The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
RESTRICTION AND MODIFICATION SYSTEMS
Abstract
Orthologs and paralogs are two fundamentally different types of homologous genes that evolved, respectively, by vertical descent from a single ancestral gene and by duplication. Orthology and paralogy are key concepts of evolutionary genomics. A ...Read More
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The RM system, an important immune system for bacteria that prevents the uptake of exogenous DNA, is largely variable in terms of copy number and constitution.45 , 46”
From Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity (2016) · cites this paper as [46]
Citations
Cites
DNA Restriction Enzyme from E. coli
Meselson, M. S., & Yuan, R. T. (1968) · Nature · doi:10.1038/2171110a0 · Cited by 819
Group I introns as mobile genetic elements: Facts and mechanistic speculations — a review
Dujon, B. (1989) · Gene · doi:10.1016/0378-1119(89)90034-6 · Cited by 478
Restriction Endonucleases in the Analysis and Restructuring of DNA Molecules
Nathans, D., & Smith, H. O. (1975) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.44.070175.001421 · Cited by 467
Substrate and sequence specificity of a eukaryotic DNA methylase
Gruenbaum, Y., Cedar, H., & Razin, A. (1982) · Nature · doi:10.1038/295620a0 · Cited by 436
DNA Nucleotide Sequence Restricted by the RI Endonuclease
Hedgpeth, J., Goodman, H. M., & Boyer, H. W. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.11.3448 · Cited by 363
McrA and McrB restriction phenotypes of someE.colistrains and implications for gene cloning
Raleigh, E. A., Murray, N. E., Revel, H. R. B., Blumenthal, R., Westaway, D. A., Reith, A. D., Rigby, P. W. J., Elhai, J., & Hanahan, D. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.4.1563 · Cited by 342
Self-citationDNA Restriction and Modification Mechanisms in Bacteria
Boyer, H. W. (1971) · Annual Review of Microbiology · doi:10.1146/annurev.mi.25.100171.001101 · Cited by 330
Restriction and Modification of DNA
Meselson, M. S., Yuan, R., & Heywood, J. (1972) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.41.070172.002311 · Cited by 290
The construction in vitro of transducing derivatives of phage lambda
Borck, J. (1976) · Medical Entomology and Zoology · Cited by 259
The great GATC: DNA methylation in E. coli
Barras, F., & Marinus, M. G. (1989) · Trends in Genetics · doi:10.1016/0168-9525(89)90054-1 · Cited by 209
Cited by
Sorted by citations
Items 701–713 of 713
Semary, N. A. H. E., Fadiel, A., Eichenbaum, K. D., & Alhusayni, S. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48010105
“M) systems, acting as prokaryotic immune mechanisms that protect host genomes from foreign DNA through precise self/non-self-discrimination [28].”
It’s not me, it’s you: Anti-phage nuclease specificity inside a bacterium
Hong, A., & Bondy‐Denomy, J. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1013959
Cornuault, J. K. (2018) · theses.fr (ABES) · doi:10.70675/55d00c01zb915z43d1z8f0bzeead74fa3383
Carvalho, A. F. P. (2021) · theses.fr (ABES) · doi:10.70675/c6b25a92z329cz4e32za110z1b3dadd1a6a0
Single Phage and Cocktail Therapy
(2026) · Royal Society of Chemistry eBooks · doi:10.1039/9781837072026-00105
Evolutionary dynamics and functional divergence of DNA methyltransferase in Poaceae
Hai, J.-H., Lei, J.-Q., Han, Q., Feng, Y., Yu, H., & Li, L. (2026) · Journal of Systematics and Evolution · doi:10.1111/jse.70082
Hitzeschock knackt Restriktionsbarriere
Schulze, L., & Stahl, J. (2026) · BIOspektrum · doi:10.1007/s12268-026-2765-0
Restriction Endonucleases: Basics and Applications
Nasir, B., Haq, I. U., & Ali, H. (2026) · Springer eBooks · doi:10.1007/978-981-92-2642-9_2
The Single‐Stranded DNA Platform: A Potential Broad‐Spectrum Vector for Editing Genes in Prokaryotes
Wang, H., Wang, Y., Chang, D., Fang, J., Zheng, Z., Wang, X., Yang, H., & Liu, Z. (2026) · BioEssays · doi:10.1002/bies.70172
“While corresponding methyltransferase (MTase) methylates identical sites within bacteria’s own DNA during replication, enabling REase to distinguish between “self” and “non-self” DNA [82].”
Ndlazi, F. P., Geza, E., & Madoroba, E. (2026) · Microorganisms · doi:10.3390/microorganisms14092003
“BsuMI; Table 6), a component of a restriction–modification system that protects endogenous DNA from cleavage and defends against bacteriophage predation [133,134].”
Kupplung der DNA-Methyltransferase M.SssI mit Triplehelix-bildenden Oligodesoxynucleotiden
Monami, A., & Weinhold, E. G. (2007) · RWTH Publications (RWTH Aachen)
Metadata
- Authors
- Wilson, G. G., & Murray, N. E.
- Affiliations
- New England Biolabs (United States) (US)
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 1991-12
- Volume
- 25
- Issue
- 1
- Pages
- 585-627
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2179631201
- Cited by
- 714
- References
- 94
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 14 · 2023: 22 · 2022: 15 · 2021: 13 · 2020: 18 · 2019: 20 · 2018: 18 · 2017: 14 · 2016: 22 · 2015: 18 · 2014: 30 · 2013: 22 · 2012: 33
- FWCI
- 9.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
- Keywords
- restriction-modification systems, restriction enzymes, DNA methylation, DNA methyltransferases, bacterial defense against foreign DNA, gene duplication, homologous genes, orthology, paralogy
- MeSH terms
- Cloning, Molecular, DNA, Bacterial, DNA, Viral, Genes, Bacterial, Methylation, Terminology as Topic, Substrate Specificity, DNA Restriction-Modification Enzymes, Gene Expression Regulation, Bacterial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
