The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Messenger RNA Stability and Its Role in Control of Gene Expression in Bacteria and Phages
Abstract
▪ Abstract The stability of mRNA in prokaryotes depends on multiple factors and it has not yet been possible to describe the process of mRNA degradation in terms of a unique pathway. However, important advances have been made in the past 10 years with the characterization of the cis-acting RNA elements and the trans-acting cellular proteins that control mRNA decay. The trans-acting proteins are mainly four nucleases, two endo- (RNase E and RNase III) and two exonucleases (PNPase and RNase II), and poly(A) polymerase. RNase E and PNPase are found in a multienzyme complex called the degradosome. In addition to the host nucleases, phage T4 encodes a specific endonuclease called RegB. The cis-acting elements that protect mRNA from degradation are stable stem-loops at the 5′ end of the transcript and terminators or REP sequences at their 3′ end. The rate-limiting step in mRNA decay is usually an initial endonucleolytic cleavage that often occurs at the 5′ extremity. This initial step is followed by directional 3′ to 5′ degradation by the two exonucleases. Several examples, reviewed here, indicate that mRNA degradation is an important step at which gene expression can be controlled. This regulation can be either global, as in the case of growth rate–dependent control, or specific, in response to changes in the environmental conditions.
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Cites
Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd
Fleischmann, R. D., Adams, M. D., White, O., Clayton, R. A., Kirkness, E. F., Kerlavage, A. R., Bult, C. J., Tomb, J.-F., Dougherty, B. A., Merrick, J. M., et al. (1995) · Science · doi:10.1126/science.7542800 · Cited by 5,654
The complete genome sequence of the gram-positive bacterium Bacillus subtilis.
Kunst, F., Ogasawara, N., Moszer, I., Albertini, A. M., Alloni, G., Azevedo, V., Bertero, M. G., Bessières, P., Bolotin, A., Borchert, S., et al. (1997) · Nature · doi:10.1038/36786 · Cited by 3,679
Modulation of Chemical Composition and Other Parameters of the Cell by Growth Rate
Bremer, H. J. (1999) · Cited by 915
A DEAD-box RNA helicase in the Escherichia coli RNA degradosome
Py, B., Higgins, C. F., Krisch, H. M., & Carpousis, A. J. (1996) · Nature · doi:10.1038/381169a0 · Cited by 553
Carpousis, A. J., Van Houwe, G., Ehretsmann, C., & Krisch, H. M. (1994) · Cell · doi:10.1016/0092-8674(94)90363-8 · Cited by 433
Donovan, W. P., & Kushner, S. R. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.1.120 · Cited by 430
Ribonuclease E is a 5′-end-dependent endonuclease
Mackie, G. A. (1998) · Nature · doi:10.1038/27246 · Cited by 418
Bycroft, M., Hubbard, T. J. P., Proctor, M., Freund, S. M. V., & Murzin, A. G. (1997) · Cell · doi:10.1016/s0092-8674(00)81844-9 · Cited by 407
A 5'-terminal stem-loop structure can stabilize mRNA in Escherichia coli.
Emory, S. A., Bouvet, P., & Belasco, J. G. (1992) · Genes & Development · doi:10.1101/gad.6.1.135 · Cited by 312
Ribonuclease E organizes the protein interactions in the Escherichia coli RNA degradosome
Vanzo, N. F., Li, Y. S., Py, B., Blum, E., Higgins, C. F., Raynal, L. C., Krisch, H. M., & Carpousis, A. J. (1998) · Genes & Development · doi:10.1101/gad.12.17.2770 · Cited by 299
Cited by
Smith, C. J., & Osborn, A. M. (2009) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2008.00629.x · Cited by 937
Mehta, T., Coppi, M. V., Childers, S. E., & Lovley, D. R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8634-8641.2005 · Cited by 494
The RNA Degradosome of Escherichia coli: An mRNA-Degrading Machine Assembled on RNase E
Carpousis, A. J. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093440 · Cited by 445
Strategies to Optimize Protein Expression in E. coli
Francis, D. M., & Page, R. (2010) · Current Protocols in Protein Science · doi:10.1002/0471140864.ps0524s61 · Cited by 272
PNPASE and RNA trafficking into mitochondria
Wang, G., Shimada, E., Koehler, C. M., & Teitell, M. A. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.10.001 · Cited by 84
“PNPASE degrades RNA by phosphorolysis and can also function as a template independent polymerase [17-23].”
Background
Metadata
- Authors
- Grunberg-Manago, M.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 1999-12
- Volume
- 33
- Issue
- 1
- Pages
- 193-227
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2133286749
- Cited by
- 285
- References
- 104
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Grunberg-Manago, M. (1999). Messenger RNA Stability and Its Role in Control of Gene Expression in Bacteria and Phages. Annual Review of Genetics. https://doi.org/10.1146/annurev.genet.33.1.193
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