Cited by 714Genomics and Phylogenetic StudiesChromosomal and Genetic VariationsGenome Rearrangement Algorithms

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RESTRICTION AND MODIFICATION SYSTEMS

Wilson, Geoffrey G., Murray, Noreen E.·1991·Annual Review of Genetics

DOI 10.1146/annurev.ge.25.120191.003101

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Abstract

Orthologs and paralogs are two fundamentally different types of homologous genes that evolved, respectively, by vertical descent from a single ancestral gene and by duplication. Orthology and paralogy are key concepts of evolutionary genomics. A ...Read More

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Background
Transgenerational Epigenetic Inheritance Under Environmental Stress by Genome-Wide DNA Methylation Profiling in Cyanobacterium
Hu, L., Xiao, P., Jiang, Y., Dong, M., Chen, Z., Li, H., Hu, Z., Lei, A., & Wang, J. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01479 · Cited by 33
Molecular Phylogenetics of Restriction Endonucleases
Bujnicki, J. M. (2004) · Nucleic acids and molecular biology · doi:10.1007/978-3-642-18851-0_3 · Cited by 33
Cloning and analysis of the four genes coding for Bpu10I restriction- modification enzymes
Stankevicius, K. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.4.1084 · Cited by 33
Identification of the Active Oligomeric State of an Essential Adenine DNA Methyltransferase from Caulobacter crescentus
Shier, V. K., Hancey, C. J., & Benkovic, S. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010688200 · Cited by 33
Asp34 of Pvu II endonuclease is directly involved in DNA minor groove recognition and indirectly involved in catalysis 1 1Edited by R. Ebright
Horton, J. R., Nastri, H. G., Riggs, P. D., & Cheng, X. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2269 · Cited by 33
A widespread phage-encoded kinase enables evasion of multiple host antiphage defence systems
Jiang, S., Chen, C., Huang, W., He, Y., Du, X., Wang, Y., Ou, H., Deng, Z., Xu, C., Jiang, L., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01851-2 · Cited by 32
Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
Guo, X., Söderholm, A., Sandesh Kanchugal, P., Isaksen, G. V., Warsi, O., Eckhard, U., Trigüis, S., Gogoll, A., Jerlström-Hultqvist, J., Åqvist, J., et al. (2021) · eLife · doi:10.7554/elife.61818 · Cited by 32
Decoding the microbiome: advances in genetic manipulation for gut bacteria
Chen, Z., Jin, W., Hoover, A., Chao, Y., & Ma, Y. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.05.007 · Cited by 31
Structure of HinP1I endonuclease reveals a striking similarity to the monomeric restriction enzyme MspI
Yang, Z. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki337 · Cited by 32
“Their principal biological function is to protect the host genome against invading foreign DNA (1).”
Background
Functional Analysis of the M.HpyAIV DNA Methyltransferase of Helicobacter pylori
Skoglund, A., Björkholm, B., Nilsson, C., Andersson, A. F., Jernberg, C., Schirwitz, K., Enroth, C., Krabbe, M., & Engstrand, L. G. (2007) · Journal of Bacteriology · doi:10.1128/jb.00108-07 · Cited by 32
“The modification event requires a methyltransferase (MTase) that transfers a methyl group to a specifically recognized DNA sequence and thereby protects this site from digestion by a corresponding restriction endonuclease (REase) (45, 46).”
Background
Multiplication of a restriction–modification gene complex
Sadykov, M. R., Asami, Y., Niki, H., Handa, N., Itaya, M., Tanokura, M., & Kobayashi, I. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03464.x · Cited by 32
“RM gene complexes have a compact gene organization reminiscent of viruses and transposons (Wilson and Murray, 1991).”
Background
Specificity in Protein–DNA Interactions: Energetic Recognition by the (Cytosine-C5)-methyltransferase from HhaI
Huang, N., & MacKerell, A. D. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.10.042 · Cited by 32
Simultaneous DNA Binding, Bending, and Base Flipping
Hopkins, B. B., & Reich, N. O. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404573200 · Cited by 32
Reactions of BglI and Other Type II Restriction Endonucleases with Discontinuous Recognition Sites
Gormley, N. A., Bath, A. J., & Halford, S. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.6928 · Cited by 32
Evidence for Horizontal Transfer of the Eco T38I Restriction- Modification Gene to Chromosomal DNA by the P2 Phage and Diversity of Defective P2 Prophages in Escherichia coli TH38 Strains
Kita, K., Kawakami, H., & Tanaka, H. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.7.2296-2305.2003 · Cited by 31
MethylViewer: computational analysis and editing for bisulfite sequencing and methyltransferase accessibility protocol for individual templates (MAPit) projects
Pardo, C. E., Carr, I., Hoffman, C. J., Darst, R. P., Markham, A. F., Bonthron, D. T., & Kladde, M. P. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq716 · Cited by 31
“These modifications protect against degradation by cognate restriction endonucleases (6).”
Background
Generation of new DNA binding specificity by truncation of the type IC EcoDXXI hsdS gene.
MacWilliams, M. P., & Bickle, T. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00855.x · Cited by 31
Restriction Endonucleases that Bridge and Excise Two Recognition Sites from DNA
Marshall, J. J. T., Gowers, D. M., & Halford, S. E. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.12.070 · Cited by 30
Bisulfite Sequencing Protocol Displays both 5-Methylcytosine and N4-Methylcytosine
Vilkaitis, G., & Klimašauskas, S. (1999) · Analytical Biochemistry · doi:10.1006/abio.1999.4116 · Cited by 30
qDNAmod: a statistical model-based tool to reveal intercellular heterogeneity of DNA modification from SMRT sequencing data
Feng, Z., Li, J., Zhang, J.-R., & Zhang, X. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1097 · Cited by 30
“Both of the proteins encoded by the R gene and the M gene need to form a complex with the protein encoded by the S gene to be functional (38).”
Background
Identification of a new subfamily of HNH nucleases and experimental characterization of a representative member, HphI restriction endonuclease
Cymerman, I. A., Obarska-Kosińska, A., Skowronek, K. J., Lubys, A., & Bujnicki, J. M. (2006) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.21156 · Cited by 30
“enzymes that exhibit identical recognition and cleavage specificities.(8,9) This dissimilarity precluded evolutionary classification and hampered identification of functionally important residues.”
Background
The First High-Resolution DNA “Methylome”
Schöb, H., & Grossniklaus, U. (2006) · Cell · doi:10.1016/j.cell.2006.09.002 · Cited by 30
“In prokaryotes, DNA methylation is part of a system of defense against bacteriophages and occurs at both cytosine and adenine residues (Wilson and Murray, 1991).”
Background
Control of expression of LlaI restriction in Lactococcus lactis
O’Sullivan, D. J., & Klaenhammer, T. R. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00748.x · Cited by 30
“It is postulated that positioning the methylase gene before the restriction gene may allow sufficient expression of methylation before restriction (Wilson and Murray, 1991).”
Background
A prediction of the amino acids and structures involved in DNA recognition by type I DNA restriction and modification enzymes.
Sturrock, S., & Dryden, D. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3408 · Cited by 37
Enzymatic approaches for profiling cytosine methylation and hydroxymethylation
Wang, T., Loo, C. E., & Kohli, R. M. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101314 · Cited by 29
Phase-variable restriction/modification systems are required for Helicobacter pylori colonization
Gauntlett, J. C., Nilsson, H., Fulurija, A., Marshall, B. J., & Benghezal, M. (2014) · Gut Pathogens · doi:10.1186/s13099-014-0035-z · Cited by 29
“DNA at specific recognition sequences and the mod component methylates the same sequence to prevent restriction [3].”
Background
Purification of the Novel Endonuclease, Hpy188I, and Cloning of Its Restriction-Modification Genes Reveal Evidence of Its Horizontal Transfer to the Helicobacter pylori Genome
Xu, Q. S., Stickel, S. K., Roberts, R. J., Blaser, M. J., & Morgan, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910303199 · Cited by 29
Molecular characterization of the restriction endonuclease gene (scrFIR) associated with the ScrFI restriction/modification system from Lactococcus lactis subsp. cremoris UC503
Twomey, D. P., Gabillet, N., Daly, C., & Fitzgerald, G. F. (1997) · Microbiology · doi:10.1099/00221287-143-7-2277 · Cited by 29
“…and MTase activities in type I1 systems are invariably relatively close to each other, with intervening distances between the respective genes rarely greater than 0.7 kb (Wilson & Murray, 1991), the ORF between the two ScrFI MTase genes was investigated to determine if it encoded the ScrFI ENase.”
Influential
DNA Virus Contribution to Host Evolution
Villarreal, L. P. (1999) · Elsevier eBooks · doi:10.1016/b978-012220360-2/50016-7 · Cited by 29

Authors: Wilson, G. G., & Murray, N. E.
Affiliations: New England Biolabs (United States) (US)
Venue: Annual Review of Genetics
Publisher: Annual Reviews
Published: 1991-12
Volume: 25
Issue: 1
Pages: 585-627
ISSN: 0066-4197 (ISSN-L)
1545-2948
DOI: 10.1146/annurev.ge.25.120191.003101
OpenAlex: W2179631201
Cited by: 714
References: 94
Citations by year: 2026: 11 · 2025: 13 · 2024: 14 · 2023: 22 · 2022: 15 · 2021: 13 · 2020: 18 · 2019: 20 · 2018: 18 · 2017: 14 · 2016: 22 · 2015: 18 · 2014: 30 · 2013: 22 · 2012: 33
FWCI: 9.78
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
Keywords: restriction-modification systems, restriction enzymes, DNA methylation, DNA methyltransferases, bacterial defense against foreign DNA, gene duplication, homologous genes, orthology, paralogy
MeSH terms: Cloning, Molecular, DNA, Bacterial, DNA, Viral, Genes, Bacterial, Methylation, Terminology as Topic, Substrate Specificity, DNA Restriction-Modification Enzymes, Gene Expression Regulation, Bacterial

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