Cited by 714Genomics and Phylogenetic StudiesChromosomal and Genetic VariationsGenome Rearrangement Algorithms

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RESTRICTION AND MODIFICATION SYSTEMS

Wilson, Geoffrey G., Murray, Noreen E.·1991·Annual Review of Genetics

DOI 10.1146/annurev.ge.25.120191.003101

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Abstract

Orthologs and paralogs are two fundamentally different types of homologous genes that evolved, respectively, by vertical descent from a single ancestral gene and by duplication. Orthology and paralogy are key concepts of evolutionary genomics. A ...Read More

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DNA Restriction Enzyme from E. coli
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“An early example is the restriction modification system (Luria, 1953; Wilson, 1991), and more recently, the CRISPR–Cas9 system (Jansen et al., 2002; Horvath and Barrangou, 2010).”
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“The last gene of this transcription unit encodes HsdS, the specificity subunit of a type I restriction/modification (R/M) system (58).”
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Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression inCampylobacter jejunistrain NCTC11168
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Background
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The Battle between Bacteria and Bacteriophages: A Conundrum to Their Immune System
Teklemariam, A. D., Al-Hindi, R. R., Qadri, I., Alharbi, M. G., Ramadan, W. S., Ayubu, J., Al-Hejin, A. M., Hakim, R. F., Hakim, F. F., Hakim, R. F., et al. (2023) · Antibiotics · doi:10.3390/antibiotics12020381 · Cited by 52
Phage-Encoded Colanic Acid-Degrading Enzyme Permits Lytic Phage Infection of a Capsule-Forming Resistant Mutant Escherichia coli Strain
Kim, M. S., Kim, Y. D., Hong, S. S., Park, K., Ko, K. S., & Myung, H. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.02606-14 · Cited by 52
“The latter may involve restriction modification or the CRISPR (clustered regularly interspaced short palindromic repeat)-Cas (CRISPR-associated) system (10, 12, 13).”
Background
Cloning and sequence analysis of the genes coding for Eco57l type IV restriction-modification enzymes
Janulaitis, A., Vaisvila, R., Timinskas, A., Klimašauskas, S., & Butkus, V. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.22.6051 · Cited by 52
Crystal structure of Rv2118c: an AdoMet-dependent methyltransferase from Mycobacterium tuberculosis H37Rv
Gupta, A., Kumar, P. H., Dineshkumar, T. K., Varshney, U., & Subramanya, H. S. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4935 · Cited by 52
The significance of distance and orientation of restriction endonuclease recognition sites in viral DNA genomes
Krüger, D. H., Kupper, D., Meisel, A., Reuter, M., & Schroeder, C. (1995) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1995.tb00200.x · Cited by 52
Stopped-Flow Kinetics of Methyl Group Transfer between the Corrinoid-Iron-Sulfur Protein and Acetyl-Coenzyme A Synthase from Clostridium t hermoaceticum
Tan, X. S., Sewell, C., & Lindahl, P. A. (2002) · Journal of the American Chemical Society · doi:10.1021/ja016676r · Cited by 52
Characterization of an Extremely Thermostable Restriction Enzyme, Psp GI, from a Pyrococcus Strain and Cloning of the Psp GI Restriction-Modification System in Escherichia coli
Morgan, R., Xiao, J.-P., & Xu, S.-Y. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3669-3673.1998 · Cited by 52
“Among the cloned restriction endonucleases, some enzymes with the same or related DNA recognition sequences have similar amino acid sequences (30 to 100% identity) (30).”
Background
High-resolution crystal structure of the restriction-modification controller protein C.AhdI from Aeromonas hydrophila
McGeehan, J. E., Streeter, S. D., Papapanagiotou, I., Fox, G. C., & Kneale, G. G. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.12.025 · Cited by 51
“Non-specific DNA binding has been shown to modulate the Lac system regulation by affecting ( 1 ) the thermodynamic equilibrium by the reduction of free protein in solution, (2) the kinetics of the system by increasing operator target location from diffusion alone (e.g.”
Background
Transcriptome Analysis of Adaptive Heat Shock Response of Streptococcus thermophilus
Li, J., Bi, Y.-T., Dong, C., Yang, J., & Liang, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025777 · Cited by 51
“The general function of the restriction-modification system implicates in cellular defense and represents a barrier against foreign DNA through destroying them [25].”
Background
Restriction enzymes and their use in molecular biology: An overview
Felice, F. D., Micheli, G., & Camilloni, G. (2019) · Journal of Biosciences · doi:10.1007/s12038-019-9856-8 · Cited by 50
Homologous Recombination Drives Both Sequence Diversity and Gene Content Variation in Neisseria meningitidis
Kong, Y., Ma, J. H., Warren, K., Tsang, R. S. W., Low, D. E., Jamieson, F., Alexander, D. C., & Hao, W. (2013) · Genome Biology and Evolution · doi:10.1093/gbe/evt116 · Cited by 49
“The restriction and modification system (RMS) in bacteria generally consists of a sequence-specific restriction enzyme (restriction endonuclease) and a modification enzyme (methyltransferase) encoded by adjacent genes on the chromosome (Wilson and Murray 1991).”
Background
Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate‐based restriction system in S almonella
Cao, B., Cheng, Q., Gu, C., Yao, F., DeMott, M. S., Zheng, X., Deng, Z., Dedon, P. C., & You, D. (2014) · Molecular Microbiology · doi:10.1111/mmi.12692 · Cited by 49
“M systems are based on DNA nucleobase modifications until the recent discovery of the PT-dependent restriction system in bacteria (Xu et al., 2010).”
Background
Restriction enzymes in cells, not eppendorfs
King, G., & Murray, N. E. (1994) · Trends in Microbiology · doi:10.1016/0966-842x(94)90649-1 · Cited by 49
Self-citation
The eco72IC gene specifies a trans-acting factor which influences expression of both DNA methyltransferase and endonuclease from the Eco72I restriction-modification system
Rimšelienė, R., Vaisvila, R., & Janulaitis, A. (1995) · Gene · doi:10.1016/0378-1119(94)00794-s · Cited by 49
The domains of a type I DNA methyltransferase
Cooper, L. P., & Dryden, D. T. F. (1994) · Journal of Molecular Biology · doi:10.1016/0022-2836(94)90008-6 · Cited by 49
The Type IIB restriction endonucleases
Marshall, J. J. T., & Halford, S. E. (2010) · Biochemical Society Transactions · doi:10.1042/bst0890410 · Cited by 48
Translocation and specific cleavage of bacteriophage T7 DNA in vivo by Eco KI
García, L. R., & Molineux, I. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12430 · Cited by 48
High efficiency, restriction-deficientin vitropackaging extracts for bacteriophage lambda DNA using a newE.colilysogen
Gunther, E. J., Murray, N. E., & Glazer, P. M. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.16.3903 · Cited by 48
Self-citation
Genome-wide analysis of restriction-modification system in unicellular and filamentous cyanobacteria
Zhao, F., Zhang, X., Liang, C., Wu, J., Bao, Q., & Qin, S. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00255.2005 · Cited by 47
“In Type I RM system, HsdR, HsdM, and HsdS form a complex (R2M2S1) to perform both endonuclease and MTase activities (4, 34, 55).”
BackgroundMethodInfluential
A game of resistance: War between bacteria and phages and how phage cocktails can be the solution
Costa, P., Pereira, C., Romalde, J. L., & Almeida, A. (2024) · Virology · doi:10.1016/j.virol.2024.110209 · Cited by 49
Evasion of type I and type II DNA restriction systems by Incl1 plasmid Collb‐P9 during transfer by bacterial conjugation
Read, T. D., Thomas, A. T., & Wilkins, B. M. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb01366.x · Cited by 47
Evidence of Horizontal Transfer of the Eco O109I Restriction-Modification Gene to Escherichia coli Chromosomal DNA
Kita, K., Tsuda, J., Kato, T., Okamoto, K., Yanase, H., & Tanaka, M. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.21.6822-6827.1999 · Cited by 47
“A molecular mass of 11,455 Da is in good agreement with the predicted sizes of other C proteins, which associate with several type II R-M systems and regulate the expression of R-M genes (1, 37).”
Background
Genetic Dissection of the Francisella novicida Restriction Barrier
Gallagher, L. A., McKevitt, M. T., Ramage, E. R., & Manoil, C. (2008) · Journal of Bacteriology · doi:10.1128/jb.01188-08 · Cited by 46
“Incoming DNA is cleaved (restricted) if it has not been modified by methylation at specific sequences (24, 35).”
Background
Adaptative Potential of the Lactococcus Lactis IL594 Strain Encoded in Its 7 Plasmids
Górecki, R. K., Koryszewska-Bagińska, A., Gołębiewski, M., Żylińska, J., Grynberg, M., & Bardowski, J. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022238 · Cited by 47
“The last gene of this transcription unit encodes HsdS, the specifity subunit of a type I restriction modification system [45].”
Population and genomic analysis of the genus Halorubrum
Fullmer, M. S., Soucy, S. M., Swithers, K. S., Makkay, A. M., Wheeler, R., Ventosa, A., Gogarten, J. P., & Papke, R. T. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00140 · Cited by 46
“This record serves the organism by recognizing and destroying sequences that resemble previously encountered MGEs.”
BackgroundInfluential
DNA Base Flipping: A General Mechanism for Writing, Reading, and Erasing DNA Modifications
Hong, S., & Cheng, X. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-43624-1_14 · Cited by 46
“…Flipping in the Recognition of Modified Bases 4.1 Eukaryotic SRA Domains The function of 5mC and N6mA in prokaryotes was classically understood in the context of restriction-modification systems, in which methylated bacterial DNA is protected from restriction digestion (Wilson and Murray 1991).”
BackgroundInfluential
Comparative Genomics of the Listeria monocytogenes ST204 Subgroup
Fox, E. M., Allnutt, T. R., Bradbury, M. I., Fanning, S., & Chandry, P. S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02057 · Cited by 46
“These systems can target foreign invading DNA with restriction endonucleases, and associated methyltransferases protect host DNA from restriction (Wilson and Murray, 1991; Murphy et al., 2013).”
Background
An Asymmetric Complex of Restriction Endonuclease MspI on Its Palindromic DNA Recognition Site
Xu, Q., Kucera, R. B., Roberts, R. J., & Guo, H. (2004) · Structure · doi:10.1016/j.str.2004.07.014 · Cited by 46
“MspI displays no significant sequence homology to other REases, withfrom invading foreign DNA (Wilson and Murray, 1991; Bickle and Kruger, 1993).”
Background
DNA Cleavage by the Type IC Restriction-Modification EnzymeEcoR124II
Dreier, J., MacWilliams, M. P., & Bickle, T. A. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0672 · Cited by 46
“The cofactors required for these reactions are S-adenosylmethionine (AdoMet) for methylation, and Mg2+, AdoMet and ATP for restriction (reviewed by Bickle, 1993; Bickle & Kru ¨ ger, 1993; Wilson & Murray, 1991 ).”
Background
Cloning and sequencing of genes encoding the TthHB8I restriction and modification enzymes: comparison with the isoschizomeric TaqI enzymes
Barany, F., Danzitz, M. J., Zebala, J. A., & Mayer, A. N. (1992) · Gene · doi:10.1016/0378-1119(92)90296-2 · Cited by 46

Authors: Wilson, G. G., & Murray, N. E.
Affiliations: New England Biolabs (United States) (US)
Venue: Annual Review of Genetics
Publisher: Annual Reviews
Published: 1991-12
Volume: 25
Issue: 1
Pages: 585-627
ISSN: 0066-4197 (ISSN-L)
1545-2948
DOI: 10.1146/annurev.ge.25.120191.003101
OpenAlex: W2179631201
Cited by: 714
References: 94
Citations by year: 2026: 11 · 2025: 13 · 2024: 14 · 2023: 22 · 2022: 15 · 2021: 13 · 2020: 18 · 2019: 20 · 2018: 18 · 2017: 14 · 2016: 22 · 2015: 18 · 2014: 30 · 2013: 22 · 2012: 33
FWCI: 9.78
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
Keywords: restriction-modification systems, restriction enzymes, DNA methylation, DNA methyltransferases, bacterial defense against foreign DNA, gene duplication, homologous genes, orthology, paralogy
MeSH terms: Cloning, Molecular, DNA, Bacterial, DNA, Viral, Genes, Bacterial, Methylation, Terminology as Topic, Substrate Specificity, DNA Restriction-Modification Enzymes, Gene Expression Regulation, Bacterial

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