The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Genetics of Aging in the Fruit Fly,Drosophila melanogaster
Abstract
▪ Abstract Research into the mechanisms underlying the process of aging is emerging as an exciting area of biomedical research. Observations challenging the fundamental assumptions of aging have begun to rejuvenate the field, opening up aging research to fresh ideas and approaches. Genetic approaches, which have been successfully used to understand other complex biological phenomena, are beginning to reveal important patterns and conservations between the processes of aging in a variety of species including yeast, nematodes, flies, and mice. A combination of candidate and random gene alteration approaches, particularly in the fruitfly model system, Drosophila melanogaster, should prove to be especially valuable for elucidating the primary physiological systems involved in aging and life span determination.
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“Genes that regulate lifespan in animal models6–9 and human studies10–14 as well as multiple experimental paradigms, such as caloric restriction, heterochronic parabiosis and partial epigenetic reprogramming, have demonstrated that it is possible to manipulate ageing biology to ‘rejuvenate’ physiological functioning in complex model organisms15–28.”
From Measuring biological age using omics data (2022) · cites this paper as [7]
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Metadata
- Authors
- Helfand, S. L., & Rogina, B.
- Affiliations
- UConn Health (US)
- ORCID
- Rogina, Blanka
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2003-12
- Volume
- 37
- Issue
- 1
- Pages
- 329-348
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2165469555
- Cited by
- 152
- References
- 100
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 12 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 7
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r03es011463-02, 1r03ag014532-01)
- National Institute on Aging (AG14532, R03AG020816, R37AG016667, AG20816)
- National Institute of Environmental Health Sciences (ES11463)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- aging, Drosophila melanogaster, candidate gene approach, random mutagenesis
- MeSH terms
- Aging, Animals, Antioxidants, Chromatin, Drosophila melanogaster
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