation, and Repair

Noble, P. W., & Jiang, D. (2012) · Proceedings of the American Thoracic Society · Cited by 1

Hyaluronan as an Immune Regulator in Human Diseases

Jiang, D., Liang, J., & Noble, P. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00052.2009 · Cited by 1,060

Regulation of lung injury and repair by Toll-like receptors and hyaluronan

Jiang, D., Liang, J., Fan, J., Yu, S., Chen, S., Luo, Y., Prestwich, G. D., Mascarenhas, M. M., Garg, H. G., Quinn, D. A., et al. (2005) · Nature Medicine · doi:10.1038/nm1315 · Cited by 1,401

Hyaluronan Fragments Stimulate Endothelial Recognition of Injury through TLR4

Taylor, K. R., Trowbridge, J. M., Rudisill, J. A., Termeer, C. C., Simon, J. C., & Gallo, R. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310859200 · Cited by 545