The DOI matches its Crossref record; 185 of the 185 references it cites were found in a registry or an index.
Control and Biochemical Nature of the Ecdysteroidogenic Pathway
Abstract
Molting is elicited by a critical titer of ecdysteroids that includes the principal molting hormone, 20-hydroxyecdysone (20E), and ecdysone (E), which is the precursor of 20E but also has morphogenetic roles of its own. The prothoracic glands are the predominate source of ecdysteroids, and the rate of synthesis of these polyhydroxylated sterols is critical for molting and metamorphosis. This review concerns three aspects of ecdysteroidogenesis: (a) how the brain neuropeptide prothoracicotropic hormone (PTTH) initiates a transductory cascade in cells of the prothoracic gland, which results in an increased rate of ecdysteroid biosynthesis (upregulation); (b) how the concentrations of 20E in the hemolymph feed back on the prothoracic gland to decrease rates of ecdysteroidogenesis (downregulation); and (c) how the prothoracic gland cells convert cholesterol to the precursor of E and then 20E, a series of reactions only now being understood because of the use of a combination of classical biochemistry and molecular genetics.
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“On the other hand, plants produce ECs via mevalonic acid (MVA) and cholesterol [21,22,115,116].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [115]
In the citing paper
“Additionally, invertebrates cannot synthesize ECs; rather, they consume phytosterols and convert them into ECs.”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [115]
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“ECDYSTEROIDS are produced by the PROTHORACIC GLANDS and released into the HAEMOLYMPH , primarily as α-ecdysone (αE), which is then converted by peripheral tissues to the biologically active form, 20E (Ref”
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Metadata
- Authors
- Gilbert, L. I., Rybczynski, R., & Warren, J. T.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- Annual Review of Entomology
- Publisher
- Annual Reviews
- Published
- 2002-01
- Volume
- 47
- Issue
- 1
- Pages
- 883-916
- ISSN
- 0066-4170 (ISSN-L)
- 1545-4487
- OpenAlex
- W2157228103
- Cited by
- 532
- References
- 185
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 16 · 2023: 14 · 2022: 14 · 2021: 21 · 2020: 32 · 2019: 20 · 2018: 11 · 2017: 13 · 2016: 20 · 2015: 21 · 2014: 31 · 2013: 28 · 2012: 26
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Entomology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- ecdysteroid biosynthesis, 20-hydroxyecdysone, ecdysone, prothoracic gland, prothoracicotropic hormone, molting, metamorphosis, cholesterol conversion, steroidogenesis, insect endocrinology
- MeSH terms
- Animals, Insecta, Down-Regulation, Ecdysteroids
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