Insights into the molecular basis of the hormonal control of molting and metamorphosis from Manduca sexta and Drosophila melanogaster

Riddiford, Lynn M; Hiruma, Kiyoshi; Zhou, Xiaofeng; Nelson, Charles A

doi:10.1016/j.ibmb.2003.06.001

Cited by 547Neurobiology and Insect Physiology ResearchDevelopmental Biology and Gene RegulationInsect Resistance and Genetics

Insights into the molecular basis of the hormonal control of molting and metamorphosis from Manduca sexta and Drosophila melanogaster

Riddiford, Lynn M, Hiruma, Kiyoshi, Zhou, Xiaofeng, Nelson, Charles A·2003·Insect Biochemistry and Molecular Biology

DOI 10.1016/j.ibmb.2003.06.001

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Abstract

This short review summarizes our current knowledge about the role of transcription factors regulated by ecdysteroids and juvenile hormone (JH) in larval molting and metamorphosis in the tobacco hornworm, Manduca sexta, and Drosophila melanogaster. We show new evidence that EcR-A/USP-2 and E75A contribute to the down-regulation of MHR3 after the peak of ecdysteroid. Also, there is suggestive evidence that both MHR4 and betaFTZ-F1 may regulate the expression of dopa decarboxylase as the ecdysteroid titer declines. We summarize the regulation by JH of the Broad transcription factor that normally appears in the epidermis in the final larval instar and specifies pupal cuticle formation at the metamorphic molt. Premature expression of different Broad isoforms also is shown to cause precocious degeneration of the prothoracic glands as well as to prevent ecdysteroid release during its presence.

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The EcR/USP complex binds to ecdysone response elements (EcRE) to regulate 20E-responsive gene transcription, such as HR3.
“This complex binds to ecdysone response elements (EcRE) to regulate 20E-responsive gene transcription [36], such as hormone receptor 3 (HR3), an early-late gene in the 20E pathway [38].”
From G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone (2020) · cites this paper as [36]
20E initiates insect larval molting from one instar to the next and metamorphic molting from larva to adult.
“20-hydroxyecdysone (20E), which is also known as the insect molting hormone, initiates insect larval molting from one instar to the next (molting), or the metamorphic molting from larva to adult (metamorphosis) [35, 36].”
From G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone (2020) · cites this paper as [36]

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Authors: Riddiford, L. M., Hiruma, K., Zhou, X., & Nelson, C. A.
Affiliations: University of Washington (US)
Corresponding author: Riddiford, Lynn M
ORCID: Riddiford, Lynn M
Venue: Insect Biochemistry and Molecular Biology
Publisher: Elsevier BV
Published: 2003-12
Volume: 33
Issue: 12
Pages: 1327-1338
ISSN: 0965-1748 (ISSN-L)
DOI: 10.1016/j.ibmb.2003.06.001
OpenAlex: W2019125169
Cited by: 547
References: 94
Citations by year: 2026: 11 · 2025: 15 · 2024: 16 · 2023: 11 · 2022: 22 · 2021: 39 · 2020: 29 · 2019: 27 · 2018: 19 · 2017: 30 · 2016: 29 · 2015: 29 · 2014: 33 · 2013: 25 · 2012: 27
FWCI: 1.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Insect Biochemistry and Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
National Institutes of Health
National Institute of General Medical Sciences (R01GM060122, GM 60122)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
Keywords: molting, metamorphosis, ecdysteroids, juvenile hormone, transcription factors, Manduca sexta, Drosophila melanogaster, aromatic L-amino acid decarboxylase, prothoracic gland, precocious metamorphosis
MeSH terms: Animals, Drosophila melanogaster, Insect Hormones, Larva, Metamorphosis, Biological, Pupa, Transcription Factors, Manduca, Gene Expression Regulation, Developmental, Molting

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Insights into the molecular basis of the hormonal control of molting and metamorphosis from Manduca sexta and Drosophila melanogaster

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